Flavonoid-Based Cancer Therapy: An Updated Review.

abstract：:As chemotherapy with temozolomide is far from providing satisfactory clinical outcomes for patients with glioblastoma, more efficient drugs and drug combinations are urgently needed. The anti-malarial artesunate was previously shown to exert a profound cytotoxic effect on various tumor cell lines including those deriv...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karpel-Massler G,Westhoff MA,Kast RE,Dwucet A,Nonnenmacher L,Wirtz CR,Debatin KM,Halatsch ME

更新日期：2014-02-01 00:00:00

abstract：:Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activity was induction of apoptosis. An in vitro hollow fiber mode...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Larsson DE,Hassan SB,Oberg K,Granberg D

更新日期：2012-09-01 00:00:00

abstract：:Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiolo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Delgado A,Fabrias G,Bedia C,Casas J,Abad JL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) wo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ergun S,Güney S,Temiz E,Petrovic N,Gunes S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. METHODS:New hydrazone ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ünver H,Berber B,Demirel R,Koparal AT

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia (CML), also recognized as chronic myelogenous leukemia, is initiated in some types of blood-forming cells of the bone marrow. The therapeutic approach to CML is usually chemotherapy; however, severe side effects and complications are major problems in the clinical research. Thus, rec...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tavakolfar S,Mousavi E,Almasirad A,Amanzadeh A,Atyabi SM,Yaghamii P,Samiee-Sadr S,Salimi M

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Inflammation is a vital reaction of the natural immune system that protects against encroaching agents. However, uncontrolled inflammation can lead to complications. Trigonella foenum-graecum is traditionally used as an anti-inflammatory herb. OBJECTIVES:The current study was conducted to explore the anti...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Asif M,Yousaf HM,Saleem M,Saadullah M,Chohan TA,Shamas MU,Yaseen HS,Mahrukh,Yousaf MU,Yaseen M

更新日期：2020-10-04 00:00:00

abstract：:In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Adhikari S,Choudhury S,Mitra PS,Dubash JJ,Sajankila SP,Roy R

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The development of cancer stem-like cells (CSCs) is one of the main causes of ovarian cancer tolerance to radiotherapy. Autophagy is an adaptive process by which cells repair damage due to radiation. As a metabolite of riboflavin, lumiflavin can enhance the chemotherapeutic effects of cisplatin on ovarian ca...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Wu M,Huang Y,Song Z,Yang R

更新日期：2021-01-04 00:00:00

abstract：:The success of anticancer therapy is limited due to the resistance caused by tumor cells to cytotoxic agents, which interfere with the effectiveness of various chemotherapeutic agents. Several mechanisms for decreased effectiveness of anti-cancer drugs have been examined however the most widely studied mechanism is th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kumar R,Kaur M,Silakari O

更新日期：2014-06-01 00:00:00

abstract：:Polyphenol-protein interaction (PPI) is reversible in that polyphenol-protein complex can be dissociated and release the free polyphenols. The aim of this study is to evaluate the contribution of polyphenol-protein interaction on improving the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging capacity of polyphe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cao H,Chen X,Yamamoto K

更新日期：2012-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are emerging as important regulators in various pathobiological processes in cancer. Genistein, as a major isoflavonoid isolated from dietary soybean, possesses a wide variety of biological activities particularly in cancer prevention. However, the molecular mechanisms by which genistein elicits its...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xu L,Xiang J,Shen J,Zou X,Zhai S,Yin Y,Li P,Wang X,Sun Q

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD:To explore a new therapeutic candid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Souza RP,Bonfim-Mendonça PS,Damke GMZF,de-Assis Carvalho ARB,Ratti BA,Dembogurski DSO,da-Silva VRS,Silva SO,Da-Silva DB,Bruschi ML,Maria-Engler SS,Consolaro MEL

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The present study was carried out to evaluate the anticancer property of an alkylamino phenol derivative -2-((3,4-Dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol) (THTMP) against human breast cancer cells. The cytotoxicity of the THTMP was assessed to know its specificity towards breast cancer ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Palanivel S,Yli-Harja O,Kandhavelu M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its prevalence in compounds possessing a wide range of pharmacological properties including anticancer/antitumor activities. Though a number of methods have been reported for the synthesis of this class of compounds, some ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Prasad MG,Lakshmi CV,Katari NK,Pal M

更新日期：2020-01-01 00:00:00

abstract：:In the early 1960s, inorganic pyrophosphate (PPi) was found to be present in body fluids and to act as a natural inhibitor of calcification by its interaction with hydroxyapatite. In addition to inhibiting the formation of calcium phosphate, PPi also inhibited dissolution of hydroxyapatite crystals, which made it inte...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Widler L,Jahnke W,Green JR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Curcumin is a natural hydrophobic product showing anticancer activity. Many studies show its potential use in the field of cancer treatment due to its safety and efficiency. However, its application is limited due to its low water-solubility and poor selective delivery to cancer. OBJECTIVE:A Y-shaped folic ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng R,Zhu W,Chu W,Teng F,Meng N,Deng P,Song Z

更新日期：2017-01-01 00:00:00

abstract：:Breast cancer is the heterogeneous disease and leading cause of death in women, worldwide. It is generally caused by the perturbation of various signaling pathways responsible for cell apoptosis. Due to genetic variability, different signaling pathways are disrupted in different breast cancer patients; so, to overcome...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Thakur RS,Ahirwar B

更新日期：2017-01-01 00:00:00

abstract：:The discovery of cis-platin and its second and third generation analogues created a hope in cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been used for the treatment of some cancers from a long time. The third generation analogues have superior anti-cancer profiles for curing a fe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ali I,Wani WA,Saleem K,Haque A

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：:Integration of geriatric assessment into cancer clinical practice is strongly needed in squamous cell carcinoma of the head and neck (SCCHN) due to the frequent discrepancy between chronologic and biologic age. Comprehensive Geriatric Assessment (CGA) is a multidimensional assessment tool that examines age-related dom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Perri F,Ionna F,Pavone E,Longo F,Caponigro F

更新日期：2013-11-01 00:00:00

abstract：:Classical chemotherapeutic agents such as mitotic inhibitors (spindle poisons), alkylating agents, antimetabolites, topoisomerase inhibitors, and anthracenediones (anthracyclines) inhibit DNA synthesis and mitosis, thereby killing or impeding the proliferation of rapidly dividing cells. During the last decade, targete...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kontos CK,Christodoulou MI,Scorilas A

更新日期：2014-03-01 00:00:00

abstract：:A series of novel thiohydantoin derivatives were synthesized and evaluated for the abilities of inhibiting cell proliferation and prostate specific antigen (PSA) expression in prostate cancer cells. These derivatives selectively inhibited proliferation of AR positive LNCaP cells and PSA expression except compounds 5i ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Liu J,Liu B,Jing Y,Zhao G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis is physiological process in embryogenesis, organ development, endometrial vasculature in menstrual cycle and wound healing. Angiogenesis has also been associated with several pathological conditions such as cancer, arthritis, atherosclerosis, etc. Out of the many growth factor responsible for an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Bhanushali U,Kalekar-Joshi S,Kulkarni-Munshi R,Yellanki S,Medishetty R,Kulkarni P,Chelakara RS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Tankyrases are known for their multifunctionalities within the poly(ADPribose) polymerases family and playing vital roles in various cellular processes which include the regulation of tumour suppressors. Tankyrases, which exist in two isoforms; Tankyrase 1 and 2, are highly homologous and an integral part of...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Peters XQ,Malinga TH,Agoni C,Olotu FA,Soliman MES

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Gemin D (GD) is an ellagitannin found in several plant species rich in phenolic compounds. Its many beneficial properties include antioxidant and antitumoral. OBJECTIVE:The present study assessed the genotoxicity, cytotoxicity, antigenotoxicity, and anticytotoxicity of GD by in vitro and in vivo assays. ME...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carneiro CC,de Moraes-Filho AV,Fernandes AS,da Costa Santos S,de Melo E Silva D,Chen LC

更新日期：2017-01-01 00:00:00

abstract：:Protein kinase B (PKB or Akt) is a central component of the PI3K - PKB - mTOR signalling cascade and is firmly established as an attractive target for pharmacological intervention in cancer. A number of small molecule inhibitors with well-defined, direct molecular interactions with PKB are now known, covering a range ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Collins I

更新日期：2009-01-01 00:00:00

abstract：:The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality. The disclosure of their chemical structure similar to that of hydroxy methyl glutaryl-CoA (HMG-CoA) revealed their ability to compet...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Garcia-Ruiz C,Morales A,Fernandez-Checa JC

更新日期：2012-05-01 00:00:00

abstract：:The respiratory epithelium expresses the cholinergic system including nicotinic receptors (nAChRs). It was reported that normal human bronchial epithelial cells (BEC), which are the precursor for squamous cell carcinomas, and small airway epithelial cells (SAEC), which are the precursor for adenocarcinomas, have sligh...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Grozio A,Catassi A,Cavalieri Z,Paleari L,Cesario A,Russo P

更新日期：2007-07-01 00:00:00