Therapeutic targeting of malignant glioma.

abstract：:Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for treatment of glioblastomas and in phase II for several other tumors. This drug is the first anti-angiogenic small molecule targeting the integrins αvβ3, αvβ5 and αvβ1. It was developed by us in the early 90s by a novel procedure, the spatia...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mas-Moruno C,Rechenmacher F,Kessler H

更新日期：2010-12-01 00:00:00

abstract：AIM:The aim of this study is to explore the therapeutic potential of S-allylcysteine (SAC) organosulphur compound as potent immune checkpoint inhibitor PD-L1. BACKGROUND:Natural compounds have been showing tremendous anticancerous potential via suppressing the expression of genes involved in development and progressio...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Khan F,Pandey P,Mishra R,Arif M,Kumar A,Jafri A,Mazumder R

更新日期：2020-07-28 00:00:00

abstract：:The evasion of cancer cells from the induction of cell death pathways results in the resistance of tumor to current treatment modalities. Therefore, the resistance to cell death, one of the hallmarks of cancer, is a major target in the development of new approaches to selectively affect cancer cells. The complex inter...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hartman ML,Czyz M

更新日期：2012-10-01 00:00:00

abstract：:Common therapy of cancer such as chemotherapy have various side effects for the patients. In recent studies, new therapeutic approaches in cancer treatment are adjuvant therapy, along with a reduction in side effects of chemotherapy drugs. Treatment by herbal medicines may have some advantages over treatment with sing...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tajaldini M,Asadi J

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies showed that compounds combining adamantane and monoterpenoid fragments are active against TDP1 enzyme. This investigation is focused on th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mozhaitsev ES,Zakharenko AL,Suslov EV,Korchagina DV,Zakharova OD,Vasil'eva IA,Chepanova AA,Black E,Patel J,Chand R,Reynisson J,Leung IKH,Volcho KP,Salakhutdinov NF,Lavrik OI

更新日期：2019-01-01 00:00:00

abstract：:A series of novel thiohydantoin derivatives were synthesized and evaluated for the abilities of inhibiting cell proliferation and prostate specific antigen (PSA) expression in prostate cancer cells. These derivatives selectively inhibited proliferation of AR positive LNCaP cells and PSA expression except compounds 5i ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Liu J,Liu B,Jing Y,Zhao G

更新日期：2016-01-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare but typically aggressive malignancy. Radical surgery remains the potentially curative option. However, about one third of patients initially present with distant metastases. Regarding to chemotherapy, mitotane alone or in combination with cytotoxic drugs should be the first sel...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xu YZ,Zhu Y

更新日期：2013-02-01 00:00:00

abstract：:Phospholipase A2 (PLA2), Cyclooxygenase (COX) and 5-Lipoxygenase (5-LOX) are arachidonic acid metabolizing enzymes and their inhibitors have been developed as therapeutic molecules for cancer and inflammation related disorders. In the present study, PLA2, COX 1&2 and 5-LOX inhibitory studies of Borassus flabellifer se...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Yarla NS,Azad R,Basha M,Rajack A,Kaladhar DS,Allam BK,Pragada RR,Singh KN,K SK,Pallu R,Parimi U,Bishayee A,Duddukuri GR

更新日期：2015-01-01 00:00:00

abstract：:A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1 (HSF1) and related heat shock proteins, along with the consequential inhibition of androgen receptor (AR) expression and transactivation, arresting the cell cycle i...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Y,Wang M,Beraldi E,Cong M,Zoubeidi A,Gleave M,Peng L

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Araucaria angustifolia extract (AAE) is a polyphenol-rich extract that has gained interest as a natural anticancer agent. Recent work suggests that AAE induces oxidative damage and apoptosis through its action on decreasing complex I activity of the mitochondrial Electron Transport Chain (ETC). AIMS AND MET...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Branco CS,Duong A,Machado AK,Scola G,Andreazza AC,Salvador M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Despite a number of measures having been taken for cancer management, it is still the second leading cause of death worldwide. p53 is the protein principally being targeted for cancer treatment. Targeting p53 localization may be an effective strategy in chemotherapy as it controls major cell death pathways b...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kamil M,Haque E,Mir SS,Irfan S,Hasan A,Sheikh S,Alam S,Ansari KM,Nazir A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. OBJECTIVE:The present study ai...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rizzk YW,El-Deen IM,Mohammed FZ,Abdelhamid MS,Khedr AIM

更新日期：2019-01-01 00:00:00

abstract：:A majority of breast cancers (BC) display characteristics of epithelial cells and express estrogen receptors and/or HER-2 (a member of the epidermal growth factor receptor family). About one-fifth of BC is constituted of basal cells for which there is no specific category of proliferation regulators. Insulin-like grow...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mester J,Redeuilh G

更新日期：2008-12-01 00:00:00

abstract：:Primary liver cancer is one of the most commonly occurring cancers worldwide. Hepatocellular carcinoma (HCC) represents the majority of primary liver cancer and is the 3rd most common cause of cancer-related deaths globally. Survival rates of patients with HCC are dependent upon early detection as concomitant liver dy...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sokolowski KM,Koprowski S,Kunnimalaiyaan S,Balamurugan M,Gamblin TC,Kunnimalaiyaan M

更新日期：2016-01-01 00:00:00

abstract：:The success of anticancer therapy is limited due to the resistance caused by tumor cells to cytotoxic agents, which interfere with the effectiveness of various chemotherapeutic agents. Several mechanisms for decreased effectiveness of anti-cancer drugs have been examined however the most widely studied mechanism is th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kumar R,Kaur M,Silakari O

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Nowadays, the interaction between natural products and microRNAs provides a promising field for exploring the chemo preventive agents for various cancers.As a member of microRNAs, the expression of let-7f-5p is universally down regulated in colorectal cancer (CRC). The present study aimed to unco...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng Y,Liu X,Han Y,Chen M,Zhang L,Hu Y,Chen L,Chen G,Li N

更新日期：2020-07-30 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：AIM:The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents. BACKGROUND:Cancer is the second leading cause of deaths in United States. The current recovery rate from the advanced treatment for the cancer is unacceptably low. Therefore, identificat...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gangapuram M,Eyunni S,Zhang W,Redda KK

更新日期：2021-01-12 00:00:00

abstract：:Replication fork reversal and restart has gained immense interest as a central response mechanism to replication stress following DNA damage. Although the exact mechanism of fork reversal has not been elucidated precisely, the involvement of diverse pathways and different factors has been demonstrated, which are centr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Jain CK,Mukhopadhyay S,Ganguly A

更新日期：2020-01-01 00:00:00

abstract：:Compounds that can bind and stabilize non-canonical DNA structures are named quadruplex and are of interest in anticancer drug design due to their selective inhibitions of telomerase and consequent effects on cell proliferation. In this study, we report novel Co/Cu [II] complex compounds as G-quadruplex DNA binding li...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Saour K,Lafta D

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cinnamic acid (CA), also known as 3-phenyl-2-propenoic acid, is a naturally occurring aromatic fatty acid found commonly in cinnamon, grapes, tea, cocoa, spinach and celery. Various studies have identified CA to have anti-proliferative action on glioblastoma, melanoma, prostate and lung carcinoma cells. OBJ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pal A,Tapadar P,Pal R

更新日期：2020-08-07 00:00:00

abstract：:In the early 1960s, inorganic pyrophosphate (PPi) was found to be present in body fluids and to act as a natural inhibitor of calcification by its interaction with hydroxyapatite. In addition to inhibiting the formation of calcium phosphate, PPi also inhibited dissolution of hydroxyapatite crystals, which made it inte...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Widler L,Jahnke W,Green JR

更新日期：2012-02-01 00:00:00

abstract：:The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug metabolizing and antioxidant enzymes. Characterization of TA was done by using FT-IR and NMR. TA dose depend...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karakurt S,Adali O

更新日期：2016-01-01 00:00:00

abstract：:Integration of geriatric assessment into cancer clinical practice is strongly needed in squamous cell carcinoma of the head and neck (SCCHN) due to the frequent discrepancy between chronologic and biologic age. Comprehensive Geriatric Assessment (CGA) is a multidimensional assessment tool that examines age-related dom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Perri F,Ionna F,Pavone E,Longo F,Caponigro F

更新日期：2013-11-01 00:00:00

abstract：:Polyphenol-protein interaction (PPI) is reversible in that polyphenol-protein complex can be dissociated and release the free polyphenols. The aim of this study is to evaluate the contribution of polyphenol-protein interaction on improving the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging capacity of polyphe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cao H,Chen X,Yamamoto K

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD:To explore a new therapeutic candid...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Souza RP,Bonfim-Mendonça PS,Damke GMZF,de-Assis Carvalho ARB,Ratti BA,Dembogurski DSO,da-Silva VRS,Silva SO,Da-Silva DB,Bruschi ML,Maria-Engler SS,Consolaro MEL

更新日期：2018-01-01 00:00:00

abstract：:Urothelial cell carcinoma is one of the most common malignancies of the urinary tract. The standard of care, intravesical chemo- and immunotherapy, while effective, is associated with a considerable side-effect profile and approximately 30% of patients either fail to respond to treatment or suffer recurrent disease wi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Carradori S,Cristini C,Secci D,Gulia C,Gentile V,Di Pierro GB

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates the expression of many genes relevant to carcinogenesis. By analogy to selective estrogen receptor modulator for treatment of cancer, selective or partial PPARγ agonists are considered clinically important for chemo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Joshi H,Marulkar K,Gota V,Ramaa CS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Curcumin is a natural polyphenol and lead compound of the rhizomes of curcuma longa that it has been widely used for pharmacological activities. OBJECTIVE:In this study, series of novel derivatives of curcumin, which this group was linked to a 2-amino-4-phenylpyran-3-carbonitrile system, have been synthesiz...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Arjomandi OK,Almasi S,Hosseinzadeh L,Kavoosi M,Adibi H

更新日期：2020-10-02 00:00:00

abstract：:β-Glucans are polysaccharides of β-D-glucose extracted from the cell walls of different species of mushrooms, yeast, oat, barley, seaweeds, algae and bacteria. Modern biomedical research has identified β-glucans as biological response modifiers (BRM) with anti-tumor properties that elicit potent immune responses throu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Albeituni SH,Yan J

更新日期：2013-06-01 00:00:00