Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents.

abstract：:Evidence supports that a variety of cancers are sparked by the growth of cells that exhibit characteristics of stem cells. Such cancer-initiating cells are capable of populating a tumor with a heterogeneous group of daughter cells while still maintaining the ability to self-renew. Several groups have recently reported...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Murphy SK

更新日期：2010-02-01 00:00:00

abstract：:Gestational trophoblastic neoplasia is a rare malignancy, which can occur after any type of pregnancy. The incidence varies according to the geographical location and ethnic origin. Although most patients with gestational trophoblastic neoplasia are cured by conventional chemotherapy and surgery, some suffer resistant...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Alazzam M,Tidy J,Hancock BW,Powers H

更新日期：2010-02-01 00:00:00

abstract：:Primary liver cancer is one of the most commonly occurring cancers worldwide. Hepatocellular carcinoma (HCC) represents the majority of primary liver cancer and is the 3rd most common cause of cancer-related deaths globally. Survival rates of patients with HCC are dependent upon early detection as concomitant liver dy...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sokolowski KM,Koprowski S,Kunnimalaiyaan S,Balamurugan M,Gamblin TC,Kunnimalaiyaan M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:High-risk human papillomavirus (HR-HPV) persistent infection is the main cause of cervical cancer and its precancerous lesions. A previous study showed that HPV16 and HPV58 infections were the most common infection types in the local region. Some studies also declared that HPV58 E7 variants increased the ris...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tian S,Zhang L,Li Y,Cao D,Quan S,Guo Y,Yang X,Yang T

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the dr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Varshosaz J,Fardshouraki S,Mirian M,Safaeian L,Jandaghian S,Taymouri S

更新日期：2020-01-01 00:00:00

abstract：:The discovery of cis-platin and its second and third generation analogues created a hope in cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been used for the treatment of some cancers from a long time. The third generation analogues have superior anti-cancer profiles for curing a fe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ali I,Wani WA,Saleem K,Haque A

更新日期：2013-02-01 00:00:00

abstract：:The evasion of cancer cells from the induction of cell death pathways results in the resistance of tumor to current treatment modalities. Therefore, the resistance to cell death, one of the hallmarks of cancer, is a major target in the development of new approaches to selectively affect cancer cells. The complex inter...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hartman ML,Czyz M

更新日期：2012-10-01 00:00:00

abstract：:Protein kinases are one of the largest known families of enzyme characterized by having a well conserved ATP binding pocket. Most of the synthetic kinase inhibitors are ATP-competitive, but display some potential problems, like selectivity, discrepancy between the in vitro and in vivo inhibition assays and an high ris...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cozza G,Bortolato A,Menta E,Cavalletti E,Spinelli S,Moro S

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Bendamustine, an N-mustard-benzoimidazole hybrid conjugate, was recently approved for the treatment of chronic lymphocytic leukemia. However, the short half-life of bendamustine may limit its clinical applications. OBJECTIVE:The purpose of this study is to design and synthesize compounds with a more favorab...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Detroja D,Chen TL,Lin YW,Yen TY,Wu MH,Tsai TH,Mehariya K,Kakadiya R,Lee TC,Shah A,Su TL

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Curcumin is a natural hydrophobic product showing anticancer activity. Many studies show its potential use in the field of cancer treatment due to its safety and efficiency. However, its application is limited due to its low water-solubility and poor selective delivery to cancer. OBJECTIVE:A Y-shaped folic ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng R,Zhu W,Chu W,Teng F,Meng N,Deng P,Song Z

更新日期：2017-01-01 00:00:00

abstract：:A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1 (HSF1) and related heat shock proteins, along with the consequential inhibition of androgen receptor (AR) expression and transactivation, arresting the cell cycle i...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Y,Wang M,Beraldi E,Cong M,Zoubeidi A,Gleave M,Peng L

更新日期：2015-01-01 00:00:00

abstract：:Sphingolipids are membrane lipids that play important roles in the regulation of cell functions and homeostasis. Alterations in their metabolism have been associated with several pathologies. For this reason, therapeutic strategies based on the design of small molecules to restore sphingolipid levels to their physiolo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Delgado A,Fabrias G,Bedia C,Casas J,Abad JL

更新日期：2012-05-01 00:00:00

abstract：:Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the grow...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rengasamy P

更新日期：2017-01-01 00:00:00

abstract：:The respiratory epithelium expresses the cholinergic system including nicotinic receptors (nAChRs). It was reported that normal human bronchial epithelial cells (BEC), which are the precursor for squamous cell carcinomas, and small airway epithelial cells (SAEC), which are the precursor for adenocarcinomas, have sligh...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Grozio A,Catassi A,Cavalieri Z,Paleari L,Cesario A,Russo P

更新日期：2007-07-01 00:00:00

abstract：:In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important modes of cancer treatment. Many of those therapeutic agents used in th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Adhikari S,Choudhury S,Mitra PS,Dubash JJ,Sajankila SP,Roy R

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Obesity is characterized by increased long chain fatty acids (LCFA) uptake and impaired lipid metabolism in hepatocytes. Consequently, an enhanced intracellular lipid content, including sphingolipids, may lead to lipotoxicity. It is believed that resveratrol (RSV), one of the most extensively studied plant-d...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Charytoniuk T,Harasim-Symbor E,Polak A,Drygalski K,Berk K,Chabowski A,Konstantynowicz-Nowicka K

更新日期：2019-01-01 00:00:00

abstract：:Cancer and many chronic inflammatory diseases are associated with increased amounts of reactive oxygen species (ROS). The potential cellular and tissue damage created by ROS has significant impact on many disease and cancer states and natural therapeutics are becoming essential in regulating altered redox states. We h...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Burrow H,Kanwar RK,Mahidhara G,Kanwar JR

更新日期：2011-10-01 00:00:00

abstract：:A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： García-Moreno E,Gascón S,García de Jalón JA,Romanos E,Rodriguez-Yoldi MJ,Cerrada E,Laguna M

更新日期：2015-01-01 00:00:00

abstract：:Breast cancer is the most common cancer among women, and ranks second among cancer deaths in women. Approximately 60% of all breast cancer patients have hormone-dependent breast cancer, which contains estrogen receptors and requires estrogen for tumor growth. Estradiol is biosynthesized from androgens by the cytochrom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Díaz-Cruz ES,Brueggemeier RW

更新日期：2006-05-01 00:00:00

abstract：:Cancer is the main cause of death, so the search for active agents to be used in the therapy of this disease, is necessary. According to studies conducted, substances derived from natural products have shown to be promising in this endeavor. To these researches, one can associate with the aid of computational chemistr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cavalcanti ÉBVS,Félix MB,Scotti L,Scotti MT

更新日期：2019-01-01 00:00:00

abstract：:A large group of aminoalkyl and aminoalkanol derivatives of selected dicarboximides were synthesized and characterized by 1HNMR, 13CNMR and ESI MS spectra analysis. The thirty nine new compounds were tested for their cytotoxic properties in human chronic (K562), acute leukemia (HL-60), and cervical cancer cells (HeLa)...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kuran B,Napiórkowska M,Kossakowski J,Cieślak M,Kaźmierczak-Barańska J,Królewska K,Nawrot B

更新日期：2016-01-01 00:00:00

abstract：:As chemotherapy with temozolomide is far from providing satisfactory clinical outcomes for patients with glioblastoma, more efficient drugs and drug combinations are urgently needed. The anti-malarial artesunate was previously shown to exert a profound cytotoxic effect on various tumor cell lines including those deriv...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karpel-Massler G,Westhoff MA,Kast RE,Dwucet A,Nonnenmacher L,Wirtz CR,Debatin KM,Halatsch ME

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The existence of drug-resistance and lack of selectivity encourages scientists to search for novel and more selective cytotoxic agents. OBJECTIVES:In this work, novel 1,3,4-triarylpyrazole derivatives were synthesized to study their cytotoxicity on MCF7 (human breast Cell Line). In addition, QSAR studies we...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ismail MMF,Farrag AM,Harras MF

更新日期：2019-01-01 00:00:00

abstract：:Effective elicitation of endogenous immunity is associated with improved prognosis for cancer patients. Clinical evidence in hematological and solid cancers shows that intratumoral injection of immunostimulatory genes primes and augments endogenous T cell responses. The ability of pro-inflammatory chemokines/cytokines...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Phan-Lai V,Kievit FM,Florczyk SJ,Wang K,Disis ML,Zhang M

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Edible and medicinal plants are still an interesting source of promising biologically active substances to drug discovery and development. At a time of increasing cancer incidence in the world, alleviating the bothersome side effects of radiotherapy in debilitated cancer patients is becoming an important cha...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karpiński TM,Adamczak A,Ożarowski M

更新日期：2020-10-29 00:00:00

abstract：:To search for novel anticancer agents, we designed and synthesized a series of new triazolyl berberine derivatives. The evaluation of all the synthesized compounds and their anticancer activities against a panel of four human cancer cell lines including MCF-7 (breast), MCF-7/ADR (breast), SW-1990 (pancreatic), SMMC-77...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Jin X,Yan L,Li HJ,Wang RL,Hu ZL,Jiang YY,Cao YB,Yan TH,Sun QY

更新日期：2015-01-01 00:00:00

abstract：:Of late medicinal plants and functional foods rich in bioactive phytochemicals have received growing attention as potential agents for cancer chemoprevention. Accumulating evidence from epidemiological studies as well as laboratory data supports the anticancer properties of garlic widely used as a medicinal herb and s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nagini S

更新日期：2008-04-01 00:00:00

abstract：AIM:This study aimed to characterize the cellular basis of the platinum cytotoxicity of two novel platinum complexes, 3Pt and 1Pt, in comparison with that of cisplatin. 3Pt comprises anionic phosphate moieties, while 1Pt comprises neutral aromatic ligands. METHODS:We compared the cytotoxic potency of 3Pt and 1Pt with ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Igarashi K,Yamamoto N,Hayashi K,Takeuchi A,Miwa S,Odani A,Tsuchiya H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:A number of benzimidazole derivatives such as benomyl and carbendazim have been known for their potential role as agricultural fungicides. Simultaneously carbendazim has also been found to inhibit proliferation of mammalian tumor cells specifically drug and multidrug resistant cell lines. OBJECTIVE:To under...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Goyal K,Sharma A,Arya R,Sharma R,Gupta GK,Sharma AK

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Elderly patients with metastatic colorectal cancer (mCRC) differ from the general population and are underrepresented in clinical trials. We, retrospectively, analyzed the safety and efficacy of XELOX regimen in the treatment of elderly patients affected by mCRC. PATIENTS AND METHODS:One-hundred-eleven consecu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Berretta M,Aprile G,Nasti G,Urbani M,Bearz A,Lutrino S,Foltran L,Ferrari L,Talamini R,Fiorica F,Lleshi A,Canzonieri V,Lestuzzi C,Borsatti E,Fisichella R,Tirelli U

更新日期：2013-11-01 00:00:00