Effects of limonoid cedrelone on MDA-MB-231 breast tumor cells in vitro.

abstract：BACKGROUND:Esophageal cancer responds poorly to traditional therapies, and novel treatments are needed. The phytochemical curcumin is a potential treatment for Esophageal Squamous Cell Carcinoma (ESCC). A curcumin metabolite, tetrahydrocurcumin (THCUR), has anti-cancer effects and greater bioavailability than curcumin....

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pendleton EG,Jamasbi RJ,Geusz ME

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer is the most common cancer among women, and ranks second among cancer deaths in women. Approximately 60% of all breast cancer patients have hormone-dependent breast cancer, which contains estrogen receptors and requires estrogen for tumor growth. Estradiol is biosynthesized from androgens by the cytochrom...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Díaz-Cruz ES,Brueggemeier RW

更新日期：2006-05-01 00:00:00

abstract：:Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underly...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cao HX,Zhu KX,Fan JG,Qiao L

更新日期：2014-01-01 00:00:00

abstract：:As chemotherapy with temozolomide is far from providing satisfactory clinical outcomes for patients with glioblastoma, more efficient drugs and drug combinations are urgently needed. The anti-malarial artesunate was previously shown to exert a profound cytotoxic effect on various tumor cell lines including those deriv...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karpel-Massler G,Westhoff MA,Kast RE,Dwucet A,Nonnenmacher L,Wirtz CR,Debatin KM,Halatsch ME

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug metabolizing and antioxidant enzymes. Characterization of TA was done by using FT-IR and NMR. TA dose depend...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karakurt S,Adali O

更新日期：2016-01-01 00:00:00

abstract：:The sequence specificity of the anti-tumour drug, cisplatin, was determined in a DNA sequence that contained seven telomeric repeats and a run of ten consecutive guanine bases. Cisplatin preferentially forms DNA adducts at consecutive guanine sequences. Hence these DNA sequences were examined in order to gain an insig...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Murray V,Kandasamy N

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC oncogenes and MYC regulated genes are strong candidates as therapeutic targets for SCLC. c-MYC plays a fundamental role in cancer stem cell properties and ma...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tokgun O,Tokgun PE,Inci K,Akca H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent malignancies and thus the development of novel therapeutic agents for managing lung cancer is imperative. Tetrandrine, a bis-benzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore, has been found to exert cytotoxic effects on cancerous cells....

journal_title：Anti-cancer agents in medicinal chemistry

authors： Niu N,Qu T,Xu J,Lu X,Bodwell GJ,Zhao Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:6-Gingerol (6G) and 6-Shogaol (6S) are the main active components of ginger. 6-Gingerol is known for its anti-metastatic and anti-invasive pharmacological activities on cancer cells, besides, 6-Shogaol also inhibits breast cancer cell invasion. OBJECTIVE:In this study, radioiodination (131I) of 6G and 6S wa...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karatay KB,Kılçar AY,Derviş E,Müftüler FZB

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. METHODS:New hydrazone ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ünver H,Berber B,Demirel R,Koparal AT

更新日期：2019-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest types of cancers. Median survival rate is very poor with the currently available chemotherapeutical regimens. Therefore, discovery of new antineoplastic agents against PDA is one of the focused areas of contemporary research. The present study was und...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Goswami A,Shah BA,Batra N,Kumar A,Guru SK,Bhushan S,Malik FA,Joshi A,Singh J

更新日期：2016-01-01 00:00:00

abstract：:The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pre-clinical development with only a single compound evaluated in human...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Senapedis W,Crochiere M,Baloglu E,Landesman Y

更新日期：2016-01-01 00:00:00

abstract：:In human pathologies, therapeutic treatments are often limited by the lack of selectivity of drugs and their elevated effective concentrations. Targeting these agents to a defined tissue could enhance their selectivity and then diminish their side effects when compared to drugs that accumulate in the entire body. Targ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Schmitt F,Juillerat-Jeanneret L

更新日期：2012-06-01 00:00:00

abstract：:Angiogenesis inhibitors have a major role in the treatment of varying cancers today. While originally thought to be independent of resistance, increasing data suggests varying mechanisms that bring about drug resistance, either intrinsically or through adaptation. The role of vascular endothelial growth factor single ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tavakoli J,Aragon-Ching JB

更新日期：2010-10-01 00:00:00

abstract：:The discovery of cis-platin and its second and third generation analogues created a hope in cancer chemotherapy. Cis-platin and its second generation analogue carboplatin have been used for the treatment of some cancers from a long time. The third generation analogues have superior anti-cancer profiles for curing a fe...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ali I,Wani WA,Saleem K,Haque A

更新日期：2013-02-01 00:00:00

abstract：:Epigenetic modifications can affect numerous mechanisms used by neoplastic cells to evade immune control. In melanoma epigenetic defects, caused by dysregulations in the expression of genome writers, erasers, or readers, play a significant role in the reduced expression of molecules required for efficient immune recog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

更新日期：2017-01-01 00:00:00

abstract：:Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due t...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cerella C,Dicato M,Jacob C,Diederich M

更新日期：2011-03-01 00:00:00

abstract：:Because invasion is, either directly or via metastasis formation, the main cause of death in cancer patients, development of efficient anti-invasive agents is an important research challenge. We have established a screening program for potentially anti-invasive compounds. The assay is based on organotypic confronting ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Bracke ME,Vanhoecke BW,Derycke L,Bolca S,Possemiers S,Heyerick A,Stevens CV,De Keukeleire D,Depypere HT,Verstraete W,Williams CA,McKenna ST,Tomar S,Sharma D,Prasad AK,DePass AL,Parmar VS

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. METHODS:we evaluated ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ramamoorthy MD,Kumar A,Ayyavu M,Dhiraviam KN

更新日期：2018-01-01 00:00:00

abstract：:As early as the 1920s, the eminent physician and chemist, Otto Warburg, nominated for a second Nobel Prize for his work on fermentation, observed that the core metabolic signature of cancer cells is a high glycolytic flux. Warburg averred that the prime mover of cancer is defective mitochondrial respiration, which dri...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oronsky BT,Oronsky N,Fanger GR,Parker CW,Caroen SZ,Lybeck M,Scicinski JJ

更新日期：2014-01-01 00:00:00

abstract：:Indole compounds, found in cruciferous vegetables, are potent anti-cancer agents. Studies with indole-3-carbinol (I3C) and its dimeric product, 3,3'-diindolylmethane (DIM) suggest that these compounds have the ability to deregulate multiple cellular signaling pathways, including PI3K/Akt/mTOR signaling pathway. These ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ahmad A,Biersack B,Li Y,Kong D,Bao B,Schobert R,Padhye SB,Sarkar FH

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Vitamin D (VD) deficiency affects individuals of different ages in many countries. VD deficiency may be related to several diseases, including cancer. OBJECTIVE:This study aimed to review the relationship between VD deficiency and cancer. METHODS:We describe the proteins involved in cancer pathogenesis and...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Camara AB,Brandao IA

更新日期：2019-01-01 00:00:00

abstract：:The article has been withdrawn at the request of the editor of the journal Anti-Cancer Agents in Medicinal Chemistry. Bentham Science apologizes to the readers of the journal for any inconvenience this may cause. Bentham Science Disclaimer:It is a condition of publication that manuscripts submitted to this journal ha...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ristau BT,Fuller TW,Rios R,Ho C,Tomaszewski JJ

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. OBJECTIVE:The present study ai...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rizzk YW,El-Deen IM,Mohammed FZ,Abdelhamid MS,Khedr AIM

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Esophageal cancer remains an aggressive disease with poor survival rates. FAK and IGF-1R are two important tyrosine kinases important for cell survival signaling and found to be upregulated in esophageal cancer. Our hypothesis is that a novel small molecule compound that disrupts FAK and IGF-1R protein-pro...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ucar DA,Cox A,He DH,Ostrov DA,Kurenova E,Hochwald SN

更新日期：2011-09-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is dysregulated in various tumour types such as glioblastoma multiforme (GBM), breast cancer, ovarian carcinoma, non-small cell lung cancer and other cancers. As the intracellular tyrosine kinase of the EGFR activates signalling cascades leading to cell proliferation, angiog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Loew S,Schmidt U,Unterberg A,Halatsch ME

更新日期：2009-07-01 00:00:00

abstract：:In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It w...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Srivastava SK,Kumar V,Agarwal SK,Mukherjee R,Burman AC

更新日期：2009-03-01 00:00:00

abstract：:Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activity was induction of apoptosis. An in vitro hollow fiber mode...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Larsson DE,Hassan SB,Oberg K,Granberg D

更新日期：2012-09-01 00:00:00

abstract：:Radiolabelled peptides have shown to be an important class of radiopharmaceuticals for imaging and therapy of malignancies expressing receptors of regulatory peptides. These peptides have high affinity and specificity for their receptors. The majority of these receptors are present at different levels in different tis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Breeman WA,Kwekkeboom DJ,de Blois E,de Jong M,Visser TJ,Krenning EP

更新日期：2007-05-01 00:00:00

abstract：:A solid tumour forms an organ-like structure that is comprised of cancer cells as well as stroma cells (fibroblasts, inflammatory cells) that are embedded in an extracellular matrix and are nourished by vascular network. However, tumoral microenvironment is heterogeneous due to the abnormal vasculature network and hig...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cosse JP,Michiels C

更新日期：2008-10-01 00:00:00