Garlic-derived allyl sulfides in cancer therapy.

abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Abdel-Rasol M,El-Beih NM,Yahya SMM,Ismail MA,El-Sayed WM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Tumor recurrence and metastasis are still leading causes of cancer mortality worldwide. The influence of traditional treatment strategies against metastatic tumors may still be limited. To search for novel and powerful agents against tumors has become a major research focus. In this study, Artemisinin (ARM),...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Li Y,Zhou X,Liu J,Yuan X,He Q

更新日期：2020-01-01 00:00:00

abstract：:Cancer is the main cause of death, so the search for active agents to be used in the therapy of this disease, is necessary. According to studies conducted, substances derived from natural products have shown to be promising in this endeavor. To these researches, one can associate with the aid of computational chemistr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cavalcanti ÉBVS,Félix MB,Scotti L,Scotti MT

更新日期：2019-01-01 00:00:00

abstract：:Because invasion is, either directly or via metastasis formation, the main cause of death in cancer patients, development of efficient anti-invasive agents is an important research challenge. We have established a screening program for potentially anti-invasive compounds. The assay is based on organotypic confronting ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Bracke ME,Vanhoecke BW,Derycke L,Bolca S,Possemiers S,Heyerick A,Stevens CV,De Keukeleire D,Depypere HT,Verstraete W,Williams CA,McKenna ST,Tomar S,Sharma D,Prasad AK,DePass AL,Parmar VS

更新日期：2008-02-01 00:00:00

abstract：:Epigenetic modifications can affect numerous mechanisms used by neoplastic cells to evade immune control. In melanoma epigenetic defects, caused by dysregulations in the expression of genome writers, erasers, or readers, play a significant role in the reduced expression of molecules required for efficient immune recog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

更新日期：2017-01-01 00:00:00

abstract：:Life expectancy has impressively increased over the past century and the US population over 65 years is rapidly growing, especially those over 80 years. In fact, persons older than 80 years have increased by more than 250% between the years 1960 and 2000, and it is expected that the population aged >75 years will trip...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ciancia R,Tirelli U,Ribera J,Spina M

更新日期：2013-11-01 00:00:00

abstract：:Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least investigated families. In the review, we have provided a comprehensive listing of 133 of these compounds for which anti-tumor activity has been documented within the literature. We have compiled and studied their chemical structur...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mangal M,Khan MI,Agarwal SM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. OBJECTIVE:The present study ai...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rizzk YW,El-Deen IM,Mohammed FZ,Abdelhamid MS,Khedr AIM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. METHODS:New hydrazone ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ünver H,Berber B,Demirel R,Koparal AT

更新日期：2019-01-01 00:00:00

abstract：:A concept that currently steers the development of cancer therapies has been that agents directed against specific proteins that facilitate tumorigenesis or maintain a malignant phenotype will have greater efficacy, less toxicity and a more sustained response relative to traditional cytotoxic chemotherapeutic agents. ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Driscoll JJ,Minter A,Driscoll DA,Burris JK

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE AND METHOD:A new series of benzothiazole-piperazine derivatives was synthesized and a complete chemical characterization of the novel compounds was provided. In vitro cytotoxic activities were screened against colorectal (HCT-116), breast (MCF-7) and hepatocellular (Huh7) cancer cell lines by Sulforhodamine B...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gurdal EE,Turgutalp B,Gulcan HO,Ercetin T,Sahin MF,Durmaz I,Atalay RC,Nguyen QD,Sippl W,Yarim M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:High-risk human papillomavirus (HR-HPV) persistent infection is the main cause of cervical cancer and its precancerous lesions. A previous study showed that HPV16 and HPV58 infections were the most common infection types in the local region. Some studies also declared that HPV58 E7 variants increased the ris...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tian S,Zhang L,Li Y,Cao D,Quan S,Guo Y,Yang X,Yang T

更新日期：2020-11-05 00:00:00

abstract：:The androgen receptor (AR) plays a crucial role in the physiological and pathological functions of androgen. As a transcription factor, the AR modulates androgen activity by regulating the transcription of target genes that are involved in numerous physiological functions and pathological disorders, such as acne vulga...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Shi Q,Shih CC,Lee KH

更新日期：2009-10-01 00:00:00

abstract：:The systematic improvement of methods used for unraveling physiological and pathological role of proteases, as well as for elucidation of relevant hydrolase structures contributes to the progress in the area of new inhibitor-like drugs development. Many of protease inhibitors have entered clinics and are now successfu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Białas A,Kafarski P

更新日期：2009-09-01 00:00:00

abstract：:The article has been withdrawn at the request of the editor of the journal Anti-Cancer Agents in Medicinal Chemistry. Bentham Science apologizes to the readers of the journal for any inconvenience this may cause. Bentham Science Disclaimer:It is a condition of publication that manuscripts submitted to this journal ha...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ristau BT,Fuller TW,Rios R,Ho C,Tomaszewski JJ

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNAbased clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) wo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ergun S,Güney S,Temiz E,Petrovic N,Gunes S

更新日期：2018-01-01 00:00:00

abstract：:Classical chemotherapeutic agents such as mitotic inhibitors (spindle poisons), alkylating agents, antimetabolites, topoisomerase inhibitors, and anthracenediones (anthracyclines) inhibit DNA synthesis and mitosis, thereby killing or impeding the proliferation of rapidly dividing cells. During the last decade, targete...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kontos CK,Christodoulou MI,Scorilas A

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. METHODS:we evaluated ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ramamoorthy MD,Kumar A,Ayyavu M,Dhiraviam KN

更新日期：2018-01-01 00:00:00

abstract：:Melanoma is the more dangerous skin cancer, and metastatic melanoma still carries poor prognosis. Despite recent therapeutic advances, prolonged survival remains rare and research is still required. Propolis extracts from many countries have attracted a great deal of attention for their biological properties. We here ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Benguedouar L,Lahouel M,Gangloff SC,Durlach A,Grange F,Bernard P,Antonicelli F

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of mortality worldwide. Despite several advances made in the treatment strategies, the cure for cancer remains still a challenge. Currently used treatment modalities pose several side effects and remain ineffective in the later stages. Thiazolidinediones (TZDs) have been sh...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Uwabagira N,Sarojini BK,Prabhu A

更新日期：2020-01-01 00:00:00

abstract：:We developed a drug-delivery system comprising a novel platinum drug (Pt(II) complex) entrapped within β-Casein (β-CN) nanoparticles referred to as nano-vehicles. Fluorescence spectroscopy, UV-Vis spectrometry, dynamic light scattering (DLS), and scanning electron microscopy (SEM) were used to characterize the β-CN-Pt...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Divsalar A,Razmi M,Saboury AA,Seyedarabi A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Lung cancer is one of the most prevalent malignancies and thus the development of novel therapeutic agents for managing lung cancer is imperative. Tetrandrine, a bis-benzyltetrahydroisoquinoline alkaloid isolated from Stephania tetrandra S. Moore, has been found to exert cytotoxic effects on cancerous cells....

journal_title：Anti-cancer agents in medicinal chemistry

authors： Niu N,Qu T,Xu J,Lu X,Bodwell GJ,Zhao Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The development of cancer stem-like cells (CSCs) is one of the main causes of ovarian cancer tolerance to radiotherapy. Autophagy is an adaptive process by which cells repair damage due to radiation. As a metabolite of riboflavin, lumiflavin can enhance the chemotherapeutic effects of cisplatin on ovarian ca...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Wu M,Huang Y,Song Z,Yang R

更新日期：2021-01-04 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality in the world because current treatments, including both surgical and non-surgical ones, cannot effectively cure this disease. Increasing evidence has revealed the importance of cancer stem cells (CSCs) in hepatocarcinogenesis, an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Lau CK,Yang ZF,Fan ST

更新日期：2011-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) are produced as normal products of cellular metabolism, which are essential for numerous cell biological functions. Due to aberrant metabolism, oncogenic signaling activation and mitochondrial dysfunction, cancer cells generate excessive ROS that cause severe oxidative damage, finally lea...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheng Y,Qi Y

更新日期：2017-01-01 00:00:00

abstract：:A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： García-Moreno E,Gascón S,García de Jalón JA,Romanos E,Rodriguez-Yoldi MJ,Cerrada E,Laguna M

更新日期：2015-01-01 00:00:00

abstract：:This review summarizes the reported molecular mechanisms underlying the antileukemic property of Sesquiterpene Lactones (SLs). This systematic review was registered in the PROSPERO database and conducted following the PRISMA Statements. The MeSH terms, Sesquiterpenes, Lactones and Leukemia were used in four databases ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： da Silva Castro E,Alves Antunes LA,Revoredo Lobo JF,Ratcliffe NA,Borges RM,Rocha L,Burth P,Fonte Amorim LM

更新日期：2018-01-01 00:00:00

abstract：:A number of N-alkylated 4-anilinofuro[2,3-b]quinoline derivatives were synthesized and evaluated in vitro against PC-3, A549, and MCF-7 cancer cells and M-10 normal human mammary epithelial cells. The known antimitotic CIL-102 was moderately active against the growth of PC-3 prostate cancer cells with an IC50 value of...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Lo WF,Chou YW,Tseng CH,Shiu YH,Chen YW,Yang SC,Chen YL,Lin MF,Tzeng CC

更新日期：2015-01-01 00:00:00

abstract：:Indole compounds, found in cruciferous vegetables, are potent anti-cancer agents. Studies with indole-3-carbinol (I3C) and its dimeric product, 3,3'-diindolylmethane (DIM) suggest that these compounds have the ability to deregulate multiple cellular signaling pathways, including PI3K/Akt/mTOR signaling pathway. These ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ahmad A,Biersack B,Li Y,Kong D,Bao B,Schobert R,Padhye SB,Sarkar FH

更新日期：2013-09-01 00:00:00