Development of small molecular probes for the molecular imaging of apoptosis.

abstract：:Histone deacetylase inhibitors (HDACIs) represent one of the most promising, recently developed classes of anticancer agents already approved by the U.S. FDA. The effectiveness of these new drugs has currently being explored in a variety of cancer cell lines, in vitro, animal models, in vivo, as well as in clinical tr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Katafygiotis P,Giaginis C,Patsouris E,Theocharis S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The DNA repair enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a current inhibition target to improve the efficacy of cancer chemotherapy. Previous studies showed that compounds combining adamantane and monoterpenoid fragments are active against TDP1 enzyme. This investigation is focused on th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mozhaitsev ES,Zakharenko AL,Suslov EV,Korchagina DV,Zakharova OD,Vasil'eva IA,Chepanova AA,Black E,Patel J,Chand R,Reynisson J,Leung IKH,Volcho KP,Salakhutdinov NF,Lavrik OI

更新日期：2019-01-01 00:00:00

abstract：:The Src family of kinases has nine known members, all of which are nonreceptor tyrosine kinases involved in signal transduction in both normal and cancer cells. Interest in these kinases has increased recently because of the development, initial clinical success, and low toxicity of pharmacologic inhibitors. c-Src is ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Johnson FM,Gallick GE

更新日期：2007-11-01 00:00:00

abstract：:The systematic improvement of methods used for unraveling physiological and pathological role of proteases, as well as for elucidation of relevant hydrolase structures contributes to the progress in the area of new inhibitor-like drugs development. Many of protease inhibitors have entered clinics and are now successfu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Białas A,Kafarski P

更新日期：2009-09-01 00:00:00

abstract：:The evasion of cancer cells from the induction of cell death pathways results in the resistance of tumor to current treatment modalities. Therefore, the resistance to cell death, one of the hallmarks of cancer, is a major target in the development of new approaches to selectively affect cancer cells. The complex inter...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hartman ML,Czyz M

更新日期：2012-10-01 00:00:00

abstract：:The metabolism of alkylating agents is accompanied by the generation of reactive oxygen species. The aim of this study was to treat estrogen receptor-positive and estrogen receptor-negative human breast cancer cells, MCF-7 and MDA-MB-231, respectively, with cisplatin and five different berenil-platinum (II) complexes,...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Agnieszka G,Ewa A,Anna B,Krzysztof B,Monika C,Elżbieta S

更新日期：2014-01-01 00:00:00

abstract：:The sequence specificity of the anti-tumour drug, cisplatin, was determined in a DNA sequence that contained seven telomeric repeats and a run of ten consecutive guanine bases. Cisplatin preferentially forms DNA adducts at consecutive guanine sequences. Hence these DNA sequences were examined in order to gain an insig...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Murray V,Kandasamy N

更新日期：2012-03-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a key regulator of authophagy. Natural products show anticancer activity and often induce apoptosis or autophagy. The crosstalk between these two types of cell death makes autophagy an interesting target since drugs targetin...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sun H,Wang Z,Yakisich JS

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Despite a number of measures having been taken for cancer management, it is still the second leading cause of death worldwide. p53 is the protein principally being targeted for cancer treatment. Targeting p53 localization may be an effective strategy in chemotherapy as it controls major cell death pathways b...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kamil M,Haque E,Mir SS,Irfan S,Hasan A,Sheikh S,Alam S,Ansari KM,Nazir A

更新日期：2019-01-01 00:00:00

abstract：:High grade gliomas (HGGs) are primary CNS cancers with more than 95% of patients experiencing tumor recurrence following radiation therapy, chemotherapy, and/or an anti-angiogenic therapy. Populations of glioma 'stem-like' cells (GSCs) exist in both proliferative and non-proliferative states and are capable of tumor r...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gorin FA,Pasupuleti N,Mahajan D,Dugar S

更新日期：2017-01-01 00:00:00

abstract：:A physiologically stable thiolate gold(I) derivative [Au(Spyrimidine)(PTA-CH2Ph)]Br has shown inhibition in colon cancer proliferation of Caco-2/TC7, Caco-2/PD7 and HTC-116-luc2 cell lines via apoptotic pathway and S-phase arrest in the cell cycle. Intraperitoneal injection of [Au(Spyrimidine)(PTA-CH2Ph)]Br in athymic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： García-Moreno E,Gascón S,García de Jalón JA,Romanos E,Rodriguez-Yoldi MJ,Cerrada E,Laguna M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines. METHODS:In this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sarathbabu S,Marimuthu SK,Ghatak S,Vidyalakshmi S,Gurusubramanian G,Ghosh SK,Subramanian S,Zhang W,Kumar NS

更新日期：2019-01-01 00:00:00

abstract：:In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It w...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Srivastava SK,Kumar V,Agarwal SK,Mukherjee R,Burman AC

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Targeted imaging and therapy (theranostics) is a promising approach for the simultaneous improvement of cancer diagnosis, prognosis and management. Therapeutic and imaging reagents are coupled to tumor-targeting molecules such as antibodies, providing a basis for truly personalized medicine. However, the dev...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Chouman K,Woitok M,Mladenov R,Kessler C,Weinhold E,Hanz G,Fischer R,Meinhold-Heerlein I,Bleilevens A,Gresch G,Haugg AM,Zeppernick F,Bauerschlag D,Maass N,Stickeler E,Kolberg K,Hussain AF

更新日期：2017-01-01 00:00:00

abstract：:Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the grow...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rengasamy P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The ratio of live cells to total cells in a sample is a definition for cell viability or cell toxicity. The assessment of the viable cells plays a critical role in all processes of the cell culture workflows. Overall, they are used to evaluate the survival of cells and also to optimize culture ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Nozhat Z,Khalaji MS,Hedayati M,Kia SK

更新日期：2020-12-30 00:00:00

abstract：BACKGROUND:Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the dr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Varshosaz J,Fardshouraki S,Mirian M,Safaeian L,Jandaghian S,Taymouri S

更新日期：2020-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is dysregulated in various tumour types such as glioblastoma multiforme (GBM), breast cancer, ovarian carcinoma, non-small cell lung cancer and other cancers. As the intracellular tyrosine kinase of the EGFR activates signalling cascades leading to cell proliferation, angiog...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Loew S,Schmidt U,Unterberg A,Halatsch ME

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates the expression of many genes relevant to carcinogenesis. By analogy to selective estrogen receptor modulator for treatment of cancer, selective or partial PPARγ agonists are considered clinically important for chemo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Joshi H,Marulkar K,Gota V,Ramaa CS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Cinnamic acid (CA), also known as 3-phenyl-2-propenoic acid, is a naturally occurring aromatic fatty acid found commonly in cinnamon, grapes, tea, cocoa, spinach and celery. Various studies have identified CA to have anti-proliferative action on glioblastoma, melanoma, prostate and lung carcinoma cells. OBJ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pal A,Tapadar P,Pal R

更新日期：2020-08-07 00:00:00

abstract：AIM:This study aimed to characterize the cellular basis of the platinum cytotoxicity of two novel platinum complexes, 3Pt and 1Pt, in comparison with that of cisplatin. 3Pt comprises anionic phosphate moieties, while 1Pt comprises neutral aromatic ligands. METHODS:We compared the cytotoxic potency of 3Pt and 1Pt with ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Igarashi K,Yamamoto N,Hayashi K,Takeuchi A,Miwa S,Odani A,Tsuchiya H

更新日期：2015-01-01 00:00:00

abstract：:As cancers are one of the most important causes of human morbidity and mortality worldwide, researchers try to discover novel compounds and therapeutic approaches to decrease survival of cancer cells, angiogenesis, proliferation and metastasis. In the last decade, use of special phytochemical compounds and flavonoids ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Hosseinzadeh E,Hassanzadeh A,Marofi F,Alivand MR,Solali S

更新日期：2020-01-01 00:00:00

abstract：:The importance of monoclonal antibodies in oncology has increased drastically following the discovery of Milstein and Kohler. Since the first approval of the monoclonal antibody, i.e. Rituximab in 1997 by the FDA, there was a decline in further applications but this number has significantly increased over the last thr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kaur N,Goyal A,Sindhu RK

更新日期：2020-01-01 00:00:00

abstract：:As early as the 1920s, the eminent physician and chemist, Otto Warburg, nominated for a second Nobel Prize for his work on fermentation, observed that the core metabolic signature of cancer cells is a high glycolytic flux. Warburg averred that the prime mover of cancer is defective mitochondrial respiration, which dri...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oronsky BT,Oronsky N,Fanger GR,Parker CW,Caroen SZ,Lybeck M,Scicinski JJ

更新日期：2014-01-01 00:00:00

abstract：:Replication fork reversal and restart has gained immense interest as a central response mechanism to replication stress following DNA damage. Although the exact mechanism of fork reversal has not been elucidated precisely, the involvement of diverse pathways and different factors has been demonstrated, which are centr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Jain CK,Mukhopadhyay S,Ganguly A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In the present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. METHODS:Glucosamine was orally adminis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheki M,Jafari S,Najafi M,Mahmoudzadeh A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Nowadays, the interaction between natural products and microRNAs provides a promising field for exploring the chemo preventive agents for various cancers.As a member of microRNAs, the expression of let-7f-5p is universally down regulated in colorectal cancer (CRC). The present study aimed to unco...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng Y,Liu X,Han Y,Chen M,Zhang L,Hu Y,Chen L,Chen G,Li N

更新日期：2020-07-30 00:00:00

abstract：BACKGROUND:Curcumin is a natural hydrophobic product showing anticancer activity. Many studies show its potential use in the field of cancer treatment due to its safety and efficiency. However, its application is limited due to its low water-solubility and poor selective delivery to cancer. OBJECTIVE:A Y-shaped folic ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng R,Zhu W,Chu W,Teng F,Meng N,Deng P,Song Z

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. OBJECTIVE:The present study ai...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Rizzk YW,El-Deen IM,Mohammed FZ,Abdelhamid MS,Khedr AIM

更新日期：2019-01-01 00:00:00