Antileukemic Properties of Sesquiterpene Lactones: A Systematic Review.

abstract：BACKGROUND:A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. OBJECTIVE:In the present work, it was aimed to obtain derivatives of perillyl alcohol through microbial biotransformation and investiga...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oturanel CE,Kıran İ,Özşen Ö,Çiftçi GA,Atlı Ö

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Silver nanoparticles (AgNPs) are one of the most investigated nanostructures in recent years, which gives more challenging and promising qualities in different biomedical applications. The AgNPs synthesized by the green approach provide potential healthcare benefits over chemical approaches, including improv...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mishra V,Nayak P,Singh M,Tambuwala MM,Aljabali AA,Chellappan DK,Dua K

更新日期：2020-09-18 00:00:00

abstract：:Classical chemotherapeutic agents such as mitotic inhibitors (spindle poisons), alkylating agents, antimetabolites, topoisomerase inhibitors, and anthracenediones (anthracyclines) inhibit DNA synthesis and mitosis, thereby killing or impeding the proliferation of rapidly dividing cells. During the last decade, targete...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kontos CK,Christodoulou MI,Scorilas A

更新日期：2014-03-01 00:00:00

abstract：AIM:The aim of this study is to explore the therapeutic potential of S-allylcysteine (SAC) organosulphur compound as potent immune checkpoint inhibitor PD-L1. BACKGROUND:Natural compounds have been showing tremendous anticancerous potential via suppressing the expression of genes involved in development and progressio...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Khan F,Pandey P,Mishra R,Arif M,Kumar A,Jafri A,Mazumder R

更新日期：2020-07-28 00:00:00

abstract：:Compounds that can bind and stabilize non-canonical DNA structures are named quadruplex and are of interest in anticancer drug design due to their selective inhibitions of telomerase and consequent effects on cell proliferation. In this study, we report novel Co/Cu [II] complex compounds as G-quadruplex DNA binding li...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Saour K,Lafta D

更新日期：2016-01-01 00:00:00

abstract：:Glioblastoma (GBM), the most common primary brain tumor in adults, is one of the most aggressive human cancers associated with high mortality. Standard treatments following diagnosis include surgical resection, radiotherapy and adjunctive chemotherapy. However, almost all patients develop disease progression following...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sathornsumetee S

更新日期：2011-10-01 00:00:00

abstract：:Cancer is the second leading cause of death, preceded only by cardiovascular diseases, and there is epidemiological evidence that demonstrate this tendency is emerging worldwide. Brazil has an extensive vegetal biodiversity with more than 55,000 species listed. Such biodiversity collaborates with the finding of compou...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Fuzer AM,Filho JC,Becceneri AB,Dos Santos DA,da Silva MF,Vieira PC,Fernandes JB,Selistre-de-Araujo HS,Cazal CM,Cominetti MR

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Araucaria angustifolia extract (AAE) is a polyphenol-rich extract that has gained interest as a natural anticancer agent. Recent work suggests that AAE induces oxidative damage and apoptosis through its action on decreasing complex I activity of the mitochondrial Electron Transport Chain (ETC). AIMS AND MET...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Branco CS,Duong A,Machado AK,Scola G,Andreazza AC,Salvador M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Glucosamine is a widely prescribed dietary supplement used in the treatment of osteoarthritis. In the present study, the chemoprotectant ability of glucosamine was evaluated against cisplatin-induced genotoxicity and cytotoxicity in rat bone marrow cells. METHODS:Glucosamine was orally adminis...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cheki M,Jafari S,Najafi M,Mahmoudzadeh A

更新日期：2019-01-01 00:00:00

abstract：:Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underly...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cao HX,Zhu KX,Fan JG,Qiao L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:To explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines. METHODS:In this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sarathbabu S,Marimuthu SK,Ghatak S,Vidyalakshmi S,Gurusubramanian G,Ghosh SK,Subramanian S,Zhang W,Kumar NS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Chronic myeloid leukemia (CML), also recognized as chronic myelogenous leukemia, is initiated in some types of blood-forming cells of the bone marrow. The therapeutic approach to CML is usually chemotherapy; however, severe side effects and complications are major problems in the clinical research. Thus, rec...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Tavakolfar S,Mousavi E,Almasirad A,Amanzadeh A,Atyabi SM,Yaghamii P,Samiee-Sadr S,Salimi M

更新日期：2016-01-01 00:00:00

abstract：:The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality. The disclosure of their chemical structure similar to that of hydroxy methyl glutaryl-CoA (HMG-CoA) revealed their ability to compet...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Garcia-Ruiz C,Morales A,Fernandez-Checa JC

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Multiparametric Magnetic Resonance Imaging (mpMRI) has become a very useful tool in the management of PCa. Particularly, there is a great interest in using mpMRI for men on Active Surveillance (AS) for low risk PCa. The aim of this systematic review was to critically review the latest literature concerning th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Cantiello F,Manno S,Russo GI,Cimino S,Privitera S,Morgia G,Cicione A,Damiano R

更新日期：2018-01-01 00:00:00

abstract：:We developed a drug-delivery system comprising a novel platinum drug (Pt(II) complex) entrapped within β-Casein (β-CN) nanoparticles referred to as nano-vehicles. Fluorescence spectroscopy, UV-Vis spectrometry, dynamic light scattering (DLS), and scanning electron microscopy (SEM) were used to characterize the β-CN-Pt...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Divsalar A,Razmi M,Saboury AA,Seyedarabi A

更新日期：2014-01-01 00:00:00

abstract：:The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential part in the proper separation of spindle poles and the correct formation of bipolar mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis followed by mitotic arrest and the formation of characteristic monoaster s...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Zhang Y,Xu W

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the dr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Varshosaz J,Fardshouraki S,Mirian M,Safaeian L,Jandaghian S,Taymouri S

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Inflammation is a vital reaction of the natural immune system that protects against encroaching agents. However, uncontrolled inflammation can lead to complications. Trigonella foenum-graecum is traditionally used as an anti-inflammatory herb. OBJECTIVES:The current study was conducted to explore the anti...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Asif M,Yousaf HM,Saleem M,Saadullah M,Chohan TA,Shamas MU,Yaseen HS,Mahrukh,Yousaf MU,Yaseen M

更新日期：2020-10-04 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Indoleamine-2,3-dioxygenase 1 (IDO1), which catalyzes the degradation of L-tryptophan (L-Trp) to N-formyl kynurenine (NFK) in the first and rate-limiting step of Kynurenine (KYN) pathway has been identified as a promising therapeutic target for cancer immunotherapy. The small molecule Epacadost...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Xia Z,Nan Y,Liu C,Lin G,Gu K,Chen C,Zhao W,Ju D,Dong X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:A number of benzimidazole derivatives such as benomyl and carbendazim have been known for their potential role as agricultural fungicides. Simultaneously carbendazim has also been found to inhibit proliferation of mammalian tumor cells specifically drug and multidrug resistant cell lines. OBJECTIVE:To under...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Goyal K,Sharma A,Arya R,Sharma R,Gupta GK,Sharma AK

更新日期：2018-01-01 00:00:00

abstract：:The hypothesis that vitamin D deficiency increases the risk of clinical prostate cancer has stimulated an extensive body of research. Ecologic studies have shown that mortality rates from prostate cancer are inversely correlated with levels of ultraviolet radiation, the principal source of vitamin D. Human prostate ce...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Schwartz GG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:T-LAK cell-originated protein kinase (TOPK) belongs to the serine/threonine protein kinase family. It is highly expressed in RPMI7951 melanoma cells. Scutellarin (SCU) is an active ingredient extracted from Erigeron breviscapus (Vant.) Hand.-Mazz. Its main physiological functions are related to its anti-infl...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mu X,Wang L,Zhang Z,Ge R,Zhang J,Mou K,Liu W,Lv S

更新日期：2020-08-10 00:00:00

abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Abdel-Rasol M,El-Beih NM,Yahya SMM,Ismail MA,El-Sayed WM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cancer is the second leading cause of mortality worldwide. Despite several advances made in the treatment strategies, the cure for cancer remains still a challenge. Currently used treatment modalities pose several side effects and remain ineffective in the later stages. Thiazolidinediones (TZDs) have been sh...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Uwabagira N,Sarojini BK,Prabhu A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Curcumin is a natural hydrophobic product showing anticancer activity. Many studies show its potential use in the field of cancer treatment due to its safety and efficiency. However, its application is limited due to its low water-solubility and poor selective delivery to cancer. OBJECTIVE:A Y-shaped folic ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Feng R,Zhu W,Chu W,Teng F,Meng N,Deng P,Song Z

更新日期：2017-01-01 00:00:00

abstract：:Natural product extracts are a rich source of small molecules that display antitumor activity. Cantharidin, in the form of the dried body of the Chinese blister beetles: Mylabris phalerata or M. cichorii, displays antitumor activity and induces apoptosis in many types of tumor cells. Cantharidin has been used as an an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Liu D,Chen Z

更新日期：2009-05-01 00:00:00

abstract：:Cilengitide, a cyclic RGD pentapeptide, is currently in clinical phase III for treatment of glioblastomas and in phase II for several other tumors. This drug is the first anti-angiogenic small molecule targeting the integrins αvβ3, αvβ5 and αvβ1. It was developed by us in the early 90s by a novel procedure, the spatia...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mas-Moruno C,Rechenmacher F,Kessler H

更新日期：2010-12-01 00:00:00

abstract：:Effective elicitation of endogenous immunity is associated with improved prognosis for cancer patients. Clinical evidence in hematological and solid cancers shows that intratumoral injection of immunostimulatory genes primes and augments endogenous T cell responses. The ability of pro-inflammatory chemokines/cytokines...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Phan-Lai V,Kievit FM,Florczyk SJ,Wang K,Disis ML,Zhang M

更新日期：2014-02-01 00:00:00

abstract：AIM:The aim of our research work is the synthesis of tetrahydroisoquinoline derivatives as anti-Angiogenesis and anti-cancer agents. BACKGROUND:Cancer is the second leading cause of deaths in United States. The current recovery rate from the advanced treatment for the cancer is unacceptably low. Therefore, identificat...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gangapuram M,Eyunni S,Zhang W,Redda KK

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates the expression of many genes relevant to carcinogenesis. By analogy to selective estrogen receptor modulator for treatment of cancer, selective or partial PPARγ agonists are considered clinically important for chemo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Joshi H,Marulkar K,Gota V,Ramaa CS

更新日期：2017-01-01 00:00:00