Cytotoxic Sesquiterpenes from Sonchus oleraceus.

abstract：:Resistance to chemotherapy, biological and targeted therapies is an important clinical problem. Resistance can arise and/or be selected for multiple mechanisms of action. Unfortunately, acquired resistance to antitumor agents or regimens is nearly inevitable in all patients with metastatic disease. Until recently, it ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oronsky B,Oronsky N,Knox S,Fanger G,Scicinski J

更新日期：2014-01-01 00:00:00

abstract：:In the early 1960s, inorganic pyrophosphate (PPi) was found to be present in body fluids and to act as a natural inhibitor of calcification by its interaction with hydroxyapatite. In addition to inhibiting the formation of calcium phosphate, PPi also inhibited dissolution of hydroxyapatite crystals, which made it inte...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Widler L,Jahnke W,Green JR

更新日期：2012-02-01 00:00:00

abstract：:Life expectancy has impressively increased over the past century and the US population over 65 years is rapidly growing, especially those over 80 years. In fact, persons older than 80 years have increased by more than 250% between the years 1960 and 2000, and it is expected that the population aged >75 years will trip...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ciancia R,Tirelli U,Ribera J,Spina M

更新日期：2013-11-01 00:00:00

abstract：:Acetogenins (ACG) are naturally occurring compounds that are chemically one of the least investigated families. In the review, we have provided a comprehensive listing of 133 of these compounds for which anti-tumor activity has been documented within the literature. We have compiled and studied their chemical structur...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Mangal M,Khan MI,Agarwal SM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Intrinsic resistance to apoptotic cell death due to co-occurrence of mutated KRAS and p53 is frequently reported in pancreatic cancer that renders them aggressive, highly proliferative and metastatic. In addition, these cancer types are less sensitive to apoptosis inducing drugs where promotion of autophagic...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Pal S,Salunke-Gawalib S,Konkimallaa VB

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Despite a number of measures having been taken for cancer management, it is still the second leading cause of death worldwide. p53 is the protein principally being targeted for cancer treatment. Targeting p53 localization may be an effective strategy in chemotherapy as it controls major cell death pathways b...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kamil M,Haque E,Mir SS,Irfan S,Hasan A,Sheikh S,Alam S,Ansari KM,Nazir A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. OBJECTIVE:In the present work, it was aimed to obtain derivatives of perillyl alcohol through microbial biotransformation and investiga...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oturanel CE,Kıran İ,Özşen Ö,Çiftçi GA,Atlı Ö

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its prevalence in compounds possessing a wide range of pharmacological properties including anticancer/antitumor activities. Though a number of methods have been reported for the synthesis of this class of compounds, some ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Prasad MG,Lakshmi CV,Katari NK,Pal M

更新日期：2020-01-01 00:00:00

abstract：:A novel process for the preparation of two ketomethylenic antifolates, 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]- phenyl}-2-oxo-ethyl) pentanedioic acid and 2-(2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-phenyl}-2-oxo-ethyl) pentanedioic acid is described herein. Both compounds were compared with met...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Stoicescu DF,Rotaru M

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. METHODS:we evaluated ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Ramamoorthy MD,Kumar A,Ayyavu M,Dhiraviam KN

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Acute myeloid leukemia is the collective name for different types of leukemias of myeloid origin affecting blood and bone marrow. The overproduction of immature myeloblasts (white blood cells) is the characteristic feature of AML, thus flooding the bone marrow and reducing its capacity to produce normal bloo...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Dogra R,Bhatia R,Shankar R,Bansal P,Rawal RK

更新日期：2018-01-01 00:00:00

abstract：:A series of novel thiohydantoin derivatives were synthesized and evaluated for the abilities of inhibiting cell proliferation and prostate specific antigen (PSA) expression in prostate cancer cells. These derivatives selectively inhibited proliferation of AR positive LNCaP cells and PSA expression except compounds 5i ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Liu J,Liu B,Jing Y,Zhao G

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The development of cancer stem-like cells (CSCs) is one of the main causes of ovarian cancer tolerance to radiotherapy. Autophagy is an adaptive process by which cells repair damage due to radiation. As a metabolite of riboflavin, lumiflavin can enhance the chemotherapeutic effects of cisplatin on ovarian ca...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Wu M,Huang Y,Song Z,Yang R

更新日期：2021-01-04 00:00:00

abstract：:Despite being long lived, anthracyclines remain the "evergreen" drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidru...

journal_title：Anti-cancer agents in medicinal chemistry

authors： da Ros M,Iorio AL,Lucchesi M,Stival A,de Martino M,Sardi I

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Liposomes have been employed to improve pharmacokinetics and reduce side effects of drugs. They can be functionalized with antibodies for targeted delivery. While the monoclonal antibody trastuzumab has been employed in the therapy of HER2-positive breast cancer, the resistance developed during treatment has...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Eloy JO,Petrilli R,Brueggemeier RW,Marchetti JM,Lee RJ

更新日期：2017-01-01 00:00:00

abstract：:Ras association domain family member 5 (RASSF5, also named NORE1) is an identified member of the RASSF gene family which could bind selectively to activate Ras and function as an antineoplastic effector in multiple cellular regulations. While highly expressed in majority of normal tissues, RASSF5 is epigenetically ina...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Li S,Teng J,Li H,Chen F,Zheng J

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Elderly patients with metastatic colorectal cancer (mCRC) differ from the general population and are underrepresented in clinical trials. We, retrospectively, analyzed the safety and efficacy of XELOX regimen in the treatment of elderly patients affected by mCRC. PATIENTS AND METHODS:One-hundred-eleven consecu...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Berretta M,Aprile G,Nasti G,Urbani M,Bearz A,Lutrino S,Foltran L,Ferrari L,Talamini R,Fiorica F,Lleshi A,Canzonieri V,Lestuzzi C,Borsatti E,Fisichella R,Tirelli U

更新日期：2013-11-01 00:00:00

abstract：:High grade gliomas (HGGs) are primary CNS cancers with more than 95% of patients experiencing tumor recurrence following radiation therapy, chemotherapy, and/or an anti-angiogenic therapy. Populations of glioma 'stem-like' cells (GSCs) exist in both proliferative and non-proliferative states and are capable of tumor r...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gorin FA,Pasupuleti N,Mahajan D,Dugar S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Colorectal cancer is among the leading causes of death worldwide. The incidence of deaths is expected to be 11.4 million in 2030. OBJECTIVE:We aimed to evaluate the in vitro and in vivo antioxidant and antitumor activities of a novel Bithiophene- Fluorobenzamidine (BFB) against DMH-induced colorectal cancer...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Abdel-Rasol M,El-Beih NM,Yahya SMM,Ismail MA,El-Sayed WM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Bendamustine, an N-mustard-benzoimidazole hybrid conjugate, was recently approved for the treatment of chronic lymphocytic leukemia. However, the short half-life of bendamustine may limit its clinical applications. OBJECTIVE:The purpose of this study is to design and synthesize compounds with a more favorab...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Detroja D,Chen TL,Lin YW,Yen TY,Wu MH,Tsai TH,Mehariya K,Kakadiya R,Lee TC,Shah A,Su TL

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Peniciketal A (Pe-A), a spiroketal compound, shows potent anticancer activities in human acute monocytic leukemia. However, the detailed mechanisms and potent targets of Pe-A remain largely unexplored. Here, we investigated the differentially expressed proteins between the Pe-A-treated group and the control ...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Gao X,Zhou Y,Sun H,Liu D,Zhang J,Zhang J,Liu W,Pan X

更新日期：2019-01-01 00:00:00

abstract：:Recently mutual interactions of chemotherapy and immunotherapy have been widely accepted, and several synergistic mechanisms have been elucidated as well. Although much attention has focused on the combination of DC vaccine and chemotherapy, there are still many problems remaining to be resolved, including the optimal...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Dong W,Wei R,Shen H,Ni Y,Meng L,Du J

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug metabolizing and antioxidant enzymes. Characterization of TA was done by using FT-IR and NMR. TA dose depend...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Karakurt S,Adali O

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the dr...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Varshosaz J,Fardshouraki S,Mirian M,Safaeian L,Jandaghian S,Taymouri S

更新日期：2020-01-01 00:00:00

abstract：:The success of anticancer therapy is limited due to the resistance caused by tumor cells to cytotoxic agents, which interfere with the effectiveness of various chemotherapeutic agents. Several mechanisms for decreased effectiveness of anti-cancer drugs have been examined however the most widely studied mechanism is th...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Kumar R,Kaur M,Silakari O

更新日期：2014-06-01 00:00:00

abstract：:Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic activity was induction of apoptosis. An in vitro hollow fiber mode...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Larsson DE,Hassan SB,Oberg K,Granberg D

更新日期：2012-09-01 00:00:00

abstract：:As early as the 1920s, the eminent physician and chemist, Otto Warburg, nominated for a second Nobel Prize for his work on fermentation, observed that the core metabolic signature of cancer cells is a high glycolytic flux. Warburg averred that the prime mover of cancer is defective mitochondrial respiration, which dri...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Oronsky BT,Oronsky N,Fanger GR,Parker CW,Caroen SZ,Lybeck M,Scicinski JJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:To explore the cytotoxic and apoptotic activity of the pierisin-6 protein in HPV HeLa and HepG2 cell lines. METHODS:In this study, isolation, and purification of cytotoxic Prierisin-6 from the larvae of Pieris napi by affinity column chromatography techniques. Characterization of full-length mRNA of pierisi...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Sarathbabu S,Marimuthu SK,Ghatak S,Vidyalakshmi S,Gurusubramanian G,Ghosh SK,Subramanian S,Zhang W,Kumar NS

更新日期：2019-01-01 00:00:00

abstract：:Natural product extracts are a rich source of small molecules that display antitumor activity. Cantharidin, in the form of the dried body of the Chinese blister beetles: Mylabris phalerata or M. cichorii, displays antitumor activity and induces apoptosis in many types of tumor cells. Cantharidin has been used as an an...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Liu D,Chen Z

更新日期：2009-05-01 00:00:00

abstract：:Effective elicitation of endogenous immunity is associated with improved prognosis for cancer patients. Clinical evidence in hematological and solid cancers shows that intratumoral injection of immunostimulatory genes primes and augments endogenous T cell responses. The ability of pro-inflammatory chemokines/cytokines...

journal_title：Anti-cancer agents in medicinal chemistry

authors： Phan-Lai V,Kievit FM,Florczyk SJ,Wang K,Disis ML,Zhang M

更新日期：2014-02-01 00:00:00