The effect of labetalol on urinary prostacyclin secretion during surgery.

Abstract:

:The effects of labetalol on the secretion of prostacyclin and plasma-renin activity (PRA) were evaluated, relative to a control group in 24 patients undergoing hip osteotomy. They were randomly assigned to two groups (G-I and G-II) with 12 patients each. Patients allocated to both groups received standard anaesthesia (thiopentone, pancuronium, fentanyl and nitrous oxide). Patients belonging to Group II were given labetalol at a dose of 0.8 mg kg-1. The stable metabolite of PGI2, 6-keto-PGF1 alpha was quantified from urine samples by radioimmunoassay (RIA). Cortisol, PRA and aldosterone were determined from blood samples. A significant increase in 6-keto-PGF1 alpha elimination was observed in G-I. Labetalol administration partially but significantly inhibited this increase. We believe that prostacyclin is involved not through the beta 1 but through the alpha 1 receptors in the secretion of renin.

journal_name

Eur J Anaesthesiol

authors

Arroyo JL,Iribarren MJ,Dawson E,Roux C,Carrascosa F,De Castro J,Carrasco MS

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

33-7

issue

1

eissn

0265-0215

issn

1365-2346

journal_volume

3

pub_type

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