Development of a radioimmunoassay procedure for sulforidazine and its comparison with a high-performance liquid chromatographic method.

abstract：BACKGROUND:Drug blood levels can only serve as a surrogate because of the lack of information on the drug's direct pharmacological effects in the individual patient. Measurement of the mammalian target of rapamycin (mTOR) activity dependent on the phosphorylation status of p70 S6 kinase (p70 S6K) offers a practical way...

journal_title：Therapeutic drug monitoring

authors： Hartmann B,He X,Keller F,Fischereder M,Guba M,Schmid H

更新日期：2013-04-01 00:00:00

abstract：:The aims of this study were to determine the relationship between saliva and plasma methadone concentrations and the influence of variability in saliva pH. Saliva and plasma samples were taken before the daily dose of methadone in 60 patients undergoing methadone maintenance treatment (MMT). Saliva pH was measured imm...

journal_title：Therapeutic drug monitoring

authors： Shiran MR,Hassanzadeh-Khayyat M,Iqbal MZ,Lagundoye O,Seivewright N,Lennard MS,Tucker GT,Rostami-Hodjegan A

更新日期：2005-10-01 00:00:00

abstract：:We report a clinically relevant suspected interaction between acyclovir and the antiepileptic drugs phenytoin (PHT) and valproic acid (VPA). In a child receiving PHT and VPA therapy, a 6-day acyclovir treatment reduced PHT and VPA plasma concentrations to subtherapeutic values. This probably worsened both clinical sta...

journal_title：Therapeutic drug monitoring

authors： Parmeggiani A,Riva R,Posar A,Rossi PG

更新日期：1995-06-01 00:00:00

abstract：:Major advances in immunosuppression and reductions in the rates of acute rejection have led to increasing graft and patient survival rates during the past two decades. Chronic dysfunction of the renal allograft, however, remains a major clinical problem and probably represents the end result of the complex interplay b...

journal_title：Therapeutic drug monitoring

authors： Kaplan B,Srinivas TR,Meier-Kriesche HU

更新日期：2002-02-01 00:00:00

abstract：:The use of alternative strategies to the traditional pre-dose/trough (C0) blood sampling for cyclosporine (CsA) therapeutic drug monitoring has the potential to revolutionize analytical practices which have, in many centers, been established for some 20 years. While the C0 sample has previously been recommended, curre...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Russ GR,Cervelli MJ,Juneja R,McDonald SP,Mathew TH

更新日期：2002-08-01 00:00:00

abstract：INTRODUCTION:Gabapentin (Neurontin) and levetiracetam (Keppra) are anticonvulsants with novel structures and suggested therapeutic ranges of 2-10 mg/L and 6-20 mg/L, respectively. Gabapentin is also used extensively to manage neuropathic pain, and for this indication, wherein higher doses are prescribed, plasma concent...

journal_title：Therapeutic drug monitoring

authors： Juenke JM,Brown PI,Johnson-Davis KL,McMillin GA

更新日期：2011-04-01 00:00:00

abstract：:The pharmacokinetics of senkyunolide A, one of the major bioactive ingredients in the traditional Chinese medicinal herb Rhizoma Chuanxiong, which is commonly used for the treatment of cardiovascular diseases, was studied in rats. After intravenous (IV) administration, senkyunolide A was extensively distributed (Vd/F:...

journal_title：Therapeutic drug monitoring

authors： Yan R,Lin G,Ko NL,Tam YK

更新日期：2007-02-01 00:00:00

abstract：:Plasma concentrations of isepamicin, a new aminoglycoside antibiotic, were determined by radioimmunoassay (RIA), microbiological assay (MA), and high-performance liquid chromatography (HPLC) in healthy volunteers after administration of 7.5 mg/kg intramuscular dosages once daily for 10 days. Plasma samples were collec...

journal_title：Therapeutic drug monitoring

authors： Lin CC,Veals J,Korduba C,Hilbert MJ,Nomeir A

更新日期：1997-12-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A (CYP3A) isoenzyme metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML). The aim of this study was to investigate the influence of...

journal_title：Therapeutic drug monitoring

authors： Skoglund K,Richter J,Olsson-Strömberg U,Bergquist J,Aluthgedara W,Ubhayasekera SJ,Vikingsson S,Svedberg A,Söderlund S,Sandstedt A,Johnsson A,Aagesen J,Alsenhed J,Hägg S,Peterson C,Lotfi K,Gréen H

更新日期：2016-04-01 00:00:00

abstract：:The solubility and stability of amphotericin B in human serum in vitro was assessed using a sensitive high performance liquid chromatographic technique. The solubility of amphotericin B at concentrations ranging from 0.5 micrograms/ml to 10 micrograms/ml in human serum at pH 7.4, at 37 degrees C, and in 5% CO2 (simula...

journal_title：Therapeutic drug monitoring

authors： Edmonds LC,Davidson L,Bertino JS Jr

更新日期：1989-01-01 00:00:00

abstract：:Vancomycin is widely used in the prophylaxis and treatment of infections in neutropenic patients with cancer. The objective of this study was to analyze liver damage effects on vancomycin pharmacokinetics and determine the necessity for liver function evaluation when selecting vancomycin dosing schedules in these pati...

journal_title：Therapeutic drug monitoring

authors： Aldaz A,Ortega A,Idoate A,Giráldez J,Brugarolas A

更新日期：2000-06-01 00:00:00

abstract：:The selection of an appropriate therapy and dosing regimen is a significant challenge in the treatment of cancer. Although there are recommended standardized chemotherapy protocols for some types of cancer, protocol changes that usually only occur after large clinical trials demonstrate improvements and individual pat...

journal_title：Therapeutic drug monitoring

authors： Knezevic CE,Clarke W

更新日期：2020-02-01 00:00:00

abstract：:Monitoring plasma concentrations of therapeutic drugs presents special problems when these drugs are metabolized to compounds that have pharmacologic activity. This presentation reviews several methods for evaluating the pharmacologic activity of drug metabolites and describes the impact of active drug metabolites on ...

journal_title：Therapeutic drug monitoring

authors： Atkinson AJ Jr,Stec GP,Lertora JJ,Ruo TI,Thenot JP

更新日期：1980-01-01 00:00:00

abstract：:Hydroxylation of midazolam (MDZ) is mediated almost exclusively by CYP3A isoforms. The authors describe a high-performance liquid chromatography assay involving MDZ, 1'-hydroxymidazolam, and 4-hydroxymidazolam in plasma. The compounds were eluted on an Ultrasphere ODS, 3-microm particle size, 7.5 cm x 4.6 mm reversed-...

journal_title：Therapeutic drug monitoring

authors： Carrillo JA,Ramos SI,Agundez JA,Martinez C,Benitez J

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:In psychopharmacology, treatment with psychotropic drugs is often suboptimal, mainly because of the high interindividual variability in pharmacokinetic properties. Therapeutic drug monitoring (TDM) can be a valuable tool for monitoring the individual effects of a prescribed dosage in a patient, and it facili...

journal_title：Therapeutic drug monitoring

authors： Wang J,Huang H,Yao Q,Lu Y,Zheng Q,Cheng Y,Xu X,Zhou Q,Wu D,Zhang M,Li X,Zhang J

更新日期：2015-10-01 00:00:00

abstract：:The authors report a case that offers insight into the diagnostic challenges of "Munchausen Syndrome by Proxy." Initial presentation with history of fever and later with intractable vomiting led to invasive and expensive diagnostic evaluation before confirming the diagnosis. Certain toxic effects of emetine were clini...

journal_title：Therapeutic drug monitoring

authors： Bader AA,Kerzner B

更新日期：1999-04-01 00:00:00

abstract：:Phenytoin is an effective anticonvulsant, but high serum phenytoin concentrations may be associated with serious toxicity. The upper limit for the therapeutic serum concentration of phenytoin is considered to be 80 micromol/L. However, in some situations higher serum concentrations are needed to control seizures. The ...

journal_title：Therapeutic drug monitoring

authors： Kozer E,Parvez S,Minassian BA,Kobayashi J,Verjee Z,Koren G

更新日期：2002-06-01 00:00:00

abstract：:A stabilized therapeutic drug monitoring procedure incorporating the novel Empore solid-phase extraction membrane (SPEM) for isolation of the antiarrhythmic drugs mexiletine (MEX) and flecainide (FLEC) from serum is described. Routinely, serum (0.5 ml), adjusted to pH 4.5, is passed through an octyl (C8) SPEM to extra...

journal_title：Therapeutic drug monitoring

authors： Lensmeyer GL,Wiebe DA,Doran TC

更新日期：1992-10-01 00:00:00

abstract：:The DuPont theophylline assay reagent kit, a particle-enhanced turbidimetric inhibition immunoassay (PETINIA) method adapted for use on a centrifugal fast analyzer, was evaluated. It was compared with fluorescence polarization immunoassay (FPIA). Day-to-day precision was 4.7% at 6.8 micrograms/ml, and 3.3% at 26.6 mic...

journal_title：Therapeutic drug monitoring

authors： Lawrence JL,Elser RC

更新日期：1986-01-01 00:00:00

abstract：:The study assessed the removal of mycophenolic acid (MPA) and its major glucuronide metabolite (MPAG) during continuous venovenous hemofiltration (CVVHF) and continuous venovenous hemodiafiltration (CVVHDF) in 4 heart transplant recipients treated for at least 6 days with mycophenolate mofetil (MMF) in addition to cyc...

journal_title：Therapeutic drug monitoring

authors： Cussonneau X,Bolon-Larger M,Prunet-Spano C,Bastien O,Boulieu R

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:There is a high coincidence between obesity and psychiatric disorders including depression. Depressive disorders are commonly treated with antidepressants, including the selective serotonin reuptake inhibitor Lexapro (escitalopram). Although candidates for elective Roux-en-Y gastric bypass (RYGB) surgery may...

journal_title：Therapeutic drug monitoring

authors： Marzinke MA,Petrides AK,Steele K,Schweitzer MA,Magnuson TH,Reinblatt SP,Coughlin JW,Clarke W

更新日期：2015-06-01 00:00:00

abstract：:We describe the case of a pediatric patient on azathioprine therapy with previously undiagnosed homozygote thiopurine S-methyltransferase (TPMT) deficiency, resulting in myelotoxic thiopurine metabolite levels. The patient was successfully treated with a very low azathioprine dose of 50 mg once a week (4% of standard ...

journal_title：Therapeutic drug monitoring

authors： van Moorsel SA,Bevers N,Meurs M,van Rossum LK,Hooymans PM,Wong DR

更新日期：2017-02-01 00:00:00

abstract：:Studies examining associations between antidepressant response and plasma levels of bupropion and its metabolites have yielded contradictory findings. There have been no such studies in youth. This study explored such associations in 8 boys and 8 girls, age 11 to 17 years, all prescribed bupropion sustained release (S...

journal_title：Therapeutic drug monitoring

authors： Daviss WB,Perel JM,Brent DA,Axelson DA,Rudolph GR,Gilchrist R,Nuss S,Birmaher B

更新日期：2006-04-01 00:00:00

abstract：:The present study aims to determine the population pharmacokinetic parameters of cyclosporine (CsA) after multiple oral administration of the microemulsion formulation, Neoral, in kidney transplant patients and to propose a limited sampling strategy to predict AUC(0-4h) using them and the Bayesian method. The AUC(0-4h...

journal_title：Therapeutic drug monitoring

authors： Tokui K,Kimata T,Uchida K,Yuasa H,Hayashi Y,Itatsu T,Nabeshima T

更新日期：2004-06-01 00:00:00

abstract：:The interlaboratory variability in the assay of theophylline and various anticonvulsant drugs was evaluated in a 16-month prospective study by using two independent experimental approaches: (a) a conventional method based on the distribution of quality control (QC) lyophilized human sera spiked with the test drugs (ph...

journal_title：Therapeutic drug monitoring

authors：

更新日期：1991-03-01 00:00:00

abstract：:The relationship between changes in cyclosporin (CyA) dose or CyA blood concentration and the reciprocal creatinine concentration was investigated by cross-correlation analysis over the first 3 postoperative months in 32 consecutive heart and heart-lung recipients. Exploratory analysis suggested that early changes in ...

journal_title：Therapeutic drug monitoring

authors： Trull AK,Best NG,Tan KK,Hue KL,Higenbottam TW,Large S,Wallwork J

更新日期：1992-08-01 00:00:00

abstract：:A method for the quantitative determination of the tricyclic antidepressant drug amitriptyline (AT) and its active major metabolite, nortriptyline (NT), in plasma is described. The method involves a three-step extraction procedure, no derivatization, and a rapid run on a gas--liquid chromatograph equipped with a nitro...

journal_title：Therapeutic drug monitoring

authors： Hals PA,Lundgren TI,Aarbakke J

更新日期：1982-01-01 00:00:00

abstract：:The prevalence of gestational ethanol exposure and subsequent fetal exposure has been assessed in a cohort of mother-infant dyads in a Mediterranean city (Barcelona, Spain) by meconium analysis of fatty acid ethyl esters (FAEEs) after showing in this population a high prevalence of meconium opiates (8.7%), cocaine (4....

journal_title：Therapeutic drug monitoring

authors： Garcia-Algar O,Kulaga V,Gareri J,Koren G,Vall O,Zuccaro P,Pacifici R,Pichini S

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) time courses in serum and physiological and behavioral effects associated with smoking 1 or 4 "light cannabis" cigarettes were studied. Biomarkers to differentiate light cannabis versus illegal and medical cannabis use were also investigated. METHODS:Sera ...

journal_title：Therapeutic drug monitoring

authors： Pichini S,Mannocchi G,Berretta P,Zaami S,Pirani F,Pacifici R,Busardò FP

更新日期：2020-02-01 00:00:00