Impact of active metabolites on monitoring plasma concentrations of therapeutic drugs.

abstract：BACKGROUND:Desmopressin (D-amino D-arginine vasopressin: dDAVP) is used for the treatment of patients with hemophilia A and Von Willebrand disease. Studies on the rationale of dosing are scarce and mainly focus on the underlying causes of the vast differences in desmopressin response among individuals. The aim of this ...

journal_title：Therapeutic drug monitoring

authors： de Jager NCB,Heijdra JM,Pistorius M,Kruip MJHA,Leebeek FWG,Cnossen MH,Mathôt RAA

更新日期：2020-12-01 00:00:00

abstract：:Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of salivary caffeine concentrations is less invasive than blood sampling, especially in very sick premature neonates. Caffeine ci...

journal_title：Therapeutic drug monitoring

authors： Lee TC,Charles BG,Steer PA,Flenady VJ

更新日期：1996-06-01 00:00:00

abstract：:Steady state serum concentrations of risperidone and 9-hydroxyrisperidone (9-OH-risperidone), the active moiety, were measured in 42 patients. The concentration-to-dose ratios (C/D) varied by a factor of 20, from 1.8 to 36.8 (nmol/l)/(mg/24 hours), and 90% of the active moiety was constituted of 9-OH-risperidone. No c...

journal_title：Therapeutic drug monitoring

authors： Olesen OV,Licht RW,Thomsen E,Bruun T,Viftrup JE,Linnet K

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that 5-fluorouracil (5-FU) dosing by use of pharmacokinetic (PK) parameters is superior to the traditional body surface area (BSA) method in colorectal cancer therapy. The purpose of this study was to compare the estimated efficacy and toxicity of the use of PK-guided versus BSA-based ...

journal_title：Therapeutic drug monitoring

authors： Yang R,Zhang Y,Zhou H,Zhang P,Yang P,Tong Q,Lyu Y,Han Y

更新日期：2016-02-01 00:00:00

abstract：:Steady-state serum concentrations of quetiapine were recorded in 62 psychiatric patients under routine conditions. Doses were administered twice daily, and serum quetiapine levels were measured in the morning about 12 hours after the last dose. Eight patients were in monotherapy, whereas the rest received various addi...

journal_title：Therapeutic drug monitoring

authors： Hasselstrøm J,Linnet K

更新日期：2004-10-01 00:00:00

abstract：:The purpose of the present study was to examine the effects of rifampicin on the single oral dose pharmacokinetics and pharmacodynamics of brotizolam. Thirteen healthy male volunteers received rifampicin 450 mg/day, or matched placebo, for 7 days in a double-blind randomized crossover manner. On the sixth day they rec...

journal_title：Therapeutic drug monitoring

authors： Ujiie Y,Fukasawa T,Yasui-Furukori N,Suzuki A,Tateishi T,Otani K

更新日期：2006-06-01 00:00:00

abstract：:The emerging nation of South Africa, in common with some other countries, notably Eastern Europe, is heir to decades of neglect with regards to the exposure of the majority of its population to toxic materials. In this short review, the major toxic health hazards are described. For most of these risks there are now pr...

journal_title：Therapeutic drug monitoring

authors： Stewart MJ

更新日期：2002-02-01 00:00:00

abstract：:Central venous access catheters are commonly used in clinical oncology. The double lumen variant is applied in pharmacokinetic studies for simultaneous administration and blood sampling when frequent blood collections are necessary. Occlusion of one lumen, a common complication, necessitates the investigator perform b...

journal_title：Therapeutic drug monitoring

authors： de Jonge ME,Mathôt RA,van Dam SM,Rodenhuis S,Beijnen JH

更新日期：2003-06-01 00:00:00

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 3A (CYP3A) isoenzyme metabolic activity varies between individuals and is therefore a possible candidate of influence on the therapeutic outcome of the tyrosine kinase inhibitor imatinib in patients with chronic myeloid leukemia (CML). The aim of this study was to investigate the influence of...

journal_title：Therapeutic drug monitoring

authors： Skoglund K,Richter J,Olsson-Strömberg U,Bergquist J,Aluthgedara W,Ubhayasekera SJ,Vikingsson S,Svedberg A,Söderlund S,Sandstedt A,Johnsson A,Aagesen J,Alsenhed J,Hägg S,Peterson C,Lotfi K,Gréen H

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Thiopurine S-methyltransferase (TPMT) is an excellent example of an enzyme whose pharmacogenetic polymorphisms affect efficacy and toxicity of a drug. The association between TPMT activity and thiopurine-related myelosuppression is well recognized. To study the significance of TPMT deficiency in thiopurine m...

journal_title：Therapeutic drug monitoring

authors： Misdaq M,Andag R,Oellerich M,Asif AR,von Ahsen N

更新日期：2012-10-01 00:00:00

abstract：:Four different immunoassays were used to measure cyclosporine A (CsA) plasma (20 degrees C) levels in heart and kidney transplant recipients. Two radioimmunoassays (RIAs) (Sandimmune and Cyclotrac) and the fluorescence polarization immunoassay (FPIA) were based on polyclonal antibodies, whereas the fourth (Cyclotrac-S...

journal_title：Therapeutic drug monitoring

authors： Hesse CJ,Baan CC,Daane R,Stolk BJ,Jutte NH,Hendriks GF,Weimar W

更新日期：1990-11-01 00:00:00

abstract：:Three automated immunoassays for digoxin in serum were evaluated--Abbott TDxII, Baxter Stratus, and Behring OPUS. The accuracy and precision of the assays were assessed by weighed-in controls and an external quality control program. Coefficients of variation of all methods in serum were < or = 10% at weighed-in concen...

journal_title：Therapeutic drug monitoring

authors： Dodds HM,Norris RL,Johnson AG,Pond SM

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:A fast and easy-to-use liquid chromatography-tandem mass spectrometry method for the determination and quantification of 6 triazoles [fluconazole (FLZ), isavuconazole (ISZ), itraconazole (ITZ), hydroxy-itraconazole (OH-ITZ), posaconazole (PSZ), and voriconazole (VRZ)] in human plasma and serum was developed ...

journal_title：Therapeutic drug monitoring

authors： Müller C,Gehlen D,Blaich C,Prozeller D,Liss B,Streichert T,Wiesen MHJ

更新日期：2017-10-01 00:00:00

abstract：:The DuPont theophylline assay reagent kit, a particle-enhanced turbidimetric inhibition immunoassay (PETINIA) method adapted for use on a centrifugal fast analyzer, was evaluated. It was compared with fluorescence polarization immunoassay (FPIA). Day-to-day precision was 4.7% at 6.8 micrograms/ml, and 3.3% at 26.6 mic...

journal_title：Therapeutic drug monitoring

authors： Lawrence JL,Elser RC

更新日期：1986-01-01 00:00:00

abstract：:Nineteen acutely disturbed psychotic Asian patients were treated with a single intramuscular injection of 50 mg of zuclopenthixol acetate in Viscoleo. Patients were assessed clinically before and after treatment using the Brief Psychiatric Rating Scale (BPRS). Serum zuclopenthixol and the inactive geometric isomer tra...

journal_title：Therapeutic drug monitoring

authors： Tan CH,Low BL,Ng LL,Khoo YM,Lee HS

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Buprenorphine is currently under investigation as a pharmacotherapy to treat pregnant women for opioid dependence. This research evaluates buprenorphine (BUP), norbuprenophine (NBUP), buprenorphine-glucuronide (BUP-Gluc), and norbuprenorphine-glucuronide (NBUP-Gluc) pharmacokinetics after high-dose (14-20 mg...

journal_title：Therapeutic drug monitoring

authors： Concheiro M,Jones HE,Johnson RE,Choo R,Huestis MA

更新日期：2011-10-01 00:00:00

abstract：:We have suggested previously that acute tolerance to the chronotropic effect of cocaine develops and that tolerance is incomplete, such that the heart-rate decline in the presence of stable plasma cocaine concentrations approaches a plateau that exceeds the baseline heart rate. One possible mechanism for heart-rate de...

journal_title：Therapeutic drug monitoring

authors： Ambre JJ

更新日期：1993-12-01 00:00:00

abstract：:This study develops a population pharmacokinetic model for lamotrigine (LTG) in Spanish and German patients diagnosed with epilepsy. LTG steady-state plasma concentration data from therapeutic drug monitoring were collected retrospectively from 600 patients, with a total of 1699 plasma drug concentrations. The data we...

journal_title：Therapeutic drug monitoring

authors： Rivas N,Buelga DS,Elger CE,Santos-Borbujo J,Otero MJ,Domínguez-Gil A,García MJ

更新日期：2008-08-01 00:00:00

abstract：:It is generally accepted that chemical testing of biologic fluids is the most objective means of diagnosis of drug use. The presence of a drug analyte in a biologic specimen can be used to document exposure. The standard for drug testing in toxicology is an immunoassay screen conducted on a urine sample, followed by c...

journal_title：Therapeutic drug monitoring

authors： Kintz P,Samyn N

更新日期：2002-04-01 00:00:00

abstract：:A reverse-phase high-performance liquid chromatographic (HPLC) method for the measurement of lamotrigine (LTG) simultaneously with phenobarbitone (PB), phenytoin (PHT), and carbamazepine (CBZ) is described using hexobarbital as the internal standard. The method uses the chromophore at 307 nm to detect LTG in the prese...

journal_title：Therapeutic drug monitoring

authors： Ramachandran S,Underhill S,Jones SR

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:The Clinical Pharmacology Quality Assurance (CPQA) program provides semiannual proficiency testing (PT) of antiretroviral analytes for 11 US and international clinical pharmacology laboratories (CPLs) to ensure interlaboratory comparability. In this article, we provide estimates of the main sources of variab...

journal_title：Therapeutic drug monitoring

authors： Browne RW,Rosenkranz SL,Wang Y,Taylor CR,DiFrancesco R,Morse GD

更新日期：2019-08-01 00:00:00

abstract：:Prescribed daily doses (PDDs) of antiepileptic drugs (AED) (N03A ATC group) were recorded for drugs used in monotherapy or in combination therapy in the University Hospitals in Ostrava, Czech Republic and Huddinge, Sweden. Plasma concentrations were used as an indicator of the quality of treatment. PDDs were compared ...

journal_title：Therapeutic drug monitoring

authors： Koristkova B,Sjöqvist F,Grundmann M,Bergman U

更新日期：2006-10-01 00:00:00

abstract：:A radioimmunoassay (RIA) procedure for the determination of sulforidazine in human plasma was developed using an antiserum raised in rabbits immunized with N-(2-carboxyethyl)desmethylsulforidazine-porcine thyroglobulin conjugate. The RIA procedure can measure as low as 40 pg of sulforidazine in a 200-microliter human ...

journal_title：Therapeutic drug monitoring

authors： Chakraborty BS,Hawes EM,Midha KK

更新日期：1988-01-01 00:00:00

abstract：:A computer-based approach for estimating pharmacokinetic data and predicting plasma drug concentrations based on two measurements of plasma drug concentrations was compared with a standard two-point method for estimating aminoglycoside (AG) pharmacokinetic parameters. The computer-based technique was also used to pred...

journal_title：Therapeutic drug monitoring

authors： Bachmann K,Pongsin V,Forney R Jr,Gronau G

更新日期：1985-01-01 00:00:00

abstract：:The efficacy of low-dose, ritonavir-boosted saquinavir (SQV/rtv) once daily plus 2 nucleoside retrotranscriptase inhibitors (NRTIs) in pregnant human immunodeficiency virus (HIV)-1-infected women was prospectively evaluated, ensuring a SQV minimum concentration (Cmin) >/=100 ng/mL with a therapeutic drug monitoring st...

journal_title：Therapeutic drug monitoring

authors： Lopez-Cortes LF,Ruiz-Valderas R,Rivero A,Camacho A,Marquez-Solero M,Santos J,García-Lazaro M,Viciana P,Rodriguez-Baños J,Ocampo A

更新日期：2007-04-01 00:00:00

abstract：:Two published case reports showed that addition of risperidone (1 and 2 mg/d) to a clozapine treatment resulted in a strong increase of clozapine plasma levels. As clozapine is metabolized by cytochrome P450 isozymes, a study was initiated to assess the in vivo interaction potential of risperidone on various cytochrom...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Bondolfi G,Zullino D,Bryois C,Fuciec M,Savary L,Jonzier-Perey M,Baumann P

更新日期：2001-06-01 00:00:00

abstract：:Effect of diabetes mellitus on mycophenolic acid (MPA) pharmacokinetics and catalytic activity of inosine monophosphate dehydrogenase (IMPDH) was investigated in maintenance kidney transplant recipients. Demographically matched diabetic (n=9) and nondiabetic (n=9) patients were included in a 12-hour open-label, steady...

journal_title：Therapeutic drug monitoring

authors： Patel CG,Richman K,Yang D,Yan B,Gohh RY,Akhlaghi F

更新日期：2007-12-01 00:00:00

abstract：:Aminoglycosides have rightly remained a cost-effective anti-microbial strategy for the treatment of gram-positive infections for some 25 years. However, in recent years there has been a review of the traditional thrice-daily administration regimen in favor of an extended dosing interval strategy that takes into accoun...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Sallustio BC,Vinks AA,LeGatt DF,Verjee ZH,El Desoky E

更新日期：1999-08-01 00:00:00

abstract：:A method for analyzing flecainide in plasma was developed and assessed. Based on the use of C18 extraction columns eight or fewer times, the rapid and simple extraction procedure provided consistent, high-efficiency flecainide extraction (>85%). Using reverse-phase, high-performance liquid chromatography with fluorome...

journal_title：Therapeutic drug monitoring

authors： Wilson KM,Schneider JJ,Ravenscroft PJ

更新日期：1998-08-01 00:00:00