Preliminary buprenorphine sublingual tablet pharmacokinetic data in plasma, oral fluid, and sweat during treatment of opioid-dependent pregnant women.

abstract：:In this report we describe a rapid and sensitive micromethod using high performance liquid chromatography (HPLC) with electrochemical detection (ED) to measure morphine concentration in serum or plasma. The separation of morphine and the internal standard 5-hydroxyquinoline, from interfering compounds present in plasm...

journal_title：Therapeutic drug monitoring

authors： Vandenberghe H,MacLeod SM,Chinyanga H,Soldin SJ

更新日期：1982-01-01 00:00:00

abstract：:The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT ass...

journal_title：Therapeutic drug monitoring

authors： Wallemacq P,Maine GT,Berg K,Rosiere T,Marquet P,Aimo G,Mengozzi G,Young J,Wonigeit K,Kretschmer R,Wermuth B,Schmid RW

更新日期：2010-04-01 00:00:00

abstract：:The emergence of point-of-care assays enabling bedside testing such as the VerifyNow P2Y12 system might prove useful in clinical settings. The aim of this study was to evaluate the ability of the VerifyNow P2Y12 assay to estimate the inhibition of platelet aggregation provided by clopidogrel in the absence of baseline...

journal_title：Therapeutic drug monitoring

authors： Lordkipanidzé M,Pharand C,Nguyen TA,Schampaert E,Diodati JG

更新日期：2008-06-01 00:00:00

abstract：:A method is described for the determination of vigabatrin in 50 microliters of plasma by isocratic high-performance liquid chromatography using fluorescence detection. The procedure involves protein precipitation with methanol followed by precolumn derivatisation with o-phthaldialdehyde reagent. Separation of the deri...

journal_title：Therapeutic drug monitoring

authors： Tsanaclis LM,Wicks J,Williams J,Richens A

更新日期：1991-05-01 00:00:00

abstract：:For the evaluation and interpretation of pharmacokinetic data reliable quantitative determinations are a requirement that can only be met by well-characterized and fully validated analytical methods. To cope with these requirements a method is being established that is based on an integrated and automated fiber-optic ...

journal_title：Therapeutic drug monitoring

authors： Gygax D,Botta L,Ehrat M,Graf P,Lefèvre G,Oroszlan P,Pfister C

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Drug of abuse consumption throughout pregnancy is a serious public health problem and an important economic cost to the health system. The aim of this work was to compare maternal interview and hair analysis to determine drug consumption throughout pregnancy and to study relations among maternal i...

journal_title：Therapeutic drug monitoring

authors： Lendoiro E,González-Colmenero E,Concheiro-Guisán A,de Castro A,Cruz A,López-Rivadulla M,Concheiro M

更新日期：2013-06-01 00:00:00

abstract：:A study was conducted to determine whether assay-specific quantitative differences exist in the determination of vancomycin serum concentrations obtained from patients with renal dysfunction. Vancomycin serum concentrations were obtained during the first week of therapy for each of three time intervals: 48-96 h, 96-14...

journal_title：Therapeutic drug monitoring

authors： Peckman HJ,Dupuis RE,Sawyer WT,Brouwer KL,Cross RE

更新日期：1996-12-01 00:00:00

abstract：:A population pharmacokinetic model was developed after administration of orogastric and/or intravenous indomethacin for the treatment of patent ductus arteriosus in preterm infants. Plasma indomethacin concentrations (n=227) were obtained from 90 preterm infants of median gestational age 27 weeks, mean postnatal age o...

journal_title：Therapeutic drug monitoring

authors： Al Za'abi M,Donovan T,Tudehope D,Woodgate P,Collie LA,Charles B

更新日期：2007-12-01 00:00:00

abstract：:An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the tricyclic antidepressant clomipramine and six metabolites: desmethylclomipramine, 2- and 8-hydroxy-clomipramine, 2- and 8-hydroxydesmethylclomipramine and didesmethyl-clomipramine in plasma and urine. I...

journal_title：Therapeutic drug monitoring

authors： Nielsen KK,Brøsen K

更新日期：1993-04-01 00:00:00

abstract：:The aminoglycoside antibiotics gentamicin and tobramycin have been monitored traditionally by measuring peak and trough drug levels in serum. We found interpretation of these data to be hazardous, due to variations in the drug administration-specimen collection process and routine medical events and practices. We desc...

journal_title：Therapeutic drug monitoring

authors： Gorsky JE,Latts JR

更新日期：1983-06-01 00:00:00

abstract：:Two published case reports showed that addition of risperidone (1 and 2 mg/d) to a clozapine treatment resulted in a strong increase of clozapine plasma levels. As clozapine is metabolized by cytochrome P450 isozymes, a study was initiated to assess the in vivo interaction potential of risperidone on various cytochrom...

journal_title：Therapeutic drug monitoring

authors： Eap CB,Bondolfi G,Zullino D,Bryois C,Fuciec M,Savary L,Jonzier-Perey M,Baumann P

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:The aim of the study is to characterize the pharmacokinetics and the gastrointestinal side effect profiles of enteric-coated mycophenolate sodium (EC-MPS) in de novo kidney transplant patients of Hispanic ethnicity. MATERIALS AND METHODS:The pharmacokinetic study of EC-MPS was conducted in 11 de novo kidney ...

journal_title：Therapeutic drug monitoring

authors： Shah T,Tellez-Corrales E,Yang JW,Qazi Y,Wang J,Wilson J,Hutchinson I,Min DI

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Paclitaxel (PTX; Taxol, Abraxane) is used in many regimens for breast cancer, non-small cell lung cancer (NSCLC), and ovarian cancer. Multiple studies have demonstrated that PTX exhibits a greater than 10-fold interpatient variability of clearance rates when patients are dosed according to body surface area ...

journal_title：Therapeutic drug monitoring

authors： Cline DJ,Zhang H,Lundell GD,Harney RL,Riaz HK,Jarrah J,Li Y,Miyazaki M,Courtney JB,Baburina I,Salamone SJ

更新日期：2013-12-01 00:00:00

abstract：:Monitoring plasma concentrations of therapeutic drugs presents special problems when these drugs are metabolized to compounds that have pharmacologic activity. This presentation reviews several methods for evaluating the pharmacologic activity of drug metabolites and describes the impact of active drug metabolites on ...

journal_title：Therapeutic drug monitoring

authors： Atkinson AJ Jr,Stec GP,Lertora JJ,Ruo TI,Thenot JP

更新日期：1980-01-01 00:00:00

abstract：:A sensitive and specific direct-injection high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass-spectrometry (HPLC-APCI-MS-MS) method has been developed for the rapid identification and quantitation of seven tricyclic antidepressants-amitriptyline, nortriptyline, doxepin, dosulepi...

journal_title：Therapeutic drug monitoring

authors： Kollroser M,Schober C

更新日期：2002-08-01 00:00:00

abstract：:The effect of storage time and temperature on the stability of FK 506 in patient blood samples and quality control samples was assessed with the Abbott IMx microparticle enzyme immunoassay. Blood FK 506 concentrations measured at days 0, 2, 3, 4, 7, and 14 were stable at room (22 degrees C), refrigerator (4 degrees C)...

journal_title：Therapeutic drug monitoring

authors： Freeman DJ,Stawecki M,Howson B

更新日期：1995-06-01 00:00:00

abstract：:The preferred dose of netilmicin was determined in each of 39 patients with severe gram-negative sepsis treated at two centres. The dose was based upon the attainment of recommended serum concentrations. Patient age varied from 18 to 87 years (mean 58), estimated creatinine clearance from 20 to 150 ml/min (mean 71), a...

journal_title：Therapeutic drug monitoring

authors： Batra HK,Mawer GE,Ganguli LA,Keaney MG,Noone P

更新日期：1986-01-01 00:00:00

abstract：:A rapid and reliable micro procedure for the high pressure liquid chromatographic analysis of cimetidine. N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, in serum or plasma is described. The percentage analytical recovery of cimetidine and internal standard (beta-hydroxypropyl-theophy...

journal_title：Therapeutic drug monitoring

authors： Soldin SJ,Fingold DR,Fenje PC,Mahon WA

更新日期：1979-01-01 00:00:00

abstract：:There are data suggesting an association between mycophenolic acid (MPA) levels and acute rejection and toxicity in renal transplant recipients treated with mycophenolate mofetil (MMF), and therefore, knowledge of factors determining MPA levels may aid in accurate adjustment of MMF dosage. A total of 4970 samples take...

journal_title：Therapeutic drug monitoring

authors： Borrows R,Chusney G,James A,Stichbury J,Van Tromp J,Cairns T,Griffith M,Hakim N,McLean A,Palmer A,Papalois V,Taube D

更新日期：2005-08-01 00:00:00

abstract：:To investigate the pharmacokinetics of naloxone in healthy volunteers, we undertook an open-label crossover study in which six male volunteers received naloxone on five occasions: intravenous (0.8 mg), intramuscular (0.8 mg), intranasal (0.8 mg), intravenous (2 mg), and intranasal (2 mg). Samples were collected for 4 ...

journal_title：Therapeutic drug monitoring

authors： Dowling J,Isbister GK,Kirkpatrick CM,Naidoo D,Graudins A

更新日期：2008-08-01 00:00:00

abstract：:The monitoring of plasma olanzapine concentrations has been found to be an important and useful tool for optimizing psychiatric treatment. The present study investigated the effect that clinical factors, such as smoking and age, and functional polymorphisms of UGT1A4, CYP1A2, and CYP2D6 genes have on plasma olanzapine...

journal_title：Therapeutic drug monitoring

authors： Nozawa M,Ohnuma T,Matsubara Y,Sakai Y,Hatano T,Hanzawa R,Shibata N,Arai H

更新日期：2008-02-01 00:00:00

abstract：:A simple and sensitive method is presented for the determination of gold in various biological matrices by flameless atomic absorption spectrometry (FAAS). The effects of the biological media on the atomic absorption of gold and the application of some of the important fundamental principles in relation to the measure...

journal_title：Therapeutic drug monitoring

authors： Sharma RP

更新日期：1982-01-01 00:00:00

abstract：:A variety of medications are used in treating patients infected with the human immunodeficiency virus (HIV). These medications are used to control viremia and to prevent and treat opportunistic infections. An individual is often required to take numerous drugs at the same time and thus clinicians are confronted with p...

journal_title：Therapeutic drug monitoring

authors： Dasgupta A,Okhuysen PC

更新日期：2001-12-01 00:00:00

abstract：:The pharmacokinetics of oxycodone have been determined after single-dose administration by the intravenous (4.6-7.3 mg), oral (tablets, 9.1 mg and syrup, 9.1 mg), and rectal (30 mg) routes, in 48 patients undergoing minor surgery. There were no significant differences in the mean elimination half-lives between the int...

journal_title：Therapeutic drug monitoring

authors： Leow KP,Smith MT,Watt JA,Williams BE,Cramond T

更新日期：1992-12-01 00:00:00

abstract：:In a crossover study balanced for sex, treatments, and treatment order, we have investigated the pharmacokinetics of diltiazem after single oral doses in 10 healthy middle-aged volunteers. The diltiazem doses employed were 60 mg and 120 mg and contained 1.85 MBq [14C] diltiazem. The absorption was rapid and did not di...

journal_title：Therapeutic drug monitoring

authors： Höglund P,Nilsson LG

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound, exhibits a nonlinear, concentration-dependent pharmacokinetic profile, and has a narrow therapeutic range...

journal_title：Therapeutic drug monitoring

authors： Aliwarga T,Cloyd JC,Goel V,Brundage RC,Marino SE,Leppik IE,Remmel RP

更新日期：2011-02-01 00:00:00

abstract：:Urinary excretion of lipocalin-type prostaglandin D synthase (L-PGDS) has been suggested to be a useful biomarker of early diabetic nephropathy. We studied whether L-PGDS is also a marker of gentamicin (GM)-induced renal damage in the "creatinine-blind" range. A prospective study was conducted in 6 patients who were g...

journal_title：Therapeutic drug monitoring

authors： Nakayama H,Echizen H,Gomi T,Shibuya Y,Nakamura Y,Nakano K,Arashi H,Itai T,Ohnishi S,Tanaka M,Orii T

更新日期：2009-02-01 00:00:00

abstract：:Steady-state serum concentrations of quetiapine were recorded in 62 psychiatric patients under routine conditions. Doses were administered twice daily, and serum quetiapine levels were measured in the morning about 12 hours after the last dose. Eight patients were in monotherapy, whereas the rest received various addi...

journal_title：Therapeutic drug monitoring

authors： Hasselstrøm J,Linnet K

更新日期：2004-10-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) is commonly employed to optimize the dosing of certain drugs, including digoxin, aminoglycosides, theophylline, and phenytoin. Studies were reviewed in order to (a) evaluate the effect of TDM on the occurrence of toxic drug reactions (TDRs) and (b) identify factors that may modify or ...

journal_title：Therapeutic drug monitoring

authors： Ried LD,Horn JR,McKenna DA

更新日期：1990-01-01 00:00:00

abstract：:Recent literature has urged caution in the interpretation of vancomycin serum concentrations in patients with end-stage renal disease (ESRD), because falsely elevated levels in excess of 70% have been reported with the most commonly used fluorescence polarization immunoassay (FPIA). The purpose of this study was to ev...

journal_title：Therapeutic drug monitoring

authors： Smith PF,Petros WP,Soucie MP,Copeland KR

更新日期：1998-04-01 00:00:00