Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat.

abstract：:Eight commercial digoxin immunoassay methods were tested in 17 subjects taking spironolactone (but not digoxin) to evaluate cross-reactivity from parent drug and/or metabolites. Four of these methods showed significant (up to 1.9 nmol/L) and variable "apparent digoxin" concentrations, despite the absence of digoxin in...

journal_title：Therapeutic drug monitoring

authors： Morris RG,Lagnado PY,Lehmann DR,Frewin DB,Glistak ML,Burnet RB

更新日期：1987-06-01 00:00:00

abstract：:To interpret blood levels of tricyclic antidepressants, we studied the distributions of amitriptyline and nortriptyline in human blood and explored their control by plasma factors. Each compound (300 ng/ml) was added to whole adult blood and to cord blood with decreased alpha-1-glycoprotein (AGP). Drugs (250 ng/ml) we...

journal_title：Therapeutic drug monitoring

authors： Amitai Y,Kennedy EJ,DeSandre P,Frischer H

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Recently, high-dose oral synthetic delta-9-tetrahydrocannabinol (THC) was shown to alleviate cannabis withdrawal symptoms. The present data describe cannabinoid pharmacokinetics in chronic, daily cannabis smokers who received high-dose oral THC pharmacotherapy and later a smoked cannabis challenge. METHODS:...

journal_title：Therapeutic drug monitoring

authors： Milman G,Bergamaschi MM,Lee D,Mendu DR,Barnes AJ,Vandrey R,Huestis MA

更新日期：2014-04-01 00:00:00

abstract：:The current article describes a new assay to measure thiopurine methyltransferase (TPMT) activity from red blood cells. This method is based on the measurement of the reaction product 6-methylmercaptopurine (6-MMP) by high-performance liquid chromatography (HPLC). 6-MMP is extracted by ethyl acetate with recoveries of...

journal_title：Therapeutic drug monitoring

authors： Menor C,Fueyo JA,Escribano O,Cara C,Fernández-Moreno MD,Román ID,Guijarro LG

更新日期：2001-10-01 00:00:00

abstract：:We presented a case of subtherapeutic linezolid concentration in a patient with bullous pemphigoid characterized by large area skin anabrosis complicated by methicillin-resistant Staphylococcus aureus infections. ...

journal_title：Therapeutic drug monitoring

authors： Chen C,Zhang M,Chen H,Fang J

更新日期：2020-08-01 00:00:00

abstract：:Plasma levels of 6-mercaptopurine were determined in 22 consecutive children with acute lymphoblastic leukemia on oral remission maintenance therapy during the time period of August 1984 to January 1988. Each child received the drug once daily for up to 3 years and was studied repeatedly (1-12 times). An HPLC method w...

journal_title：Therapeutic drug monitoring

authors： Hayder S,Lafolie P,Björk O,Peterson C

更新日期：1989-11-01 00:00:00

abstract：:A simple and rapid reversed-phase C-18 high-performance liquid chromatography (HPLC) assay without a prior extraction step for dihydroquinidine (HQD) in serum is described. The method is selective and useful for monitoring HQD and its presumed metabolites, quinidine (QD), N-oxide QD, 3-hydroxy QD (3-OHQD), and 10-11-d...

journal_title：Therapeutic drug monitoring

authors： Camsonne R,Moulin MA,Albessard F,Perault M

更新日期：1984-01-01 00:00:00

abstract：:Cefsulodin is a third-generation cephalosporin with a unique specificity for Pseudomonas aeruginosa. To study the pharmacokinetics of this agent in children, a rapid and sensitive high-performance liquid chromatographic micromethod was developed for plasma and urine. Protein was precipitated from plasma with one volum...

journal_title：Therapeutic drug monitoring

authors： Ackers IM,Myers CM,Blumer JL

更新日期：1984-01-01 00:00:00

abstract：:PROTEASE INHIBITOR TDM: This study examines the importance of therapeutic drug monitoring (TDM) of protease inhibitors (PI) in adults and children infected with the human immunodeficiency virus (HIV). Pediatric patients were included because information in this population is limited. A high performance liquid chromato...

journal_title：Therapeutic drug monitoring

authors： Walson PD,Cox S,Utkin I,Gerber N,Crim L,Brady M,Koranyi K

更新日期：2003-12-01 00:00:00

abstract：:In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-d...

journal_title：Therapeutic drug monitoring

authors： Haidukewych D,Rodin EA

更新日期：1981-01-01 00:00:00

abstract：:Ultrafiltration techniques for the separation of bound and free ligand are dependent on minimal amounts of protein-bound drug leakage through the membrane devices. A dye-impregnated test strip protein assay (Chemstrip-9) provides a rapid, visual assessment of membrane protein leakage. The test strips are sensitive to ...

journal_title：Therapeutic drug monitoring

authors： Turley CP,Milligan T

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highl...

journal_title：Therapeutic drug monitoring

authors： Heil SG,van der Ende ME,Schenk PW,van der Heiden I,Lindemans J,Burger D,van Schaik RH

更新日期：2012-04-01 00:00:00

abstract：:Two hundred milligrams of valproic acid (VPA) was administered orally to seven healthy adults at 9:00 and 21:00 h for 5 consecutive days, including the morning dose on day 6. On the sixth day, blood samples were drawn at 0, 0.17, 0.33, 0.5, 0.75, 1, 1.5, 3, and 6 h after the morning dose. Binding of VPA to serum prote...

journal_title：Therapeutic drug monitoring

authors： Kodama Y,Koike Y,Kimoto H,Yasunaga F,Takeyama M,Teraoka I,Fujii I

更新日期：1992-02-01 00:00:00

abstract：:Steady-state serum concentrations of quetiapine were recorded in 62 psychiatric patients under routine conditions. Doses were administered twice daily, and serum quetiapine levels were measured in the morning about 12 hours after the last dose. Eight patients were in monotherapy, whereas the rest received various addi...

journal_title：Therapeutic drug monitoring

authors： Hasselstrøm J,Linnet K

更新日期：2004-10-01 00:00:00

abstract：:The CYP2D6*10(*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of approximately 50%. We studied the effects of the *10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole. The subjects were 63 Japanese patients with...

journal_title：Therapeutic drug monitoring

authors： Suzuki T,Mihara K,Nakamura A,Nagai G,Kagawa S,Nemoto K,Ohta I,Arakaki H,Uno T,Kondo T

更新日期：2011-02-01 00:00:00

abstract：:The commonly used immunosuppressive regimen after orthotopic heart transplantation consists of cyclosporine (CsA), azathioprine (AZA), and steroids. Although AZA therapy is generally regarded as unproblematic, its use can be associated with severe side effects, particularly myelosuppression. Since AZA is a prodrug, wh...

journal_title：Therapeutic drug monitoring

authors： Schütz E,Gummert J,Mohr FW,Armstrong VW,Oellerich M

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:The association of CYP3A5, CYP3A4, and ABCB1 single nucleotide polymorphisms (SNPs) with cyclosporine (CsA) pharmacokinetics is controversial. The authors studied the influence of these SNPs on CsA pharmacokinetics as well as on the incidence of biopsy-proven acute rejection (BPAR) and renal function after k...

journal_title：Therapeutic drug monitoring

authors： Bouamar R,Hesselink DA,van Schaik RH,Weimar W,Macphee IA,de Fijter JW,van Gelder T

更新日期：2011-04-01 00:00:00

abstract：:The effect of heparin sodium on the assay of gentamicin using the fluorescence polarization immunoassay system was investigated with varying heparin and gentamicin concentrations. Heparin had no significant effect on gentamicin concentrations as measured by this system. ...

journal_title：Therapeutic drug monitoring

authors： Jackson DS,Bertino JS Jr

更新日期：1984-01-01 00:00:00

abstract：:The immunosuppressive potential of mycophenolic acid (MPA) correlates well with MPA exposure [area under the concentration-time curve (AUC)]. Monitoring MPA AUC is important and helpful for maintaining the efficacy of mycophenolate mofetil while minimizing its side effects, but full MPA AUC monitoring is laborious, co...

journal_title：Therapeutic drug monitoring

authors： Zicheng Y,Xianghui W,Peijun Z,Da X,Weixia Z,Hongzhuan C

更新日期：2007-10-01 00:00:00

abstract：:The selection of an appropriate therapy and dosing regimen is a significant challenge in the treatment of cancer. Although there are recommended standardized chemotherapy protocols for some types of cancer, protocol changes that usually only occur after large clinical trials demonstrate improvements and individual pat...

journal_title：Therapeutic drug monitoring

authors： Knezevic CE,Clarke W

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound, exhibits a nonlinear, concentration-dependent pharmacokinetic profile, and has a narrow therapeutic range...

journal_title：Therapeutic drug monitoring

authors： Aliwarga T,Cloyd JC,Goel V,Brundage RC,Marino SE,Leppik IE,Remmel RP

更新日期：2011-02-01 00:00:00

abstract：:Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients. Intra- and interassay coefficients of variation for the new TDx technique averaged 3.2 and 5.4%, respectively. In the co...

journal_title：Therapeutic drug monitoring

authors： Klotz U

更新日期：1991-09-01 00:00:00

abstract：:Studies examining associations between antidepressant response and plasma levels of bupropion and its metabolites have yielded contradictory findings. There have been no such studies in youth. This study explored such associations in 8 boys and 8 girls, age 11 to 17 years, all prescribed bupropion sustained release (S...

journal_title：Therapeutic drug monitoring

authors： Daviss WB,Perel JM,Brent DA,Axelson DA,Rudolph GR,Gilchrist R,Nuss S,Birmaher B

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to conduct a population pharmacokinetic (PK) analysis of meropenem and to explore the optimal dosing strategy for meropenem in critically ill patients with acute kidney injury receiving treatment with continuous hemodiafiltration (CHDF). METHODS:Blood samples were obtained on days ...

journal_title：Therapeutic drug monitoring

authors： Niibe Y,Suzuki T,Yamazaki S,Suzuki T,Takahashi N,Hattori N,Nakada TA,Oda S,Ishii I

更新日期：2020-08-01 00:00:00

abstract：:Caffeine is a potentially useful alternative to theophylline for the treatment and prevention of apnea of prematurity because of its lower toxicity and longer terminal half-life. Monitoring of salivary caffeine concentrations is less invasive than blood sampling, especially in very sick premature neonates. Caffeine ci...

journal_title：Therapeutic drug monitoring

authors： Lee TC,Charles BG,Steer PA,Flenady VJ

更新日期：1996-06-01 00:00:00

abstract：:The immunosuppressants cyclosporine, tacrolimus, sirolimus, everolimus, and probably also mycophenolic acid require therapeutic drug monitoring (TDM)-guided dosing to ensure that blood concentrations are kept within the target range in transplant patients. Reliable, accurate, and precise test methods are therefore ess...

journal_title：Therapeutic drug monitoring

authors： Christians U,Vinks AA,Langman LJ,Clarke W,Wallemacq P,van Gelder T,Renjen V,Marquet P,Meyer EJ

更新日期：2015-12-01 00:00:00

abstract：:The emergence of point-of-care assays enabling bedside testing such as the VerifyNow P2Y12 system might prove useful in clinical settings. The aim of this study was to evaluate the ability of the VerifyNow P2Y12 assay to estimate the inhibition of platelet aggregation provided by clopidogrel in the absence of baseline...

journal_title：Therapeutic drug monitoring

authors： Lordkipanidzé M,Pharand C,Nguyen TA,Schampaert E,Diodati JG

更新日期：2008-06-01 00:00:00

abstract：:Assessment of renal function and relating this parameter to amino-glycoside clearance is important for an appropriate individualization of dosage regimens in patients with impaired renal function. However, it has been suggested that in cystic fibrosis (CF), creatinine clearance (CrCl) is not a good predictor of tobram...

journal_title：Therapeutic drug monitoring

authors： Town DJ,Vinks AA,Jacobs F,Heijerman HG,Bakker W

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore application of minimally invasive drug sampling techniques, such as dried blood spo...

journal_title：Therapeutic drug monitoring

authors： Beechinor RJ,Cohen-Wolkowiez M,Jasion T,Hornik CP,Lang JE,Hernandez R,Gonzalez D

更新日期：2019-12-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic interactions between the gastrokinetic drug cisapride and the antipsychotic drugs bromperidol and haloperidol were studied in 29 schizophrenic inpatients. Fourteen patients were taking bromperidol (12-24 mg/d), and 15 were taking haloperidol (12-36 mg/d). Cisapride 10 mg/d was coadm...

journal_title：Therapeutic drug monitoring

authors： Mihara K,Otani K,Yasui N,Ishida M,Kondo T,Suzuki A,Furukori H,Nagashima U,Kaneko S,Inoue Y

更新日期：1999-06-01 00:00:00