Abstract:
BACKGROUND:Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is considered the most common cause of persistent neonatal hypoglycemia. Management of PHHI involves use of medical agents and its failure is an indication of surgical intervention. Traditionally, an open pancreatectomy was the standard of care but recently laparoscopic pancreatectomy was described. We report our experience with laparoscopic pancreatectomy for PHHI for the period from March 2004 to February 2008. METHODS:A retrospective chart review was conducted for patients managed for PHHI with laparoscopic pancreatectomy for that period. Demographic and clinical data were retrieved. Descriptive data were generated, and SPSS version 10 statistical package (SPSS, Chicago, Ill) was used. RESULTS:Twelve patients diagnosed with PHHI were managed with laparoscopic pancreatectomy for that period. Median age at procedure was 11.5 months (range, 0.5-89 months). Median extent of pancreatectomy was 90% (range, 85%-95%). There were 2 (16%) conversions to open technique. One patient (8%) required reoperation 3 months after the procedure. Patients were followed up for a median of 23.5 months (range, 3-48 months). Four (33%) were euglycemic with no medications. Three patients remained on octreotide postoperatively to be euglycemic, and 3 patients needed a combination of octreotide and diazoxide. One patient remained euglycemic for 10 months then started on octreotide because of recurrence of hypoglycemia. One patient remained hypoglycemic postoperatively and required reoperation 3 months later to control symptoms. He became diabetic 4 months after reoperation on insulin. CONCLUSIONS:Our data suggest that laparoscopic pancreatectomy for medically unresponsive PHHI is feasible and safe. Longer follow-up is needed to ascertain effectiveness.
journal_name
J Pediatr Surgjournal_title
Journal of pediatric surgeryauthors
Al-Shanafey S,Habib Z,AlNassar Sdoi
10.1016/j.jpedsurg.2008.10.120subject
Has Abstractpub_date
2009-01-01 00:00:00pages
134-8; discussion 138issue
1eissn
0022-3468issn
1531-5037pii
S0022-3468(08)01135-4journal_volume
44pub_type
杂志文章abstract::The gastrointestinal tract harbors several populations of peptide containing nerve fibers. Among the gut neuropeptides are vasoactive intestinal peptide (VIP), substance P, enkephalin, and gastrin releasing peptide (GRP). We have examined specimens from five patients with pyloric stenosis and from five controls immuno...
journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(86)80189-0
更新日期:1986-04-01 00:00:00
abstract::Benign small bowel tumors are rare and usually present in late adult life. Because of its raity, a case of benign leiomyoma of the small bowel presenting with distal small bowel obstruction in childhood is reported, with a discussion of the principles of management. ...
journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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更新日期:1994-05-01 00:00:00
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journal_title:Journal of pediatric surgery
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更新日期:1995-07-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Journal of pediatric surgery
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更新日期:2000-03-01 00:00:00
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journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
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doi:10.1016/s0022-3468(81)80825-1
更新日期:1981-12-01 00:00:00
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journal_title:Journal of pediatric surgery
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doi:10.1016/j.jpedsurg.2016.09.016
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journal_title:Journal of pediatric surgery
pub_type: 历史文章,杂志文章,评审
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更新日期:2006-10-01 00:00:00
abstract::Pneumothorax is a common complication of ventilator therapy and usually responds to tube thoracostomy. Persistent pneumothorax with a large air leak may indicate the presence of a bronchopleural fistula (mean weight 1360 g) with (BPF) required FIO2 of 1.0, a peak inspiratory pressure of 33 cm H2O and were hypoxemic (x...
journal_title:Journal of pediatric surgery
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pub_type: 杂志文章,多中心研究
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更新日期:2014-06-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(96)90503-5
更新日期:1996-04-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/s0022-3468(86)80413-4
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journal_title:Journal of pediatric surgery
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doi:10.1016/j.jpedsurg.2005.01.009
更新日期:2005-04-01 00:00:00
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journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章,评审
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journal_title:Journal of pediatric surgery
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pub_type: 杂志文章,评审
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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journal_title:Journal of pediatric surgery
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.jpedsurg.2007.08.062
更新日期:2008-01-01 00:00:00
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journal_title:Journal of pediatric surgery
pub_type: 杂志文章
doi:10.1016/j.jpedsurg.2008.02.016
更新日期:2008-06-01 00:00:00