Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan.


:Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.


Clin Exp Metastasis


Beuth J,Ko HL,Schirrmacher V,Uhlenbruck G,Pulverer G




Has Abstract


1988-03-01 00:00:00












  • Improvements in population-based survival of patients presenting with metastatic rectal cancer in the south of the Netherlands, 1992-2008.

    abstract::We analysed population-based treatment and survival data of patients who presented with metastatic rectal cancer. All patients diagnosed with primary synchronous metastatic rectal cancer between 1992 and 2008 in the Eindhoven Cancer Registry area were included. Date of diagnosis was divided into three periods (1992-19...

    journal_title:Clinical & experimental metastasis

    pub_type: 历史文章,杂志文章


    authors: Lemmens VE,de Haan N,Rutten HJ,Martijn H,Loosveld OJ,Roumen RM,Creemers GJ

    更新日期:2011-03-01 00:00:00

  • MUC1 mediates transendothelial migration in vitro by ligating endothelial cell ICAM-1.

    abstract::MUC1 is a transmembrane glycoprotein expressed by normal breast epithelium and virtually all breast cancers. MUC1 is normally restricted to the apical surface of epithelia and loss of this polarized distribution in breast carcinomas is associated with lymph node metastasis. Our previous work found that MUC1 can bind i...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Rahn JJ,Chow JW,Horne GJ,Mah BK,Emerman JT,Hoffman P,Hugh JC

    更新日期:2005-01-01 00:00:00

  • Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases.

    abstract::To analyze the prognostic value of the extent of peritumoral brain edema in patients operated for single brain metastases (BM), we retrospectively evaluated pre-operative magnetic resonance images in a discovery cohort of 129 patients and a validation cohort of 118 patients, who underwent neurosurgical resection of a ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Spanberger T,Berghoff AS,Dinhof C,Ilhan-Mutlu A,Magerle M,Hutterer M,Pichler J,Wöhrer A,Hackl M,Widhalm G,Hainfellner JA,Dieckmann K,Marosi C,Birner P,Prayer D,Preusser M

    更新日期:2013-04-01 00:00:00

  • Inhibition of protein synthesis, pulmonary localization and pulmonary tumour formation by drug-treated tumour cells as a means of predicting their chemosensitivity.

    abstract::Mouse mammary carcinoma cells were exposed in vitro to increasing concentrations of doxorubicin hydrochloride [adriamycin (ADR)] or 5-fluorouracil (5-FU). Uptake of [75Se]selenomethionine (75SeM) in a methionine-deficient medium measured the resulting inhibition of protein synthesis by the tumour cells. This was compa...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Lai T,Stonebridge BR,Black J,Symes MO

    更新日期:1989-07-01 00:00:00

  • Selective antimetastatic effect of heparins in preclinical human melanoma models is based on inhibition of migration and microvascular arrest.

    abstract::Use of heparin derivatives in several cancer types revealed that anticoagulant therapies have a beneficiary side effect: delay of tumor progression. Since there are no data on human melanoma, we have analyzed the effect of heparins in preclinical models. Neither unfractionated heparin (UFH), nor its low molecular weig...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Bereczky B,Gilly R,Rásó E,Vágó A,Tímár J,Tóvári J

    更新日期:2005-01-01 00:00:00

  • The invasive and metastatic properties of hormone-independent but hormone-responsive variants of MCF-7 human breast cancer cells.

    abstract::We have previously isolated a series of MCF-7 human breast cancer cell variants which no longer require estrogen-supplementation for tumor growth in nude mice (Clarke et al. Proc Natl Acad Sci USA 86: 3649-3653, 1989). We now report that these hormone-independent and hormone-responsive variants (MIII, MCF7/LCC1) can i...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Thompson EW,Brünner N,Torri J,Johnson MD,Boulay V,Wright A,Lippman ME,Steeg PS,Clarke R

    更新日期:1993-01-01 00:00:00

  • Lymphatic metastasis in breast cancer: importance and new insights into cellular and molecular mechanisms.

    abstract::Lymph node metastasis is the main prognosis factor in a number of malignancies, including breast carcinomas. The means by which lymph node metastases arise is not fully understood, and many questions remain about their importance in the further spread of breast cancer. Nevertheless, a number of key cellular and molecu...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Eccles S,Paon L,Sleeman J

    更新日期:2007-01-01 00:00:00

  • Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma.

    abstract::Evidence suggests that multiple tumors, including pancreatic adenocarcinoma, display heterogeneity in parameters that are critical for tumor formation, progression and metastasis. Understanding heterogeneity in solid tumors is increasingly providing a plethora of new diagnostic and therapeutic approaches. In this stud...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Dembinski JL,Krauss S

    更新日期:2009-01-01 00:00:00

  • Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanoma.

    abstract::The exact cellular and molecular mechanisms involved in melanoma tumorigenesis remain obscure. Previous gene expression profiling analyses performed upon NHEM and human melanoma samples identified WFDC1 as one of the most frequently down-regulated genes. Here we further showed that NHEM readily express WFDC1 but expre...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Liu S,Howell P,Ren S,Fodstad O,Zhang G,Samant R,Shevde L,Xi Y,Pannell LK,Riker AI

    更新日期:2009-01-01 00:00:00

  • Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases.

    abstract::The growth of metastatic prostate cancer cells in the bone involves an intimate interaction between the tumor cells and various elements of the bone microenvironment, resulting in increased rate of bone turnover and rapid tumor growth. The alpha(v)beta3 integrin has been shown to play an important role in tumor growth...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Nemeth JA,Cher ML,Zhou Z,Mullins C,Bhagat S,Trikha M

    更新日期:2003-01-01 00:00:00

  • Distinctive alterations of invasiveness, drug resistance and cell-cell organization in 3D-cultures of MCF-7, a human breast cancer cell line, and its multidrug resistant variant.

    abstract::Growth of human tumor cells as three-dimensional (3D) multicellular spheroids modifies their invasive properties. Here we study the differences in the biological features of MCF-7, a human breast cancer cell line, and its multidrug resistant variant (MDR-MCF-7) cultured as spheroids or as monolayers. Three-dimensional...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: dit Faute MA,Laurent L,Ploton D,Poupon MF,Jardillier JC,Bobichon H

    更新日期:2002-01-01 00:00:00

  • Functional blocking of specific integrins inhibit colonic cancer migration.

    abstract::For more effective oncological management of disseminated colorectal cancer, therapies must be devised that target the different individual stages of metastasis development. Recent work showed that integrin subunits alpha2, alpha6 and beta4 are involved in the colorectal cancer cell extravasation process. By means of ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Robertson JH,Yang SY,Winslet MC,Seifalian AM

    更新日期:2009-01-01 00:00:00

  • The role of intraperitoneal chemotherapy in the surgical management of pancreatic ductal adenocarcinoma: a systematic review.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor prognosis, particularly for patients with metastatic disease. Treatment for oligometastatic presentation has been reported in recent literature, but the role of intraperitoneal chemotherapy for patients with peritoneal metastases (PM) remain...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章,评审


    authors: Brind'Amour A,Webb M,Parapini M,Sidéris L,Segedi M,Chung SW,Chartier-Plante S,Dubé P,Scudamore CH,Kim PTW

    更新日期:2021-01-24 00:00:00

  • Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts.

    abstract::Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of the triple-negative MDA-MB-468 cell line or a transplantable ER-positive patient derived xenograft (ED-03), and assessed using human-specific, tandem-nested RT-qPCR for markers relating to d...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Tachtsidis A,Le AV,Blick T,Gunasinghe D,De Sousa E,Waltham M,Dobrovic A,Thompson EW

    更新日期:2019-08-01 00:00:00

  • Thymosin beta15 expression in tumor cell lines with varying metastatic potential.

    abstract::We previously isolated thymosin beta15 from highly metastatic Dunning rat prostatic carcinoma cells. Immunohistochemical study of human prostate cancer specimens revealed a general correlation between Gleason grade and thymosin beta15 expression, with high-grade (more malignant) tumors showing increased staining compa...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Bao L,Loda M,Zetter BR

    更新日期:1998-04-01 00:00:00

  • Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells.

    abstract::Pancreatic cancer demonstrates a strong resistance to anticancer drugs, presumably due to its resistance to drug induced apoptosis. Although gemcitabine (GEM) might be partially effective for treating advanced pancreatic cancer, its efficacy is still less than satisfactory. Galectin-3 (gal-3), a member of the β-galact...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Kobayashi T,Shimura T,Yajima T,Kubo N,Araki K,Wada W,Tsutsumi S,Suzuki H,Kuwano H,Raz A

    更新日期:2011-04-01 00:00:00

  • Estradiol increases ER-negative breast cancer metastasis in an experimental model.

    abstract::Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental mo...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Yang X,Belosay A,Du M,Fan TM,Turner RT,Iwaniec UT,Helferich WG

    更新日期:2013-08-01 00:00:00

  • Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors.

    abstract::The growth and metastatic behavior of three human tumor cell lines and a human colon carcinoma previously passaged in vivo were compared between nude mice and scid mice after xenotransplantation. The three human tumor lines included a bladder carcinoma (T24B), a melanoma (RPMI 7931) and a lacZ gene-transduced breast c...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Xie X,Brünner N,Jensen G,Albrectsen J,Gotthardsen B,Rygaard J

    更新日期:1992-05-01 00:00:00

  • Soft tissue invasion of papillary thyroid carcinoma.

    abstract::Extrathyroidal extension (ETE) of papillary thyroid carcinoma (PTC) is common and clinical presentation can vary from minimal to extensive locoregional involvement. Although PTC is generally considered the most benign among all thyroid carcinomas, it may present with local invasion with poor prognosis. Our retrospecti...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Lin JD,Hsueh C,Chao TC

    更新日期:2016-08-01 00:00:00

  • Stereotactic radiation therapy in oligometastatic colorectal cancer: outcome of 102 patients and 150 lesions.

    abstract::To evaluate the local control (LC), progression free survival (PFS), out-field PFS, overall survival (OS), toxicity and failure predictors of SRT in a series of various sites oligometastatic CRC patients. Patients with oligometastatic CRC disease were analyzed retrospectively. The SRT prescribed dose was dependent on ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Dell'Acqua V,Surgo A,Kraja F,Kobiela J,Zerella MA,Spychalski P,Gandini S,Francia CM,Ciardo D,Fodor C,Ferrari AM,Piperno G,Cattani F,Vigorito S,Pansini F,Petz W,Orecchia R,Leonardi MC,Jereczek-Fossa BA

    更新日期:2019-08-01 00:00:00

  • Identification of S100A14 as a metastasis-promoting molecule in a murine organotropic metastasis model.

    abstract::Cancer metastasis shows great diversity in target organs, routes and molecular mechanisms depending on the type of cancer and even on the individual patients. To identify key molecules involved in metastasis, we constructed a murine model system including multiple sublines with different organotropism and pathways of ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Sugino T,Ichikawa-Tomikawa N,Tanaka M,Shishito N,Miura T,Abe M,Muramatsu K,Oishi T,Kakuda Y,Kawata T,Akiyama Y

    更新日期:2019-08-01 00:00:00

  • Naturally occurring resistance of bone marrow mononuclear and metastatic cancer cells to anticancer agents.

    abstract::Numerous cancer patients fail standard chemotherapy or develop resistance to chemotherapy during the course of treatment. The purpose of this study is to elucidate the overall response of cells obtained from cancer patients and from normal individuals to chemotherapeutic agents. We analysed the chemosensitivity of can...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Richard C,Yau J,Th'ng JP,Duivenvoorden WC

    更新日期:2006-01-01 00:00:00

  • The lack of correlation between experimental metastatic potential and platelet aggregating activity of B16 melanoma clones viewed in relation to tumor cell heterogeneity.

    abstract::Two widely used B16 melanoma cell lines of low and high lung colonizing potential (B16-F1 and B16-F10) were compared in their ability to induce platelet aggregation. The results of these experiments showed a reproducible difference in platelet aggregating activity of these two cell lines which directly correlated with...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Kimura AK,Mehta P,Xiang JH,Lawson D,Dugger D,Kao KJ,Lee-Ambrose L

    更新日期:1987-04-01 00:00:00

  • Impact of decompressive laminectomy on the functional outcome of patients with metastatic spinal cord compression and neurological impairment.

    abstract::Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a ...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Younsi A,Riemann L,Scherer M,Unterberg A,Zweckberger K

    更新日期:2020-04-01 00:00:00

  • Role of extracellular matrix proteins in regulation of human glioma cell invasion in vitro.

    abstract::Primary brain tumors lack the metastatic behavior that is in part believed to be promoted by the extracellular matrix (ECM) components of the basement membrane. This study was intended to examine the influence of the ECM components present in the basement membrane that may act as natural barriers to tumor cell invasio...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Chintala SK,Gokaslan ZL,Go Y,Sawaya R,Nicolson GL,Rao JS

    更新日期:1996-09-01 00:00:00

  • Therapeutic efficacy of two different cytostatic-linked phosphonates in combination with razoxane in the transplantable osteosarcoma of the rat.

    abstract::Two new compounds, 4-[4-[bis-(2-chloroethyl)-amino-]phenyl]-1- hydroxybutane-1,1-bisphosphonic acid (BAD) and aminotris-(methylenephosphonato)-diamminoplatinum(II) (ADP) that both have cytostatic and osteotropic properties, have shown good therapeutic efficacy against an osteosarcoma which metastasizes and kills by lu...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Klenner T,Wingen F,Keppler B,Valenzuela-Paz P,Amelung F,Schmähl D

    更新日期:1990-07-01 00:00:00

  • Diagnostic identification of malignant cells in the cerebrospinal fluid by tumor-specific qRT-PCR.

    abstract::Tumor specific quantitative RT-PCRs for two neuroblastoma specific molecular markers, tyrosine hydroxylase (TH) and GD2 synthase, were used to unequivocally demonstrate the neoplastic nature of the cells present in the cerebrospinal fluid of a neuroblastoma patient. After radical surgery of two separate tumoral lesion...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Rosanda C,Gambini C,Carlini B,Conte M,De Bernardi B,Garaventa A,Corrias MV

    更新日期:2006-01-01 00:00:00

  • KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha.

    abstract::Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas. We show here that KiSS1 is also a metastasis suppressor in human ovarian cancer. Ov...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Jiang Y,Berk M,Singh LS,Tan H,Yin L,Powell CT,Xu Y

    更新日期:2005-01-01 00:00:00

  • Control of pulmonary metastases of rat mammary cancer by inhibition of uPA and COX-2, singly and in combination.

    abstract::Tumor cell metastasis can be suppressed by the attenuation of proteolytic and angiogenic events that are mediated by tumor and endothelial cells. Combinations of specific inhibitors directed to separate stages of the metastatic cascade may improve the potential for adjuvant therapies. Amiloride is an effective plasmin...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Evans DM,Sloan Stakleff KD

    更新日期:2004-01-01 00:00:00

  • Isolation and characterization of a low metastatic variant from EL-4 mouse T-lymphoma.

    abstract::A variant cell line (EL-4ad) which adhered to a tissue culture dish was isolated from highly metastatic EL-4 murine T-lymphoma. The experimental and spontaneous metastatic ability of EL-4ad was lower than that of the EL-4 parent cell line. The cell surface phenotypes of both cell lines were CD2+3+4-8-45+TCR alpha beta...

    journal_title:Clinical & experimental metastasis

    pub_type: 杂志文章


    authors: Ota T,Tanino M,Kohno H,Funamoto H,Odashima S

    更新日期:1992-09-01 00:00:00