Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan.

Abstract:

:Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.

journal_name

Clin Exp Metastasis

authors

Beuth J,Ko HL,Schirrmacher V,Uhlenbruck G,Pulverer G

doi

10.1007/BF01784842

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

115-20

issue

2

eissn

0262-0898

issn

1573-7276

journal_volume

6

pub_type

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