Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan.

abstract：:The urokinase-type plasminogen activator (UPA) and its inhibitor PAI-1 are thought to play an important part in gastric cancer (GC) invasion and metastasis. Little is known about the behavior and prognostic impact of the receptor for UPA (UPAR). The aims of the present study were: (1) to measure UPAR, UPA and PAI-1 le...

journal_title：Clinical & experimental metastasis

authors： Plebani M,Herszènyi L,Carraro P,De Paoli M,Roveroni G,Cardin R,Tulassay Z,Naccarato R,Farinati F

更新日期：1997-07-01 00:00:00

abstract：:Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of the triple-negative MDA-MB-468 cell line or a transplantable ER-positive patient derived xenograft (ED-03), and assessed using human-specific, tandem-nested RT-qPCR for markers relating to d...

journal_title：Clinical & experimental metastasis

authors： Tachtsidis A,Le AV,Blick T,Gunasinghe D,De Sousa E,Waltham M,Dobrovic A,Thompson EW

更新日期：2019-08-01 00:00:00

abstract：:The effect of thioglycollate-elicited macrophages (TG-M phi) on natural killer (NK)-cell activity and metastases formation in mice was investigated. Intravenously (i.v.) inoculated TG-M phi inhibited spleen NK activity of normal mice and abrogated polyinosinic: polycytidylic (poly I:C) induced augmentation of NK cell ...

journal_title：Clinical & experimental metastasis

authors： Gorelik E,Wiltrout RH,Brunda MJ,Bere WE,Herberman RB

更新日期：1985-04-01 00:00:00

abstract：:Numerous cancer patients fail standard chemotherapy or develop resistance to chemotherapy during the course of treatment. The purpose of this study is to elucidate the overall response of cells obtained from cancer patients and from normal individuals to chemotherapeutic agents. We analysed the chemosensitivity of can...

journal_title：Clinical & experimental metastasis

authors： Richard C,Yau J,Th'ng JP,Duivenvoorden WC

更新日期：2006-01-01 00:00:00

abstract：:Recent studies have indicated that KHT fibrosarcoma or B16 melanoma cell variants capable of forming experimental metastases in the lungs of mice after i.v. injection are created stochastically at high rates (approximately 10(-5)/cell/generation). Expression of this phenotype is unstable and hence expanding population...

journal_title：Clinical & experimental metastasis

authors： Young SD,Hill RP

更新日期：1986-07-01 00:00:00

abstract：:The idea for this Special Issue originated from our recent review in Nature Reviews Clinical Oncology entitled "Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?" Martin et al. (Nat Rev Clin Oncol 14:32-44, 2017). While preparing this review, it became evident that an overwhelmi...

journal_title：Clinical & experimental metastasis

authors： Martin OA,Anderson RL

更新日期：2018-04-01 00:00:00

abstract：:Metastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a ...

journal_title：Clinical & experimental metastasis

authors： Younsi A,Riemann L,Scherer M,Unterberg A,Zweckberger K

更新日期：2020-04-01 00:00:00

abstract：:Emerging evidence suggests that gap junctional intercellular communication (GJIC) and expression of connexins (Cx) contribute to the metastatic potential of breast cancer cells. To more directly address this, an aggressive bone metastasis breast cancer cell line, MDA-MET (MET), was stably transfected with human Cx43 c...

journal_title：Clinical & experimental metastasis

authors： Li Z,Zhou Z,Donahue HJ

更新日期：2008-01-01 00:00:00

abstract：:The interaction between circulating tumor cells and blood components, mainly platelets, plays an important role during metastasis. In this study, we prepared liposomes containing the platelet aggregation inhibitor Cilostazol (Cil-L). The objective of this study was to investigate the effect of this Cil-L on platelet a...

journal_title：Clinical & experimental metastasis

authors： Wenzel J,Zeisig R,Fichtner I

更新日期：2010-01-01 00:00:00

abstract：:Development of central nervous system (CNS) metastases in breast cancer (BC) is associated with poor prognosis. The incidence of CNS metastases in metastatic BC is reported to be about 10-16 %, but different subtypes of BC are associated with different risk of developing CNS metastases. We retrospectively analysed the...

journal_title：Clinical & experimental metastasis

authors： Minisini AM,Moroso S,Gerratana L,Giangreco M,Iacono D,Poletto E,Guardascione M,Fontanella C,Fasola G,Puglisi F

更新日期：2013-12-01 00:00:00

abstract：:As a reliable model for osteosarcoma is lacking, three human cell lines (SaOS-2, U2OS and 143B) were evaluated in cell-based assays for proliferation, adhesion, migration, invasion, anchorage-independent growth, angiogenesis, mineralised nodule formation, plasmid transfection and oligonucleotide transfection. Tumor ta...

journal_title：Clinical & experimental metastasis

authors： Dass CR,Ek ET,Contreras KG,Choong PF

更新日期：2006-01-01 00:00:00

abstract：:GPR56, a non-classical adhesion receptor, was previously reported to suppress tumor growth and metastasis in xenograft models using human melanoma cell lines. To understand whether GPR56 plays similar roles in the development of endogenous tumors, we analyzed cancer progression in Gpr56 (-/-) mice using a variety of t...

journal_title：Clinical & experimental metastasis

authors： Xu L,Begum S,Barry M,Crowley D,Yang L,Bronson RT,Hynes RO

更新日期：2010-04-01 00:00:00

abstract：:Prostate cancer metastases form selectively in the bone marrow. Previously we demonstrated motility was important for the formation of primary prostatic epithelial cell colonies in bone marrow stroma (BMS) co-culture. In this study we looked at the influence of motility factors on the colony formation of epithelial ce...

journal_title：Clinical & experimental metastasis

authors： Lang SH,Clarke NW,George NJ,Testa NG

更新日期：1999-06-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:This study was carried out to clarify the presentation, treatment options, and prognosis of renal cell carcinoma (RCC) metastasis to the bladder in which we do not yet have a comprehensive understanding. A systematic Medline, Web of Science, Embase, Google, and Ichushi Web search was performed to identify articles des...

journal_title：Clinical & experimental metastasis

authors： Matsumoto K,Hayakawa N,Nakamura S,Oya M

更新日期：2015-02-01 00:00:00

abstract：:Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being 2 years. The metastatic lesions often arise in the skeleton, and current treatment options are primarily palliative. Using guidelines set forth by the National ...

journal_title：Clinical & experimental metastasis

authors： Gallaher J,Cook LM,Gupta S,Araujo A,Dhillon J,Park JY,Scott JG,Pow-Sang J,Basanta D,Lynch CC

更新日期：2014-12-01 00:00:00

abstract：:Evidence suggests that multiple tumors, including pancreatic adenocarcinoma, display heterogeneity in parameters that are critical for tumor formation, progression and metastasis. Understanding heterogeneity in solid tumors is increasingly providing a plethora of new diagnostic and therapeutic approaches. In this stud...

journal_title：Clinical & experimental metastasis

authors： Dembinski JL,Krauss S

更新日期：2009-01-01 00:00:00

abstract：:To evaluate the local control (LC), progression free survival (PFS), out-field PFS, overall survival (OS), toxicity and failure predictors of SRT in a series of various sites oligometastatic CRC patients. Patients with oligometastatic CRC disease were analyzed retrospectively. The SRT prescribed dose was dependent on ...

journal_title：Clinical & experimental metastasis

authors： Dell'Acqua V,Surgo A,Kraja F,Kobiela J,Zerella MA,Spychalski P,Gandini S,Francia CM,Ciardo D,Fodor C,Ferrari AM,Piperno G,Cattani F,Vigorito S,Pansini F,Petz W,Orecchia R,Leonardi MC,Jereczek-Fossa BA

更新日期：2019-08-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Human fibrosarcoma HT1080 cell surface phenotype analysis revealed the expression of "cluster of differentiation 15" (CD15) antigen and to a lesser extent, of "very late antigen-4" (VLA-4). Expression of "endothelial-leukocyte adhesion molecule-1" (ELAM-1) was negligible on resting human umbilical vascular endothelial...

journal_title：Clinical & experimental metastasis

authors： Yudoh K,Matsui H,Tsuji H

更新日期：1997-11-01 00:00:00

abstract：:This short review offers an update on the first and second Multicenter Selective Lymphadenectomy Trials (MSLT-I and MSLT-II) for patients with melanoma, and briefly traces the development of intraoperative lymphatic mapping and sentinel node biopsy. ...

journal_title：Clinical & experimental metastasis

authors： Morton DL

更新日期：2012-10-01 00:00:00

abstract：:About 30-40% of patients with renal cell carcinoma (RCC) will develop metastasis after curative nephrectomy. There is a strong need to identify the early metastasis with conventional and molecular risk factors. The present study aimed to test if analysis of the CA9 gene can provide useful information to predict early ...

journal_title：Clinical & experimental metastasis

authors： Li G,Feng G,Gentil-Perret A,Genin C,Tostain J

更新日期：2007-01-01 00:00:00

abstract：:A number of papers have been published on the clinical correlation of the expression of the 67 kDa laminin binding protein (LBP) with the metastatic potential of solid tumors. Both mRNA and protein expression levels have been reported, but both the relationship between them and the molecular nature of the 67 kDa surfa...

journal_title：Clinical & experimental metastasis

authors： Landowski TH,Uthayakumar S,Starkey JR

更新日期：1995-09-01 00:00:00

abstract：:The purpose of this study was to identify possible alterations in proto-oncogenes (c-fos, c-jun, c-erbB1, c-erbB2 and c-myc) at the protein level in primary lung carcinomas and simultaneous metastatic lymph nodes of 21 patients. The analysis showed that proteins of c-jun and c-myc were expressed in a significantly hig...

journal_title：Clinical & experimental metastasis

authors： Volm M,van Kaick G,Mattern J

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Metastasis to bone from endometrial adenocarcinoma is rare, when metastasises it usually locates in axial skeleton. Metastasis to extremities is extremely rare. Additionally the detection of the bone metastasis as a presenting feature is uncommon. In the present study we report the 10th cases of bone metasta...

journal_title：Clinical & experimental metastasis

authors： Kaya A,Olmezoglu A,Eren CS,Bayol U,Altay T,Karapinar L,Ozturk H,Oztekin D,Guvenli Y,Karadogan I

更新日期：2007-01-01 00:00:00

abstract：:To analyze the prognostic value of the extent of peritumoral brain edema in patients operated for single brain metastases (BM), we retrospectively evaluated pre-operative magnetic resonance images in a discovery cohort of 129 patients and a validation cohort of 118 patients, who underwent neurosurgical resection of a ...

journal_title：Clinical & experimental metastasis

authors： Spanberger T,Berghoff AS,Dinhof C,Ilhan-Mutlu A,Magerle M,Hutterer M,Pichler J,Wöhrer A,Hackl M,Widhalm G,Hainfellner JA,Dieckmann K,Marosi C,Birner P,Prayer D,Preusser M

更新日期：2013-04-01 00:00:00

abstract：:Circulating microRNAs have been described as head and neck cancer biomarkers in multiple anatomical subsites including the oral cavity, nasopharynx, larynx, salivary glands and the skin. While there is an expanding volume of published literature showing the significance of individual or panels of microRNAs, the clinic...

journal_title：Clinical & experimental metastasis

authors： Dharmawardana N,Ooi EH,Woods C,Hussey D

更新日期：2019-06-01 00:00:00

abstract：:Previous studies have shown that thrombospondin (TSP) is an adhesion factor for some human tumor cells. The previous studies have shown further that tumor cells which utilize TSP as an adhesion factor also synthesize it. This study continues the effort to understand how TSP production and expression are regulated in h...

journal_title：Clinical & experimental metastasis

authors： Varani J,Riser BL,Hughes LA,Carey TE,Fligiel SE,Dixit VM

更新日期：1989-05-01 00:00:00

abstract：:To aid in therapy selection for patients with spinal bone metastases (SBM), predictive models have been developed. These models consider SBM from breast cancer a positive predictive factor, but do not take phenotypes based on estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors into ac...

journal_title：Clinical & experimental metastasis

authors： Bollen L,Wibmer C,Wang M,van der Linden YM,Leithner A,Bünger CE,Jensen AB,Fiocco M,Bratschitsch G,Pondaag W,Bovée JV,Dijkstra PD

更新日期：2015-01-01 00:00:00

abstract：:Bone sialoprotein (BSP) and osteopontin (OPN) are important factors in the metastasis of breast cancer, which were examined as targets for antineoplastic therapy by siRNA. In addition, the effect of gene silencing on their transcription factor Runx2 and their interaction partners integrin β(3) and matrix metalloprotei...

journal_title：Clinical & experimental metastasis

authors： Reufsteck C,Lifshitz-Shovali R,Zepp M,Bäuerle T,Kübler D,Golomb G,Berger MR

更新日期：2012-06-01 00:00:00