Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan.

abstract：:We performed repetitive molecular staging using, nested rt-PCR for PSA and PSM at the peripheral blood (PB) and bone marrow (BM) of patients with prostate cancer (Pr.Ca) and benign prostate hyperplasia (BPH) after transrectal ultrasonography-guided biopsy (TRUS-B; 6-9 biopsies/patient), Pr.Ca patients after radical pr...

journal_title：Clinical & experimental metastasis

authors： Koutsilieris M,Lembessis P,Luu-The V,Sourla A

更新日期：1999-01-01 00:00:00

abstract：:Metastasis is the most devastating aspect of cancer and it is the main cause of morbidity and mortality in cancer patients. Tumor cell adhesion to the vascular endothelial cell lining is an important step in metastatic progression and is prompted by platelets. Mucin 1 is over-expressed and aberrantly glycosylated in m...

journal_title：Clinical & experimental metastasis

authors： Sudha T,Phillips P,Kanaan C,Linhardt RJ,Borsig L,Mousa SA

更新日期：2012-06-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metastatic propensity is significantly influenced by the genetic background upon which tumors arise. We have also established that human gene expression profiles predictive of metastasis are not only present in mouse tumors with both high and low metastatic c...

journal_title：Clinical & experimental metastasis

authors： Yang H,Crawford N,Lukes L,Finney R,Lancaster M,Hunter KW

更新日期：2005-01-01 00:00:00

abstract：:MUC1 is a transmembrane glycoprotein expressed by normal breast epithelium and virtually all breast cancers. MUC1 is normally restricted to the apical surface of epithelia and loss of this polarized distribution in breast carcinomas is associated with lymph node metastasis. Our previous work found that MUC1 can bind i...

journal_title：Clinical & experimental metastasis

authors： Rahn JJ,Chow JW,Horne GJ,Mah BK,Emerman JT,Hoffman P,Hugh JC

更新日期：2005-01-01 00:00:00

abstract：:Breast cancer has a predilection for metastasis to the bone marrow. The preprotachykinin-I (PPT-I) gene has a central role in the early migration of breast cancer cells into the bone marrow, making this organ a latent repository of the cancer cells. This study investigated whether the invasive and metastatic potential...

journal_title：Clinical & experimental metastasis

authors： Castro TA,Cohen MC,Rameshwar P

更新日期：2005-01-01 00:00:00

abstract：:Despite an initial response to antihormonal therapies, the development of resistance will occur in a significant number of breast cancer patients. The mechanisms that underlie acquired resistance are not yet clear. Using a previously established in vitro cell model of tamoxifen resistance in MCF7 cells, shown to displ...

journal_title：Clinical & experimental metastasis

authors： Hiscox S,Morgan L,Barrow D,Dutkowskil C,Wakeling A,Nicholson RI

更新日期：2004-01-01 00:00:00

abstract：:Activation of nuclear factor-κB (NF-κB) has been implicated in metastasis of pancreatic cancer. We investigated the effects of the novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) on the inhibition of liver metastasis of pancreatic cancer in a mouse model of clinical liver metastasis. Nude mice were xenogr...

journal_title：Clinical & experimental metastasis

authors： Suzuki K,Aiura K,Matsuda S,Itano O,Takeuchi O,Umezawa K,Kitagawa Y

更新日期：2013-04-01 00:00:00

abstract：:The anti-metastatic efficacy and safety of a newly-developed matrix metalloproteinase (MMP) inhibitor were examined. MMI-166, a N-sulfonylamino acid derivative, inhibited the enzyme activity of MMP-2, 9, and 14 but not MMP-1, 3 or 7. Daily oral administration of MMI-166 resulted in potent inhibition of metastatic lung...

journal_title：Clinical & experimental metastasis

authors： Maekawa R,Maki H,Wada T,Yoshida H,Nishida-Nishimoto K,Okamoto H,Matsumoto Y,Tsuzuki H,Yoshioka T

更新日期：2000-01-01 00:00:00

abstract：:Experimental hepatic metastasis of colorectal tumors is frequently studied by local intrahepatic tumor cell implantation. However, although a variety of factors of the implantation procedure may markedly influence tumor growth characteristics, standards are not defined yet. Herein, we studied the effect of different m...

journal_title：Clinical & experimental metastasis

authors： Kollmar O,Schilling MK,Menger MD

更新日期：2004-01-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 p...

journal_title：Clinical & experimental metastasis

authors： Gabril M,Girgis H,Scorilas A,Rotondo F,Wala S,Bjarnason GA,Ding Q,Evans A,Tawedrous E,Pasic M,Finelli A,Al-Haddad S,Yousef GM

更新日期：2016-01-01 00:00:00

abstract：:Little is known about the biological characteristics that determine the prognosis of colorectal cancer (CRC) liver metastases. In previous work we reported three different histological patterns of the tumour-liver interface of CRC liver metastases, termed the pushing, replacement and desmoplastic growth pattern (GP). ...

journal_title：Clinical & experimental metastasis

authors： Van den Eynden GG,Bird NC,Majeed AW,Van Laere S,Dirix LY,Vermeulen PB

更新日期：2012-08-01 00:00:00

abstract：:Osteopontin (OPN) is a glycosylated, secreted phosphoprotein that functions both as a cell attachment and chemotactic factor. Elevated expression of OPN confers enhanced metastatic ability on transformed cells, suggesting that OPN may contribute to the malignant progression of tumors. Migration of mammary carcinoma ce...

journal_title：Clinical & experimental metastasis

authors： Khan SA,Cook AC,Kappil M,Günthert U,Chambers AF,Tuck AB,Denhardt DT

更新日期：2005-01-01 00:00:00

abstract：:Previous studies have shown that thrombospondin (TSP) is an adhesion factor for some human tumor cells. The previous studies have shown further that tumor cells which utilize TSP as an adhesion factor also synthesize it. This study continues the effort to understand how TSP production and expression are regulated in h...

journal_title：Clinical & experimental metastasis

authors： Varani J,Riser BL,Hughes LA,Carey TE,Fligiel SE,Dixit VM

更新日期：1989-05-01 00:00:00

abstract：:Solid tumors consist of genetically and phenotypically diverse subpopulations of cancer cells with unique capacities for growth, differentiation, and invasion. While the molecular and microenvironmental bases for heterogeneity are increasingly appreciated, the outcomes of such intratumor heterogeneity, particularly in...

journal_title：Clinical & experimental metastasis

authors： Carey SP,Starchenko A,McGregor AL,Reinhart-King CA

更新日期：2013-06-01 00:00:00

abstract：:Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of the triple-negative MDA-MB-468 cell line or a transplantable ER-positive patient derived xenograft (ED-03), and assessed using human-specific, tandem-nested RT-qPCR for markers relating to d...

journal_title：Clinical & experimental metastasis

authors： Tachtsidis A,Le AV,Blick T,Gunasinghe D,De Sousa E,Waltham M,Dobrovic A,Thompson EW

更新日期：2019-08-01 00:00:00

abstract：:The exact cellular and molecular mechanisms involved in melanoma tumorigenesis remain obscure. Previous gene expression profiling analyses performed upon NHEM and human melanoma samples identified WFDC1 as one of the most frequently down-regulated genes. Here we further showed that NHEM readily express WFDC1 but expre...

journal_title：Clinical & experimental metastasis

authors： Liu S,Howell P,Ren S,Fodstad O,Zhang G,Samant R,Shevde L,Xi Y,Pannell LK,Riker AI

更新日期：2009-01-01 00:00:00

abstract：:The colon carcinoma cell line HT-29 was used to explore the potential of interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) to modify integrin expression and adhesive functions of tumor cells in vitro and to examine corresponding metastatic effects in vivo. Preincubation of HT-29 cells with 100 U/ml of I...

journal_title：Clinical & experimental metastasis

authors： Herzberg F,Schöning M,Schirner M,Topp M,Thiel E,Kreuser ED

更新日期：1996-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with increasing incidence. Despite curative surgical resection and advanced chemotherapy, its survival rate remains low. The presence of microvascular invasion and occult metastasis is one of the major causes for this poor outcome. MDM2 Binding...

journal_title：Clinical & experimental metastasis

authors： Bi Q,Ranjan A,Fan R,Agarwal N,Welch DR,Weinman SA,Ding J,Iwakuma T

更新日期：2015-04-01 00:00:00

abstract：:The growth of metastatic prostate cancer cells in the bone involves an intimate interaction between the tumor cells and various elements of the bone microenvironment, resulting in increased rate of bone turnover and rapid tumor growth. The alpha(v)beta3 integrin has been shown to play an important role in tumor growth...

journal_title：Clinical & experimental metastasis

authors： Nemeth JA,Cher ML,Zhou Z,Mullins C,Bhagat S,Trikha M

更新日期：2003-01-01 00:00:00

abstract：:Brain metastases are the most common intracranial tumors in adults, accounting for more than 50% of all such cases. The approach to and management of brain metastases have evolved significantly in recent years due to several reasons. These include advances in neurosurgical and radiotherapeutic techniques, improved sys...

journal_title：Clinical & experimental metastasis

authors： Thiagarajan A,Yamada Y

更新日期：2017-10-01 00:00:00

abstract：:The urokinase-type plasminogen activator (UPA) and its inhibitor PAI-1 are thought to play an important part in gastric cancer (GC) invasion and metastasis. Little is known about the behavior and prognostic impact of the receptor for UPA (UPAR). The aims of the present study were: (1) to measure UPAR, UPA and PAI-1 le...

journal_title：Clinical & experimental metastasis

authors： Plebani M,Herszènyi L,Carraro P,De Paoli M,Roveroni G,Cardin R,Tulassay Z,Naccarato R,Farinati F

更新日期：1997-07-01 00:00:00

abstract：:In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent vali...

journal_title：Clinical & experimental metastasis

authors： Yin G,Li C,Chen H,Luo Y,Orlandini LC,Wang P,Lang J

更新日期：2017-02-01 00:00:00

abstract：:We have previously reported that induction of MMP-2 activation by Concanavalin A (ConA) in MDA-MB-231 human breast cancer cells involves both transcriptional and post-transcriptional mechanisms, and that the continuous presence of ConA is required for MMP-2 activation (Yu et al. Cancer Res, 55, 3272-7, 1995). In an ef...

journal_title：Clinical & experimental metastasis

authors： Yu M,Sato H,Seiki M,Spiegel S,Thompson EW

更新日期：1998-02-01 00:00:00

abstract：:Tumor metastasis often confers poor prognosis for cancer patients due to lack of comprehensive strategy in dealing with cells growing in different environment. Current anticancer therapies have incomplete effectiveness because they were designed assuming metastatic tumors behave similarly in different organs. We hypot...

journal_title：Clinical & experimental metastasis

authors： Alsaggar M,Yao Q,Cai H,Liu D

更新日期：2016-02-01 00:00:00

abstract：:Breast cancer metastasizes to bone with high frequency and incidence. However, studies of breast cancer metastasis to bone have been limited by two factors. First, the number of models that colonize bone are limited. Second, detection of bone metastases is too insensitive or too laborious for routine, large-scale stud...

journal_title：Clinical & experimental metastasis

authors： Harms JF,Welch DR

更新日期：2003-01-01 00:00:00

abstract：:Evidence suggests that multiple tumors, including pancreatic adenocarcinoma, display heterogeneity in parameters that are critical for tumor formation, progression and metastasis. Understanding heterogeneity in solid tumors is increasingly providing a plethora of new diagnostic and therapeutic approaches. In this stud...

journal_title：Clinical & experimental metastasis

authors： Dembinski JL,Krauss S

更新日期：2009-01-01 00:00:00

abstract：:Human tissue factor pathway inhibitor-2 (TFPI-2), also known as placental protein (PP5) and matrix-associated serine protease inhibitor (MSPI), is a 32-kDa extracellular matrix (ECM) protein consisting of three tandomly arranged Kunitz-type domains that inhibits plasmin, trypsin, chymotrypsin, cathepsin G and plasma k...

journal_title：Clinical & experimental metastasis

authors： Konduri SD,Tasiou A,Chandrasekar N,Nicolson GL,Rao JS

更新日期：2000-01-01 00:00:00

abstract：:Melanoma is an aggressive cutaneous malignancy with rapidly rising incidence. Diagnosis of controversial melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges. Despite these challenge...

journal_title：Clinical & experimental metastasis

authors： Ankeny JS,Labadie B,Luke J,Hsueh E,Messina J,Zager JS

更新日期：2018-08-01 00:00:00

abstract：:Secreted protein, acidic and rich in cysteine (SPARC, also known as osteonectin or BM-40) is a glycoprotein component of the extracellular matrix that has been reported to be involved with a variety of cellular processes. Although SPARC expression levels are frequently altered in a variety of tumor types, the exact im...

journal_title：Clinical & experimental metastasis

authors： Wong SY,Crowley D,Bronson RT,Hynes RO

更新日期：2008-01-01 00:00:00

abstract：:Proliferation capacity and MHC class I antigen expression of two Lewis lung carcinoma (3LL) metastatic variants (C87, BC215) grown under defined experimental conditions (serum-free defined medium or 10 per cent serum) have been studied following exposure to MoAb 135-13C which recognizes on these cells a tumor surface ...

journal_title：Clinical & experimental metastasis

authors： Sacchi A,Piaggio G,Rizzo MA,Falcioni R,Kennel SJ

更新日期：1989-01-01 00:00:00