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The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury.

Abstract：

OBJECTIVE:There is evidence to suggest that anemia after severe traumatic brain injury (sTBI) is detrimental. However, there is a paucity of evidence supporting the use of transfusion of packed red blood cells in patients with sTBI. To understand the acute effect of packed red blood cell transfusion on cerebral oxygenation and metabolism in patients with sTBI. DESIGN:Prospective clinical study. SETTING:Addenbrooke's Neurosciences Critical Care Unit, a 21-bed tertiary academic unit. PATIENTS:Thirty patients with sTBI. INTERVENTIONS:Patients were randomized by computer random number generator to one of three transfusion thresholds: 8, 9, or 10 g/dL. When the patients' hemoglobin concentration fell below their assigned threshold, two units of packed red blood cells were transfused over 2 hours. A 1-hour period of stabilization was observed before final data collection. MEASUREMENTS AND MAIN RESULTS:The primary outcome was change in brain tissue oxygen (Pbto2). Secondary outcomes included dependence of baseline hemoglobin concentration and baseline Pbto2 on the relationship of transfusion and Pbto2, and the effect of transfusion on lactate pyruvate ratio (LPR) and brain pH as markers of cerebral metabolic state. Fifty-seven percent of patients experienced an increase in Pbto2 during the course of the study, whereas in 43% of patients, Pbto2 either did not change or decreased. Multivariable generalized estimating equation analysis revealed change in hemoglobin concentration to significantly and positively associated with change in Pbto2 [0.10 kPa/(g/dL) 95% confidence interval 0.03-0.17, p = 0.003]. Improvement in Pbto2 was not associated with baseline hemoglobin concentration or low Pbto2 (<1 kPa). Fifty-six percent of patients experienced an increase in LPR. No significant relationship between change in LPR or transfusion on pHbt and change in hemoglobin could be demonstrated. CONCLUSIONS:Transfusion of packed red blood cells acutely results in improved brain tissue oxygen without appreciable effect on cerebral metabolism. TRIAL REGISTRATION:ISRCTN89085577.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Zygun DA,Nortje J,Hutchinson PJ,Timofeev I,Menon DK,Gupta AK

doi

10.1097/CCM.0b013e318194ad22

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

1074-8

issue

eissn

0090-3493

issn

1530-0293

pii

00003246-200903000-00040

journal_volume

pub_type

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The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury.