Skeletal muscle glutathione is depleted in critically ill patients.

abstract：OBJECTIVES:Lung contusion is a major risk factor for the development of acute respiratory distress syndrome. We set to determine the role of toll-like receptor 3 and the binding of double-stranded RNA in the pathogenesis of sterile injury following lung contusion. DESIGN:Toll-like receptor 3 expression was analyzed in...

journal_title：Critical care medicine

authors： Suresh MV,Thomas B,Machado-Aranda D,Dolgachev VA,Kumar Ramakrishnan S,Talarico N,Cavassani K,Sherman MA,Hemmila MR,Kunkel SL,Walter NG,Hogaboam CM,Raghavendran K

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to highlight the link between induced hypothermia and increased survival duration as observed in the septic model developed by the laboratory. To reach this objective, survival duration and blood oxygen transport capacity were measured at two temperatures-38 °C (induced normothermia...

journal_title：Critical care medicine

authors： Léon K,Pichavant-Rafini K,Quéméner E,Sébert P,Egreteau PY,Ollivier H,Carré JL,L'Her E

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVES:To explore the relationship between timing of continuous renal replacement therapy commencement and clinical outcomes in critically ill patients with acute kidney injury. The primary outcomes were all-cause mortality at 28 and 90 days. DESIGN:Nested observational cohort study using data from the Randomized ...

journal_title：Critical care medicine

authors： Jun M,Bellomo R,Cass A,Gallagher M,Lo S,Lee J,Randomized Evaluation of Normal Versus Augmented Level of Replacement Therapy (RENAL) Study Investigators.

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of human albumin administered for therapeutic purposes. DESIGN:Retrospective compilation of spontaneously reported serious adverse events. SETTING:Records of serious adverse event reports received from 1990 through 1997 by nine major suppliers of therapeutic human albumin worldwide. ...

journal_title：Critical care medicine

authors： von Hoegen I,Waller C

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of a newly appointed neurointensivist on neurosciences intensive care unit (NICU) patient outcomes and quality of care variables. DESIGN:Observational cohort with historical controls. SETTING:Ten-bed neurointensive care unit in tertiary university hospital. PATIENTS:Mortality, length...

journal_title：Critical care medicine

authors： Varelas PN,Conti MM,Spanaki MV,Potts E,Bradford D,Sunstrom C,Fedder W,Hacein Bey L,Jaradeh S,Gennarelli TA

更新日期：2004-11-01 00:00:00

abstract：:Critically ill patients who fear impending death may die suddenly. We studied prospectively the incidence of death in critically ill surgical patients who articulated the fear that they were about to die. Physiologic, environmental, and behavioral correlates which might influence perceptions of impending death were ex...

journal_title：Critical care medicine

authors： Poulton TJ,Butdorf MB

更新日期：1986-07-01 00:00:00

abstract：:This report describes an unusual hemolytic transfusion reaction. A group O donor was inadvertently transfused with 100 ml of group A red cells during the course of plasmapheresis. Granulocytopenia, thrombocytopenia, hypofibrinogenemia and low levels of factors V, VIII, and IX developed immediately after the infusion. ...

journal_title：Critical care medicine

authors： McKenna PJ,Scheinman HZ

更新日期：1975-01-01 00:00:00

abstract：OBJECTIVES:The primary objective of this study was to identify which patient demographic, patient health, and hospital characteristics were associated with in-hospital mortality. A secondary objective was to determine the relative influence of these characteristics on mortality. DESIGN AND SETTING:Public-use data for ...

journal_title：Critical care medicine

authors： Banta JE,Joshi KP,Beeson L,Nguyen HB

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To determine the relative distribution of fluid within the extracellular fluid volume (ECFV) and the effect on oxygen delivery after infusing either normal saline or 5% albumin in cardiac surgical patients. DESIGN:Prospective, randomized, unblinded, interventional study. SETTING:Cardiac surgical intensive c...

journal_title：Critical care medicine

authors： Ernest D,Belzberg AS,Dodek PM

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVES:A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure ...

journal_title：Critical care medicine

authors： Meyer N,Harhay MO,Small DS,Prescott HC,Bowles KH,Gaieski DF,Mikkelsen ME

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:To test whether hospital-based physicians made different intensive care unit and life-sustaining treatment decisions for otherwise identical black and white patients with end-stage cancer and life-threatening hypoxia. DESIGN:We conducted a randomized trial of the relationship between patient race and physic...

journal_title：Critical care medicine

authors： Barnato AE,Mohan D,Downs J,Bryce CL,Angus DC,Arnold RM

更新日期：2011-07-01 00:00:00

abstract：:To further define cardiovascular abnormalities in patients with septic shock, serial conventional hemodynamic measurements combined with two-dimensional echocardiographic studies were performed at the bedside in 21 patients admitted for an acute episode of sepsis-related circulatory failure. Measurements obtained duri...

journal_title：Critical care medicine

authors： Jardin F,Brun-Ney D,Auvert B,Beauchet A,Bourdarias JP

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:To test the hypotheses that, for uncontrolled hemorrhagic shock (UHS) in rats, mild hypothermia, compared with normothermia, would increase long-term survival as well as moderate hypothermia, oxygen breathing would increase survival further, and hypothermia and oxygen would mitigate visceral ischemia (dysoxia...

journal_title：Critical care medicine

authors： Takasu A,Stezoski SW,Stezoski J,Safar P,Tisherman SA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Procalcitonin may be associated with reduced antibiotic usage compared to usual care. However, individual randomized controlled trials testing this hypothesis were too small to rule out harm, and the full cost-benefit of this strategy has not been evaluated. The purpose of this analysis was to evaluate the ef...

journal_title：Critical care medicine

authors： Heyland DK,Johnson AP,Reynolds SC,Muscedere J

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:To create a novel tool to predict favorable neurologic outcomes during ICU stay among children with critical illness. DESIGN:Logistic regression models using adaptive lasso methodology were used to identify independent factors associated with favorable neurologic outcomes. A mixed effects logistic regressio...

journal_title：Critical care medicine

authors： Gupta P,Rettiganti M,Gossett JM,Daufeldt J,Rice TB,Wetzel RC

更新日期：2018-01-01 00:00:00

abstract：:To evaluate the effect of meconium on pulmonary surface tension properties, the mechanics of 30 excised, separated canine pulmonary lobes were studied. Meconia were blended in normal saline to produce solutions of 10% and 20%. Solutions were filtered to remove large particles and instilled endobronchially into the can...

journal_title：Critical care medicine

authors： Chen CT,Toung TJ,Rogers MC

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:A hallmark of amniotic fluid embolism is the induction of coagulation defects. Little is known about the nature of these defects or the causative agent or agents. The purpose of this study was to assess the effects of meconium containing (native) meconium-amniotic-fluid infusion (MAFI) and meconium-free (cent...

journal_title：Critical care medicine

authors： Petroianu GA,Altmannsberger SH,Maleck WH,Assmus HP,Friedberg C,Bergler WF,Rüfer R

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether changing heat and moisture exchangers (HMEs) every 96 hrs rather than 24 hrs would affect their efficacy to preserve the heat and moisture of inspiratory gases. The impact of a prolonged use of the HME on its microbial colonization was also assessed. DESIGN:Pros...

journal_title：Critical care medicine

authors： Thomachot L,Boisson C,Arnaud S,Michelet P,Cambon S,Martin C

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:To describe the physiologic mechanisms of ventilator-induced lung injury and to define the major ventilator and host-dependent risk factors that contribute to such injury. DATA SOURCE:Basic science and clinical studies related to ventilator-induced barotrauma and lung pathophysiology. STUDY SELECTION:Empha...

journal_title：Critical care medicine

authors： Parker JC,Hernandez LA,Peevy KJ

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:We previously reported gene expression-based endotypes of pediatric septic shock, endotypes A and B, and that corticosteroid exposure was independently associated with increased mortality among pediatric endotype A patients. The Vasopressin vs Norepinephrine as Initial Therapy in Septic Shock trial tested th...

journal_title：Critical care medicine

authors： Wong HR,Hart KW,Lindsell CJ,Sweeney TE

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Several studies report calcium mishandling, sarcomere disarray, and caspase activation during heart failure. Although active caspases have been shown to cleave myofibrillar proteins, little is known regarding their effects on calcium handling proteins. Therefore, we aimed to explore how endotoxin-induced casp...

journal_title：Critical care medicine

authors： Neviere R,Hassoun SM,Decoster B,Bouazza Y,Montaigne D,Maréchal X,Marciniak C,Marchetti P,Lancel S

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Tea has been around for centuries, and its medicinal properties have been purported in the literature but never fully confirmed. Interleukin-8 is a principle neutrophil chemoattractant and activator in humans. We determined the effects of theaflavin, a black tea-derived polyphenol, on tumor necrosis factor-al...

journal_title：Critical care medicine

authors： Aneja R,Odoms K,Denenberg AG,Wong HR

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVES:To determine whether mean arterial blood pressure excursions below the lower limit of cerebral blood flow autoregulation during cardiopulmonary bypass are associated with acute kidney injury after surgery. SETTING:Tertiary care medical center. PATIENTS:Four hundred ten patients undergoing cardiac surgery w...

journal_title：Critical care medicine

authors： Ono M,Arnaoutakis GJ,Fine DM,Brady K,Easley RB,Zheng Y,Brown C,Katz NM,Grams ME,Hogue CW

更新日期：2013-02-01 00:00:00

abstract：:The focus on improving education in critical care medicine must begin early in medical school training and further be promoted during residency if there is to be an increase in intensivists in the hospital workforce. This is "critical" to healthcare reform movements that are endorsing full-time critical care coverage ...

journal_title：Critical care medicine

authors： Croley WC,Rothenberg DM

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:To use a standardized tool for a multicenter assessment of antibiotic appropriateness in ICUs and identify local antibiotic stewardship improvement opportunities. DESIGN:Pilot point prevalence conducted on October 5, 2016; point prevalence survey conducted on March 1, 2017. SETTING:ICUs in 12 U.S. acute ca...

journal_title：Critical care medicine

authors： Trivedi KK,Bartash R,Letourneau AR,Abbo L,Fleisher J,Gagliardo C,Kelley S,Nori P,Rieg GK,Silver P,Srinivasan A,Vargas J,Ostrowsky B,Partnership for Quality Care (PQC) Inpatient Antimicrobial Stewardship Working Group.

更新日期：2020-07-01 00:00:00

abstract：:Hemodynamic effects of controlled mechanical ventilation (CMV), intermittent mandatory ventilation (IMV), and intermittent mandatory ventilation with 5 cm H20 PEEP (IMV 5 peep) were studied in 20 patients after aortocoronary bypass surgery. Significant increases in cardiac index (CI) and stroke volume index (SI) (p le...

journal_title：Critical care medicine

authors： Mathru M,Rao TL,El-Etr AA,Pifarre R

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVES:Cognitive deficits after traumatic brain injury are a leading cause of disability worldwide, yet no effective pharmacologic treatments exist to improve cognition. Traumatic brain injury increases proinflammatory cytokines, which trigger excess function of α5 subunit-containing γ-aminobutyric acid type A rece...

journal_title：Critical care medicine

authors： Khodaei S,Avramescu S,Wang DS,Sheng H,Chan NK,Lecker I,Fernandez-Escobar A,Lei G,Dewar MB,Whissell PD,Baker AJ,Orser BA

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To quantify the therapeutic efficacy of loop diuretics in acute renal failure using Bayesian evidence synthesis, because despite widespread use, the role of diuretics is controversial. DATA SOURCE:Randomized controlled trials or nonrandomized studies, 1966 to January 2007, identified from MEDLINE and EMBASE ...

journal_title：Critical care medicine

authors： Sampath S,Moran JL,Graham PL,Rockliff S,Bersten AD,Abrams KR

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To evaluate a novel combination of preoperative, intraoperative, and postoperative variables (including the Parsonnet, and the Acute Physiology and Chronic Health Evaluation II and III [APACHE II and III] scores) in cardiac surgery patients in order to predict hospital outcome, complications, and length of st...

journal_title：Critical care medicine

authors： Turner JS,Morgan CJ,Thakrar B,Pepper JR

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:Sepsis results in organ dysfunction caused by a dysregulated host response, in part related to the immune response of a severe infection. Mesenchymal stromal cells are known to modulate the immune response, and expression of stromal cell-derived factor-1 regulates mobilization of neutrophils from the bone ma...

journal_title：Critical care medicine

authors： Kwon MY,Ghanta S,Ng J,Tsoyi K,Lederer JA,Bronson RT,El-Chemaly S,Chung SW,Liu X,Perrella MA

更新日期：2020-05-01 00:00:00