Critical care checklists, the Keystone Project, and the Office for Human Research Protections: a case for streamlining the approval process in quality-improvement research.

abstract：OBJECTIVES:To measure total serum nitrite and nitrate concentrations in children with the sepsis syndrome as an indicator of endogenous nitric oxide production. To determine if there is an association between total serum nitrite and nitrate concentrations and vascular responsiveness to norepinephrine. DESIGN:A prospec...

journal_title：Critical care medicine

authors： Wong HR,Carcillo JA,Burckart G,Shah N,Janosky JE

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:The antimetabolite drug, 5-fluorouracil, inhibits microbial growth. Coating of central venous catheters with 5-fluorouracil may reduce the risk of catheter infection. Our objective was to compare the safety and efficacy of central venous catheters externally coated with 5-fluorouracil with those coated with c...

journal_title：Critical care medicine

authors： Walz JM,Avelar RL,Longtine KJ,Carter KL,Mermel LA,Heard SO,5-FU Catheter Study Group.

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:To investigate the concentrations of reduced and total glutathione in relation to the muscle free amino acid pattern in critically ill patients and matched healthy controls. DESIGN:Prospective case control. SETTING:University hospital intensive care unit (ICU). PATIENTS:Eleven critically ill patients in th...

journal_title：Critical care medicine

authors： Hammarqvist F,Luo JL,Cotgreave IA,Andersson K,Wernerman J

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:Cardiac surgery is frequently followed by postoperative delirium, which is associated with increased 1-year mortality, late cognitive deficits, and higher costs. Currently, there are no recommendations for pharmacologic prevention of postoperative delirium. Impaired cholinergic transmission is believed to pla...

journal_title：Critical care medicine

authors： Gamberini M,Bolliger D,Lurati Buse GA,Burkhart CS,Grapow M,Gagneux A,Filipovic M,Seeberger MD,Pargger H,Siegemund M,Carrel T,Seiler WO,Berres M,Strebel SP,Monsch AU,Steiner LA

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Acute lung injury is a detrimental complication for victims of burn accidents. Airway obstruction plays an important role in pulmonary dysfunction in these patients. In this study, we tested the hypothesis that aerosolized anticoagulants will reduce the degree of airway obstruction and improve pulmonary funct...

journal_title：Critical care medicine

authors： Enkhbaatar P,Cox RA,Traber LD,Westphal M,Aimalohi E,Morita N,Prough DS,Herndon DN,Traber DL

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:To assess the intrarater and interrater reliability of electrocardiogram (ECG) interpretation in critically ill patients and to assess the effect of knowledge of cardiac troponin values on these reliability estimates. DESIGN:Prospective cohort study. SETTING:Fifteen-bed medical-surgical intensive care unit....

journal_title：Critical care medicine

authors： Lim W,Qushmaq I,Cook DJ,Devereaux PJ,Heels-Ansdell D,Crowther MA,Tkaczyk A,Meade MO,Cook RJ

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Our goal was to demonstrate explicitly that lower-frequency positive-pressure ventilation not only preserves adequate oxygenation and acid-base status in hemorrhagic states, but also that "normal" or higher respiratory rates significantly compromise hemodynamics, even with moderate degrees of hemorrhage. DES...

journal_title：Critical care medicine

authors： Pepe PE,Lurie KG,Wigginton JG,Raedler C,Idris AH

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:The mortality of critically ill patients associated with intestinal ischemia/reperfusion remains very high, which results from multiorgan dysfunction or failure due to intestinal injury induced by intestinal ischemia/reperfusion. This study was carried out to investigate whether intestinal ischemia/reperfusio...

journal_title：Critical care medicine

authors： Zhou J,Huang WQ,Li C,Wu GY,Li YS,Wen SH,Lei WL,Liu KX

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To provide a meta-analysis of current literature concerning the validation of thoracic impedance cardiography (TIC) and to explain the variations in the reported results from the differences in the studies. DATA SOURCES:A computer-assisted search of English-language, German, and Dutch literature was performe...

journal_title：Critical care medicine

authors： Raaijmakers E,Faes TJ,Scholten RJ,Goovaerts HG,Heethaar RM

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVES:Hyperammonemia is a key contributing factor for cerebral edema in acute liver failure. Continuous renal replacement therapy may help reduce ammonia levels. However, the optimal timing, mode, intensity, and duration of continuous renal replacement therapy in this setting are unknown. We aimed to study continu...

journal_title：Critical care medicine

authors： Warrillow S,Fisher C,Bellomo R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:To define a curriculum that outlines the core knowledge residents should possess upon completion of graduate training in order to be able to formulate and initiate a treatment plan for the critically ill patient. DATA SOURCES:Requirements for training program certification as outlined by the Accreditation C...

journal_title：Critical care medicine

authors：

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVES:Under "Rory's Regulations," New York State Article 28 acute care hospitals were mandated to implement sepsis protocols and report patient-level data. This study sought to determine how well cases reported under state mandate align with discharge records in a statewide administrative database. DESIGN:Observa...

journal_title：Critical care medicine

authors： Prescott HC,Cope TM,Gesten FC,Ledneva TA,Friedrich ME,Iwashyna TJ,Osborn TM,Seymour CW,Levy MM

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To determine the impact of the rotation of antimicrobial agents on the rates of infection, intestinal colonization, and acquisition with antimicrobial-resistant Gram-negative bacteria. DESIGN:Pre- and postintervention design. SETTING:A 19-bed, medical intensive care unit. PATIENTS:Individuals admitted to t...

journal_title：Critical care medicine

authors： Warren DK,Hill HA,Merz LR,Kollef MH,Hayden MK,Fraser VJ,Fridkin SK

更新日期：2004-12-01 00:00:00

abstract：SUBJECT:After transient global cerebral ischemia, selective vulnerable brain areas show delayed neurodegeneration with characteristics of apoptosis. Recent data demonstrate potent neuroprotective effects of the application of endogenous growth hormones such as brain-derived neurotrophic factor (BDNF) after focal cerebr...

journal_title：Critical care medicine

authors： Popp E,Padosch SA,Vogel P,Schäbitz WR,Schwab S,Böttiger BW

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To describe and identify factors associated with mortality rate and quality of life 1 yr after prolonged mechanical ventilation. DESIGN:Prospective, observational cohort study with patient recruitment over 26 months and follow-up for 1 yr. SETTING:Intensive care units at a tertiary care university hospital....

journal_title：Critical care medicine

authors： Chelluri L,Im KA,Belle SH,Schulz R,Rotondi AJ,Donahoe MP,Sirio CA,Mendelsohn AB,Pinsky MR

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that intra-coronary transfusion of circulation-derived autologous CD34+ cells can improve ischemia-related left ventricular dysfunction in patients with severe diffuse coronary artery disease refractory to medication and unsuitable for coronary intervention. DESIGN:A prospect...

journal_title：Critical care medicine

authors： Lee FY,Chen YL,Sung PH,Ma MC,Pei SN,Wu CJ,Yang CH,Fu M,Ko SF,Leu S,Yip HK

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Although thrombocytopenia in the intensive care unit (ICU) is associated with a poorer outcome, the precise relationship between the time course of platelet counts and the mortality rate has not been well defined. OBJECTIVE:To describe the time course of the platelet count in relation to the mortality rate ...

journal_title：Critical care medicine

authors： Akca S,Haji-Michael P,de Mendonça A,Suter P,Levi M,Vincent JL

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:Unplanned readmission of hospitalized patients to an intensive care unit (ICU) is associated with a worse outcome, but our ability to identify who is likely to deteriorate after ICU dismissal is limited. The objective of this study is to develop and validate a numerical index, named the Stability and Workload...

journal_title：Critical care medicine

authors： Gajic O,Malinchoc M,Comfere TB,Harris MR,Achouiti A,Yilmaz M,Schultz MJ,Hubmayr RD,Afessa B,Farmer JC

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:Racial/ethnic differences in palliative care resource use after stroke have been recognized, but it is unclear whether patient or hospital characteristics drive this disparity. We sought to determine whether palliative care use after intracerebral hemorrhage and ischemic stroke differs between hospitals serv...

journal_title：Critical care medicine

authors： Faigle R,Ziai WC,Urrutia VC,Cooper LA,Gottesman RF

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to test the hypothesis that cocaine-induced cerebral vasodilation in newborn sheep is mediated via beta-adrenergic receptor activation. DESIGN:The cerebral effects of a single intravenous injection of cocaine (4 mg/kg) given 30 mins after pretreatment with propranolol (1 mg/kg...

journal_title：Critical care medicine

authors： O'Brien TP,Pane MA,Traystman RJ,Gleason CA

更新日期：1999-04-01 00:00:00

abstract：:In 179 healthy boys and girls, the relationship between body surface area (S) in dm2 and body weight (bw) in kg was investigated. The body surface was calculated from the DuBois and DuBois formula. For infants below 20 kg, the relationship followed the regression equation S=3.6kg + 9; r=0.996. For infants with bw betw...

journal_title：Critical care medicine

authors： Lindahl S,Okmian L

更新日期：1981-11-01 00:00:00

abstract：OBJECTIVES:To determine the rate of unplanned PICU readmissions, examine the characteristics of index admissions associated with readmission, and compare outcomes of readmissions versus index admissions. DESIGN:Retrospective cohort analysis. SETTING:Ninety North American PICUs that participated in the Virtual Pediatr...

journal_title：Critical care medicine

authors： Edwards JD,Lucas AR,Stone PW,Boscardin WJ,Dudley RA

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:Explosive traumatic injury to an extremity may lead to both local and distant organ injury. Regional traumatic tissue hypothermia has been reported to offer systemic protection; here we investigated the protective effects of regional limb hypothermia on local tissue trauma and the lungs. Furthermore, the opt...

journal_title：Critical care medicine

authors： Ning J,Mo L,Zhao H,Lu K,Wang L,Lai X,Yang B,Zhao H,Sanders RD,Ma D

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the epidemiology of hyperammonemia unrelated to liver failure in the critical care setting. DESIGN:Retrospective case series. SETTING:Critically ill patients admitted to ICUs at Mayo Clinic, Rochester, MN (medical ICU, two mixed medical-surgical ICUs, coronary care unit, or the cardiosurgical I...

journal_title：Critical care medicine

authors： Sakusic A,Sabov M,McCambridge AJ,Rabinstein AA,Singh TD,Mukesh K,Kashani KB,Cook D,Gajic O

更新日期：2018-09-01 00:00:00

abstract：:The current definition of sepsis is life-threatening, acute organ dysfunction secondary to a dysregulated host response to infection. Criteria to operationalize this definition can be judged by six domains of usefulness (reliability, content, construct and criterion validity, measurement burden, and timeliness). The r...

journal_title：Critical care medicine

authors： Seymour CW,Coopersmith CM,Deutschman CS,Gesten F,Klompas M,Levy M,Martin GS,Osborn TM,Rhee C,Warren DK,Watson RS,Angus DC

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:To test the hypothesis that after cecal ligation and puncture in the rat, there is increased expression of the tumor necrosis factor (TNF)/interleukin-1-dependent, acute-phase reactant alpha 1-acid glycoprotein in the liver, and that this change correlates temporally with increased abundance of TNF-alpha in ...

journal_title：Critical care medicine

authors： Andrejko KM,Deutschman CS

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:To describe the impact of choice of therapy on renal recovery. DESIGN:Literature review. MAIN RESULTS:Randomized controlled trials conducted have not shown a benefit of continuous renal replacement therapy in mortality over intermittent renal replacement therapy. However, renal recovery is another importan...

journal_title：Critical care medicine

authors： Uchino S

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:To assess whether the delivered nitric oxide (NO) concentration is affected by a change in the ventilatory setting during neonatal mechanical ventilatory support. DESIGN:Prospective, experimental study. SETTING:Laboratory at Nagoya City University Medical School. INTERVENTIONS:This study was performed by u...

journal_title：Critical care medicine

authors： Yamaguchi N,Togari H,Suzuki S

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The 2003 global outbreak of severe acute respiratory syndrome (SARS) provided numerous challenges to the delivery of critical care. The Toronto critical care community has learned important lessons from SARS, which will help in preparation for future disease outbreaks. OBJECTIVES:The objectives of this stud...

journal_title：Critical care medicine

authors： Booth CM,Stewart TE

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of lorazepam and midazolam for long-term sedation of critically ill, mechanically ventilated patients. DESIGN:Double-blind, randomized, controlled study. SETTING:Medical intensive care unit in a university teaching hospital. PATIENTS:Sixty-four evaluable adult patients admitte...

journal_title：Critical care medicine

authors： Swart EL,van Schijndel RJ,van Loenen AC,Thijs LG

更新日期：1999-08-01 00:00:00