Whole-body PET/CT scanning: estimation of radiation dose and cancer risk.

Abstract:

PURPOSE:To estimate the radiation dose from whole-body fluorine 18 ((18)F)-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies and to evaluate the induced cancer risk to U.S. and Hong Kong populations. MATERIALS AND METHODS:Fluorine 18-FDG PET/CT studies obtained by using a 64-detector CT unit and one of three CT protocols were evaluated. CT protocol A consisted of 120 kV; rotation time, 0.5 second; pitch, 0.984; 100-300 mA; and noise level, 20. CT protocol B was the same as A, except for a fixed tube current of 250 mA. CT protocol C consisted of 140 kV; rotation time, 0.5 second; pitch, 0.984; 150-350 mA; and noise level, 3.5. CT doses were measured in a humanoid phantom equipped with thermoluminescent dosimeters. Doses from (18)F-FDG PET scanning were estimated by multiplying the (18)F-FDG radioactivity (370 MBq) with dose coefficients. Effective doses were calculated according to International Commission on Radiological Protection publication 103. Lifetime attributable risk (LAR) of cancer incidence was estimated according to the National Academies' Biological Effects of Ionizing Radiation VII Report. RESULTS:Effective doses with protocols A, B, and C, respectively, were 13.45, 24.79, and 31.91 mSv for female patients and 13.65, 24.80, and 32.18 mSv for male patients. The LAR of cancer incidence associated with the dose was higher in the Hong Kong population than in the U.S. population. For 20-year-old U.S. women, LARs of cancer incidence were between 0.231% and 0.514%, and for 20-year-old U.S. men, LARs of cancer incidence were between 0.163% and 0.323%; LARs were 5.5%-20.9% higher for the Hong Kong population. The induced cancer risks decreased when age at exposure increased. CONCLUSION:Whole-body PET/CT scanning is accompanied by substantial radiation dose and cancer risk. Thus, examinations should be clinically justified, and measures should be taken to reduce the dose.

journal_name

Radiology

journal_title

Radiology

authors

Huang B,Law MW,Khong PL

doi

10.1148/radiol.2511081300

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

166-74

issue

1

eissn

0033-8419

issn

1527-1315

pii

2511081300

journal_volume

251

pub_type

杂志文章
  • Intracranial hemorrhage in asymptomatic neonates: prevalence on MR images and relationship to obstetric and neonatal risk factors.

    abstract:PURPOSE:To retrospectively evaluate the prevalence of neonatal intracranial hemorrhage (ICH) and its relationship to obstetric and neonatal risk factors. MATERIALS AND METHODS:Pregnant women were recruited for a prospective study of neonatal brain development; the study was approved by the institutional review board a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2422060133

    authors: Looney CB,Smith JK,Merck LH,Wolfe HM,Chescheir NC,Hamer RM,Gilmore JH

    更新日期:2007-02-01 00:00:00

  • Immunoglobulin G4-related periaortitis and periarteritis: CT findings in 17 patients.

    abstract:PURPOSE:To retrospectively evaluate computed tomographic (CT) findings of immunoglobulin G4 (IgG4)-related disease involving the vascular system. MATERIALS AND METHODS:This study was approved by the institutional review board, and all patients included had consented to the use of their medical records for the purpose ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11102250

    authors: Inoue D,Zen Y,Abo H,Gabata T,Demachi H,Yoshikawa J,Miyayama S,Nakanuma Y,Matsui O

    更新日期:2011-11-01 00:00:00

  • Heterotopic bone formation after hip surgery: prevention with single-dose postoperative hip irradiation.

    abstract::From 1981 to 1986, 23 patients (24 hips) were treated with single-dose irradiation after hip surgery in an attempt to prevent heterotopic bone formation. All patients were at high risk for the development of heterotopic ossification because of the presence of heterotopic bone in either hip secondary to trauma or previ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.168.3.3136510

    authors: Lo TC,Healy WL,Covall DJ,Dotter WE,Pfeifer BA,Torgerson WR,Wasilewski SA

    更新日期:1988-09-01 00:00:00

  • Thalamic resting-state functional networks: disruption in patients with mild traumatic brain injury.

    abstract:PURPOSE:To explore the neural correlates of the thalamus by using resting-state functional magnetic resonance (MR) imaging and to investigate whether thalamic resting-state networks (RSNs) are disrupted in patients with mild traumatic brain injury (MTBI). MATERIALS AND METHODS:This HIPAA-compliant study was approved b...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11110014

    authors: Tang L,Ge Y,Sodickson DK,Miles L,Zhou Y,Reaume J,Grossman RI

    更新日期:2011-09-01 00:00:00

  • Superior vena caval obstruction: detection using CT.

    abstract::A review of 210 chest computed tomographic (CT) examinations demonstrating upper chest masses revealed 16 cases of superior vena caval obstruction (SVCO); 11 of these were clinically occult. Two of the occult cases subsequently became clinically evident. Contrast-enhanced chest CT permits the diagnosis of clinically o...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.157.2.4048460

    authors: Bechtold RE,Wolfman NT,Karstaedt N,Choplin RH

    更新日期:1985-11-01 00:00:00

  • Recurrent Glioblastoma: Combination of High Cerebral Blood Flow with MGMT Promoter Methylation Is Associated with Benefit from Low-Dose Temozolomide Rechallenge at First Recurrence.

    abstract::Purpose To determine if the combination of high cerebral blood flow (CBF) and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is associated with benefit from a second round of low-dose temozolomide (TMZ) (ie, rechallenge) in patients with glioblastoma at first recurrence. Materials and Methods The i...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016152152

    authors: Kim C,Kim HS,Shim WH,Choi CG,Kim SJ,Kim JH

    更新日期:2017-01-01 00:00:00

  • CT imaging of colitis.

    abstract::Computed tomography (CT) is widely used to assess patients with nonspecific abdominal pain or who are suspected of having colitis. The authors recommend multidetector CT with oral, rectal, and intravenous contrast material and thin sections, which can accurately demonstrate inflammatory changes in the colonic wall and...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiol.2403050818

    authors: Thoeni RF,Cello JP

    更新日期:2006-09-01 00:00:00

  • Radiological visualization of the vestibular aqueduct. Technique and morphological features.

    abstract::Thin-section tomography in the lateral and off-lateral projections permits radiographic visualization of the vestibular aqueduct, which is seen as an inverted J. The proximal curved portion has a constant configuration, while the distal straight portion varies according to the width of the external aperture and may be...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/117.3.621

    authors: Gado MH,Arenberg IK

    更新日期:1975-12-01 00:00:00

  • Spinal arteriovenous malformation: evaluation of change in venous oxygenation with susceptibility-weighted MR imaging after treatment.

    abstract:PURPOSE:To evaluate the efficacy of susceptibility-weighted (SW) magnetic resonance (MR) imaging for the assessment of the posttreatment change in oxygen saturation in the draining vein in patients with spinal arteriovenous malformation (AVM). MATERIALS AND METHODS:The study protocol was approved by the institutional ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.09090286

    authors: Fujima N,Kudo K,Terae S,Hida K,Ishizaka K,Zaitsu Y,Asano T,Yoshida D,Tha KK,Haacke EM,Sasaki M,Shirato H

    更新日期:2010-03-01 00:00:00

  • Gray-scale ultrasonography of the thyroid.

    abstract::Gray-scale ultrasonography of the thyroid was performed in 33 patients, utilizing a commercially available scanning unit and an aqueous gel coupling medium. Solid and cystic lesions could readily be differentiated, but it was impossible to tell benign lesions from malignant tumors. The ultrasound appearance of thyroid...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/120.2.381

    authors: Chilcote WS

    更新日期:1976-08-01 00:00:00

  • Scimitar syndrome: four new cases examined with CT.

    abstract::Four new cases of scimitar syndrome illustrate the complex derangement of the right lung architecture. Computed tomography (CT) helped in demonstrating the hyparterial relationship of the right bronchus to the pulmonary artery, the course and termination of the scimitar vein, the mediastinal shift, unusual fissures, a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.159.1.3952300

    authors: Godwin JD,Tarver RD

    更新日期:1986-04-01 00:00:00

  • Bile cytology. A routine addition to percutaneous biliary drainage.

    abstract::Exfoliative cytology of bile aspirated from percutaneously placed combined external/internal biliary drainage catheters yielded positive results in 34% of 100 cases. There were no false-positive results. Bile cytology is a simple, inexpensive, and useful method which can establish a diagnosis of malignant biliary obst...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.3.6647860

    authors: Muro A,Mueller PR,Ferrucci JT Jr,Taft PD

    更新日期:1983-12-01 00:00:00

  • Chronic lumbar extradural hematoma: CT findings.

    abstract::The CT findings in two surgically proved cases of spontaneous chronic extradural hematoma are presented. Tapered convex margins, a length greater than 2 cm, and associated normal intervertebral disks are findings that help distinguish chronic extradural hematoma from an extruded disk. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.148.3.6878690

    authors: Levitan LH,Wiens CW

    更新日期:1983-09-01 00:00:00

  • Dermal calcifications in fixed orientation: the tattoo sign.

    abstract::Calcifications located in the dermis of the breast may appear indistinguishable from intramammary calcifications. The authors present a sign, called the tattoo sign, that can help radiologists identify dermal calcifications. When mammograms are compared, calcifications that maintain a fixed relationship to each other ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.192.1.8208930

    authors: Homer MJ,D'Orsi CJ,Sitzman SB

    更新日期:1994-07-01 00:00:00

  • Aortic elasticity and left ventricular function after arterial switch operation: MR imaging--initial experience.

    abstract:PURPOSE:To prospectively assess aortic dimensions, aortic elasticity, aortic valve competence, and left ventricular (LV) systolic function in patients after the arterial switch operation (ASO) by using magnetic resonance (MR) imaging. MATERIALS AND METHODS:Informed consent was obtained from all participants for this l...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2492072013

    authors: Grotenhuis HB,Ottenkamp J,Fontein D,Vliegen HW,Westenberg JJ,Kroft LJ,de Roos A

    更新日期:2008-12-01 00:00:00

  • Can optical imaging assist in characterization of the onset of angiogenesis in developing hepatic metastases in mice livers?

    abstract::Optical imaging currently can be used to characterize some of the early steps in the angiogenic pathway in vivo in animals. Liu and Matsui have provided valuable information in regard to the sequential changes in the origin and nature of newly formed blood vessels during progressive stages of growth of hepatic colorec...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2432061988

    authors: Kruskal JB

    更新日期:2007-05-01 00:00:00

  • Central nervous system tumors in children: detection by magnetic resonance imaging.

    abstract::Fifty-one pediatric patients who were suspected of having central nervous system (CNS) tumors underwent magnetic resonance (MR) imaging using a 0.35 T Diasonics MT/S system. Pulse intervals (TR) ranged from 0.5 to 2.0 seconds with echo delays (TE) of 28 and 56 msec. The ability of MR and contrast-enhanced CT to detect...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.155.1.3975390

    authors: Kucharczyk W,Brant-Zawadzki M,Sobel D,Edwards MB,Kelly WM,Norman D,Newton TH

    更新日期:1985-04-01 00:00:00

  • Depiction of transplant renal vascular anatomy and complications: unenhanced MR angiography by using spatial labeling with multiple inversion pulses.

    abstract:PURPOSE:To evaluate the ability to depict anatomy and complications of renal vascular transplant with unenhanced magnetic resonance (MR) angiography with spatial labeling with multiple inversion pulses (SLEEK) and to compare the results with color Doppler (CD) ultrasonography (US), digital subtraction angiography (DSA)...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14131800

    authors: Tang H,Wang Z,Wang L,Hu X,Wang Q,Li Z,Li J,Meng X,Wang Y,Hu D

    更新日期:2014-06-01 00:00:00

  • Pulmonary nodules: detection with thick-section spiral CT versus conventional CT.

    abstract::Spiral volumetric computed tomography (CT) with single breath-hold technique was compared with conventional sequential CT in 39 patients. The spiral CT protocol consisted of a 10 mm/sec table feed during a 24-second breath hold at 145 mA, with reconstruction of images at 10-mm intervals; one (n = 21) or two (n = 18) s...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.187.2.8475300

    authors: Remy-Jardin M,Remy J,Giraud F,Marquette CH

    更新日期:1993-05-01 00:00:00

  • Rheumatoid arthritis of the cervical spine: early and progressive radiographic features.

    abstract::One hundred thirty-three cervical spine radiographs of 50 patients with rheumatoid arthritis were examined. The patients were a representative random sample chosen from among 675 patients followed up for more than 10 years. The frequency of occurrence for each radiographic finding was correlated with the duration of r...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.165.1.3628760

    authors: Wolfe BK,O'Keeffe D,Mitchell DM,Tchang SP

    更新日期:1987-10-01 00:00:00

  • High-grade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging.

    abstract:PURPOSE:To determine whether perfusion-weighted and proton spectroscopic MR imaging can be used to differentiate high-grade primary gliomas and solitary metastases on the basis of differences in vascularity and metabolite levels in the peritumoral region. MATERIALS AND METHODS:Fifty-one patients with a solitary brain ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2223010558

    authors: Law M,Cha S,Knopp EA,Johnson G,Arnett J,Litt AW

    更新日期:2002-03-01 00:00:00

  • Arterial Spin Labeling to Predict Brain Tumor Grading in Children: Correlations between Histopathologic Vascular Density and Perfusion MR Imaging.

    abstract::Purpose To compare arterial spin labeling (ASL) data between low- and high-grade brain tumors in children to establish a cutoff to distinguish low- from high-grade neoplasms and to assess potential correlations between cerebral blood flow (CBF) and quantitative histologic microvascular data. Materials and Methods Appr...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016152228

    authors: Dangouloff-Ros V,Deroulers C,Foissac F,Badoual M,Shotar E,Grévent D,Calmon R,Pagès M,Grill J,Dufour C,Blauwblomme T,Puget S,Zerah M,Sainte-Rose C,Brunelle F,Varlet P,Boddaert N

    更新日期:2016-11-01 00:00:00

  • Prostaglandins and angioplasty. An experimental study in canine arteries.

    abstract::To prevent platelet aggregation following percutaneous transluminal angioplasty (PTA), cyclooxygenase inhibitors such as acetylsalicylic acid (ASA) and indomethacin are recommended. However, ASA blocks both the proaggregating effects of thromboxane (TXA2) and the antiaggregating and vasodilating effects of prostacycli...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.3.6227930

    authors: Zollikofer CL,Cragg AH,Einzig S,Castaneda-Zuniga WR,Castaneda F,Rysavy JA,Bruhlmann WF,Shebuski RJ,Amplatz K

    更新日期:1983-12-01 00:00:00

  • Important imaging finding e-mail alert system: experience after 3 years of implementation.

    abstract:PURPOSE:To evaluate the effectiveness of an important finding alert (IFA) system that uses e-mail technology to alert referring physicians to an important but nonurgent imaging finding. MATERIALS AND METHODS:The institutional review board approved the study; the requirement for informed consent was waived. The authors...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2531082217

    authors: Abujudeh HH,Kaewlai R,Choy G,Whelton DG,Rosenthal DI

    更新日期:2009-09-01 00:00:00

  • Transfemoral catheterization: mechanical versus manual control of bleeding.

    abstract::This study compared hand-held arterial compression with compression by a mechanical clamp to achieve hemostasis following transfemoral catheterization in 3,255 patients from six different hospitals. The time spent in manual compression of the artery averaged 33.5 minutes compared with 19.9 minutes using the clamp. The...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.154.1.3880610

    authors: Semler HJ

    更新日期:1985-01-01 00:00:00

  • Alzheimer disease: improved visual interpretation of PET images by using three-dimensional stereotaxic surface projections.

    abstract:PURPOSE:To compare the diagnostic usefulness of three-dimensional (3D) stereotaxic surface projection (SSP) with that of standard transaxial display in brain positron emission tomography (PET) in Alzheimer disease (AD). MATERIALS AND METHODS:Standard transaxial section display and 3D-SSP PET image sets obtained after ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.198.3.8628880

    authors: Burdette JH,Minoshima S,Vander Borght T,Tran DD,Kuhl DE

    更新日期:1996-03-01 00:00:00

  • Colonic strictures in infants following intestinal ischemia. Treatment by balloon catheter dilatation.

    abstract::Successful balloon catheter dilatation through the defunctionalized limb of a colostomy was performed in three infants with postischemic colonic stricture. This experience suggests that balloon catheter dilatation can be an alternative to surgical resection in treating delayed ischemic colonic stricture. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.149.2.6622690

    authors: Ball WS Jr,Seigel RS,Goldthorn JF,Kosloske AM

    更新日期:1983-11-01 00:00:00

  • Radiographic features of gastrointestinal graft-vs.-host disease.

    abstract::Five patients underwent bone-marrow transplantation, and graft-vs.-host disease (GVHD) developed. Radiographic features are described. Three patients showed an abrupt transition at the jejuno-ileal junction from normal small bowel to ileal loops which were narrowed, tubular, separated, edematous, and, generally, witho...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.138.2.7005940

    authors: Rosenberg HK,Serota FT,Koch P,Borden S 4th,August CS

    更新日期:1981-02-01 00:00:00

  • Non-Hodgkin lymphoma of the lungs.

    abstract::Twenty-seven consecutive cases of pulmonary involvement by non-Hodgkin in lymphoma, including 2 cases of primary pulmonary disease, were anlyzed. The radiological manifestations of illness were divided into (a) nodular (subpleural, deep parenchymal, or perihilar), (b) pneumonic-alveolar (segmental or lobar), (c) bronc...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/132.3.569

    authors: Balikian JP,Herman PG

    更新日期:1979-09-01 00:00:00

  • MR imaging evaluation of cardiovascular risk in metabolic syndrome.

    abstract::Metabolic syndrome has become an important public health problem and has reached epidemic proportions globally. Metabolic syndrome is characterized by a cluster of metabolic abnormalities in an individual, with insulin resistance as the main characteristic. The major adverse consequence of metabolic syndrome is cardio...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiol.12110772

    authors: van der Meer RW,Lamb HJ,Smit JW,de Roos A

    更新日期:2012-07-01 00:00:00