Prostaglandins and angioplasty. An experimental study in canine arteries.

Abstract:

:To prevent platelet aggregation following percutaneous transluminal angioplasty (PTA), cyclooxygenase inhibitors such as acetylsalicylic acid (ASA) and indomethacin are recommended. However, ASA blocks both the proaggregating effects of thromboxane (TXA2) and the antiaggregating and vasodilating effects of prostacyclin (PGI2). The authors measured the contractile response of dilated canine carotid arteries in situ and in vitro using an isometric force transducer. Following PTA, contraction of the arterial wall was significantly reduced (p less than 0.01). By blocking cyclooxygenase with indomethacin (3 micrograms/ml), contraction was greatly improved (p less than 0.001). These results suggest that PTA may result in marked release of prostacyclin by the damaged arterial wall, which could account for the decreased responsiveness of the artery to exogenous norepinephrine.

journal_name

Radiology

journal_title

Radiology

authors

Zollikofer CL,Cragg AH,Einzig S,Castaneda-Zuniga WR,Castaneda F,Rysavy JA,Bruhlmann WF,Shebuski RJ,Amplatz K

doi

10.1148/radiology.149.3.6227930

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

681-5

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

149

pub_type

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