Abstract：
:Leishmania spp. and Trypanosoma cruzi are parasites belonging to the Trypanosomatidae family and the causative agents for two very important neglected tropical diseases (NTDs), namely leishmaniasis and trypanosomiasis, respectively. Together, they affect millions of people worldwide and the number of cases is constantly rising; thus, further effort on identifying and developing non-toxic, affordable and effective new drug is urgently needed to overcome this alarming situation. Exploring natural products from fungal and bacterial origin remains hitherto a valuable approach to find new hits and candidates for the development of new drugs against these protozoal human infections. Endophytes, which are microorganisms (fungal and bacterial) inhabiting plant tissues, represent a promising source, as they hold potential to produce a high number of distinct chemical scaffolds. These structurally diverse natural products have previously been successfully tested against a wide range of pathogenic microorganisms. The present review provides an update of endophytic compounds exerting anti-trypanosomal and anti-leishmanial effects and their predicted pharmacokinetic properties.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Hzounda Fokou JB,Dize D,Etame Loe GM,Nko'o MHJ,Ngene JP,Ngoule CC,Boyom FFdoi
10.1007/s00436-020-07035-1subject
Has Abstractpub_date
2021-01-06 00:00:00eissn
0932-0113issn
1432-1955pii
10.1007/s00436-020-07035-1pub_type
杂志文章,评审abstract：:This study aimed to compare the sensitivity of five diagnostic methods commonly used for the detection of Toxoplasma gondii in tissues of naturally infected pigs. We purchased 20 heads of pigs in butcher shops in the city of Ilhéus, Bahia. Brain and tongue fragments were taken from each animal for the performance of P...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2514-1
更新日期：2012-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5896-5
更新日期：2018-07-01 00:00:00
abstract：:Species-specific PCR primers targeting the mitochondrial cytochrome c oxidase subunit I (mtCOI) locus were generated that allow for the specific identification of the most common Eimeria species infecting turkeys (i.e., Eimeria adenoeides, Eimeria meleagrimitis, Eimeria gallopavonis, Eimeria meleagridis, Eimeria dispe...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4361-y
更新日期：2015-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931730
更新日期：1992-01-01 00:00:00
abstract：:The development of the metacestode stages of Arostrilepis microtis (Eucestoda: Hymenolepididae) studied on the basis of an experimental infection of springtails (Collembola: Entomobryidae) is described for the first time. A complete description of the ontogeny from oncosphere to fully a developed metacestode is given....
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5929-0
更新日期：2018-08-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0684-7
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4705-7
更新日期：2015-12-01 00:00:00
abstract：:Severe and complicated malaria is usually caused by Plasmodium falciparum malaria (PF) but it has been increasingly observed that Plasmodium vivax malaria (PV), which was otherwise considered to be benign malaria, with a low case-fatality ratio, can also occasionally result in severe disease as with PF malaria. There ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2776-7
更新日期：2012-06-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06477-6
更新日期：2020-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1250-1
更新日期：2005-02-01 00:00:00
abstract：:Chagas disease, caused by the protozoan Trypanosoma cruzi, is considered to be a multifactorial disease associated with host and parasite genetics, which influence clinical aspects of the disease and other host conditions. In order to understand better the evolution of the disease, this study intended to evaluation of...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5969-5
更新日期：2018-09-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5036-z
更新日期：2016-06-01 00:00:00
abstract：:Hymenolepis diminuta is a zoonotic cestode parasitizing the small intestine of rodents (definitive hosts). Humans can accidentally enter into the life cycle of this tapeworm via the ingestion of infected insects (intermediate hosts) containing cestode cysticercoids in their body cavity. More than two centuries after t...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-020-06663-x
更新日期：2020-07-01 00:00:00
abstract：:Discoid granules were isolated from the tegument of adult Schistosoma mansoni by differential centrifugation of freeze-thaw extracts. Comparison of proteins and glycoproteins from discoid granules, surface membranes and the soluble fraction implied that discoid granules and the surface membrane were functionally linke...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00539573
更新日期：1988-01-01 00:00:00
abstract：:Anopheles (Cellia) stephensi Liston 1901 is one of the major malaria vectors in the Indian subcontinent, Iran, and the Middle East. Three races in this species, namely A. stephensi stephensi (type form), A. stephensi variety mysorensis, and A. stephensi intermediate form, have earlier been reported by several investig...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-0930-7
更新日期：2008-06-01 00:00:00
abstract：:The biochemical and structural changes that occur during the conversion of Toxoplasma gondii tachyzoites to bradyzoites and the formation of tissue cyst are not well understood. Maintaining cells infected with T. gondii type II and III strains under stress conditions induces the tachyzoite-bradyzoite in vitro differen...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5738-x
更新日期：2018-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5818-6
更新日期：2018-05-01 00:00:00
abstract：:The aim of this review is to present briefly background information on 27 tick-borne viruses ("tiboviruses") that have been detected in Europe, viz flaviviruses tick-borne encephalitis (TBEV), louping-ill (LIV), Tyuleniy (TYUV), and Meaban (MEAV); orthobunyaviruses Bahig (BAHV) and Matruh (MTRV); phleboviruses Grand A...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-012-2910-1
更新日期：2012-07-01 00:00:00
abstract：:To seek natural products for the development of environment friendly mosquito control agents, fumigant activity of eleven essential oil compounds and the joint action of the active compounds were evaluated against Culex pipiens pallens adults. Fumigant bioassay demonstrated that carvacrol exhibited the highest fumigan...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-4028-0
更新日期：2014-10-01 00:00:00
abstract：:Mosquitoes are the major vector for the transmission of malaria, dengue fever, yellow fever, filariasis, schistosomiasis, and Japanese encephalitis. Mosquito control is facing a threat because of the emergence of resistance to synthetic insecticides. Insecticides of botanical origin may serve as suitable alternative b...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3709-4
更新日期：2014-02-01 00:00:00
abstract：:In the present study, the morphology and morphometric characterization of Dujardinnascaris mujibii (Heterocheilidae) and Hysterothylacium aduncum (Anisakidae), new nematode parasites infecting the sea bream Pagrus pagrus (Osteichthyes, Sparidae), were described for the first time from the Gulf of Suez and Hurghada Cit...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3270-6
更新日期：2013-02-01 00:00:00
abstract：:The source of chemical anthelmintics (levamisole, flubendazole, and thiabendazole) had limited the success of gastrointestinal nematodiasis control in sheep and goats and thus awakened interest in the study of medicinal plant extracts as alternative sources of anthelmintics. The egg hatching and larvicidal effect of i...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2218-y
更新日期：2011-07-01 00:00:00
abstract：:Culex pipiens pallens is the mosquito vector of a number of human pathogens such as Wuchereria bancrofti, Brugia malayi, and epidemic encephalitis B virus. Female C. pipiens pallens play an important role in transmitting pathogens by sucking blood, which is essential for reproduction. In the present study, a subtracti...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0506-y
更新日期：2007-08-01 00:00:00
abstract：:Sarcocystis neurona is the parasite associated with equine protozoal myeloencephalitis (EPM). Recently, cats (Felis domesticus) have been implicated as a potential intermediate host in the life cycle of S. neurona. This study was initiated to determine whether cats have antibodies that react to S. neurona antigens sim...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360100503
更新日期：2002-01-01 00:00:00
abstract：:The performance of a rapid immunochromatographic test for the detection of Dirofilaria immitis antigens (Speed Diro™; BVT-Virbac, France) was assessed in 49 experimentally infected dogs and in 244 naturally infected animals; 142 dogs and 102 cats. In experimentally infected dogs, Speed Diro™ showed a sensitivity of 90...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5709-2
更新日期：2018-01-01 00:00:00
abstract：:Three monoclonal antibodies generated by immunization of mice with Plasmodium berghei-infected red blood cells were found to react with the 75-kDa heat-shock protein (HSP70) present in liver stages and erythrocytic forms of the parasites. These antibodies were shown to react with a recombinant protein encoding the car...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932618
更新日期：1994-01-01 00:00:00
abstract：:Thelaziasis is an ocular infection of several mammals caused by nematodes of the genus Thelazia (Spirurida, Thelaziidae). The adults live in the lachrymal ducts and conjunctival sacs of infected animals, and transmission occurs by means of different species of muscids. T. rhodesi, T. skrjabini, and T. gulosa affect ma...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0432-4
更新日期：2007-06-01 00:00:00
abstract：:Ivermectin at single doses of 0.2-1.0 mg/kg body weight reduced the microfilarial counts of subperiodic Brugia malayi in Presbytis cristata by 59.9%-89.6% of initial counts, 4 weeks after treatment. Adult filaricidal activity was poor, live adult worms being recovered from all animals at autopsy. There was no serious ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00539462
更新日期：1988-01-01 00:00:00
abstract：:The ethanolic leaf extract of Cassia obtusifolia was investigated for their larvicidal and oviposition deterrence effects against Anopheles stephensi. Concentrations ranging from 25 to 125 mg/l were assessed at 24 h post-treatment against late third instar larvae. The leaf extract had significant larvicidal effect wit...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1197-8
更新日期：2009-01-01 00:00:00
abstract：:Spermiogenesis of the monozoic cestode Khawia armeniaca (Cholodkovski, 1915), a parasite of Capoeta capoeta sevangi (De Filippi, 1865) (Pisces: Cyprinidae), has been investigated by means of transmission electron microscopy for the first time. The present results show that the type of spermiogenesis in K. armeniaca sh...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0155-6
更新日期：2006-09-01 00:00:00
