Gut microbiota of animals living in polluted environments are a potential resource of anticancer molecules.

Abstract:

:Cancer is a prominent cause of morbidity and mortality worldwide, in spite of advances in therapeutic interventions and supportive care. In 2018 alone, there were 18·1 million new cancer cases and 9·6 million deaths indicating the need for novel anticancer agents. Plant-based products have often been linked with protective effects against communicable and non-communicable diseases. Recently, we have shown that animals such as crocodiles thrive in polluted environments and are often exposed to carcinogenic agents, but still benefit from prolonged lifespan. The protective mechanisms shielding them from cancer could be attributed to the immune system, and/or it is possible that their gut microbiota produce anticancer molecules. In support, several lines of evidence suggest that gut microbiota plays a critical role in the physiology of its host. Here, we reviewed the available literature to assess whether the gut microbiota of animals thriving in polluted environment possess anticancer molecules.

journal_name

J Appl Microbiol

authors

Soopramanien M,Khan NA,Siddiqui R

doi

10.1111/jam.14981

subject

Has Abstract

pub_date

2020-12-23 00:00:00

eissn

1364-5072

issn

1365-2672

pub_type

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