Abstract:
:Acute phase serum (APS) given at the time of challenge with Plasmodium berghei inhibited the generation to immunity to the infecting plasmodia. Administered with a single dose of vaccine, it inhibited induction of immunity by the vaccine. Three weekly doses, the last given two weeks before infection, induced immunity. Administration of vaccine simultaneously with infection neither aggravated nor ameliorated the infection. These results indicate that the effect of administration of APS on immunity generated by immunization or infection is dose- and time-dependent. The depression of immunity induced by this serum is thus temporary, the host finally overcoming the depression and responding to the plasmodial antigen in the serum. The interaction of vaccine and infection observed indicates that the introduction of vaccine is not detrimental to the individual incubating infection; rather, the vaccine is rendered useless, the reducing the aggregate benefit of the immunization to the group.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Alder JD,Brooks-Alder B,Kreier JPdoi
10.1007/BF00536022subject
Has Abstractpub_date
1987-01-01 00:00:00pages
116-22issue
2eissn
0932-0113issn
1432-1955journal_volume
74pub_type
杂志文章abstract::Four controlled studies, one each in Australia, Germany, the United Kingdom, and the United States, involving 30 calves each were conducted to evaluate the effect of simulated rainfall on the efficacy of Ivomec Pour-On against infections of Cooperia spp. At 3 weeks before treatment the calves were infected orally with...
journal_title:Parasitology research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Parasitology research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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doi:10.1007/BF00932944
更新日期:1994-01-01 00:00:00
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Parasitology research
pub_type: 杂志文章,评审
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journal_title:Parasitology research
pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00