A randomized, controlled trial of banding ligation plus drug therapy versus drug therapy alone in the prevention of esophageal variceal rebleeding.

Abstract:

BACKGROUND & AIMS:Both medications with beta-blockers and isosorbide-5-mononitrate and endoscopic variceal ligation have been proven plausible in the prevention of variceal rebleeding. However, the relative efficacy and safety of the combined treatment for preventing rebleeding remains unresolved. METHODS:Patients with history of esophageal variceal bleeding were enrolled. Emergency ligation was performed in patients with acute variceal bleeding. After hemodynamic stability, eligible patients were randomized to either the Medication group, using nadolol plus isorsorbide-5-mononitrate, or the Combined group, receiving banding ligation in addition to medications. Patients in the two groups with rebleeding from esophageal varices were treated with band ligation. The end points were rebleeding from varices or death. RESULTS:After a median follow up of 23 months, recurrent upper gastrointestinal bleeding developed in 51% in the Medication group and 38% in the Combined group (P = 0.21). Recurrent bleeding from esophageal varices occurred in 26 patients (43%) in the Medication group and in 16 patients (26%) in the Combined group (P = 0.07). Recurrent bleeding from gastroesophageal varices occurred in 48% of Medication group and 28% of Combined group (P = 0.05). The frequency of adverse effects and mortality rates were similar between both groups (P = 0.28). CONCLUSIONS:Combined ligation with medications was marginally more effective than medication alone in the prevention of gastroesophageal variceal rebleeding with similar adverse effects and mortality.

authors

Lo GH,Chen WC,Chan HH,Tsai WL,Hsu PI,Lin CK,Chen TA,Lai KH

doi

10.1111/j.1440-1746.2009.05792.x

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

982-7

issue

6

eissn

0815-9319

issn

1440-1746

pii

JGH5792

journal_volume

24

pub_type

杂志文章,随机对照试验
  • Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus-related advanced fibrosis or cirrhosis.

    abstract:BACKGROUND AND AIM:A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients with chronic hepatitis B (CHB). We investigated whether the achievement of sc-LS by antiviral therapy (AVT) reduced the risk of developing hepatocellular carcinoma (HCC)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13854

    authors: Kim BS,Seo YS,Kim YS,Lee CH,Lee HA,Um SH,Yoo JJ,Kim SG,Suh SJ,Jung YK,Ahn SH,Han KH,Yim HJ,Kim SU,Korean Transient Elastography Study Group.

    更新日期:2018-02-01 00:00:00

  • Intervention on gut microbiota may change the strategy for management of colorectal cancer.

    abstract::Dysbiosis in the gut microbiota composition due to environmental or genetic variations can disrupt the immune system and may promote several diseases such as colorectal cancer (CRC). Gut microbiota can alter the toxicity and efficiency of an extensive range of CRC treatment methods, especially surgery, chemotherapy, r...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.15369

    authors: Taghinezhad-S S,Mohseni AH,Fu X

    更新日期:2020-12-08 00:00:00

  • Molecular epidemiology of hepatitis C in Australia.

    abstract::The aim of this study was to determine the distribution of hepatitis C virus (HCV) genotypes in Australian patients with hepatitis C and to identify factors associated with particular genotypes. Serum isolates of HCV-RNA were genotyped using a commercial oligonucleotide hybridization (line probe) assay. Relationships ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1998.tb00761.x

    authors: Kaba S,Dutta U,Byth K,Crewe EB,Khan MH,Coverdale SA,Lin R,Liddle C,Farrell GC

    更新日期:1998-09-01 00:00:00

  • Significance of RCAS1 antigen in hepatocellular, cholangiocellular and pancreatic carcinomas.

    abstract::Since receptor-binding cancer antigen expressed on SiSo cells (RCAS1) was first reported as a tumor-associated antigen of gynecologic cancer, its function and practical value as a tumor marker have been investigated in various types of carcinomas. Basic research has indicated that RCAS1 expression in cancer cells cont...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2005.03840.x

    authors: Enjoji M,Nakashima M,Yamaguchi K,Kotoh K,Nakamuta M

    更新日期:2005-08-01 00:00:00

  • Rabeprazole treatment attenuated Helicobacter pylori-associated gastric mucosal lesion formation in Mongolian gerbils.

    abstract:BACKGROUND AND AIM:Although rabeprazole (RPZ), a proton pump inhibitor, has been reported to have a bactericidal effect on Helicobacter pylori (H. pylori), no studies have been conducted regarding the effect of RPZ on gastric mucosal lesion formation caused by this bacterium. In the present study, we investigated the e...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2003.03038.x

    authors: Suzuki H,Miyazawa M,Nagahashi S,Sato M,Bessho M,Nagata H,Miura S,Ishii H

    更新日期:2003-07-01 00:00:00

  • Bioactive food chemicals and gastrointestinal symptoms: a focus of salicylates.

    abstract::Bioactive food chemicals are substances present in food that are capable of interacting with living cells causing changes in physiological functions. Salicylic acid (SA), a plant hormone involved in plant immune response, is one such bioactive food chemical. Aspirin, a commercially available SA, might play beneficial ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.13702

    authors: Malakar S

    更新日期:2017-03-01 00:00:00

  • High, but not low, dietary retinoids aggravate manifestation of rat liver fibrosis.

    abstract:BACKGROUND:Although there is strong implication that retinoids regulate Ito cell proliferation and collagen synthesis, results from in vivo studies on the relationship between vitamin A and liver fibrosis are conflicting. The present study focuses on the role of vitamin A in carbon tetrachloride (CCl4)-induced fibrosis...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2002.02804.x

    authors: Vollmar B,Heckmann C,Richter S,Menger MD

    更新日期:2002-07-01 00:00:00

  • Endoscopic management of acute calculous cholangitis.

    abstract::Acute cholangitis is associated with significant morbidity and mortality. Endoscopic drainage procedures have been shown to be a safe and effective mode of treatment in acute cholangitis. As there is paucity of large series on endoscopic management of acute cholangitis, a study was performed to evaluate safety and eff...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1746.1997.tb00386.x

    authors: Sharma BC,Agarwal DK,Baijal SS,Saraswat VA,Choudhuri G,Naik SR

    更新日期:1997-12-01 00:00:00

  • Genetic aspects of Wilson's disease.

    abstract::Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.1990.tb01427.x

    authors: Frydman M

    更新日期:1990-07-01 00:00:00

  • Trans fatty acids in diets act as a precipitating factor for gut inflammation?

    abstract::Fatty acids in our daily diet are broadly classified into cis and trans fatty acids (TFAs). TFAs are formed during the manufacturing process of hydrogenated vegetable oils such as margarine. Modern diets such as deep-fried products, frozen foods, and packaged snacks commonly include large quantities of margarine conta...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.12270

    authors: Okada Y,Tsuzuki Y,Ueda T,Hozumi H,Sato S,Hokari R,Kurihara C,Watanabe C,Tomita K,Komoto S,Kawaguchi A,Nagao S,Miura S

    更新日期:2013-12-01 00:00:00

  • Clinical features of hepatocellular carcinoma with extrahepatic metastases.

    abstract:BACKGROUND:There are few detailed clinical reports about extrahepatic metastases of hepatocellular carcinoma (HCC). The purpose of the present study was to elucidate the clinical features of extrahepatic metastases of HCC. METHODS:The clinical records of 482 patients who had been diagnosed as having HCC during the per...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03919.x

    authors: Natsuizaka M,Omura T,Akaike T,Kuwata Y,Yamazaki K,Sato T,Karino Y,Toyota J,Suga T,Asaka M

    更新日期:2005-11-01 00:00:00

  • Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification.

    abstract:BACKGROUND AND AIM:Thiopurines (TPs) are effective in reducing clinical and endoscopic recurrence in postoperative patients with Crohn's disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. We aimed to explore whether TPs could prevent SR and identify risk factors associated with S...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13922

    authors: Guo J,Chen BL,Chen ZH,Luo XP,Qiu Y,Zhang SH,Feng R,He Y,Zeng ZR,Song XM,Ben-Horin S,Mao R,Chen MH

    更新日期:2018-03-01 00:00:00

  • Using transjugular intrahepatic portosystemic shunt as the first-line therapy in secondary prophylaxis of variceal hemorrhage.

    abstract:BACKGROUND AND AIM:This study aims to evaluate and compare the survival and other portal hypertension-related complications of patients with portal pressure gradient (PPG) ≥ 25 mmHg using transjugular intrahepatic portosystemic shunt (TIPS) as the first-line and second-line therapies in secondary prophylaxis of varicea...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14761

    authors: Liu J,Shi Q,Xiao S,Zhou C,Zhou B,Yuan F,Zheng C,Lin S,Qian K,Feng G,Xiong B

    更新日期:2020-02-01 00:00:00

  • Involvement of RhoA in progression of human hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:The activation of Rho proteins has been shown to lead to loss of polarity in cancer cells, as well as reorganization of the cytoskeleton and facilitation of cell motility, possibly resulting in their malignant potential. The clinicopathological significance of RhoA, however, is not yet well known in ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04534.x

    authors: Wang D,Dou K,Xiang H,Song Z,Zhao Q,Chen Y,Li Y

    更新日期:2007-11-01 00:00:00

  • Hepatitis B virus infection in dialysis patients.

    abstract::Hepatitis B virus (HBV) infection remains a major issue among dialysis patients. It is associated with a high risk of hepatic complication. The liver disease runs a unique clinical course in dialysis patients, as it can progress with modest hepatic inflammation and prominent fibrosis. The conventional cut-off level of...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2005.03837.x

    authors: Wong PN,Fung TT,Mak SK,Lo KY,Tong GM,Wong Y,Loo CK,Lam EK,Wong AK

    更新日期:2005-11-01 00:00:00

  • Evaluation of the hepatic reduction of a nitroxide radical in rats receiving ascorbic acid, glutathione or ascorbic acid oxidase by in vivo electron spin resonance study.

    abstract:BACKGROUND:A nitroxide radical, 4-hydroxyl-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL), is directly reduced to hydroxylamine by ascorbic acid (AsA). Ascorbic acid is oxidized to dehydroascorbic acid (DHA) by ascorbic acid oxidase (AAOx), and DHA is reduced to AsA by glutathione (GSH). In the present study, in vivo and...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2004.03201.x

    authors: Tada M,Yokoyama H,Ito O,Ohya H,Ogata T

    更新日期:2004-01-01 00:00:00

  • Campylobacter pylori infection: experience in a multiracial population.

    abstract::Over a 15-month period, 399 patients with dyspepsia were investigated for the presence of Campylobacter pylori infection. Half of the patients (50.6%) had Campylobacter organisms in the antrum of the stomach. C. pylori was found in 96.1% of patients with histological changes of chronic active gastritis in the antrum. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1990.tb01629.x

    authors: Goh KL,Peh SC,Wong NW,Parasakthi N,Puthucheary SD

    更新日期:1990-05-01 00:00:00

  • Platelet count to spleen diameter ratio non-invasively identifies severe fibrosis and cirrhosis in patients with autoimmune hepatitis.

    abstract:BACKGROUND AND AIM:Non-invasive markers are essential to assess the progression of chronic liver diseases to fibrosis/ cirrhosis and the effectiveness of therapeutic strategies. The aim of this study was to evaluate the ability of non-invasive markers to identify significant fibrosis, severe fibrosis, and cirrhosis in ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13407

    authors: Sheptulina A,Shirokova E,Nekrasova T,Blum H,Ivashkin V

    更新日期:2016-12-01 00:00:00

  • Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non-alcoholic steatohepatitis and in primary human hepatic stellate cells.

    abstract:BACKGROUND:The parasympathetic nervous system (PNS), via neurotransmitter acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear. AIMS:We aimed to determine the fibrogenic responses of human hepatic stellate cells (hHSC) to ACh and the relevance ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13085

    authors: Morgan ML,Sigala B,Soeda J,Cordero P,Nguyen V,McKee C,Mouraliderane A,Vinciguerra M,Oben JA

    更新日期:2016-02-01 00:00:00

  • Growing cavernous haemangioma of the liver: 11-fold increase in volume in a decade.

    abstract::A 57 year old Japanese male was incidentally found to have a 7.5 cm diameter hepatic haemangioma. Eleven years later he was operated on because the haemangioma had grown into a 17 cm mass causing upper abdominal fullness. Volumetry on computerized tomograms disclosed that the haemangioma had grown from 123 cm3 to 1343...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1991.tb00880.x

    authors: Yoshida J,Yamasaki S,Yamamoto J,Kosuge T,Takayama T,Hasegawa H,Takayasu K,Muramatsu Y,Moriyama N,Hirohashi S

    更新日期:1991-07-01 00:00:00

  • Cyclo-oxygenase-2 inhibitors suppress epithelial cell kinetics and delay gastric wound healing in rats.

    abstract:BACKGROUND AND AIMS:The present study examined the effects of NS-398, a specific cyclo-oxygenase-2 inhibitor, on gastric mucosal cell kinetics and gastric wound healing following acid-induced injury. METHODS:Male Sprague-Dawley rats were fasted for 24 h and then 0.6 mol/L hydrochloric acid (HCl; 1 mL) was administered...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2000.02242.x

    authors: Sun WH,Tsuji S,Tsujii M,Gunawan ES,Sawaoka H,Kawai N,Iijima H,Kimura A,Kakiuchi Y,Yasumaru M,Sasaki Y,Kawano S,Hori M

    更新日期:2000-07-01 00:00:00

  • Sustained low hepatitis B viral load predicts good outcome after curative resection in patients with hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:Little is known about the role of hepatitis B virus (HBV) factors in the long-term prognosis of hepatocellular carcinoma (HCC) after resection. The objective of the present study was to identify the changing patterns of HBV levels and its effect on outcome after resection. METHODS:This study recruit...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2010.06416.x

    authors: An HJ,Jang JW,Bae SH,Choi JY,Cho SH,Yoon SK,Han JY,Lee KH,Kim DG,Jung ES

    更新日期:2010-12-01 00:00:00

  • Do young hepatocellular carcinoma patients with relatively good liver function have poorer outcomes than elderly patients?

    abstract:BACKGROUND AND AIM:The risk of hepatocellular carcinoma (HCC) is known to be age dependent; the influence of age on prognosis is, however, controversial. The aim of this study was to compare the tumor characteristics and survival rates of young and old HCC patients, with respect to tumor stage. METHODS:We reviewed the...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04914.x

    authors: Cho SJ,Yoon JH,Hwang SS,Lee HS

    更新日期:2007-08-01 00:00:00

  • Persistent ileitis after ileal salvage from a failed Kock pouch.

    abstract::A case of persistent ileitis following the refashioning of a Kock ileal pouch into a Brooke ileostomy for severe pouchitis is reported. Preserving the terminal ileum by a salvage procedure may not be a safe alternative to pouch excision with the formation of a new end ileostomy in the surgical management of pouchitis ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1992.tb00999.x

    authors: de Silva HJ,Mortensen NJ

    更新日期:1992-07-01 00:00:00

  • Gastric emptying function changes in patients with thyroid cancer after withdrawal of thyroid hormone therapy.

    abstract:BACKGROUND:Hypothyroidism is commonly thought to cause decreased gastric emptying but is mostly associated with autoimmune disease. In the present study the gastric emptying function of thyroid cancer patients with severe hypothyroidism of short duration was evaluated with a radionuclide solid meal gastric emptying stu...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2003.03326.x

    authors: Kao PF,Lin JD,Chiu CT,Hsu HT,See LC,Tzen KY

    更新日期:2004-06-01 00:00:00

  • Oral manifestations in patients with familial adenomatous polyposis: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:The oral manifestations of familial adenomatous polyposis (FAP) have been reported in the recent literature. Therefore, there has been growing interest in the characterization of the dento-osseous anomalies because they may precede colorectal cancer and may be used as a diagnostic marker. This system...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/jgh.13149

    authors: Almeida FT,Pachêco-Pereira C,Porporatti AL,Flores-Mir C,Leite AF,De Luca Canto G,Guerra EN

    更新日期:2016-03-01 00:00:00

  • Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol-17 beta-glucuronide-induced cholestasis in rats.

    abstract::The effect of tauro-beta-muricholate (beta MC-tau) and tauro-alpha-muricholate (alpha MC-tau) on oestradiol-17 beta-glucuronide (E217G)-induced cholestasis was compared with that of tauroursodeoxycholate (UDC-tau) in rats. Like UDC-tau, alpha MC-tau and beta MC-tau infused at the rate of 0.2 mumol/min per 100 g bodywe...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1997.tb00352.x

    authors: Takikawa H,Sano N,Aiso M,Takamori Y,Yamanaka M

    更新日期:1997-01-01 00:00:00

  • Pressure-impedance analysis: Assist the diagnosis and classification of ineffective esophageal motility disorder.

    abstract:BACKGROUND AND AIM:We elucidated the clinical significance of distal contractile integral-to-esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients. METHODS:We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14981

    authors: Wu JF,Tsai IJ,Tong TW,Lin YC,Yang CH,Tseng PH

    更新日期:2020-08-01 00:00:00

  • The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location.

    abstract:BACKGROUND AND AIM:Although sporadic non-ampullary duodenal adenoma is speculated to be precancerous lesion, the relationship between adenoma and carcinoma remains unclear due to their rarity. Previous studies on sporadic non-ampullary duodenal epithelial neoplasm (SNADEN) have mainly targeted superficial tumors, like ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgh.14640

    authors: Matsueda K,Kanzaki H,Matsueda K,Nasu J,Yoshioka M,Nakagawa M,Inoue M,Inaba T,Imagawa A,Takatani M,Takenaka R,Suzuki S,Tomoda J,Yagi T,Fujiwara T,Tanaka T,Okada H

    更新日期:2019-09-01 00:00:00

  • Duodenal ulcer in China.

    abstract::The author visited China in 1981 and 1984 and obtained data comparing the incidence of duodenal ulcer in the rice eating districts of the south with the incidence in the wheat, maize and millet eating areas of the north. The evidence suggested a higher prevalence of duodenal ulcer in the rice eating areas than in the ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1992.tb01012.x

    authors: Tovey FI

    更新日期:1992-07-01 00:00:00