Abstract:
:Maternal intrauterine inflammation has been implicated in the development of periventricular leukomalacia and white matter injury in the neonate. We hypothesized that intrauterine endotoxin administration would lead to microstructural changes in the neonatal rabbit white matter in vivo that could be detected at birth using diffusion tensor magnetic resonance imaging (MRI). Term newborn rabbit kits (gestational age 31 days) born to dams exposed to saline or endotoxin in utero on gestational day 28 underwent diffusion tensor imaging, and brain sections were stained for microglia. Comparison between normal and endotoxin groups showed significant decreases in both fractional anisotropy and eigenvalue (e(1)) in all periventricular white matter regions that showed an increase in the number of activated microglial cells, indicating that after maternal inflammation, microglial infiltration may predominantly explain this change in diffusivity in the immediate neonatal period. Diffusion tensor imaging may be a clinically useful tool for detecting neuroinflammation induced by maternal infection in neonatal white matter.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Saadani-Makki F,Kannan S,Makki M,Muzik O,Janisse J,Romero R,Chugani Ddoi
10.1177/0883073809338213subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1179-89issue
9eissn
0883-0738issn
1708-8283pii
24/9/1179journal_volume
24pub_type
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