Abstract:
:To investigate the significance of electroencephalogram (EEG) discharges and their treatment, we retrospectively reviewed the charts of 22 children with atypical cognitive development that did not respond to standard educational therapy and demonstrated discharges on EEG. Most children demonstrated no obvious symptoms of seizures, and developmental regression and/or fluctuations were uncommon. The majority of children demonstrated a language and attention disorder and autism symptomatology and had multifocal discharges on EEGs. Of the 20 patients treated with antiepileptic medications, 70% demonstrated definite improvement within 1 clinic visit. This study suggests that children with EEG discharges and developmental cognitive disorders demonstrate a unique pattern of symptomatology and discharges on EEG. This study suggests that children with developmental cognitive disorders that do not respond to standard therapy may benefit from screening with an EEG and a trial of antiepileptic mediation if discharges are detected.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Frye RE,Butler I,Strickland D,Castillo E,Papanicolaou Adoi
10.1177/0883073809344743subject
Has Abstractpub_date
2010-05-01 00:00:00pages
556-66issue
5eissn
0883-0738issn
1708-8283pii
0883073809344743journal_volume
25pub_type
杂志文章abstract::The objective of this article is to review primary and secondary causes of carnitine deficiency, emphasizing recent advances in our knowledge of fatty acid oxidation. It is now understood that the cellular metabolism of fatty acids requires the cytosolic carnitine cycle and the mitochondrial beta-oxidation cycle. Carn...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:
更新日期:1995-11-01 00:00:00
abstract::The cerebellum undergoes a protracted development, making it particularly vulnerable to a broad spectrum of developmental events. Acquired destructive and hemorrhagic insults may also occur. The main steps of cerebellar development are reviewed. The normal imaging patterns of the cerebellum in prenatal ultrasound and ...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073811420148
更新日期:2011-12-01 00:00:00
abstract::Three children presented with a complex syndrome of atypical psychotic and extremely immature behavior, obesity and overgrowth, borderline retardation, and seizures (prominent in two). Weight overgrowth exceeded height overgrowth and was stratospheric (up to 8 SD above mean). Obesity seemed related to lack of satiety....
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380001500805
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Spinal muscular atrophy is an autosomal-recessive, progressive neuromuscular disease associated with extensive morbidity. Children with spinal muscular atrophy have potentially increased life spans due to improved nutrition, respiratory support, and novel pharmaceuticals. OBJECTIVES:To report on the quality...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073819900463
更新日期:2020-04-01 00:00:00
abstract::This article assessed how Indian providers and mothers value quality of life in pediatric disabilities, hypothesizing lower values with increasing disability, lower values among providers than mothers, and lower values among mothers with versus mothers without a disabled child. We asked 175 participants: "If born tomo...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818773941
更新日期:2018-08-01 00:00:00
abstract::Multiple sclerosis and acute disseminated encephalomyelitis are demyelinating disorders of the central nervous system that can present initially as an acute focal demyelinating syndrome. We report an 11-year-old girl who initially presented with intractable vomiting and hypertension and later developed a subacute onse...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389501000611
更新日期:1995-11-01 00:00:00
abstract::Erythromelalgia is a rare condition characterized by episodic painful erythema and warmth often affecting, but not limited to, the distal extremities. This condition is notoriously difficult to treat. We report a young female patient with seronegative polyarthritis who presented with a 6-year history of recurrent bout...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811427784
更新日期:2012-07-01 00:00:00
abstract::Febrile seizures are the most common form of childhood seizures. The exact mechanism promoting convulsions during a common febrile illness remains unknown, but it is accepted that genetic influences are likely to account for at least some of the cases. Previous studies reported high interleukin-1beta levels in the cer...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200070401
更新日期:2005-07-01 00:00:00
abstract::Childhood leukoencephalopathies are a broad class of diseases, which are extremely rare. The treatment and classification of these disorders are both challenging. Nearly half of children presenting with a leukoencephalopathy remain without a specific diagnosis. Leukoencephalopathy with thalamus and brain stem involvem...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073816630087
更新日期:2016-06-01 00:00:00
abstract::The authors describe the case of an 8-year-old boy, otherwise healthy, who presented with symptoms consistent with attention-deficit hyperactivity disorder (ADHD) and was started on a trial of methylphenidate. Within 4 weeks, he experienced a rapid decline in fine motor skills, with dysarthria, intention tremor, motor...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808314152
更新日期:2008-07-01 00:00:00
abstract::We report a juvenile patient who developed vertebrobasilar occlusion following nonpenetrating head and neck trauma, with complete recovery. The patient presented with transient signs of brain-stem dysfunction that were secondary to embolization and/or extension of a thrombus. He was treated with anticoagulants. We hav...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307389000500314
更新日期:1990-07-01 00:00:00
abstract::The ethical issues concerning the use of fetal tissue as a source for organ transplantation has focused interest on anencephaly. For reasons that are not entirely clear, the incidence of anencephaly has been declining. As anencephaly is easily recognized and invariably fatal, mortality figures provide an excellent ref...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389100600403
更新日期:1991-10-01 00:00:00
abstract::Metabolic disorders constitute an important cause of neurologic disease, including infantile epilepsy. The inability to characterize seizures and epilepsy syndromes precisely in infants impedes the recognition of features suggestive of specific underlying metabolic and neurodegenerative etiologies. Classification syst...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:
更新日期:2002-12-01 00:00:00
abstract::Autosomal inherited mitochondrial diseases have been of increasing interest among clinicians and mitochondrial research groups because these diseases are caused through a secondary effect on the mitochondrial DNA. It was thought that the genetic stability of mitochondrial DNA relies on the accuracy of DNA polymerase g...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808324539
更新日期:2009-04-01 00:00:00
abstract::Fusiform dilation of the internal carotid artery complicates aggressive craniopharyngioma resection and occurs mainly in children. We report a case to describe the availability of endovascular treatment for this rare entity. A 13-year-old boy presented with headache for 2 years after resection of craniopharyngioma. A ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814552105
更新日期:2015-09-01 00:00:00
abstract::This study aimed to identify the indications in which electroencephalography in the pediatric emergency department is most useful. We retrospectively reviewed the influence that the results of the emergent electroencephalogram had on the eventual disposition of patients at our pediatric emergency department. Sixty-eig...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813483570
更新日期:2014-04-01 00:00:00
abstract::Four unrelated infants with neonatal thrombocytopenia associated with congenital blindness and porencephaly have been seen over an 18-year period. The association of congenital blindness with neonatal thrombocytopenia has not previously been reported. All children had clinical purpura in the neonatal period; in three ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388800300208
更新日期:1988-04-01 00:00:00
abstract::The efficacy of modafinil in comparison with methylphenidate in treatment of pediatric attention-deficit hyperactivity disorder (ADHD) has not been thoroughly investigated. This study compared the effect of modafinil versus methylphenidate on continuous attention task in children with ADHD, using the Test of Variables...
journal_title:Journal of child neurology
pub_type: 杂志文章,随机对照试验
doi:10.1177/0883073812439101
更新日期:2012-12-01 00:00:00
abstract::The authors describe a pediatric patient with repaired hypoplastic left heart syndrome developing protein-losing enteropathy, hypocalcemia, vitamin D deficiency, and hemichorea. After correction of nutritional vitamin D deficiency with calcium and vitamin D supplementation, the chorea resolved. Hypoalbuminemia also im...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807299956
更新日期:2007-01-01 00:00:00
abstract::We analyzed, retrospectively, 92 patients with headache to determine the changes in the order of frequency of causes with the development of neuroimaging studies and its efficacy in the investigation of patients with headache. The type of headache was redefined according to the International Headache Society (IHS) dia...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389801300502
更新日期:1998-05-01 00:00:00
abstract::Möbius' syndrome is a rare congenital anomaly characterized by paralysis of the 7th and other cranial nerves and musculoskeletal abnormalities. We report a patient with Möbius' syndrome associated with arthrogryposis and mega cisterna magna in addition to the classic components of this syndrome. The case is interestin...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738040190010710
更新日期:2004-01-01 00:00:00
abstract::There are limited data on the pattern and prevalence of pediatric chronic neurologic conditions in the region. Therefore, the objective of this study was to establish the prevalence of these disorders in the Kingdom of Saudi Arabia. A multistage probability sampling design was used to select a random sample of Saudi h...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073810371510
更新日期:2011-01-01 00:00:00
abstract::A pilot case-control study was done to collect data on whether susceptibility to newborn encephalopathy and neonatal seizures is influenced by the degree of maternal-fetal sharing of HLA antigens. Cases included 13 infants with moderate or severe newborn encephalopathy and seven infants with neonatal seizures but no o...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389400900214
更新日期:1994-04-01 00:00:00
abstract::Cerebral venous sinus compression can mimic idiopathic intracranial hypertension. The authors report the case of a 12-year-old girl who presented with diplopia and papilledema 3 weeks after a head injury. Lumbar puncture confirmed raised intracranial pressure, and neuroimaging subsequently identified a skull fracture ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073807300532
更新日期:2007-03-01 00:00:00
abstract::Transient neonatal myasthenia gravis is a postsynaptic neuromuscular transmission defect occurring in 21% of infants born to women with active (and, less commonly, in remission) acquired myasthenia gravis. Although passive-transfer acetylcholine receptor (AChR) antibodies are found in the majority of these newborns, t...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307389200700202
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Acute flaccid myelitis has emerged as the leading cause of acute flaccid paralysis in children. Acute flaccid myelitis leads to significant physical disability; hence, objective outcome measures to study disease severity and progression are desirable. In addition, nerve transfer to improve motor function in ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820939392
更新日期:2020-11-01 00:00:00
abstract::Postictal psychoses are brief psychotic episodes that usually occur after poorly controlled partial complex seizure clusters. The psychosis commonly appears following a lucid interval, ranging from a few hours to days after seizure termination. An underlying structural brain abnormality is common and usually involves ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389901401209
更新日期:1999-12-01 00:00:00
abstract::The purpose of this study was to assess sleep, daytime sleepiness, and behavior problems in children suffering from headaches and in controls, with a special focus on the role of gender. A clinical group of 28 children with persistent headache complaints and a control group of 108 healthy children were included. Sleep...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/7010.2006.00239
更新日期:2006-12-01 00:00:00
abstract::Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal. For decades the diagnosis was confirmed only with pyridoxine treatment withdrawal trial. Recently described biochemical and molecular pathology improved the diagnosti...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808318543
更新日期:2008-12-01 00:00:00
abstract::Our experience with two children with Joubert syndrome demonstrates how the diagnosis, if suspected by recognition of the behavioral phenotype, can rapidly be made by employing cranial sonography. This technique also may afford prenatal diagnosis of the syndrome in future siblings of confirmed cases. We have produced ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307388800300403
更新日期:1988-10-01 00:00:00