Evidence against deacetylation and for cytochrome P450-mediated activation in acetaminophen-induced nephrotoxicity in the CD-1 mouse.

abstract：:Inhalation of dust from hard metal (HM), a mixture of tungsten carbide, cobalt, and other metals, can cause interstitial alveolitis, fibrosis, and asthma in the workplace. Some effects of HM could occur after the metals dissolve in the lung. We examined whether chloride salts of metals in HM alloys can elicit response...

journal_title：Toxicology and applied pharmacology

authors： Fedan JS,Cutler D

更新日期：2001-08-01 00:00:00

abstract：:The effects of erythropoiesis on cadmium-metallothionein (Cd-MT)2 levels in spleen, a major erythropoietic tissue, was examined following sc injection of 109CdCl2 into mice. As the concentration of Cd in plasma decreased following injection of 109CdCl2 into control mice, the levels in spleen and liver increased rapidl...

journal_title：Toxicology and applied pharmacology

authors： Min KS,Ohyanagi N,Ohta M,Onosaka S,Tanaka K

更新日期：1995-10-01 00:00:00

abstract：:Phytochemicals show promise as potential chemopreventive or chemotherapeutic agents against various cancers. Here we report the chemotherapeutic effects of berberine, a phytochemical, on human prostate cancer cells. The treatment of human prostate cancer cells (PC-3) with berberine induced dose-dependent apoptosis but...

journal_title：Toxicology and applied pharmacology

authors： Meeran SM,Katiyar S,Katiyar SK

更新日期：2008-05-15 00:00:00

abstract：:Octachlorodibenzo-p-dioxin (OCDD) is a ubiquitous environmental pollutant which has been reported to be nontoxic following acute exposure but has recently been shown to accumulate upon repeated exposure. To determine if this accumulation results in toxic effects, male Fischer 344 rats were treated with 50 micrograms/k...

journal_title：Toxicology and applied pharmacology

authors： Couture LA,Elwell MR,Birnbaum LS

更新日期：1988-03-30 00:00:00

abstract：:Nucleoside analog reverse transcriptase inhibitors (NRTIs) are known to directly inhibit mitochondrial complex I activity as well as various mitochondrial kinases. Recent observations that complex I activity and superoxide production are modulated through cAMP-dependent phosphorylation suggests a mechanism through whi...

journal_title：Toxicology and applied pharmacology

authors： Lund KC,Wallace KB

更新日期：2008-01-01 00:00:00

abstract：:Benzene exposure can result in bone marrow myelotoxicity. We examined the effects of benzene metabolites on bone marrow stromal cells of the hemopoietic microenvironment. Male B6C3F1 mouse bone marrow adherent stromal cells were plated at 4 X 10(6) cells per 2 ml of DMEM medium in 35-mm tissue culture dishes. The grow...

journal_title：Toxicology and applied pharmacology

authors： Gaido K,Wierda D

更新日期：1984-10-01 00:00:00

abstract：:The direct-acting mutagenicity of 1-nitropyrene (1-NP), a tumorigenic environmental pollutant and model nitropolycyclic aromatic hydrocarbon, was studied in Chinese hamster ovary (CHO) cells. Previous reports indicated that 1-NP, a potent direct-acting mutagen in Salmonella typhimurium, was mutagenic in CHO cells only...

journal_title：Toxicology and applied pharmacology

authors： Thornton-Manning JR,Smith BA,Beland FA,Heflich RH

更新日期：1991-07-01 00:00:00

abstract：:The effect of captopril, an angiotensin-converting enzyme inhibitor, on the progression of chronic renal disease was studied in rats subjected to partial nephrectomy. Following ablation of approximately 70% of their renal mass, rats were divided into three treatment groups: group I received a placebo treatment; group ...

journal_title：Toxicology and applied pharmacology

authors： Hall RL,Wilke WL,Fettman MJ

更新日期：1985-09-30 00:00:00

abstract：:The discovery of the cadmium (Cd)-binding protein from horse kidney in 1957 marked the birth of research on this low-molecular weight, cysteine-rich protein called metallothionein (MT) in Cd toxicology. MT plays minimal roles in the gastrointestinal absorption of Cd, but MT plays important roles in Cd retention in tis...

journal_title：Toxicology and applied pharmacology

authors： Klaassen CD,Liu J,Diwan BA

更新日期：2009-08-01 00:00:00

abstract：:This study was conducted to evaluate UDP-glucuronosyl-transferase (UDP-GT) activity, UDP-glucuronic acid (UDP-GA) concentration, and UDP-glucose (UDPG) concentration in the rat intestine and liver following oral administration of butylated hydroxyanisole (BHA), benzo[a]pyrene (BaP), 3-methylcholanthrene (3MC), phenoba...

journal_title：Toxicology and applied pharmacology

authors： Goon D,Klaassen CD

更新日期：1992-08-01 00:00:00

abstract：:Fumonisins are carcinogenic to rats and are suspected human carcinogens. However, the mechanism(s) of carcinogenesis of fumonisn B1 (FB1) is poorly understood. Multiple signal transduction pathways such as protein kinase C (PKC) have been shown to play an important role in carcinogenesis. This study was undertaken to ...

journal_title：Toxicology and applied pharmacology

authors： Yeung JM,Wang HY,Prelusky DB

更新日期：1996-11-01 00:00:00

abstract：:The pharmacokinetics of the industrially important compound triethylamine (TEA) and its metabolite triethylamine-N-oxide (TEAO) were studied in four volunteers after oral and intravenous administration. TEA was efficiently absorbed from the gastrointestinal (GI) tract, rapidly distributed, and in part metabolized into...

journal_title：Toxicology and applied pharmacology

authors： Akesson B,Vinge E,Skerfving S

更新日期：1989-09-15 00:00:00

abstract：:Our previous study revealed that 4-aminopyridine (4-AP), a specific blocker of A-type current, could also inhibit inward Na+ currents (I(Na)) with a state-independent mechanism in rat cerebellar granule cells. In the present study, we report an inhibitory effect of 4-AP on voltage-gated and tetrodotoxin (TTX)-sensitiv...

journal_title：Toxicology and applied pharmacology

authors： Lu BX,Liu LY,Liao L,Zhang ZH,Mei YA

更新日期：2005-09-15 00:00:00

abstract：:Simple alkylating agents induce cell death by activating the apoptotic pathway. In rodent fibroblasts, apoptosis triggered by DNA methylation lesions is executed via the mitochondrial damage pathway. Here, we studied cell death induced by the methylating agents methyl methanesulfonate (MMS) and N-methyl-N'-nitro-N-nit...

journal_title：Toxicology and applied pharmacology

authors： Tomicic MT,Christmann M,Fabian K,Kaina B

更新日期：2005-09-01 00:00:00

abstract：:Laboratory studies have described the carcinogenicity of fumonisin B1 (FB1) in rodents and epidemiological evidence suggests an association between FB1 (a mycotoxin produced by Fusarium moniliforme) and cancer in humans. This study was designed to reveal in rainbow trout, a species with very low spontaneous tumor inci...

journal_title：Toxicology and applied pharmacology

authors： Carlson DB,Williams DE,Spitsbergen JM,Ross PF,Bacon CW,Meredith FI,Riley RT

更新日期：2001-04-01 00:00:00

abstract：:Combretastatin A-4 (CA-4) has already entered clinical trials of solid tumors over ten years. However, the limited anticancer activity and dose-dependent toxicity restrict its clinical application. Here, we offered convincing evidence that CA-4 induced autophagy in various cancer cells, which was demonstrated by acrid...

journal_title：Toxicology and applied pharmacology

authors： Li Y,Luo P,Wang J,Dai J,Yang X,Wu H,Yang B,He Q

更新日期：2014-01-15 00:00:00

abstract：:The transplacental crossover of 14C-2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) from the maternal circulation to the fetal side of the placenta was examined in intact fetuses and following the in situ perfusion of the guinea pig placenta. Fetal, late pregnant, and nonpregnant female guinea pig lipoprotein profiles and th...

journal_title：Toxicology and applied pharmacology

authors： Ring BJ,Seitz KR,Vodicnik MJ

更新日期：1988-10-01 00:00:00

abstract：:Gastric cancer ranks as the third leading cause of cancer-related death worldwide. The uncontrolled tumor growth and robust metastasis are key factors to cause the cancer patient death. Mechanistically, aberrant activation of Notch and NF-κB signaling pathways plays pivotal roles in the initiation and metastasis of ga...

journal_title：Toxicology and applied pharmacology

authors： Xiang S,Zhao Z,Zhang T,Zhang B,Meng M,Cao Z,Zhou Q

更新日期：2020-02-01 00:00:00

abstract：:As an edible traditional Chinese herb, Fructus psoraleae (FP) has been widely used in Asia for the treatment of vitiligo, bone fracture and osteoporosis. Several cases on markedly elevated bilirubin and acute liver injury following administration of FP and its related proprietary medicine have been reported, but the m...

journal_title：Toxicology and applied pharmacology

authors： Wang XX,Lv X,Li SY,Hou J,Ning J,Wang JY,Cao YF,Ge GB,Guo B,Yang L

更新日期：2015-11-15 00:00:00

abstract：:The toxic effects of dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), mainly through activation of the aryl hydrocarbon receptor (AhR) are well documented. Fibroblast growth factor (Fgf) 21 plays critical roles in metabolic adaptation to fasting by increasing lipid oxidation and ketogenesis in the liver. T...

journal_title：Toxicology and applied pharmacology

authors： Cheng X,Vispute SG,Liu J,Cheng C,Kharitonenkov A,Klaassen CD

更新日期：2014-07-01 00:00:00

abstract：:Phenolic compounds, such as 4-tert-octylphenol (OP), have been shown to interfere with rat ovarian steroidogenesis. However, little is known about steroidogenic effects of infantile OP exposure on immature ovary. The aim of the present study was to investigate the effects of infantile OP exposure on plasma FSH, LH, es...

journal_title：Toxicology and applied pharmacology

authors： Myllymäki SA,Karjalainen M,Haavisto TE,Toppari J,Paranko J

更新日期：2005-08-22 00:00:00

abstract：:1p4studied the effect of L-2-chloropropionic acid (L-CPA)-induced (250 mg/kg/po/day for 3 days) neurotoxicity, which results in an almost total destruction of cerebellar granule cells over 5 days, on forebrain and cerebellar neurochemistry. There was a reduction in cerebellar aspartate and glutamate concentrations of ...

journal_title：Toxicology and applied pharmacology

authors： Widdowson PS,Gyte A,Simpson MG,Wyatt I,Lock EA

更新日期：1996-01-01 00:00:00

abstract：:The effect of lead exposure on beta2-adrenoceptor density and catecholamine response was studied in 26 male workers and 1 female worker, exposed to lead on average for 6 years. The systolic blood pressure in lead workers (101-160 mmHg, 124.4 +/- 14.7 mmHg) was found to be significantly higher than in controls (97-134 ...

journal_title：Toxicology and applied pharmacology

authors： Chang HR,Chen SS,Chen TJ,Ho CH,Chiang HC,Yu HS

更新日期：1996-07-01 00:00:00

abstract：:Inhalation of sulfur mustard (SM), a bifunctional alkylating agent that causes severe lung damage, is a significant threat to both military and civilian populations. The mechanisms mediating its cytotoxic effects are unknown and were investigated in the present studies. Male rats Crl:CD(SD) were anesthetized, and then...

journal_title：Toxicology and applied pharmacology

authors： Malaviya R,Sunil VR,Cervelli J,Anderson DR,Holmes WW,Conti ML,Gordon RE,Laskin JD,Laskin DL

更新日期：2010-10-15 00:00:00

abstract：:An experimental design to simulate PUVA therapy (oral 8-methoxypsoralen followed by uv radiation) has been tested in a 13-week subchronic study to determine the relative toxicities of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), 5-methylisopsoralen (5-MIP), and 3-carbethoxypsoralen (3-CEP) in inbred hairless ...

journal_title：Toxicology and applied pharmacology

authors： Dunnick JK,Forbes PD,Davies RE,Iverson WO

更新日期：1987-06-15 00:00:00

abstract：:Induction of hepatic metallothionein (MT) by urethane (ethyl carbamate) was characterized. Male CF-1 mice were treated with urethane (0, 0.5, 1.0, 1.5, and 2 g/kg; ip) and 18 hr later hepatic MT concentrations were determined with the Cd-hemoglobin radioassay. Urethane (1 g/kg and higher) significantly increased hepat...

journal_title：Toxicology and applied pharmacology

authors： Brzeznicka EA,Lehman LD,Klaassen CD

更新日期：1987-03-15 00:00:00

abstract：:It has been known for many years that administration of androgens or estrogens at critical periods of development in mammals causes severe long-term effects on the endocrine/genital systems. The environmental pollutant p-tert-octylphenol (OP) possesses a weak but clear estrogen agonist activity in in vitro and in vivo...

journal_title：Toxicology and applied pharmacology

authors： Katsuda S,Yoshida M,Watanabe G,Taya K,Maekawa A

更新日期：2000-06-15 00:00:00

abstract：:Lead (Pb) depresses growth in infants and young children. Our earlier studies using a weanling rat model of Pb exposure suggest that this Pb effect is due to depression of appetite. In the present study we examined whether this depression of appetite is consistent with a down-regulation of the appetite "set point" as ...

journal_title：Toxicology and applied pharmacology

authors： Hammond PB,Minnema DJ,Shulka R

更新日期：1990-10-01 00:00:00

abstract：:Petroleum-derived compounds, including polycyclic aromatic hydrocarbons (PAHs), commonly occur as complex mixtures in the environment. Recent studies using the zebrafish experimental model have shown that PAHs are toxic to the embryonic cardiovascular system, and that the severity and nature of this developmental card...

journal_title：Toxicology and applied pharmacology

authors： Incardona JP,Linbo TL,Scholz NL

更新日期：2011-12-01 00:00:00

abstract：:Propanil, 3,4-dichloropropionanilide, a commonly used herbicide, has been shown to induce effects on the mouse immune system. The aim of this study was to assess the immunotoxicity of propanil in occupationally exposed agricultural workers and to characterize its molecular mechanism of action. Seven agricultural worke...

journal_title：Toxicology and applied pharmacology

authors： Corsini E,Codecà I,Mangiaratti S,Birindelli S,Minoia C,Turci R,Viviani B,Facchi A,Vitelli N,Lucchi L,Galli CL,Marinovich M,Colosio C

更新日期：2007-07-15 00:00:00