Abstract：
:Laryngo-onycho-cutaneous (LOC) syndrome was reclassified as a subtype of junctional epidermolysis bullosa (JEB) based on clinical features similar to JEB and its association, in the majority of patients from the Punjab, with a unique mutation affecting the N terminus of the alpha3 chain of LM332. Although LOC syndrome is now a subtype of JEB(JEB-LOC) JEB-LOC has a distinct clinicopathologic appearance and molecular fingerprint. The intricacies of the JEB-LOC subtype are discussed in this article with regard to disease presentation, pathogenesis, management, and prognosis.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Cohn HI,Murrell DFdoi
10.1016/j.det.2009.10.010subject
Has Abstractpub_date
2010-01-01 00:00:00pages
89-92issue
1eissn
0733-8635issn
1558-0520pii
S0733-8635(09)00084-9journal_volume
28pub_type
杂志文章,评审abstract：:Liposuction of arms when properly performed with realistic expectations is almost always a "patient pleaser." Patients routinely marvel at the degree of skin contraction that typically occurs. Before and after photos, even as early as 1 week, routinely show dramatic skin contraction when significant volumes of fat are...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8635(05)70127-3
更新日期：1999-10-01 00:00:00
abstract：:This article reviews the recent dermatopathology literature involving nonmelanocytic neoplasia, with a focus on important work done over the last 5 years. The discussion includes advances in the understanding of Merkel cell carcinoma pathogenesis and prognosis; changes in the seventh edition of the American Joint Comm...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2012.06.009
更新日期：2012-10-01 00:00:00
abstract：:Contact dermatitis is a common skin disease caused by contact with irritants or allergens. Irritant contact dermatitis is a result of nonspecific irritant factors, which cause activation of mainly innate immunity, resulting in skin inflammation. Contact hypersensitivity, which manifests itself as allergic contact derm...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2007.06.002
更新日期：2007-10-01 00:00:00
abstract：:Laser skin surgery is not without risk and some degree of downtime in most situations. Patient satisfaction is key to the perceived success of the procedure. Therefore, the physician must fully explain all risks, potential complications, and expected morbidity associated with any laser treatment to be performed. Altho...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(03)00054-8
更新日期：2002-01-01 00:00:00
abstract：:Autoinflammatory diseases (AIDs) are characterized by recurrent episodes of systemic and organ-specific inflammation. Many of these diseases share fever as a common presenting feature. Physicians need to consider AIDs in children with recurrent, unexplained fevers, when infectious and malignant causes have been discar...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2013.04.003
更新日期：2013-07-01 00:00:00
abstract：:The basis of in-office evaluation of leg vascular disease involves Doppler ultrasound to estimate flow in arteries and veins. Arterial evaluation localizes sites of obstruction by segmental pressures obtained by Doppler signal assessment using pressure cuffs. Ankle compared with brachial arterial pressure is the most ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Solitary pink lesions can pose a particular challenge to dermatologists because they may be almost or completely featureless clinically and dermoscopically, previously requiring biopsy to exclude malignancy. However, these lesions usually are not particularly challenging histopathologically. Thus, the incorporation of...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2016.05.007
更新日期：2016-10-01 00:00:00
abstract：:Cutaneous T-cell lymphoma is a malignancy of skin-homing T cells. This unique population of lymphocytes requires alternative therapies to those used in nodal lymphomas. Although phototherapy and nitrogen mustard have been standard treatments for decades, newer therapies have been arriving with increased frequency. Mor...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2010.03.010
更新日期：2010-07-01 00:00:00
abstract：:This article presents solutions to difficult surgical repair problems. Solutions for the repair of defects in the ear (in this case the ear lobule) and upper lip are discussed. A solution is also provided for an exasperating problem that arises when cheek and neck lifts are done. An aid for the design of cutaneous fla...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The anatomic region influences the dermoscopic features of different lesions. In this article, the particular characteristics of the scalp, mucosal membranes, and lesions located on the milk line are explained. In histopathology, the benign melanocytic lesions in these locations are also named nevi of special sites, c...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2013.07.003
更新日期：2013-10-01 00:00:00
abstract：:As with other chemical-based industries, the pharmaceutical industry has the potential for innumerable irritants and allergens. Prompt reporting and recognition of employees' skin diseases, with clarification of the triggering factors, can lead to appropriate control and prevention in many situations. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：:In the same way that it often is necessary to perform chemical and biological analysis of skin and body fluids in the management of skin disease, it may be necessary to analyze the chemical environment. Some analyses, such as those for nickel, chromate, and formaldehyde, require only simple tests. Others require compl...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Contact dermatitis in the United States poses a significant public health concern. This article provides a definition of contact dermatitis and its associated risk factors. The authors discuss the epidemiology of occupational contact dermatitis including its incidence and prevalence, and describe how estimates are cal...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2011.08.004
更新日期：2012-01-01 00:00:00
abstract：:Rituximab is a chimeric, murine-human, monoclonal antibody against the CD20 antigen of B lymphocytes. It has been used off-label to treat and manage autoimmune and dermatologic diseases as an alternative or adjuvant therapy to systemic treatments. Due to cost, potential complications, and lack of data rituximab is use...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/j.det.2011.06.023
更新日期：2011-10-01 00:00:00
abstract：:Normal and malignant pigment cells are known targets for many hormones. Besides alpha-melanocyte-stimulating hormone and the steroidal hormones estrogen, testosterone, and glucocorticoids, factors produced by other epidermal cells can affect melanization and proliferation of pigment cells. Among those factors are the ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-04-01 00:00:00
abstract：:UV erythema or sunburn is a common sequela of modern man's pursuit of leisure activities. The dermatologist is frequently confronted with this painful cutaneous inflammatory response. The pathogenesis of sunburn is examined in terms of individual genetic sensitivity, environmental exposure, spectral variability, and t...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Sensitive skin is a complex problem with genetic, individual, environmental, occupational, and ethnic implications. Further work is needed to rank irritants and irritant reactions to classify sensitive skin on the basis of standard models. The development of topical products designed for sensitive and ethnic skin may ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:There are numerous cutaneous findings associated with liver diseases. Although most of these changes are nonspecific and therefore are of limited value in the actual diagnosis of hepatic disease, recognition of the association may be useful for diagnosis and for monitoring the patient's response to treatment. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1989-07-01 00:00:00
abstract：:AIDS produces profound alterations in normal immunity. Impaired cellular immunity permits new tumor formation as evidenced by the solid-organ transplant literature. The weakened cellular immune system of HIV-infected patients resembles in some ways the iatrogenic immunosuppression in solid-organ transplant recipients....
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2006.06.011
更新日期：2006-10-01 00:00:00
abstract：:Countries in the so-called "Western" world, especially in Europe, witnessed a dramatic change in ethnic backgrounds of their populations starting in the last decennia of the last century. This had repercussions on various aspects of our society, including medical practice. In dermatology for instance, pigmentary disor...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2007.04.005
更新日期：2007-07-01 00:00:00
abstract：:The term pyoderma encompasses a variety of distinct entities including impetigo (bullous and nonbullous), erysipelas, cellulitis, folliculitis, and staphylococcal scalded skin syndrome. Treatment of pyodermas centers around wound care and appropriate antibiotic selection. Triphenylmethane dyes, such as gentian violet,...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2010.08.009
更新日期：2011-01-01 00:00:00
abstract：:Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a gran...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2015.03.015
更新日期：2015-07-01 00:00:00
abstract：:Oral health is a critical component of overall health and well-being. Dental caries and periodontitis are two of the most common oral diseases and, when not treated, can have irreversible sequelae and overall psychosocial and physiologic impact on individuals, diminishing quality of life. The burden of advanced dental...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2020.05.002
更新日期：2020-10-01 00:00:00
abstract：:This article is a tribute to clinician Henry M. Lewis. The author shares practical therapeutic pearls developed and used over the years by Dr. Lewis. ...
journal_title：Dermatologic clinics
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:There have been many advances during the past few years relating to the treatment of superficial fungal infections. This article focuses on recent developments, particularly in oral therapy, but in topical therapy as well. First, the newer agents (especially fluconazole, itraconazole, and terbinafine) are reviewed, an...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70337-5
更新日期：1996-01-01 00:00:00
abstract：:Most melanocytic tumors can be characterized as a benign nevus or a melanoma by a trained pathologist using traditional histopathological methods. However, a minority demonstrates ambiguous features and continues to be a diagnostic challenge. Genetic expression profiling (GEP) assays have been developed in an effort t...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2017.06.016
更新日期：2017-10-01 00:00:00
abstract：:This article has shown that all the necessary components for successful control of gonorrhea are available. In developed countries, general improvements in economic conditions and advances in treatment and diagnosis have resulted in the lowest incidence rates of gonorrhea ever. Within these countries, however, control...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8635(05)70036-x
更新日期：1998-10-01 00:00:00
abstract：:One of the basic principles in the investigation of suspected contact dermatitis is always to test with the patient's "own" product or chemical, the one to which he or she was actually exposed. An equally basic second principle is not to rely solely on a positive test reaction. The author discusses a case of contact d...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Use of the dissecting stereomicroscope during hair transplant graft dissection has been advocated as a means of reducing hair follicle transection and improving graft growth. The study evaluated the prevalence of hair follicle transection in grafts prepared with and without the dissecting stereomicroscope. Approximate...
journal_title：Dermatologic clinics
pub_type： 杂志文章,多中心研究
doi：10.1016/s0733-8635(05)70089-9
更新日期：1999-04-01 00:00:00
abstract：:Primary cutaneous lymphomas comprise a prognostically heterogeneous group of lymphocytic skin neoplasms, which display a broad spectrum of clinical, histologic, immunophenotypic, and genetic features. The histopathological examination plays an essential role and is often the starting point in the diagnostic workup of ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2015.05.002
更新日期：2015-10-01 00:00:00
