Abstract:
:Research to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities research using a biocultural approach. This paper argues that racial/ethnic categories should not be used as a surrogate for sociocultural factors or global genomic clusters in biomedical research or clinical settings, because of the high genetic heterogeneity that exists within traditional racial/ethnic groups. Genetic ancestry is used to show variation in ancestral genomic contributions to recently admixed populations in the United States, such as African Americans and Hispanic/Latino Americans. Genetic ancestry estimates are also used to examine the relationship between ancestry-related biological and sociocultural factors affecting health disparities. To localize areas of genomes that contribute to health disparities, admixture mapping and genome-wide association studies (GWAS) are often used. Recent GWAS have identified many genetic variants that are highly differentiated among human populations that are associated with disease risk. Some of these are population-specific variants. Many of these variants may impact disease risk and help explain a portion of the difference in disease burden among racial/ethnic groups. Genetic ancestry is also of particular interest in precision medicine and disparities in drug efficacy and outcomes. By using genetic ancestry, we can learn about potential biological differences that may contribute to the heterogeneity observed across self-reported racial groups.
journal_name
Am J Phys Anthropoljournal_title
American journal of physical anthropologyauthors
Batai K,Hooker S,Kittles RAdoi
10.1002/ajpa.24144subject
Has Abstractpub_date
2020-09-16 00:00:00eissn
0002-9483issn
1096-8644pub_type
杂志文章abstract::Stature and the pattern of body proportions were investigated in a series of six time-successive Egyptian populations in order to investigate the biological effects on human growth of the development and intensification of agriculture, and the formation of state-level social organization. Univariate analyses of varian...
journal_title:American journal of physical anthropology
pub_type: 杂志文章,评审
doi:10.1002/ajpa.10223
更新日期:2003-07-01 00:00:00
abstract::Recent molecular and morphological surveys suggest that mangabeys do not represent a monophyletic group. Specifically, Cercocebus is the sister taxon of Mandrillus, whereas Lophocebus forms an unresolved trichotomy with Papio and Theropithecus. The Cercocebus-Mandrillus clade is characterized by skeletal and dental ad...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.20621
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:The objectives of this study are to describe genetic correlations between dental dimensions in a platyrrhine primate, to assess whether the brown-mantled tamarin dentition exhibits genetic modularity by tooth type, and to discuss the relationship between body size reduction and the genetic architecture of de...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23861
更新日期:2019-07-01 00:00:00
abstract::Twenty weanling 6-month-old male squirrel monkeys were allotted to the following treatments: 1) first control animals were killed at weaning; 2) second control animals were killed when 24 months old; and 3) malnourished animals were fed on a low-protein diet and killed at age 24 months. Lateral and vertical teleradiog...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330810409
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVES:Sexual dimorphism is an important biological factor underlying morphological variation in the human skeleton. Previous research found sex-related differences in the static ribcage, with males having more horizontally oriented ribs and a wider lower ribcage than females. Furthermore, a recent study found sex-...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23829
更新日期:2019-06-01 00:00:00
abstract::The robustness index (RI) is determined by multiplying dental mesiodistal and buccolingual diameters, and is used to estimate occlusal area. However, because teeth are not rectangular its calculation consistently causes overestimations. Moreover, teeth, in particular molars, are not identically shaped so overestimatio...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21511
更新日期:2011-06-01 00:00:00
abstract::Uncertainties as to the nature and implications of osteoarthritis and calcium pyrophosphate deposition disease (CPPD) in primates were subject to critical review through examination of 153 prosimians and 1,250 Old World non-prosimian primates. Osteoarthritis, calcium pyrophosphate deposition disease, and infectious ar...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330870308
更新日期:1992-03-01 00:00:00
abstract::The ∼37 million-year-old Birket Qarun Locality 2 (BQ-2), in the Birket Qarun Formation of Egypt's Fayum Depression, yields evidence for a diverse primate fauna, including the earliest known lorisiforms, parapithecoid anthropoids, and Afradapis longicristatus, a large folivorous adapiform. Phylogenetic analysis has pla...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21328
更新日期:2010-11-01 00:00:00
abstract::This study tests the hypothesis that optimum birthweight for survival is lower among hospital-born infants in Puno, Peru (altitude 3860 m) than that among their counterparts at low altitude in Tacna, Peru (altitude 600 m). The data are derived from hospital birth records for 1971 and 1972 and municipal death records f...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330560302
更新日期:1981-11-01 00:00:00
abstract::In addition to being frugivorous, Cebus and Saimiri stand out among the New World primates of similar body size in being heavily dependent on animal matter for protein (faunivory). A detailed description of the morphology and behavior of the two genera is presented with the object of evaluating the interaction and res...
journal_title:American journal of physical anthropology
pub_type: 杂志文章,评审
doi:10.1002/ajpa.1330880405
更新日期:1992-08-01 00:00:00
abstract::The methods used to study human growth and development (auxology) have not previously been applied within the setting of hominin maturation (ontogeny). Ontogeny is defined here as the pattern of biological change into an adult form, both at the individual and species level. The hominin fossil record has a lack of reco...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.24088
更新日期:2020-10-01 00:00:00
abstract::Ontogenetic samples of endocranial volumes (EVs) from great apes and humans are critical for understanding the evolution of the brain growth pattern in the hominin lineage. However, high quality ontogenetic data are scarce, especially for nonhuman primates. Here, we provide original data derived from an osteological c...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21641
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:The present study tests the effectiveness of entheseal robusticity (ER) as a potential predictor of adult age-at-death by applying multiple regression models to a large contemporary identified skeletal sample. MATERIALS AND METHODS:ER was recorded for 23 bilateral postcranial entheses on 481 adult individua...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.24083
更新日期:2020-09-01 00:00:00
abstract::Discovery of a previously unknown Bronze Age civilization (Oxus civilization) centered on the oases of Central Asia revealed the presence of large, preplanned urban centers immediately above sterile soil. Given the absence of local antecedents, the sudden appearance and proliferation of these Oxus civilization urban c...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199902)108:2<173::AID-AJPA
更新日期:1999-02-01 00:00:00
abstract::One trait that distinguishes the walking gaits of most primates from those of most mammalian nonprimates is the distribution of weight between the forelimbs and hindlimbs. Nonprimate mammals generally experience higher vertical peak substrate reaction forces on the forelimb than on the hindlimb. Primates, in contrast,...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.20385
更新日期:2006-08-01 00:00:00
abstract::The archaeological evidence of ancient cranial surgery is limited to cases of trepanation and cauterization. I report here on the only known case of cranial surgery in direct association with the osseous image of a non-trauma-induced soft tissue lesion (sinus pericranii). This case, from Alameda County, California (La...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.1330980209
更新日期:1995-10-01 00:00:00
abstract::Periodic episodes of food scarcity may highlight the adaptive value of certain anatomical traits, particularly those that facilitate the acquisition and digestion of exigent fallback foods. To better understand the selective pressures that favored the distinctive dental and locomotor morphologies of gibbons and orangu...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21119
更新日期:2009-12-01 00:00:00
abstract::Movements of forelimb joints and segments during walking in the brown lemur (Eulemur fulvus) were analyzed using cineradiography (150 frames/sec). Metric gait parameters, forelimb kinematics, and intralimb coordination are described. Calculation of contribution of segment displacements to stance propulsion shows that ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(200002)111:2<245::AID-AJPA
更新日期:2000-02-01 00:00:00
abstract::The numbers of precoccygeal vertebrae (PCV) are compared in Southern African Negroes, Bushman (San) and American Negroes. The S.A. Negro and San males have an exceptionally high frequency of an increased total PCV number whilst the frequencies are significantly lower in a combined Caucasoid sample and the Mongoloid sa...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330470311
更新日期:1977-11-01 00:00:00
abstract::Dental attrition scores from two distinct Australian Aboriginal populations were compared by principal axis analysis. The first group was composed of members of the Narrinyeri group who occupied the river basin and mouth of the River Murray. The second group consisted of members of the Kaurna tribe who occupied the co...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330650103
更新日期:1984-09-01 00:00:00
abstract::In placental mammals, pregnancy usually is associated with an increase in maternal androgens, which may significantly impact fetal growth and differentiation, and affect postnatal development and behavior. Owing to their slow life histories and challenging social conditions, determination of maternal androgens and pot...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21646
更新日期:2012-02-01 00:00:00
abstract::Four skeletal series (Corinth, Greece; Gran Quivira, New Mexico; Semna South, Sudanese Nubia, and a large group from scattered sites in England) were coded for sex, jaw, tooth group, dental attrition, dental caries, site and time period. Through thec concepts of a basal level of caries and a cariosity gradient, a sing...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.1330510414
更新日期:1979-11-01 00:00:00
abstract::This paper reports measurements of weight and recumbent length for a cross-sectional sample of 149 Shipibo infants and children between birth and 35.99 months of age from eight villages in the Peruvian Amazon Basin. The Shipibo are an Amerindian population experiencing a period of local environmental disruption and ra...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330840104
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to report and interpret a feature on the anterolateral surface of the proximal femurs of the Krapina hominid collection that we briefly described in 2006 (Periodicum Biologorum, 108, 319-329). MATERIALS AND METHODS:We recorded the presence or absence of the feature in all the pr...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23140
更新日期:2017-03-01 00:00:00
abstract::The Kolmogorov-Smirnov one-sample test is sometimes used to test seasonality in births or other annually cyclic phenomena. However, it is shown that the maximum deviation from expected (D) may differ by a factor of almost two if the cycle is initiated in different months. Thus, different results are possible from the ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330680310
更新日期:1985-11-01 00:00:00
abstract::Excessive central fat in children and adolescents is a risk factor for cardiovascular and metabolic disorders. This study aimed to compare the body fat distribution patterns of children and adolescents in Abeokuta, Nigeria with international reference standards. Five hundred seventy children aged 5 to 19 years were se...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22241
更新日期:2013-04-01 00:00:00
abstract::The mummification methods of an ancient maritime population on the northern coast of Chile are reviewed and the findings in an additional seven individuals are reported. Members of this cultural group, Chinchorro, practiced a selective, elaborate form of artificial mummification which persisted more than 4,000 years. ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330910205
更新日期:1993-06-01 00:00:00
abstract::Three fundamental ontogenetic pathways lead to the development of size differences between males and females. Males and females may grow at the same rate for different durations (bimaturism), grow for the same duration at different rates, or grow at a mix of rate and duration differences. While patterns of growth and ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21600
更新日期:2012-01-01 00:00:00
abstract::Femoral head size provides important information on body size in extinct species. Although it is well-known that femoral head size is correlated with acetabular size, the precision with which femoral head size can be estimated from acetabular size has not been quantified. The availability of accurate 3D surface models...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22591
更新日期:2014-11-01 00:00:00
abstract::Evolutionary trends for dental reduction are presented for European Upper Paleolithic and Mesolithic samples. The analysis demonstrates that the greatest decrease in tooth size occurs between the two divisions of the Upper Paleolithic, while little and insignificant change characterizes the Late Upper Paleolithic/Meso...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.1330460114
更新日期:1977-01-01 00:00:00