Abstract：
BACKGROUND:Tympanostomy tube (TT) insertion is a common procedure in children with otitis media with effusion. Post-TT otorrhea (PTTO) is a frequent post-operative complication. Biofilms are involved in chronic PTTO cases. OBJECTIVE:To describe and qualitatively analyze the geometry and sites prone to biofilms on removed TTs, relatively to their position in the ear, past medical/surgical history and PTTO presence. METHODS:Biofilms presence and topographic distribution on TTs were ex vivo evaluated by using scanning electron microscope, confocal microscope and stereo-microscope. RESULTS:Forty-eight TTs from 30 children were analyzed. Indications for removal were: 71% due to retained TTs (average time from insertion: 24.4 ± 15.1 months), 23% due to chronic PTTO, and 6% due to TT obstruction/dysfunction. Different types of bacterial biofilms were detected on all TTs, regardless the time from their insertion nor their types. Biofilms were observed more on the perpendicular junction and on the internal lumen, and more biofilm colonies were detected on the medial part, facing the middle ear mucosa. TTs removed from children with PTTO exhibited more biofilm colonies when compared to their peers. Of the 16 children who underwent adenoidectomy concomitantly with TT insertion, 10 (62%) children were sent for TT removal due to retained TTs, and 6 (38%) children due to chronic PTTO (p = 0.03). CONCLUSION:Descriptive analysis of biofilm topographic distribution demonstrated adhesions on specific TT areas: perpendicular junctions and the internal lumen. Such "prone zones" may be the future target areas for changes in TT geometry or can be specifically coated with anti-biofilm materials.
journal_name
Int J Pediatr Otorhinolaryngoljournal_title
International journal of pediatric otorhinolaryngologyauthors
Habashi N,Marom T,Steinberg D,Zacks B,Tamir SOdoi
10.1016/j.ijporl.2020.110350subject
Has Abstractpub_date
2020-11-01 00:00:00pages
110350eissn
0165-5876issn
1872-8464pii
S0165-5876(20)30493-6journal_volume
138pub_type
杂志文章abstract：INTRODUCTION:Thyroglossal duct cysts (TGDCs) result from incomplete involution of the thyroglossal duct and are resected with a Sistrunk-procedure. We studied and graded severity of postoperative complications in children who underwent this procedure, with corresponding risk factors. METHODS:In our electronic health r...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/S0165-5876(96)01464-4
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abstract：OBJECTIVES:To analyze the success rates of myringoplasty in children, to assess prognostic factors and to evaluate their interactions in the evolution of myringoplasty. METHODS:Charts of patients who had undergone a myringoplasty between 1997 and 2007 were reviewed for: patient age, sex, perforation side, etiology, si...
journal_title：International journal of pediatric otorhinolaryngology
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
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abstract：OBJECTIVE:To review the thrombotic complications of head and neck infections, including Lemierre's syndrome, and their management. METHODS:A retrospective review of pediatric patients presenting to McMaster Children's Hospital from 2009 to 2013 was undertaken. The literature was reviewed for evidence regarding the use...
journal_title：International journal of pediatric otorhinolaryngology
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doi：10.1016/j.ijporl.2016.06.013
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:Helicobacter pylori (H. Pylori) has been associated with the development of gastritis, peptic ulcer and gastric cancer. Although H. pylori infects up to more than half of the world's population, to date the precise modes of transmission has not been fully understood yet. Therefore a study was planned to inves...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2003.10.016
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abstract：OBJECTIVE:The aim of the present study is to discuss the basics of atopy in children in relationship to the principal ENT allergic disorders such as allergic rhinitis, rhinosinusitis and their impact on lower airways, allergic otitis media, and oral cavity focusing on their natural history. METHODS:An updated and exha...
journal_title：International journal of pediatric otorhinolaryngology
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更新日期：2009-12-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was to evaluate whether the arithmetic achievement of children with cochlear implants (CI) was lower or comparable to that of their normal hearing peers and to identify predictors of arithmetic achievement in children with CI. In particular we related the arithmetic achievement o...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2014.04.038
更新日期：2014-07-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2014.06.001
更新日期：2014-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2005.01.031
更新日期：2005-06-01 00:00:00
abstract：INTRODUCTION:Tympanic membrane cholesteatoma (TMC) is a rare anomaly found in pediatric patients with no significant otologic history. Its pathogenesis appears distinct from congenital mesotympanic cholesteatoma. This systematic review and meta-analysis evaluates the management of TMC. METHODS:Two authors independentl...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,meta分析,评审
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更新日期：2017-11-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 临床试验,杂志文章
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更新日期：2000-06-09 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.ijporl.2011.03.005
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of micronized flavonoid fraction in preventing cisplatin ototoxicity in a guinea pig model. METHODS:This study was conducted on 23 guinea pigs in the Animal Laboratory of Izmir Atatürk Training and Research Hospital. Animals were divided into three groups: Group 1 consisted of e...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2012.06.003
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Bacterial biofilm formation has been implicated in the high rate of persistent otorrhea after tympanostomy tube insertion. It has been suggested that the tube material may be an important factor in the development of otorrhea. Recently we reported the presence of ciprofloxacin-resistant Pseudom...
journal_title：International journal of pediatric otorhinolaryngology
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/0165-5876(87)90028-0
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2015.09.013
更新日期：2015-12-01 00:00:00
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doi：10.1016/j.ijporl.2017.10.016
更新日期：2017-12-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,评审
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更新日期：2006-02-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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更新日期：2020-06-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
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更新日期：1983-04-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.ijporl.2010.01.020
更新日期：2010-05-01 00:00:00
abstract：:Autosomal-recessive genes are responsible for about 80% of the hereditary non-syndromic hearing loss (NSHL) cases. In Iran, due to consanguineous marriages, NSHL is the second most frequent disability after intellectual disability, occurring one in 16 individuals. Enormous heterogeneity in the genetic pathology of hea...
journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
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journal_title：International journal of pediatric otorhinolaryngology
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
