当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY期刊下所有文献 > Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis.

Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis.

Abstract：

OBJECTIVE:Phospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children. METHODS:Activity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate. RESULTS:The sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P<0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r=0.26; P=0.02), which was not apparent in OSA (r=0.14; P=0.09). CONCLUSION:This study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.

journal_name

Int J Pediatr Otorhinolaryngol

journal_title

International journal of pediatric otorhinolaryngology

authors

Ezzeddini R,Darabi M,Ghasemi B,Jabbari Moghaddam Y,Abdollahi S,Rashtchizadeh N,Gharahdaghi A,Darabi M,Ansarin M,Shaaker M,Samadi A,Karamravan J

doi

10.1016/j.ijporl.2011.12.026

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

471-4

issue

4

eissn

0165-5876

issn

1872-8464

pii

S0165-5876(12)00005-5

journal_volume

76

pub_type

杂志文章

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