当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY期刊下所有文献 > Prevention of cisplatin ototoxicity: Efficacy of micronized flavonoid fraction in a guinea pig model.

Prevention of cisplatin ototoxicity: Efficacy of micronized flavonoid fraction in a guinea pig model.

Abstract：

OBJECTIVE:To evaluate the effectiveness of micronized flavonoid fraction in preventing cisplatin ototoxicity in a guinea pig model. METHODS:This study was conducted on 23 guinea pigs in the Animal Laboratory of Izmir Atatürk Training and Research Hospital. Animals were divided into three groups: Group 1 consisted of eight animals receiving cisplatin only; Group 2 contained eight animals receiving cisplatin+micronized flavonoid fraction; and Group 3 contained seven animals that received micronized flavonoid fraction only. Their cochlear reserve was evaluated by measuring the distortion product otoacoustic emission on days 0 and 7. RESULTS:In Groups 1 and 2, the intragroup signal-noise ratios were statistically different at all frequencies tested (based on negative ranks, p<0.05). In Group 3, the intragroup signal-noise ratios did not differ significantly at the frequencies tested (p>0.05). Comparison of the three groups showed statistically significant differences among the groups (p<0.05). The post hoc Bonferroni correction showed statistically significant differences among all three groups (p<0.016). The median signal-noise ratio of the three groups tended to increase (z-value was positive for all the frequencies tested; p<0.01). CONCLUSION:Micronized flavonoid fraction (Daflon) is effective against cisplatin-induced ototoxicity in guinea pigs.

journal_name

Int J Pediatr Otorhinolaryngol

journal_title

International journal of pediatric otorhinolaryngology

authors

Başoğlu MS,Eren E,Aslan H,Bingölballı AG,Oztürkcan S,Katılmış H

doi

10.1016/j.ijporl.2012.06.003

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1343-6

issue

9

eissn

0165-5876

issn

1872-8464

pii

S0165-5876(12)00341-2

journal_volume

76

pub_type

杂志文章

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