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Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children.

Abstract：

OBJECTIVE:To observe the difference in cellular senescence patterns between recurrent tonsillitis and tonsillar hypertrophy. METHODS AND MATERIALS:Forty-three patients diagnosed with recurrent tonsillitis or tonsillar hypertrophy, based on medical history and symptoms, underwent tonsillectomy. The specimens were collected and examined using senescence β-galactosidase staining for cellular senescence. Macrophages were detected by immunochemistry. RESULTS:Cellular senescence was found in both recurrent tonsillitis and tonsillar hypertrophy groups. The comparison of cellular senescence in microcompartments of tonsil tissue (germinal centre, mantle zone, subepithelial and intraepithelial) revealed a significant increase of senescent cells in germinal centres in tonsillar hypertrophy compared with that in tonsillar hypertrophy. The majority of senescent cells in both groups were CD68-positive. CONCLUSIONS:Different cellular senescence patterns were found between the two studied paediatric tonsillar diseases. Macrophage senescence may play a role in the pathogenesis of these diseases.

journal_name

Int J Pediatr Otorhinolaryngol

journal_title

International journal of pediatric otorhinolaryngology

authors

Chen S,Wang WW,Wang Y,Li YQ,Zhu LX

doi

10.1016/j.ijporl.2020.110004

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

110004

eissn

0165-5876

issn

1872-8464

pii

S0165-5876(20)30147-6

journal_volume

133

pub_type

杂志文章

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