Abstract:
:Nominations for this year's signaling breakthroughs spanned physiology, therapeutics and drug development, neuroscience, and plant signaling. Among the most exciting advances in mammalian biology were therapeutic applications of research that are overturning the conventional boundaries of signaling pathways,unexpected mechanisms to prolong life and prevent aging, new insights into schizophrenia and memory, development of a transgenic primate model, and the discovery that the cells in the lungs can "taste" noxious substances. In plant signaling,the nominations converged on the identification of the elusive receptor for the plant stress hormone abscisic acid. Finally, methodological advances were also noted with new techniques in synthetic biology enabling the precise spatiotemporal control of signaling events and increasingly facile methods for creation and analysis of proteomic data yielding tremendous increases in raw data and insights into cellular regulation.
journal_name
Sci Signaljournal_title
Science signalingauthors
Adler EMdoi
10.1126/scisignal.3103eg1subject
Has Abstractpub_date
2010-01-05 00:00:00pages
eg1issue
103eissn
1945-0877issn
1937-9145pii
3/103/eg1journal_volume
3pub_type
社论,历史文章,评审abstract::Teaching the practical aspects of signal transduction to large undergraduate classes can be challenging when there is only a finite time frame in which to engage in laboratory activities. This teaching resource describes the use of bead-based ALPHAscreen technology for a class of 300 second-year biochemistry students,...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.262tr1
更新日期:2009-03-17 00:00:00
abstract::GIV (Gα-interacting vesicle-associated protein; also known as Girdin) enhances Akt activation downstream of multiple growth factor- and G protein (heterotrimeric guanosine 5'-triphosphate-binding protein)-coupled receptors to trigger cell migration and cancer invasion. We demonstrate that GIV is a tyrosine phosphoprot...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002049
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abstract::Mineralocorticoid receptor (MR) antagonists are effective at treating heart failure. In this issue of Science Signaling, Oakley et al. provide new insight into their cardioprotective actions and highlight the importance of the opposing relationship between the MR and the related glucocorticoid receptor (GR) in the res...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aaw8715
更新日期:2019-04-16 00:00:00
abstract::Spontaneous neural differentiation of embryonic stem cells is induced by Noggin-mediated inhibition of bone morphogenetic protein 4 (BMP4) signaling. RhoA is a guanosine triphosphatase (GTPase) that regulates cytoskeletal dynamics and gene expression, both of which control stem cell fate. We found that disruption of S...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aaf0791
更新日期:2016-07-26 00:00:00
abstract::Insulin secretion from pancreatic β cells is controlled by nutrients, hormones, and neurotransmitters. Unlike the latter, which work through classic receptors, glucose and most other nutrients do not interact with membrane receptors but must be metabolized by β cells to induce insulin secretion. Studies have revealed ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003325
更新日期:2012-08-28 00:00:00
abstract::Intracranial aneurysms are common but are generally untreated, and their rupture can lead to subarachnoid hemorrhage. Because of the poor prognosis associated with subarachnoid hemorrhage, preventing the progression of intracranial aneurysms is critically important. Intracranial aneurysms are caused by chronic inflamm...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aah6037
更新日期:2017-02-07 00:00:00
abstract::This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on diffe...
journal_title:Science signaling
pub_type: 社论
doi:10.1126/scisignal.2004149
更新日期:2013-03-26 00:00:00
abstract::The mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] inhibitor rapamycin is a potent inhibitor of T and B lymphocyte growth and proliferation. In this issue of Science Signaling, So et al found that the isoform of 4E-BP (4E-BP2) in lymphocytes that regulates messenger RNA translation is more sensitive...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.aaf8190
更新日期:2016-05-31 00:00:00
abstract::The CLAVATA (CLV) and flagellin (flg) signaling pathways act through peptide ligands and closely related plasma membrane-localized receptor-like kinases (RLKs). The plant peptide CLV3 regulates stem cell homeostasis, whereas the bacterial flg22 peptide elicits defense responses. We applied multiparameter fluorescence ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aab0598
更新日期:2015-08-04 00:00:00
abstract::Natural killer group 2D (NKG2D), an activating receptor on natural killer (NK) cells and a subset of T cells, recognizes stress-inducible proteins, including MICA and ULBP2, which are present on infected or transformed cells. Whether each NKG2D ligand (NKG2DL) has a distinct biological role is not clear. Using superre...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aal3606
更新日期:2018-04-10 00:00:00
abstract::Netrin-1 displays proto-oncogenic activity in several cancers, which is thought to be due to the ability of this secreted cue to stimulate survival when bound to its receptors. We showed that in contrast to full-length, secreted netrin-1, some cancer cells produced a truncated intranuclear form of netrin-1 (ΔN-netrin-...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002456
更新日期:2012-08-07 00:00:00
abstract::Ewing's sarcoma (ES) is a rare and highly malignant cancer that grows in the bones or surrounding tissues mostly affecting adolescents and young adults. A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), which is generated from a chromosomal translocation, is...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aam8429
更新日期:2017-10-03 00:00:00
abstract::DNAX-activating protein of 12 kD (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor protein found in myeloid cells and natural killer cells, and it couples to various receptors that mediate either cellular activation or inhibition. DAP12 inhibits Toll-like receptor (TLR) signaling, ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003801
更新日期:2013-08-20 00:00:00
abstract::Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development through VEGF receptors (VEGFRs). The VEGFR immunoglobulin homology domain 2 (D2) is critical for ligand binding, and D3 provides additional interaction sites. VEGF-B and placenta growth factor (PlGF) bind to VEGFR-1 with high a...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2003905
更新日期:2013-07-02 00:00:00
abstract::The advent of deep-sequencing techniques has revealed that mutations in G protein-coupled receptor (GPCR) signaling pathways in cancer are more prominent than was previously appreciated. An emergent theme is that cancer-associated mutations tend to cause enhanced GPCR pathway activation to favor oncogenicity. Regulato...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aax8620
更新日期:2020-02-04 00:00:00
abstract::MicroRNAs (miRNAs), key posttranscriptional regulators of many biological processes, have been implicated in many diseases, including cancer. In a recent paper, Avraham and colleagues take a systems biology approach to determine whether and how miRNAs are involved in the regulation of oncogenic signaling networks down...
journal_title:Science signaling
pub_type: 评论,杂志文章,评审
doi:10.1126/scisignal.2002182
更新日期:2011-07-26 00:00:00
abstract::The interplay between calcium ion (Ca(2+)) and cyclic adenosine monophosphate (cAMP) signaling underlies crucial aspects of cell homeostasis. The membrane-bound Ca(2+)-regulated adenylyl cyclases (ACs) are pivotal points of this integration. These enzymes display high selectivity for Ca(2+) entry arising from the acti...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002299
更新日期:2012-04-10 00:00:00
abstract::Double knockout of PTEN and LKB1-genes encoding phosphatase and tensin homolog and liver kinase B1, respectively-leads to the spontaneous development of cancer in mice. PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), whereas LKB1 activates the 5' adeno...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.aac8321
更新日期:2015-09-01 00:00:00
abstract::Postsynaptic organizational protein complexes play central roles both in orchestrating synapse formation and in defining the functional properties of synaptic transmission that together shape the flow of information through neuronal networks. A key component of these organizational protein complexes is the family of s...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.abd8379
更新日期:2020-12-22 00:00:00
abstract::Mutations in AMPA receptor recycling machinery underlie cognitive impairment in an intellectual disorder and in neurodegenerative diseases. ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aan5454
更新日期:2017-05-02 00:00:00
abstract::Given its fundamental role in development and cancer, the Wnt-β-catenin signaling pathway is tightly controlled at multiple levels. RING finger protein 43 (RNF43) is an E3 ubiquitin ligase originally found in stem cells and proposed to inhibit Wnt signaling by interacting with the Wnt receptors of the Frizzled family....
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aac6757
更新日期:2015-09-08 00:00:00
abstract::Biophysical methods and x-ray crystallography have revealed that class A G protein-coupled receptors (GPCRs) can form homodimers. We combined computational approaches with receptor cross-linking, energy transfer, and a newly developed functional export assay to characterize the residues involved in the dimerization in...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aal2869
更新日期:2018-05-08 00:00:00
abstract::The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a nutrient-sensitive protein kinase that is aberrantly activated in many human cancers. Whether dysregulation of mTORC1 signaling in normal tissues increases the risk for cancer, however, is unknown. We focused on hepatocellular carcinoma, which has been l...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2002739
更新日期:2012-03-27 00:00:00
abstract::This year's signaling breakthroughs highlight insights into the pathogenesis or treatment of cancer, malaria, and neurodegenerative disorders; reveal molecular insights into cell death; and identify signals that could be leveraged to prevent plant parasitism or engineer bacteria as microbial fuel cells. ...
journal_title:Science signaling
pub_type: 社论
doi:10.1126/scisignal.aad9795
更新日期:2016-01-05 00:00:00
abstract::Inositol pyrophosphates are highly energetic inositol polyphosphate molecules present in organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate different forms of inositol pyrophosphates. The biosynthesis of these substances principally involves phosphorylation of inositol hexakisphospha...
journal_title:Science signaling
pub_type: 杂志文章,评审
doi:10.1126/scisignal.2001958
更新日期:2011-08-23 00:00:00
abstract::Microglia mediate neuroprotection and neuropathogenesis but have not been directly associated with behavior. As gatekeepers of the brain's immune system, microglia protect the brain from pathogens but also contribute to inflammation, which may negatively affect neurons. A recent study demonstrates a role for Hoxb8-exp...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.3147jc8
更新日期:2010-11-09 00:00:00
abstract::Activation of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by VEGF binding is critical for vascular morphogenesis. In addition, VEGF disrupts the endothelial barrier by triggering the phosphorylation and turnover of the junctional molecule VE-cadherin, a process mediated by the VEGFR2 downstream effec...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aad9256
更新日期:2016-07-19 00:00:00
abstract::Inhibition of protein synthesis by phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2) at Ser(51) occurs as a result of the activation of a family of kinases in response to various forms of stress. Although some consequences of eIF2alpha phosphorylation are cytoprotective, phospho...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.2000389
更新日期:2009-12-22 00:00:00
abstract::Fgr is a member of the Src family of nonreceptor tyrosine kinases, which are overexpressed and constitutively active in many human cancers. Fgr expression is restricted to myeloid hematopoietic cells and is markedly increased in a subset of bone marrow samples from patients with acute myeloid leukemia (AML). Here, we ...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aat5916
更新日期:2018-10-23 00:00:00
abstract::Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance. Ligand stimulation induces the internalization of NKG2D-DAP10 complex...
journal_title:Science signaling
pub_type: 杂志文章
doi:10.1126/scisignal.aab2724
更新日期:2015-10-27 00:00:00