Abstract:
INTRODUCTION:Antibiotics are responsible for 20-25% of the total drug-cost in the larger hospitals in Iceland. Studies from other countries, both in Europe and North-America suggest that 40-70% of both antibiotic therapy and prophylaxis is inappropriate in the larger teaching hospitals. We undertook a prospective study to determine the patterns of antimicrobial use in a university hospital. METHODS:Data on antibiotic prescriptions were collected over two four week periods in April and August 1994 on 12 wards at the National University Hospital. RESULTS:During the eight weeks 302 (30%) of 1020 hospitalized medical, surgical and gynecological patients received one or more courses of antimicrobial therapy. Presumptive infection was the reason for therapy in 73% of the cases, prophylaxis in 35% and both therapy and prophylaxis in 8%. Cephalosporins were the most commonly used drugs for antimicrobial therapy and cloxacillin for prophylaxis. Therapy was judged appropriate in only 45% of the courses. Poor drug choice (bacterologically, pharmacologically), misguided prophylaxis, wrong drug dosage or unneccessary therapy were the most frequent reason for inappropriate therapy. CONCLUSION:Because of the worldwide increase of antibiotic-resistant strains the results of this study clearly indicate the need for additional measures to improve antibiotic use.
journal_name
Laeknabladidjournal_title
Laeknabladidauthors
Gudjonsson AT,Kristinsson KG,Gudmundsson Ssubject
Has Abstractpub_date
1996-01-01 00:00:00pages
39-45issue
1eissn
0023-7213issn
1670-4959journal_volume
82pub_type
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