Abstract：
:In studies designed to determine the respective functional roles of two bulbospinal monoaminergic pathways to sympathetic preganglionic neurons, both L-dopa and precursors of 5-HT depressed transmission through excitatory spinal reflex and bulbospinal sympathetic pathways. Transmission through spinal reflex pathways was secondarily enhanced after L-dopa. Pharmacological tests indicated mediation of these affects by monoamines. After antagonism or depletion of central 5-HT, L-dopa only enhanced transmission through both pathways. The results indicate that hypotension and other sympathoinhibitory effects of L-dopa are produced at the spinal level by release of 5-HT from terminals of bulbospinal 5-HT pathways that are inhibitory to sympathetic preganglionic neurons. The excitatory effects of L-dopa are apparently mediated by release of catecholamines from bulbospinal noradrenergic pathways that are excitatory.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Franz DN,Neumayr RJ,Hare BDdoi
10.1007/978-1-4684-2511-6_13subject
Has Abstractpub_date
1977-01-01 00:00:00pages
219-232eissn
0065-2598issn
2214-8019journal_volume
90pub_type
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