Nonuniform activation and the mechanics of myocardial trabeculae with fast or slow myosin.

abstract：:The rostral nucleus of the solitary tract (rNST) plays a key role in modulating, organizing and distributing the sensory information arriving at the central nervous system from gustatory receptors. However, except for some anatomical studies of rNST synapses, the neural circuits responsible for this first stage in syn...

journal_title：Annals of the New York Academy of Sciences

authors： Bradley RM,Grabauskas G

更新日期：1998-11-30 00:00:00

abstract：:The processing of pitch, a central aspect of music perception, is neurally dissociable from other perceptual functions. Studies using behavioral-lesion techniques as well as brain imaging methods demonstrate that tonal processing recruits mechanisms in areas of the right auditory cortex. Specifically, the right primar...

journal_title：Annals of the New York Academy of Sciences

authors： Zatorre RJ

更新日期：2001-06-01 00:00:00

abstract：:Twenty female imago of Haemaphysalis concinnae ticks collected from wild vegetation in May of 2001 in the Obor region near Khabarovsk in the Russian Far East were studied. DNA was extracted with commercially available kits following manufacturer's instructions. We used broad range primers SFG3 and SFG6 proposed for am...

journal_title：Annals of the New York Academy of Sciences

authors： Mediannikov O,Ivanov L,Nishikawa M,Saito R,Sidelnikov YN,Zdanovskaya NI,Tarasevich IV,Suzuki H

更新日期：2003-06-01 00:00:00

abstract：:Cytokines (IL-1, IL-6, IL-8, IL-11, TNF, IFN-gamma, and TGF-beta) and growth factors (EGF, bFGF, aFGF, and KGF) play an important role in modulation of hormone secretion by directly influencing specific enzyme steps of steroidogenesis in various endocrine cell types. For this tabular data collection, the following enz...

journal_title：Annals of the New York Academy of Sciences

authors： Herrmann M,Scholmerich J,Straub RH

更新日期：2002-06-01 00:00:00

abstract：:In this chapter we examine whether rapists are sexually aroused by coercive, nonconsensual sex. This question is theoretically important because it speaks to a potential sexual motivation underlying rape. It is also clinically important in that it may reveal an important assessment and treatment target. We first revis...

journal_title：Annals of the New York Academy of Sciences

authors： Lalumière ML,Quinsey VL,Harris GT,Rice ME,Trautrimas C

更新日期：2003-06-01 00:00:00

abstract：:Malignancies have developed several strategies to evade immune surveillance. We have investigated pancreatic cancer cell lines and pancreatic cancer surgical specimens to evaluate possibilities of tumor escape in the Fas system, and local immune suppression. Despite Fas expression the majority of cell lines was resist...

journal_title：Annals of the New York Academy of Sciences

authors： Ungefroren H,Voss M,Bernstorff WV,Schmid A,Kremer B,Kalthoff H

更新日期：1999-06-30 00:00:00

abstract：:Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

journal_title：Annals of the New York Academy of Sciences

authors： Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

更新日期：2009-04-01 00:00:00

abstract：:The Dover sole was the species most often affected with eroded fins. Prevalence of the disease was highest on the Palos Verdes shelf, the site of a major municipal waste water discharge. Fin lesions in this species were characterized by a minimal inflammatory response and by the absence of associated microorganisms. T...

journal_title：Annals of the New York Academy of Sciences

authors： Sherwood MJ,Mearns AJ

更新日期：1978-09-29 00:00:00

abstract：:Recent cross-cultural studies of child development reveal that child rearing, while strikingly culturally variable, is everywhere designed to make the child's experience of important lessons constant, to link those lessons to emotional arousal, and to connect them to evaluations of the child's goodness and badness. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn N

更新日期：2003-10-01 00:00:00

abstract：:The LGR7/RXFP1 and LGR8/RXFP2 receptors are unique receptors among the G-protein-coupled receptors (GPCRs) in having a low-density lipoprotein class A (LDL-A) module. Their complex gene organization, among the intron-richest of the GPCRs, suggests that alternative splicing is a common occurrence. We have therefore inv...

journal_title：Annals of the New York Academy of Sciences

authors： Kern A,Bryant-Greenwood GD

更新日期：2009-04-01 00:00:00

abstract：:Evolutionary theories suggest that the expression of extended longevity depends on the organism's ability to shift energy from reproduction to somatic maintenance. New data led us to reexamine our older data and integrate the two into a larger picture of the genetic and metabolic alterations required if the animal is ...

journal_title：Annals of the New York Academy of Sciences

authors： Arking R,Buck S,Hwangbo DS,Lane M

更新日期：2002-04-01 00:00:00

abstract：:Rewards can be viewed as probability distributions of reward values. Besides expected (mean) value, a key parameter of such distributions is variance (or standard deviation), which constitutes a measure of risk. Single neurons in orbitofrontal cortex signal risk mostly separately from value. Comparable risk signals in...

journal_title：Annals of the New York Academy of Sciences

authors： Schultz W,O'Neill M,Tobler PN,Kobayashi S

更新日期：2011-12-01 00:00:00

abstract：:Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap be...

journal_title：Annals of the New York Academy of Sciences

authors： Hill C,Khashab MA,Kalloo AN,Kumbhari V

更新日期：2018-01-01 00:00:00

abstract：:Nipah virus (NiV) is a highly pathogenic paramyxovirus, which emerged in 1998 from fruit bats in Malaysia and caused an outbreak of severe respiratory disease in pigs and fatal encephalitis in humans with high mortality rates. In contrast to most paramyxoviruses, NiV can infect a large variety of mammalian species. Du...

journal_title：Annals of the New York Academy of Sciences

authors： Diederich S,Maisner A

更新日期：2007-04-01 00:00:00

abstract：:Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers. Divisome assembly occurs in two steps and involves multiple interactions between more than 20 essential and accessory ...

journal_title：Annals of the New York Academy of Sciences

authors： Egan AJ,Vollmer W

更新日期：2013-01-01 00:00:00

abstract：:Wisdom is a special kind of virtue. It is not to be identified with any outstanding cognitive ability-like having a prodigious memory or knowing a lot. Rather it consists in seeing what is most important and most valuable, either within a particular domain or in life as a whole. In the life of a wise person, that insi...

journal_title：Annals of the New York Academy of Sciences

authors： Kitcher P

更新日期：2016-11-01 00:00:00

abstract：:Methamphetamine (METH) is a major drug of abuse in the United States. A high dose of METH given to mice and rats causes long-lasting depletion of tyrosine hydroxylase activity, dopamine (DA), and DA-transporter (DAT) binding sites in the striatum. In human METH-abusers, a marked decrease of the DAT in the caudate puta...

journal_title：Annals of the New York Academy of Sciences

authors： Itzhak Y,Ali SF

更新日期：2002-06-01 00:00:00

abstract：:A type of unit discharge, termed "luxotonic," has been found in the striate cortex of unanesthetized squirrel monkeys and macaques.6, 21 The firing frequency of these units shows relatively little adaptation, continues indefinitely (hours), and reflects the level of diffuse illumination of the eye. The more numerous "...

journal_title：Annals of the New York Academy of Sciences

authors： Doty RW

更新日期：1977-01-01 00:00:00

abstract：:Content differentiation models posit that different areas of the prefrontal cortex perform similar operations but differ in terms of the content that is operated on. For example, it has been suggested that the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC) perform similar working memory or i...

journal_title：Annals of the New York Academy of Sciences

authors： Zald DH

更新日期：2007-12-01 00:00:00

abstract：:Expectation of reward facilitates motor behaviors that enable the animal to approach a location in space where the reward is expected. It is now known that the same expectation of reward profoundly modifies sensory, motor, and cognitive information processing in the brain. However, it is still unclear which brain regi...

journal_title：Annals of the New York Academy of Sciences

authors： Hikosaka O

更新日期：2007-05-01 00:00:00

abstract：:Whether T cells promote bone loss following immobilization after spinal cord injury (SCI) remains undetermined. Therefore, wild-type (WT) and T cell-deficient (Tcrb-/- ) male mice underwent sham or contusion SCI to cause hindlimb paralysis. Femurs were isolated and distal and midshaft regions were evaluated by microco...

journal_title：Annals of the New York Academy of Sciences

authors： Sahbani K,Shultz LC,Cardozo CP,Bauman WA,Tawfeek HA

更新日期：2020-10-26 00:00:00

abstract：:Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western societies mainly accounts for clinical dementia. A high proportion of women are affected by this disease, especially at a very advanced age, which might to a large extent be associated with the fact that women live l...

journal_title：Annals of the New York Academy of Sciences

authors： Candore G,Balistreri CR,Grimaldi MP,Vasto S,Listì F,Chiappelli M,Licastro F,Lio D,Caruso C

更新日期：2006-11-01 00:00:00

abstract：:The number of physiologic and metabolic phenomena amenable to analysis using magnetic resonance (MR) techniques is increasing every year. MR techniques can now evaluate tissue parameters relevant to TCA cyclemetabolism, anerobic glycolysis, ATP levels, blood-brain barrier permeability, macrophage infiltration, cytotox...

journal_title：Annals of the New York Academy of Sciences

authors： Jenkins BG,Chen YI,Kuestermann E,Makris NM,Nguyen TV,Kraft E,Brownell AL,Rosas HD,Kennedy DN,Rosen BR,Koroshetz WJ,Beal MF

更新日期：1999-01-01 00:00:00

abstract：:Since the first detection of highly pathogenic H5N1 avian influenza virus from sick goose in Guangdong province in China in 1996, scientists in China started to develop vaccines for avian influenza pandemic preparedness. An H5N2 inactivated vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, an...

journal_title：Annals of the New York Academy of Sciences

authors： Qiao C,Tian G,Jiang Y,Li Y,Shi J,Yu K,Chen H

更新日期：2006-10-01 00:00:00

abstract：:Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short-lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age-related disease processes. The diverse effects of CR have been demonstrated...

journal_title：Annals of the New York Academy of Sciences

authors： Lane MA,Black A,Handy A,Tilmont EM,Ingram DK,Roth GS

更新日期：2001-04-01 00:00:00

abstract：:The available evidence suggests that plasma leakage in dengue hemorrhagic fever is caused by the action of circulating mediators on the vascular endothelium, and that the host immune response is a critical determinant of this response. We have been exploring the role of dengue virus-specific T lymphocytes in the immun...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman AL

更新日期：2009-09-01 00:00:00

abstract：:Progression of the cell cycle is controlled by activating and inhibiting cellular factors. The delicate balance between these positive- and negative-acting regulators warrants proper cell cycle progression in normal cells and facilitates cellular response to a variety of stress stimuli. The increased activity of the p...

journal_title：Annals of the New York Academy of Sciences

authors： Wesierska-Gadek J,Krystof V

更新日期：2009-08-01 00:00:00

abstract：:A new potent inhibitor of adenosine deaminase (co-vidarabine) was used in combination studies with adenine arabinoside (vidarabine, Vira-ATM) to protect this purine nucleoside from enzymatic deamination to the more weakly active metabolite, hypoxanthine arabinoside. Comparing the combination to vidarabine alone, a sig...

journal_title：Annals of the New York Academy of Sciences

authors： Sloan BJ,Kielty JK,Miller FA

更新日期：1977-03-04 00:00:00

abstract：:The presence in the serum of specific autoantibodies, such as antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA), and antiextractable nuclear antigens (anti-ENA), is one of the diagnostic criteria for autoimmune rheumatic disease, and the requests for these tests in the last few years have grown remar...

journal_title：Annals of the New York Academy of Sciences

authors： Bonaguri C,Melegari A,Dall'Aglio P,Ballabio A,Terenziani P,Russo A,Battistelli L,Aloe R,Camisa R,Campaniello G,Sartori E,Monica C

更新日期：2009-09-01 00:00:00

abstract：:We have presented evidence indicating that P2-purinergic receptors may activate the polyphosphoinositide-phospholipase C in HL60 cells via the mediation of a pertussis-toxin-sensitive GTP-binding protein, which also mediates the actions of chemotactic peptide receptors in these and other phagocytic white blood cells. ...

journal_title：Annals of the New York Academy of Sciences

authors： Dubyak GR,Cowen DS,Lazarus HM

更新日期：1988-01-01 00:00:00