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The resorption of nanocrystalline calcium phosphates by osteoclast-like cells.

Abstract：

:Nanocrystalline calcium phosphates containing carbonate have a high similarity to bone mineral. The reactions of bone cells (primary osteoblasts and osteoclast-like cells) on these materials as well as on sintered beta-tricalcium phosphate and hydroxyapatite (HA) confirmed a good biocompatibility of the nanocrystalline samples. However, osteoclastic differentiation was constrained on the carbonate-rich samples, leading to a small number of osteoclast-like cells on the materials and few resorption pits. The grain size of the calcium phosphate ceramics (nano vs. micro) was less important than expected from to physico-chemical considerations. When comparing the nanocrystalline samples, the highest resorption rate was found for nano-HA with a low carbonate content, which strongly stimulated the differentiation of osteoclast-like cells on its surface.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Detsch R,Hagmeyer D,Neumann M,Schaefer S,Vortkamp A,Wuelling M,Ziegler G,Epple M

doi

10.1016/j.actbio.2010.03.003

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

3223-33

issue

8

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(10)00129-7

journal_volume

6

pub_type

杂志文章

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