Abstract：
UNLABELLED:Clinical studies on nasal topical medications require the standardization of 'nasosinusal normality' in order to establish control groups through a specific evaluation of the upper airways. AIM:to standardize the evaluation of candidates for control groups in clinical studies on nasal topical medications. MATERIAL AND METHODS:healthy male volunteers of 18 to 50 years of age, asymptomatic from the nasosinusal standpoint were subjected to a sequential and excluding assessment made up of clinical evaluation, immediate hypersensitivity skin test, saccharin test, flexible nasofibroscopy and nasal cytology. STUDY DESIGN:Cross-sectional contemporary cohort. RESULTS:Of the 33 people originally enrolled, 14 (42.4%) were excluded for clinical reasons. Of the 19 remaining, 2 (10.5%) had atopy diagnosed in the skin test and were excluded. 17 were tested with saccharin and presented normal mucociliary clearance. Evaluation by nasal endoscopy showed abnormality in 2 cases (11.8%) and these were excluded. The remaining 15 were submitted to nasal cytology, which proved normal, representing 45.5% of those initially included. CONCLUSION:The proposed protocol for sequential and excluding evaluation was effective in defining candidates for the establishment of control groups in clinical studies on nasal topical medications.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
Borin A,Abib E Jr,Araujo CI,Martinez LL,Rodrigues Hdoi
10.1016/s1808-8694(15)30552-8subject
Has Abstractpub_date
2009-11-01 00:00:00pages
872-8issue
6eissn
1808-8694issn
1808-8686pii
S1808-8694(15)30552-8journal_volume
75pub_type
杂志文章abstract：UNLABELLED:Graves's disease is the most common cause of hyperthyroidism. There are three current therapeutic options: anti-thyroid medication, surgery, and radioactive iodine (I 131). There are few data in the literature regarding the effects of radioiodine therapy on the larynx and voice. The aim and the AIM:os this ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31092-2
更新日期：2008-03-01 00:00:00
abstract：INTRODUCTION:In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invas...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
doi：10.1016/j.bjorl.2014.07.011
更新日期：2014-09-01 00:00:00
abstract：UNLABELLED:Hyperbaric oxygen therapy (HBOT) has enhanced the prevention and treatment of auditory ailments such as ototoxicity. OBJECTIVE:To study the effects of HBOT upon ototoxic injuries produced by amikacin. METHOD:This experimental study included 12 albino guinea pigs, whose auditory function was assessed throug...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.5935/1808-8694.20130060
更新日期：2013-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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abstract：INTRODUCTION:Sentinel lymph node biopsy is a proven method for staging the neck in patients with early oral cavity squamous cell carcinoma because it results in less comorbidity than the traditional method of selective neck dissection, with the same oncological results. However, the real effect of that method on the qu...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2020.11.015
更新日期：2020-12-27 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2018.03.006
更新日期：2019-01-01 00:00:00
abstract：UNLABELLED:Cholesteatoma may cause bone erosion, with high morbidity and mortality rates. Tumor necrosis factor-alpha (TNF-a) is one of the main cytokines involved in this process. Our goal was to evaluate the role of TNF-a in Bone Resorption and its effect on cholesteatoma. MATERIAL AND METHODS:analysis and critical ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
abstract：UNLABELLED:Auditory evoked brainstem responses (ABR) is a non-invasive electrical potential registration which evaluates the auditory tract from the middle ear to the auditory cortex in the first 12 milliseconds (ms). The ABR is an important otoneurological evaluation. AIM:Confirm the test's usefulness, major incidenc...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30601-7
更新日期：2008-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2019.09.005
更新日期：2020-01-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30083-5
更新日期：2007-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/S1808-8694(15)30144-0
更新日期：2008-11-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)31209-x
更新日期：2005-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30073-2
更新日期：2007-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2019.08.002
更新日期：2019-09-14 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章,随机对照试验
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更新日期：2016-05-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.5935/1808-8694.20130039
更新日期：2013-03-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30759-x
更新日期：2008-01-01 00:00:00
abstract：UNLABELLED:Children dysphonia studies have reported an incidence of 4.4 to 30.3%. GOALS:To establish the prevalence of dysphonia in children, based on the opinion of the parents, acoustic and vocal-perceptual assessments, associated symptoms, risk factors and videolaryngoscopy findings. MATERIALS AND METHODS:The pare...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/s1808-8694(15)30774-6
更新日期：2009-03-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2018.01.006
更新日期：2019-01-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2018.12.006
更新日期：2020-01-01 00:00:00
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journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.12.001
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:In rhinoplasty, the nasal dorsum has important relevance regarding the esthetic and functional aspects of the surgery. Its reduction should be performed with maximum accuracy and controlled resection to prevent or minimize potential complications. The septum pyramidal adjustment and repositioning consists ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2017.11.009
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Adenotonsillectomy is an invasive surgical procedure, which may encourage the search for information by the lay population through online search engines. The quality of this information, however, requires an evaluation due to the wide diversity of the available content. OBJECTIVE:To evaluate the quality, ...
journal_title：Brazilian journal of otorhinolaryngology
pub_type： 杂志文章
doi：10.1016/j.bjorl.2019.06.012
更新日期：2019-07-27 00:00:00
