Abstract:
UNLABELLED:Ototoxicity is still a challenge to medicine. The discovery of self-protecting endogenous mechanisms of the outer hair cells associated with their functional and ultra-structural assessment methods has opened new horizons in the understanding and controlling of these mechanisms. AIM:this paper aimed at establishing whether or not underdoses of gentamicin could protect the inner ear against the harmful effects of amikacin, based on these protection mechanisms and determine if the otoacoustic emission amplitudes could be associated with the level of hair cell integrity. MATERIALS AND METHODS:Experimental study. We used 31 guinea pigs. They were injected with saline solution, gentamicin and amikacin, alone and in combinations -intramuscular injections - during 12, 30 and 42 days. The otoacoustic emissions were recorded in the beginning and at the end of the experiment, comparing it with the cochlear integrity study carried out by electron microscopy. RESULTS:gentamicin underdoses did not protect the inner ear against amikacin toxicity; the reduction in otoacoustic emissions was strongly associated with an increase in hair cell lesions. CONCLUSION:these findings help understand inner ear otoprotection and ototoxicity. Establishing the correlation between the emissions amplitude an cell integrity plays an important role in the follow up of hair cell damage, with possible monitoring of ototoxicity caused by drugs in humans.
journal_name
Braz J Otorhinolaryngoljournal_title
Brazilian journal of otorhinolaryngologyauthors
de Aquino TJM,de Oliveira JAA,Rossato Mdoi
10.1016/S1808-8694(15)30144-0subject
Has Abstractpub_date
2008-11-01 00:00:00pages
843-852issue
6eissn
1808-8694issn
1808-8686pii
S1808-8694(15)30144-0journal_volume
74pub_type
杂志文章abstract:UNLABELLED:The middle latency response (MLR) to an acoustic stimulus occurs between 10 and 80 ms. The waveform is characterized by a series of peaks and troughs labeled N0, P0, Na, Pa, Nb and Pb. Certain acoustic stimuli may excite specific cochlear areas in contrast with clicks, that activate the cochlea between 1000 ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30073-2
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:Promising treatments for tympanic membrane perforation closure have been studied. Therapies derived from tissue engineering probably eliminate the need for conventional surgery. Bacterial cellulose is presented as an alternative that is safe, biocompatible, and has low toxicity. OBJECTIVES:To investigate ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
abstract:UNLABELLED:Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The disease more frequently affects the nasal mucosa and can occur independently of its clinical form or even before lesions on the skin or on other parts of the body. It is necessary to employ epidemiological surveillance of household c...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:UNLABELLED:The treatment of tinnitus is still a challenge. Acupuncture is recommended for the relief of tinnitus in traditional Chinese Medicine, although scientific evidence is lacking. AIM:The aim of this study was to assess the effect of acupuncture on the cochlear function in patients with tinnitus by analyzing ot...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30119-1
更新日期:2007-09-01 00:00:00
abstract:INTRODUCTION:The Montgomery T-tube is a device used as a combined tracheal stent and tracheostomy tube to prevent post-operative tracheal stenosis. OBJECTIVES:The purpose of this retrospective study is to evaluate the outcome following Montgomery T-tube stenting performed in for neck and airway injury in patients with...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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更新日期:2020-07-27 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
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更新日期:2008-09-01 00:00:00
abstract:UNLABELLED:Conventional CT and MRI scans have low specificity when it comes to differentiating granulation tissue from relapsing cholesteatoma. AIM:this paper aims to analyze the use of DWI and delayed post-contrast T1-weighed imaging in the detection of recurring cholesteatomas. MATERIALS AND METHOD:this is a cross-...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/S1808-8694(15)31378-1
更新日期:2008-09-01 00:00:00
abstract:INTRODUCTION:Total rhinectomy is an uncommon procedure for the treatment of nasal malignancies, usually reserved for locally advanced tumors. There are few case series studying total rhinectomy in the literature, reporting conflicting results about recurrence and metastasis. OBJECTIVE:Evaluate prognosis of total rhine...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2017.05.002
更新日期:2018-01-01 00:00:00
abstract:UNLABELLED:The Obstructive Sleep Apnea Syndrome is a chronic disease characterized by episodes upper airway collapse, and has been associated with increased cardiovascular morbidity. AIM:To correlate the neck, abdominal and pelvic circumference with the AHI and oxyhemoglobin saturation in OSA patients, and to correlat...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2011-07-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20120008
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Oropharyngeal dysphagia is a highly prevalent comorbidity in neurological patients and presents a serious health threat, which may lead to outcomes of aspiration pneumonia, ranging from hospitalization to death. This assessment proposes a non-invasive, acoustic-based method to differentiate between individ...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2017.12.008
更新日期:2018-01-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2015.04.002
更新日期:2016-03-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1590/s1808-86942011000500013
更新日期:2011-09-01 00:00:00
abstract:UNLABELLED:Children with language or learning impairment and normal hearing need phoniatric assessment to analyse various communication and development aspects targeting the differential diagnosis and therapeutic indications. OBJECTIVE:Characterize clinical and epidemiological features of a pediatric population treate...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20130029
更新日期:2013-03-01 00:00:00
abstract:UNLABELLED:Hearing loss is a sensory deprivation, which can brings several consequences, among them: language development delay, emotional and social problems, and school difficulties. In such settings, we stress the role of nursing professional, who can expand their knowledge about children's hearing health, all the w...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20130039
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:Abused children and adolescents are exposed to factors that can trigger vocal changes. OBJECTIVE:This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communicati...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2014.11.006
更新日期:2015-01-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2006-11-01 00:00:00
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journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.1016/j.bjorl.2015.11.020
更新日期:2016-01-01 00:00:00
abstract:UNLABELLED:The association between hearing and balance disorders with migraine is known since the times of the ancient Greeks, when Aretaeus from Cappadocia in 131 B.C, made an accurate and detailed description of this occurrence during a migraine episode. We present a broad review of migraine neurotological manifestat...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.1016/s1808-8694(15)30611-x
更新日期:2008-07-01 00:00:00
abstract:AIM:To assess whether or not the parameters of fixed and randomized saccadic movements, of pendular tracking and of optokinetic nystagmus in the digital vectonystagmography may show abnormalities in patients with possible diagnosis of peripheral vestibular dysfunction. METHOD:60 patients with dizziness of peripheral v...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30977-0
更新日期:2006-05-01 00:00:00
abstract:INTRODUCTION:This cross-sectional comparative study was carried out at the Diabetes outpatient clinic of LAUTECH Teaching Hospital (LTH) Ogbomoso, Nigeria. OBJECTIVE:This study assessed patterns of otologic diseases and auditory acuity among type 2 diabetics and determinants of these findings among diabetics. METHODS...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2015.10.016
更新日期:2016-09-01 00:00:00
abstract:UNLABELLED:The search for experimental (animal) models is essential to the development of clinical studies. AIM:To demonstrate, by means of micro dissection techniques, the anatomical structures of temporal bones from the primate Callithrix sp. STUDY DESIGN:Experimental. METHODS:Dissection of temporal bone structure...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/s1808-8694(15)30570-x
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:The standard therapy for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP), but its correct and frequent use is essential to control the disease. PURPOSE:To analyze adherence to CPAP among patients with OSAS treated in a multidisciplinary outpatient clinic of a public t...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20140027
更新日期:2014-04-01 00:00:00
abstract:UNLABELLED:Cleft lip and/or palate represent the most common congenital anomaly of the face. AIM:To describe the correlation between non-syndromic cleft lip and/or palate and gender, and its severity in the Brazilian population. METHODS:Cross-sectional study, between 2009 and 2011, in a sample of 366 patients. The da...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.5935/1808-8694.20120018
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:The impact of the nasal septum morphology on the severity of obstruction symptoms has not been fully explored. OBJECTIVE:This study aimed to investigate whether the morphology of the deviated nasal septum assessed by computed tomography may explain nasal obstruction severity. METHODS:The study included 3...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2020.09.004
更新日期:2020-10-10 00:00:00
abstract:INTRODUCTION:Cartilage is the grafting material of choice for certain disorders of the middle ear. The indications for its routine use remain controversial due to the possible detrimental effect on post-operative hearing. OBJECTIVE:The present study was carried out to report a personal experience with "tragal cartilag...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:10.1016/j.bjorl.2018.12.006
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:The vibration of the vocal fold lamina propria is an important factor involved in vocal production and aging may change the amount of hyaluronic acid in the vocal fold leading to dysphonia. AIMS:This study compares the concentration of hyaluronic acid in vocal folds of aged and young female rats. STUDY DES...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:Knowledge of the different imaging tests and their appropriate indications is crucial to establish the diagnosis of temporomandibular disorders, especially in patients with overlapping signs and symptoms. OBJECTIVE:To present and assess the main diagnostic imaging tests for temporomandibular disorders and...
journal_title:Brazilian journal of otorhinolaryngology
pub_type: 杂志文章,评审
doi:10.1016/j.bjorl.2015.06.010
更新日期:2016-05-01 00:00:00