Abstract:
:The influence of 6 weeks of cyclosporin A (CYA), followed by a further 6 weeks of this agent in combination with plasma exchange (PE), was defined on panel reactivity and titre of preformed cytotoxic antibodies in stable patients on haemodialysis awaiting renal transplantation. Nine individuals with antibodies to 30% or more of the donor panel were entered into the study, but three failed to complete the programme. Comprehensive data are available on the remaining six patients, one of whom was studied twice. The pattern of reactivity to the panel was unaltered, but antibody titres were significantly reduced (P less than 0.006). In one patient, a lymphocytoxic crossmatch performed between the patient and an HLA-haploidentical sibling in the last week of the trial was positive, suggesting that neither procedure was successful in removing an antibody directed against the HLA antigens of a family donor. Three cadaver renal transplants were performed during or after the trial, and while two of the grafts were unsuccessful, one survives at 60 months, with good function. From these data it is concluded that neither cyclosporin A nor its combination with plasma exchange have any effect on the panel reactivity of preformed cytotoxic antibodies, whereas the titres were significantly reduced. An important and serious side effect of the apheresis procedure was the loss of fistulae in two patients.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Swanepoel CR,Cassidy MJ,May M,Oudshoorn M,du Toit E,Wood L,Jacobs Pdoi
10.1002/jca.2920060107subject
Has Abstractpub_date
1991-01-01 00:00:00pages
28-33issue
1eissn
0733-2459issn
1098-1101journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Factors affecting progenitor cell mobilization in patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) are incompletely understood. The aim of this retrospective study was to determine which factors are crucial for effective mobilization and collection of autologous peripheral blood stem ce...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21204
更新日期:2012-01-01 00:00:00
abstract::Heparin-induced thrombocytopenia (HIT) can occur following exposure to heparin and is characterized by thrombocytopenia with increased risk for thrombosis. This condition is mediated by formation of immunoglobulin G antibodies against platelet factor 4/heparin complexes that can subsequently lead to platelet activatio...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21757
更新日期:2020-01-01 00:00:00
abstract::Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease treated successfully with plasma exchange. Jehovah's Witnesses whose religious beliefs preclude them from accepting plasma exchange may require alternative forms of therapy. We report a case of one such patient who presented with TTP, whom we succ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20150
更新日期:2007-01-01 00:00:00
abstract::Peripheral blood stem cells (PBSC) reinfusion appears to hasten hematologic reconstitution following myeloablative therapy. While procurement of PBSC adds apheresis procedures, rapid engraftment could decrease the demand for platelet transfusions. To determine the impact of PBSC collection on workload in our apheresis...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920070408
更新日期:1992-01-01 00:00:00
abstract::For many years dextran sulfate adsorption (DSA) treatment of separated plasma has been an established technology for low-density lipoprotein (LDL)-elimination. Recently a system for the treatment of whole blood based on DSA was introduced into clinical practice. To further characterize DSA treatment of whole blood, th...
journal_title:Journal of clinical apheresis
pub_type: 临床试验,杂志文章
doi:10.1002/jca.20135
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Hyperleukocytosis is commonly seen in acute and chronic leukemias. Therapeutic leukocytapheresis using an automatic cell separator can help to achieve prompt leukoreduction to reduce the rate of thrombotic events and early mortality as well as to prevent tumor lysis syndrome. AIM:In this study, we report a ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21766
更新日期:2020-04-01 00:00:00
abstract::To compare donor demographics and motivations for donation, we surveyed 159 consecutive whole blood donors (WD) and 146 consecutive plateletpheresis donors. All donors had donation experiences of at least 2 gallons (i.e., 16 previous donations). Evaluation of answers to fixed-response and open-ended questions revealed...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920080206
更新日期:1993-01-01 00:00:00
abstract::Therapeutic plasma exchange (TPE) is an increasingly utilized immunosuppressive adjunct for treatment of antibody-mediated rejection (AMR) following organ transplantation. TPE works through removal of donor-specific HLA antibodies (DSAs) in the recipient's plasma. However, there is no clear laboratory measure evaluati...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21270
更新日期:2013-08-01 00:00:00
abstract::Over the past 37 year the role of plasma exchange in the treatment of patients with renal disease has undergone several changes. The majority of the changes for the use of plasma exchange relied on randomized control trials and delineations of mechanisms that potentially would benefit from the use of plasma exchange. ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章,评审
doi:10.1002/jca.21221
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Securing adequate vascular access is essential for a successful apheresis procedure. In most, peripheral access is preferred but it is not always technically possible. Ultrasound-Guided Peripheral Vascular Access (USG-PIVA) is a well-documented technique in the setting of Emergency departments. However, limi...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21440
更新日期:2016-12-01 00:00:00
abstract::Thrombotic thrombocytopenic purpura (TTP) is a rare but severe disorder characterized by hemolytic anemia, thrombocytopenia, fever, renal failure, and neurologic manifestations. Plasma exchange is the most effective treatment for this condition reducing mortality from 90% in untreated patients to 10%. However, infecti...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20119
更新日期:2007-01-01 00:00:00
abstract::Blood component donations by apheresis have become more common in modern blood transfusion practices. We compared three apheresis instruments (Fenwal Amicus, Fresenius COM.TEC, and Trima Accel) with regard to platelet (PLT) yield, collection efficiency (CE), and collection rate (CR). The single-needle or double-needle...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章,随机对照试验
doi:10.1002/jca.21358
更新日期:2015-06-01 00:00:00
abstract::Plerixafor in combination with granulocyte-colony stimulating factor (G-CSF) is approved for autologous stem cell mobilization in poor mobilizing patients with multiple myeloma or malignant lymphoma. The purpose of this study was to evaluate efficacy and safety of plerixafor in an immediate rescue approach, administra...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21496
更新日期:2017-08-01 00:00:00
abstract::Many practitioners believe in the phenomenon of being labeled either a "black cloud" or "white cloud" while on-call. A "white-cloud" physician is usually defined as one who sees fewer cases while a "black-cloud" is one who often receives more cases. To evaluate these phenomena, a 35-month prospective study was designe...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21650
更新日期:2018-10-01 00:00:00
abstract::Sickle cell disease (SCD) patients are prone to develop complications that include stroke, acute chest syndrome, and other crises. Some of these complications require chronic transfusion therapy or red cell exchange (RCE), either for therapeutic or prophylactic reasons. Due to a discrepancy of red cell antigens betwee...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章,评审
doi:10.1002/jca.20112
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Dysphagia screening is oftentimes a focus of hospitalized patients, but dysphagia can also occur in outpatient settings. Dysphagia can be overlooked by nurses and clinicians, and it is therefore important to educate nurses on the importance of dysphagia screenings. METHODS:This was a randomized prospective ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章,随机对照试验
doi:10.1002/jca.21572
更新日期:2018-02-01 00:00:00
abstract::For therapeutic plasma exchange (TPE), continuous flow separators are known to be efficient as exemplified by Fresenius AS104 and COBE Spectra. The AS104 uses an interface monitoring system in the centrifuge during TPE, whereas Spectra uses computer algorithms to establish the plasma-cell interface. To determine the p...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.1014
更新日期:2001-01-01 00:00:00
abstract::Apheresis procedures in small children are technically challenging and require special planning with attention to extracorporeal volume. Discontinuous procedures such as extracorporeal photopheresis (ECP) require additional consideration. Alternative methods to perform ECP have been utilized in small children that req...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20231
更新日期:2010-01-01 00:00:00
abstract::Lipid-apheresis (LA) is thought to improve microcirculation. However, limited data are available on the effects on peripheral microcirculation. We investigated upper limb microcirculation of 22 patients undergoing regular LA on a weekly basis before and after LA. Using standardized semiquantitative scales, we analyzed...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20285
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Limited data are available describing indications for and outcomes of therapeutic plasma exchange (TPE) in cardiac transplantation. METHODS:In a retrospective study of patients who underwent cardiac transplantation at Duke University Medical Center from 2010 to 2014, we reviewed 3 TPE treatment patterns: ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21622
更新日期:2018-08-01 00:00:00
abstract::Dysmetabolic iron overload syndrome is a rare event causing hepatic impairment with serious long-term side effects. Here, we describe a case of metabolic syndrome-related hepatic iron overload that showed a rapid, effective, and safe response to erythrocytapheresis. J. Clin. Apheresis 31:443-447, 2016. © 2015 Wiley Pe...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21434
更新日期:2016-10-01 00:00:00
abstract::Therapeutic leukapheresis can control the white blood cell count (WBC) of pregnant women with chronic myelogenous leukemia (CML) who have hyperleukocytosis without leukostasis. The medical justification for this treatment has not been objectively documented. We report a 27-year-old woman, diagnosed with CML at 10-week...
journal_title:Journal of clinical apheresis
pub_type:
doi:10.1002/jca.21410
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Hereditary thrombotic thrombocytopenic purpura, also called Upshaw-Schulman syndrome (USS), is a rare disease caused by genetic mutations in the ADAMTS13 gene, which severely decrease the activity of ADAMTS13, a metalloprotease that cleaves von Willebrand factor multimers (VWF). Genotypically identical patie...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21664
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:A red cell exchange was performed to prevent a potentially fatal hemolytic transfusion reaction in a patient with anti-e who was transfused with e-antigen unscreened red blood cells during liver transplant surgery. CASE REPORT:A 64-year-old woman with cirrhosis due to hepatitis C was scheduled to receive a liv...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.21461
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Nanoscale particle-based drug delivery systems like long circulating liposomal doxorubicin show unique pharmacokinetic properties and improved toxicity profiles. Liposomal doxorubicin accumulates in tumor tissue due to the enhanced permeation and retention effect, but only a small fraction of a total dose ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20229
更新日期:2010-01-01 00:00:00
abstract::Granulocyte-colony stimulating factor (G-CSF) mobilizes and increases the amount of hematopoietic stem cells in peripheral blood, enabling its harvest by few apheresis procedures. The pegylated G-CSF has longer half-life and is given once only, which is more comfortable for patients, whereas the non-pegylated requires...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jca.21550
更新日期:2017-12-01 00:00:00
abstract::Transfusion-acquired babesiosis can be an asymptomatic or self-limited febrile hemolytic illness in a healthy host. A persistent, relapsing, and/or fulminant course with the development of life-threatening complications may be seen in immunocompromised or splenectomized patients. As in malaria, erythrocyte parasitemia...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.20262
更新日期:2010-01-01 00:00:00
abstract::"Leukocyte-depleted" platelet concentrates (LD-SDPC) were prepared by cotton-wool and by polyester filtration of "leukocyte-poor" PC collected by the elutriation technique. The storage characteristics of LD-SDPC were comparable to those of the filtered pools of multiple donor platelet concentrates (LD-MDPC). However, ...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/jca.2920060304
更新日期:1991-01-01 00:00:00
abstract::Photopheresis has become a key component in the therapeutic armamentarium of cutaneous T-cell lymphoma, graft-versus-host disease following stem cell transplant, and allograft rejection of solid organs such as heart. Although it is considered a new treatment modality in its present form, the field of phototherapy date...
journal_title:Journal of clinical apheresis
pub_type: 历史文章,杂志文章,评审
doi:10.1002/jca.20089
更新日期:2006-04-01 00:00:00
abstract::Complement-derived anaphylatoxin may be one of the causes of vascular injury and an indicator of activity in systemic lupus erythematosus (SLE). The present study examines the effectiveness of dextran sulfate (DS) column immunoadsorption treatment to remove anaphylatoxins (C3a, C4a, and C5a) from the blood of patients...
journal_title:Journal of clinical apheresis
pub_type: 杂志文章
doi:10.1002/(sici)1098-1101(1998)13:3<108::aid-jca3>3.
更新日期:1998-01-01 00:00:00