Abstract：
PURPOSE:A red cell exchange was performed to prevent a potentially fatal hemolytic transfusion reaction in a patient with anti-e who was transfused with e-antigen unscreened red blood cells during liver transplant surgery. CASE REPORT:A 64-year-old woman with cirrhosis due to hepatitis C was scheduled to receive a liver transplant. She had a previously documented anti-e, an antibody to the Rh(e)-antigen that is known to cause delayed hemolytic transfusion reactions. Pre-operatively and intra-operatively, she had massive hemorrhage which required transfusion of 34 e-antigen unscreened red blood cells (RBCs) most of which were incompatible. The hemoglobin dropped from 9.1 g/dL on post-operative day (POD)1 to 6.6 g/dL on POD6, with no evidence of blood loss. The bilirubin also increased from 5.0 mg/dL on POD 1 to 11.0 mg/dL on POD 6. As she was also becoming more hemodynamically unstable, a red cell exchange with 10 units of e-negative RBCs was performed on POD 6. She improved clinically and was extubated the following day. A few residual transfused e-positive red cells were detected after the red cell exchange until POD 13. CONCLUSION:This case illustrates how a red cell exchange can mitigate the potentially harmful effects of a delayed hemolytic transfusion reaction caused by red cell antibodies. With massive intraoperative blood loss it may not be possible to have antigen-negative RBCs immediately available, particularly for the e-antigen, which is present in 98% of the donor population. The ability to perform such a procedure may be life-saving in such patients. J. Clin. Apheresis 32:59-61, 2017. © 2016 Wiley Periodicals, Inc.
journal_name
J Clin Apherjournal_title
Journal of clinical apheresisauthors
Irani MS,Karafin MS,Ernster Ldoi
10.1002/jca.21461subject
Has Abstractpub_date
2017-02-01 00:00:00pages
59-61issue
1eissn
0733-2459issn
1098-1101journal_volume
32pub_type
杂志文章abstract：BACKGROUND:Dysphagia screening is oftentimes a focus of hospitalized patients, but dysphagia can also occur in outpatient settings. Dysphagia can be overlooked by nurses and clinicians, and it is therefore important to educate nurses on the importance of dysphagia screenings. METHODS:This was a randomized prospective ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,随机对照试验
doi：10.1002/jca.21572
更新日期：2018-02-01 00:00:00
abstract：:This study examined the incidence and predictors of peripheral blood stem cell (PBSC) mobilization failure in patients with multiple myeloma (MM). Retrospective data for 104 patients who received granulocyte colony-stimulating factor (G-CSF) alone or with cyclophosphamide as mobilization regimens were analyzed. The ra...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21326
更新日期：2014-12-01 00:00:00
abstract：:Folinic acid (FA) has been reported to expand the pool of peripheral blood stem cells (PBSC) after chemotherapy. We evaluated the efficacy of FA for harvesting PBSC following cytotoxic chemotherapy in 4 patients with acute leukemia. After achieving a complete remission (CR), 3 courses of chemotherapy for a consolidati...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920070410
更新日期：1992-01-01 00:00:00
abstract：:Plasma replacement for thrombotic thrombocytopenic purpura (TTP) is accomplished with various plasma products. This study sought to determine the incidence of allergic reactions with FFP or CPP as replacement in therapeutic plasma exchange (TPE). Forty-one TTP patients were identified retrospectively who received TPE ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.1025
更新日期：2001-01-01 00:00:00
abstract：:Focal segmental glomerulosclerosis (FSGS) recurs in 30% of renal allograft transplants with graft loss in half of the cases. A humoral factor may be implicated. We report on the use of therapeutic plasma exchange (TPE) in 11 patients with recurrent FSGS post transplantation. Medical records from 1989-2000 were reviewe...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10025
更新日期：2002-01-01 00:00:00
abstract：:Targeted extracorporeal granulocyte and monocyte apheresis (GMA) has produced clinical efficacy together with down modulation of specific inflammatory cytokines in patients with ulcerative colitis (UC). This study was to investigate if preoperative GMA produces immunological effect on dysregulated immune activity afte...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,随机对照试验
doi：10.1002/jca.21299
更新日期：2014-04-01 00:00:00
abstract：:Extracorporeal photopheresis (ECP) in young pediatric patients has a risk for procedural hypotension and anemia due to extracorporeal fluid shifts. A standard mitigation policy in these patients is to prime the device with packed red blood cells (RBC) or whole blood. We now report multiple episodes of hemolysis while ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21740
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Patients undergoing therapeutic plasma exchange (TPE) may present with risks for hemorrhage or thrombosis. Use of replacement fluids devoid of coagulation factors will decrease factor levels and platelet levels. There are no established guidelines for hemostasis management in these situations. MATERIALS AND...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21653
更新日期：2018-10-01 00:00:00
abstract：:Granulocyte-colony stimulating factor (G-CSF) mobilizes and increases the amount of hematopoietic stem cells in peripheral blood, enabling its harvest by few apheresis procedures. The pegylated G-CSF has longer half-life and is given once only, which is more comfortable for patients, whereas the non-pegylated requires...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,meta分析,评审
doi：10.1002/jca.21550
更新日期：2017-12-01 00:00:00
abstract：:Apheresis procedures in small children are technically challenging and require special planning with attention to extracorporeal volume. Discontinuous procedures such as extracorporeal photopheresis (ECP) require additional consideration. Alternative methods to perform ECP have been utilized in small children that req...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20231
更新日期：2010-01-01 00:00:00
abstract：:Therapeutic plasma exchange (TPE), a form of extracorporeal therapy, has been used in the management of many systemic conditions some of which include the systemic vasculitides that affect the kidneys. The following is a mini review of what is known about renal related indications for TPE in such conditions and the ev...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.20306
更新日期：2011-01-01 00:00:00
abstract：:Lipid-apheresis (LA) is thought to improve microcirculation. However, limited data are available on the effects on peripheral microcirculation. We investigated upper limb microcirculation of 22 patients undergoing regular LA on a weekly basis before and after LA. Using standardized semiquantitative scales, we analyzed...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20285
更新日期：2011-01-01 00:00:00
abstract：:Either bone marrow or peripheral blood may be harvested to provide hematopoietic stem cells (HSC) for autologous transplantation. Both, however, comprise heterogeneous cell populations. The HSC necessary for successful engraftment constitute a very small fraction of the cells harvested. After collection, the harvested...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.2920070307
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics. METHODS:This review article summarizes different indications of plasma exchange ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章,评审
doi：10.1002/jca.21676
更新日期：2019-08-01 00:00:00
abstract：:Prestorage leukocyte reduction of platelet concentrates may reduce adverse effects of transfusion while affording better quality control. Platelets and leukocytes may undergo activation during storage, which could affect the performance of leukocyte reduction filters. The purpose of this study was to evaluate the effi...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/(sici)1098-1101(1997)12:1<14::aid-jca4>3.0
更新日期：1997-01-01 00:00:00
abstract：:The cell separator MCS-3P is an apheresis system offering the flexibility to collect standardized red blood cells, plasma, and/or platelets from one donor. Two different programs were used for the red cell apheresis--RBCP (collection of one unit of red cells and two units of plasma) and RBCPS (one unit of red cells an...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920090308
更新日期：1994-01-01 00:00:00
abstract：:For many years dextran sulfate adsorption (DSA) treatment of separated plasma has been an established technology for low-density lipoprotein (LDL)-elimination. Recently a system for the treatment of whole blood based on DSA was introduced into clinical practice. To further characterize DSA treatment of whole blood, th...
journal_title：Journal of clinical apheresis
pub_type： 临床试验,杂志文章
doi：10.1002/jca.20135
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Transfusion of D+ red blood cells (RBCs) to D- recipients can be accidental or necessary due to D- RBC shortage. Alloimmunization can complicate future transfusions; implications for women of childbearing age are compounded by possible hemolytic disease of the fetus and newborn. Rh immunoprophylaxis is effec...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20225
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:Limited data are available describing indications for and outcomes of therapeutic plasma exchange (TPE) in cardiac transplantation. METHODS:In a retrospective study of patients who underwent cardiac transplantation at Duke University Medical Center from 2010 to 2014, we reviewed 3 TPE treatment patterns: ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21622
更新日期：2018-08-01 00:00:00
abstract：:The combined use of immunoadsorption (IA) and membrane filtration (MF) may markedly enhance removal of IgM and complement component C1q, supporting its use as an element of recipient desensitization in antibody-incompatible transplantation. However, coagulation factor removal may contribute to altered hemostasis, posi...
journal_title：Journal of clinical apheresis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/jca.21399
更新日期：2016-02-01 00:00:00
abstract：:Therapeutic plasma exchange (TPE) is an increasingly utilized immunosuppressive adjunct for treatment of antibody-mediated rejection (AMR) following organ transplantation. TPE works through removal of donor-specific HLA antibodies (DSAs) in the recipient's plasma. However, there is no clear laboratory measure evaluati...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21270
更新日期：2013-08-01 00:00:00
abstract：:We have recognized marked effectiveness for intermittent claudication with low-density lipoprotein (LDL) apheresis in two cases of arteriosclerosis obliterans (ASO). The Case 1 was a 73-year-old man with intermittent claudication of both lower extremities (Fontaine class II), digital subtraction angiography (DSA) reve...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20138
更新日期：2007-01-01 00:00:00
abstract：:Because the administration of hematopoietic growth factors and the use of stem cell support often fails to alleviate the neutropenic phase induced by cytotoxic drugs, several investigators have attempted to expand ex vivo hematopoietic progenitors for clinical use. These attempts have clearly shown that the cultured c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10012
更新日期：2002-01-01 00:00:00
abstract：:Since the introduction of hematopoietic growth factors, the collection of mobilized stem cells via leukapheresis has widely replaced the harvest of bone marrow in both autologous and allogeneic transplantation settings. We investigated the frequency and the extent of anticoagulant-induced electrolyte changes and the c...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/1098-1101(2000)15:4<230::aid-jca3>3.0.co;2
更新日期：2000-01-01 00:00:00
abstract：:We sought to optimize direct intravenous infusion of calcium gluconate (CaGlu) for maintaining plasma ionized calcium concentration ([Ca2+ ]) and preventing hypocalcemic reactions during 34 consecutive 1-volume therapeutic plasma exchanges (TPEs) in eight patients. CaGlu, 2 g in 50 mL of 0.9% NaCl, was prepared by our...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.21742
更新日期：2019-12-01 00:00:00
abstract：:The infusion of high-dose (275 mg/kg body weight) immune globulin intravenous (IGIV) after 466 plasma exchanges in 64 patients with autoimmune disease was studied. Side effects occurred during 15% of IGIV infusions. For the most part they were transient and mild, and could be controlled by slowing the infusion rate. T...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.2920010207
更新日期：1983-01-01 00:00:00
abstract：:Transfusion-acquired babesiosis can be an asymptomatic or self-limited febrile hemolytic illness in a healthy host. A persistent, relapsing, and/or fulminant course with the development of life-threatening complications may be seen in immunocompromised or splenectomized patients. As in malaria, erythrocyte parasitemia...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20262
更新日期：2010-01-01 00:00:00
abstract：:This study was undertaken to evaluate the relationship between the time to recovery of peripheral blood counts and CD34+ cells in the peripheral blood (PB) and apheresis collections of patients undergoing intensive chemotherapy followed by rhG-CSF. Twenty-three patients with a median age of 42 years (range 17-64) with...
journal_title：Journal of clinical apheresis
pub_type： 临床试验,杂志文章
doi：10.1002/(sici)1098-1101(1998)13:1<1::aid-jca1>3.0.
更新日期：1998-01-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease treated successfully with plasma exchange. Jehovah's Witnesses whose religious beliefs preclude them from accepting plasma exchange may require alternative forms of therapy. We report a case of one such patient who presented with TTP, whom we succ...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.20150
更新日期：2007-01-01 00:00:00
abstract：:When harvesting peripheral progenitor cells (PPC) in children, the special situation of their circulatory system has to be taken into account. Therefore, extracorporeal blood volume and product volume should be small to avoid side effects. Nine children (age 2-14 years, weight 12.8-58.5 kg) with malignancies underwent...
journal_title：Journal of clinical apheresis
pub_type： 杂志文章
doi：10.1002/jca.10050
更新日期：2003-01-01 00:00:00
