Abstract:
BACKGROUND:The treatment of chronic rhinosinusitis (CRS) often requires chronic or intermittent oral steroid therapy, which has the potential for adverse skeletal effects, including osteoporosis and increased risk of fragility fractures. The purpose of this study was to determine the prevalence of osteopenia/osteoporosis (OP) or low bone density (LBD) in patients with CRS with/without polyposis treated with oral glucocorticoids. METHODS:Retrospective chart analysis was performed at a tertiary-care rhinology practice. Patients with CRS with/without polyposis evaluated between September 2003 and July 2008 were included if they had (1) previous history of oral steroid usage (> or =5 mg daily for at least 3 months) and (2) previous bone mineral density evaluation. RESULTS:A total of 197 patients were included with a mean age of 51.1 years (range, 15-79 years). The primary presenting diagnoses included CRS with polyposis in 176 cases (89.3%) and CRS without polyposis in 21 cases (10.7%). Concomitant asthma was present in 161 patients (81.7%). Overall, the prevalence of low bone mass was 38.6%. Among men >50 years of age and postmenopausal women, the prevalence of osteopenia/OP or LBD was 62.5 and 62.2%, respectively. Comparing men >50 years of age and postmenopausal women to their respective younger populations, both had a statistically higher presence of low bone mass (p < 0.0001), with an odds ratio of 10.6 (3.9-28.7) and 34.6 (7.4-161.5), respectively. There was no statistical difference in the presence of bone loss when comparing groups by gender. A multivariable analysis of common comorbidities revealed age to be the only factor associated with increased risk for OP/osteopenia or LBD. CONCLUSION:Patients with CRS with/without polyposis treated with oral steroids who underwent bone density testing were found to have a high prevalence of LBD. High index of suspicion is required to identify at-risk patients and to initiate careful evaluation and treatment to prevent additional bone-related complications.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Rajasekaran K,Seth R,Abelson A,Batra PSdoi
10.2500/ajra.2010.24.3445subject
Has Abstractpub_date
2010-05-01 00:00:00pages
215-9issue
3eissn
1945-8924issn
1945-8932journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Standardized allergen-specific immunotherapy (SIT) has been used in China for years. However, there is no extensive study of the safety of standardized SIT in Chinese patients until now. The aim of the current study is to perform a prospective and multicenter study to evaluate the systemic reactions (SRs) of...
journal_title:American journal of rhinology & allergy
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2500/ajra.2014.28.4005
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Chronic rhinosinusitis with nasal polyps (CRSwNPs) is the most challenging form of CRS to treat. Clinical practices vary widely among physicians around the world, often with little evidence to support current therapies. METHODS:This study evaluates various medical and surgical treatments with a focus on the...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2013.27.3982
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Internal nasal valve collapse is a preventable complication of rhinoplasty, for which the spreader graft is the gold standard. More recently, the spreader flap technique has been espoused as an alternative to spreader grafting. Here, we evaluated the efficacy of this technique in a randomized trial setting. ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2014.28.3991
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the expression and distribution of superoxide anion, NADPH oxidase (NOX)1, and NOX4 in healthy, allergic nasal mucosa and nasal polyps to evaluate the possible influence of oxidative stress on the development of allergic rhinitis and nasal polyps. METHODS:The exp...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3340
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Primary ciliary dyskinesia (PCD) is a congenital hereditary disease affecting 1/20,000-60,000 people that causes chronic sinusitis, bronchiectasis, sinus hypoplasia, secretory otitis media, and low fertility. The complexity and heterogeneity of the disease make diagnosis difficult. Although the genetic orig...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3784
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Assessing surgical competency in otolaryngology is challenging, and residency programs are now responsible for ensuring the surgical competency of their graduates. Therefore, more objective assessment tools are being incorporated into the evaluation process. Objective structured assessment of technical skill...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2014.28.4051
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:B-cell responses may play a role in the pathogenesis of nasal polyposis via local IgA and IgE production and activation of eosinophils and mast cells. B-cell attracting chemokines may therefore have relevance in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNPs) Methods: Polyp and inferio...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3386
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:This study evaluates the safety and efficacy of specific sublingual immunotherapy (SLIT) against grass pollen allergens in patients >60 years of age with seasonal allergic rhinitis (SAR) and/or asthma. This study sought to assess nasal symptoms during the grass pollen season, reduce medication use, and monit...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
doi:10.2500/ajra.2014.28.4091
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to describe treatment results in patients with sinonasal inverted papilloma and to compare recent classification staging systems. METHODS:We performed a retrospective study of 79 patients with primary paranasal sinus inverted papilloma from 1978 to 2008. RESULTS:The median age at ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3421
更新日期:2010-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3638
更新日期:2011-09-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3287
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Fibrin glue has been a favorable hydrogel in cartilage tissue engineering, but implantation of chondrocyte-fibrin suspensions have resulted in volume loss. In this study, human septal cartilage chips were seeded onto a fibrin scaffold, and cellular proliferation and production of cartilaginous extracellular ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3347
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The histopathology and microbiology associated with silent sinus syndrome (SSS) have not been well described. OBJECTIVE:This study details the histopathological and microbiological characteristics in addition to radiographic findings of SSS in comparison to those of chronic maxillary sinusitis (CRS). METHO...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892421989161
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Although not so common, septoplasty carries the risk of inducing nasal deformity such as saddle nose and deviated nose. Surgical correction for those deformities is a formidable task to deal with, because the septal cartilage framework was already weakened due to previous procedure. This study was designed t...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3344
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Cigarette smoke exposure (CSE) results in extensive inflammation in the upper and lower airways. Reactive oxygen species, such as superoxide, have been shown to be potent mediators of this inflammation. METHODS:Mucosal biopsy specimens were collected from patients undergoing sinonasal surgery and were used ...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3400
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Allergen immunotherapy (AIT) has been in practice for more than 100 years. However, research in novel routes and delivery methods of immunotherapy to treat allergic rhinitis (AR) and conjunctivitis has only recently occurred in the United States, where the predominant form of AIT provided is largely via a su...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
doi:10.2500/ajra.2015.29.4148
更新日期:2015-03-01 00:00:00
abstract::Nasal obstruction is one of the most common presenting symptoms requiring medical attention at both the primary care physician and the otorhinolaryngologists' level. Nasal obstruction may be caused by anatomic, physiological, or neurologic factors. Complexity is added to this situation because, often, the causation ma...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
doi:10.2500/ajra.2013.27.3889
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Nonallergic rhinitis (NAR) is characterized by nasal symptoms similar to allergic rhinitis (AR) without an IgE-mediated immune response. Limited data are available on the natural history of NAR in its progression toward AR, particularly in children. This study evaluates the development of AR in children who...
journal_title:American journal of rhinology & allergy
pub_type: 临床试验,杂志文章
doi:10.2500/ajra.2013.27.3839
更新日期:2013-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3413
更新日期:2009-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2013.27.3848
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:A remarkable relationship between upper airway conditions and lung diseases has been reported. At the same time, sinonasal findings in chronic cough patients have not been fully examined. OBJECTIVE:The purpose of this study is to show paranasal sinus findings and lung function in chronic cough patients with...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418825094
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established. OBJECTIVE:To determine whether OD and GD are independentl...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892418824451
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:The available olfactory evaluation tests are mainly subjective methods requiring patients' collaboration. If, for any reason, the patients refuse to honestly report what they perceive, the test reliability will be questionable; this condition is potentially observable in malingering patients because of thei...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2012.26.3812
更新日期:2012-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420961969
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:The goal of endoscopic sinus surgery in chronic sinusitis is to create good drainage of the paranasal sinuses. Metal stents used to prevent lateralization of the middle concha are associated with adverse effects. OBJECTIVE:The aim of this experimental study was to evaluate the feasibility and safety of a ne...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2017.31.4401
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Gelsolin is an actin-binding protein with multiple cellular functions including apoptosis and is reported to be down-regulated in various cancers and premalignant lesions. The objective of this study was to identify gelsolin and caspase-3 expression in inverted papilloma (IP) and investigate the role of gels...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Spontaneous cerebrospinal fluid (CSF) leaks are largely attributed to idiopathic intracranial hypertension and typically present as skull base defects with or without prolapse of intracranial contents. However, in our practice, we have encountered a distinct type of spontaneous CSF leak that presents in a di...
journal_title:American journal of rhinology & allergy
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更新日期:2017-03-01 00:00:00