Embedded Pragmatic Trials in Dementia Care: Realizing the Vision of the NIA IMPACT Collaboratory.

Abstract:

:Close to 6 million Americans have Alzheimer's disease (AD) or Alzheimer's disease and related dementia (AD/ADRD). These high-need, high-cost patients are vulnerable to receiving poor quality uncoordinated care, ultimately leading to adverse health outcomes, poor quality of life, and misuse of resources. Improving the care of persons living with dementia (PLWD) and their caregivers is an urgent public health challenge that must be informed by high-quality evidence. Although prior research has elucidated opportunities to improve AD/ADRD care, the adoption of promising interventions has been stymied by the lack of research evaluating their effectiveness when implemented under real-world conditions. Embedded pragmatic clinical trials (ePCTs) in healthcare systems have the potential to accelerate the translation of evidence-based interventions into clinical practice. Building from the foundation of the National Institutes of Healthcare Systems Collaboratory, in September 2019 the National Institute on Aging Imbedded Pragmatic AD/ADRD Clinical Trials (IMPACT) Collaboratory was launched. Its mission is to build the nation's capacity to conduct ePCTs within healthcare systems for PLWD and their caregivers by (1) developing and disseminating best practice research methods, (2) supporting the design and conduct of ePCTs including pilot studies, (3) building investigator capacity through training and knowledge generation, (4) catalyzing collaboration among stakeholders, and (5) ensuring the research includes culturally tailored interventions for people from diverse backgrounds. This report presents the rationale, structure, key activities, and markers of success for the overall NIA IMPACT Collaboratory. The articles that follow in this special Issue describe the specific work of its 10 core working groups and teams. J Am Geriatr Soc 68:S1-S7, 2020.

journal_name

J Am Geriatr Soc

authors

Mitchell SL,Mor V,Harrison J,McCarthy EP

doi

10.1111/jgs.16621

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

S1-S7

eissn

0002-8614

issn

1532-5415

journal_volume

68 Suppl 2

pub_type

杂志文章
  • Factors noted to affect breast cancer treatment decisions of women aged 80 and older.

    abstract:OBJECTIVES:To identify factors that influence the breast cancer treatment decisions of women aged 80 and older. DESIGN:Medical record review. SETTING:One academic primary care clinic and two community health centers in Boston. PARTICIPANTS:Sixty-five women aged 80 and older diagnosed with breast cancer between 1994 ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03820.x

    authors: Schonberg MA,Silliman RA,McCarthy EP,Marcantonio ER

    更新日期:2012-03-01 00:00:00

  • Staphylococcus aureus bloodstream infections in older adults: clinical outcomes and risk factors for in-hospital mortality.

    abstract:OBJECTIVES:To assess clinical outcomes and identify risk factors for mortality in older adults with Staphylococcus aureus bloodstream infection (SAB). DESIGN:Retrospective review. SETTING:University of Michigan Health System, Ann Arbor. PARTICIPANTS:All patients aged 80 and older with SAB between January 2004 and Ju...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02666.x

    authors: Big C,Malani PN

    更新日期:2010-02-01 00:00:00

  • Hallucinations of widowhood.

    abstract::Widowed residents of two nursing homes who were oriented to person, time, and place were interviewed to determine the extent to which they had hallucinatory experiences of their deceased spouse. Fifty-two interviews were completed with 46 widows and six widowers. Results are reported for the widows. Twenty-eight (61%)...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1985.tb04619.x

    authors: Olson PR,Suddeth JA,Peterson PJ,Egelhoff C

    更新日期:1985-08-01 00:00:00

  • Left ventricular hypertrophy on electrocardiogram: prognostic implications from a 10-year cohort study of older subjects: a report from the Bronx Longitudinal Aging Study.

    abstract:OBJECTIVE:The objective of this study was to report on the prevalence, incidence and prognosis of left ventricular hypertrophy (LVH) on the electrocardiogram (ECG) in a cohort of ambulatory older men and women. DESIGN:A prospective, longitudinal study of 10 years duration with ECGs obtained at baseline and on an annua...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1996.tb01437.x

    authors: Kahn S,Frishman WH,Weissman S,Ooi WL,Aronson M

    更新日期:1996-05-01 00:00:00

  • The relationship between age and process of care and patient tolerance of bronchoscopy.

    abstract:OBJECTIVES:To determine whether patient age is associated with differences in flexible bronchoscopy technique and tolerance. DESIGN:Prospective cohort study. SETTING:University hospital system. PARTICIPANTS:One thousand three hundred fifty-eight adults, including 219 (16.1%) aged 70 and older, undergoing bronchoscop...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1365-2389.2003.51303.x

    authors: Hehn BT,Haponik E,Rubin HR,Lechtzin N,Diette GB

    更新日期:2003-07-01 00:00:00

  • Familial achalasia of the esophagus in mother and son: a possible pathogenetic relationship.

    abstract::Familial achalasia most often has been recorded in siblings, and only rarely (twice previously) in a parent and offspring. This report concerns a third case of achalasia in a parent and offspring (mother and son). Clinical and radiographic features of the esophageal achalasia are presented. The possibility that geneti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1979.tb01741.x

    authors: Chawla K,Chawla SK,Alexander LL

    更新日期:1979-11-01 00:00:00

  • Rehabilitation Services Use of Older Adults According to Fall-Risk Screening Guidelines.

    abstract:OBJECTIVES:To characterize rehabilitation services use of older adults according to fall-risk classification based on screening guidelines. DESIGN:Cross-sectional analysis of 2015 National Health and Aging Trends Study. SETTING:Study participants' homes. PARTICIPANTS:National sample of 7,440 community-dwelling Medic...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15625

    authors: Gell NM,Patel KV

    更新日期:2019-01-01 00:00:00

  • Diabetes mellitus in centenarians.

    abstract:OBJECTIVES:To describe the prevalence of diabetes mellitus (DM) in centenarians. DESIGN:Cross-sectional, population-based. SETTING:Forty-four counties in northern Georgia. PARTICIPANTS:Two hundred forty-four centenarians (aged 98-108, 15.8% male, 20.5% African American, 38.0% community dwelling) from the Georgia Cen...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2011.03836.x

    authors: Davey A,Lele U,Elias MF,Dore GA,Siegler IC,Johnson MA,Hausman DB,Tenover JL,Poon LW,Georgia Centenarian Study.

    更新日期:2012-03-01 00:00:00

  • Changes in Frailty After Kidney Transplantation.

    abstract:OBJECTIVES:To understand the natural history of frailty after an aggressive surgical intervention, kidney transplantation (KT). DESIGN:Prospective cohort study (December 2008-March 2014). SETTING:Baltimore, Maryland. PARTICIPANTS:Kidney transplantation recipients (N = 349). MEASUREMENTS:The Fried frailty score was ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.13657

    authors: McAdams-DeMarco MA,Isaacs K,Darko L,Salter ML,Gupta N,King EA,Walston J,Segev DL

    更新日期:2015-10-01 00:00:00

  • Development and Validation of a Fall Prevention Knowledge Test.

    abstract::Falls are a serious, persistent problem in hospitals. Ensuring that all hospital staff have adequate knowledge of how to prevent falls is the first step in prevention. We identified validated fall prevention knowledge tests (FPKTs) and planned to conduct a systematic literature review. When the review identified a lac...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15563

    authors: Dykes PC,Bogaisky M,Carter EJ,Duckworth M,Hurley AC,Jackson EM,Khasnabish S,Lindros ME,Lipsitz SR,Scanlan M,Yu SP,Bates DW,Adelman JS

    更新日期:2019-01-01 00:00:00

  • Tongue strength is associated with jumping mechanography performance and handgrip strength but not with classic functional tests in older adults.

    abstract:OBJECTIVES:To determine whether classic muscle function tests and jumping mechanography (JM) are related to tongue strength. DESIGN:Cross-sectional. SETTING:Community. PARTICIPANTS:Ninety-seven community-dwelling individuals aged 70 and older (49 female, 48 male, mean age 80.7, range 70-95) with and without identifi...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12124

    authors: Buehring B,Hind J,Fidler E,Krueger D,Binkley N,Robbins J

    更新日期:2013-03-01 00:00:00

  • Neighborhood deprivation, individual socioeconomic status, and frailty in older adults.

    abstract:OBJECTIVES:To assess how individual socioeconomic status and neighborhood deprivation affect frailty. DESIGN:Nationally representative population-based study, the English Longitudinal Study of Aging (ELSA), analyzed cross-sectionally. PARTICIPANTS:Four thousand eight hundred eighteen individuals aged 65 and older. M...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02480.x

    authors: Lang IA,Hubbard RE,Andrew MK,Llewellyn DJ,Melzer D,Rockwood K

    更新日期:2009-10-01 00:00:00

  • Racial Disparities in Hospice Outcomes: A Race or Hospice-Level Effect?

    abstract:OBJECTIVES:To determine whether there is racial variation in hospice enrollees in rates of hospitalization and hospice disenrollment and, if so, whether systematic differences in hospice provider patterns explain the variation. DESIGN:Longitudinal cohort study. SETTING:Hospice. PARTICIPANTS:Medicare beneficiaries (N...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15228

    authors: Rizzuto J,Aldridge MD

    更新日期:2018-02-01 00:00:00

  • Physical activity over the life course and its association with cognitive performance and impairment in old age.

    abstract:OBJECTIVE:To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life. DESIGN:Cross-sectional study. SETTING:Four U.S. sites. PARTICIPANTS:Nine thousand three hundred forty-four women aged 65 and older (mean 71.6) who self-reported teenage, age 30, age...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1532-5415.2010.02903.x

    authors: Middleton LE,Barnes DE,Lui LY,Yaffe K

    更新日期:2010-07-01 00:00:00

  • Changes in prealbumin, nutrient intake, and systemic inflammation in elderly recuperative care patients.

    abstract:OBJECTIVES:To determine the relationship between prealbumin, nutrient intake, and indicators of inflammation for recuperative and rehabilitative care patients. DESIGN:Prospective cohort. SETTING:Recuperative Care Unit within a Veterans Administration Nursing Home Care Unit. PARTICIPANTS:One hundred eleven men (100 w...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.01789.x

    authors: Dennis RA,Johnson LE,Roberson PK,Heif M,Bopp MM,Cook J,Sullivan DH

    更新日期:2008-07-01 00:00:00

  • An evaluative study of Silver's Cerebral Function Test.

    abstract::The aim of this study was to evaluate the usefulness of Silver's Cerebral Function Test in predicting the management and placement of patients admitted to a psychogeriatric hospital. Overall, 205 consecutively admitted patients and 54 age-matched controls living in the community were examined, thereby greatly extendin...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1977.tb00409.x

    authors: Ross N,de L Horne DJ

    更新日期:1977-06-01 00:00:00

  • Walking and talking as predictors of falls in the general population: the Leiden 85-Plus Study.

    abstract:OBJECTIVES:To compare the value of dual tasking in predicting falling in the general population of oldest old with that of easy-to-administer single tasks. DESIGN:Prospective population-based follow-up study. SETTING:Municipality of Leiden, the Netherlands. PARTICIPANTS:Representative cohort of 380 individuals, all ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2003.51468.x

    authors: Bootsma-van der Wiel A,Gussekloo J,de Craen AJ,van Exel E,Bloem BR,Westendorp RG

    更新日期:2003-10-01 00:00:00

  • Effect of a high-intensity functional exercise program on functional balance: preplanned subgroup analyses of a randomized controlled trial in residential care facilities.

    abstract:OBJECTIVES:To evaluate whether age, sex, depression, dementia disorder, nutritional status, or level of functional balance capacity influences the effect of a high-intensity functional weight-bearing exercise program on functional balance. DESIGN:Preplanned subgroup analyses of a randomized controlled trial. SETTING:...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2011.03484.x

    authors: Littbrand H,Carlsson M,Lundin-Olsson L,Lindelöf N,Håglin L,Gustafson Y,Rosendahl E

    更新日期:2011-07-01 00:00:00

  • Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women: a randomized controlled trial.

    abstract:OBJECTIVES:To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community-dwelling elderly sarcopenic women. DESIGN:Randomized controlled trial. SETTING:Urban community in Tokyo, Japan. PARTICIPANTS:One hundred fifty-five women aged 75 and older were defin...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2011.03776.x

    authors: Kim HK,Suzuki T,Saito K,Yoshida H,Kobayashi H,Kato H,Katayama M

    更新日期:2012-01-01 00:00:00

  • Predicting intellectual level from the Mini-Mental State Examination.

    abstract::The Mini-Mental State Examination and the WAIS-R were administered to 105 patients in the early stages of Alzheimer's disease. MMSE scores correlated 0.83 with full scale IQ, which indicates that the MMSE may be a reasonable alternative measure of overall intellectual functioning in Alzheimer patients, for whom more e...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1988.tb04020.x

    authors: Farber JF,Schmitt FA,Logue PE

    更新日期:1988-06-01 00:00:00

  • Current status of metals as therapeutic targets in Alzheimer's disease.

    abstract::There is accumulating evidence that interactions between beta-amyloid and copper, iron, and zinc are associated with the pathophysiology of Alzheimer's disease (AD). A significant dyshomeostasis of copper, iron, and zinc has been detected, and the mismanagement of these metals induces beta-amyloid precipitation and ne...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1046/j.1532-5415.2003.51368.x

    authors: Finefrock AE,Bush AI,Doraiswamy PM

    更新日期:2003-08-01 00:00:00

  • Drug prescribing for ambulatory patients 85 years of age and older.

    abstract::Drug prescribing for ambulatory patients greater than or equal to 85 years of age was studied using data from the 1980 National Ambulatory Medical Care Survey (NAMCS) on office visits to physicians. NAMCS is a survey by the US National Center for Health Statistics, which collected information on office visits and extr...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1984.tb05855.x

    authors: Knapp DA,Knapp DA,Wiser TH,Michocki RJ,Nuessle SJ,Knapp WK

    更新日期:1984-02-01 00:00:00

  • Urinary incontinence and its association with death, nursing home admission, and functional decline.

    abstract:OBJECTIVES:To determine whether urinary incontinence (UI) is an independent predictor of death, nursing home admission, decline in activities of daily living (ADLs), or decline in instrumental activities of daily living (IADLs). DESIGN:A population-based prospective cohort study from 1993 to 1995. SETTING:Community-d...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52207.x

    authors: Holroyd-Leduc JM,Mehta KM,Covinsky KE

    更新日期:2004-05-01 00:00:00

  • Differences in the signs and symptoms of hyperthyroidism in older and younger patients.

    abstract:OBJECTIVES:To determine if aging modifies the clinical presentation of hyperthyroidism and the signs of thyrotoxicosis in older people. DESIGN:Prospective cohort study. SETTING:A French university hospital. SUBJECTS:Eighty-four new patients with overt hyperthyroidism confirmed chemically between January 1992 and Jan...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1996.tb05637.x

    authors: Trivalle C,Doucet J,Chassagne P,Landrin I,Kadri N,Menard JF,Bercoff E

    更新日期:1996-01-01 00:00:00

  • The identification of frailty: a systematic literature review.

    abstract::An operational definition of frailty is important for clinical care, research, and policy planning. The literature on the clinical definitions, screening tools, and severity measures of frailty were systematically reviewed as part of the Canadian Initiative on Frailty and Aging. Searches of MEDLINE from 1997 to 2009 w...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.2011.03597.x

    authors: Sternberg SA,Wershof Schwartz A,Karunananthan S,Bergman H,Mark Clarfield A

    更新日期:2011-11-01 00:00:00

  • The evening meal and atherosclerosis.

    abstract::A trial by any means that can possibly prevent or retard the development of arteriosclerosis is to be recommended. Arteriosclerosis is the chief cause of strokes and heart attacks. The heavy evening meal now in vogue is characteristically rich in animal fats. Normal digestion is at its peak at about the seventh hour, ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1978.tb02404.x

    authors: Roen PB

    更新日期:1978-06-01 00:00:00

  • Senior PharmAssist: Less Hospital Use with Enrollment in an Innovative Community-Based Program.

    abstract:OBJECTIVES:To evaluate changes in acute health services use of Senior PharmAssist participants. DESIGN:Retrospective analysis. SETTING:Community-based, nonprofit program in Durham County, North Carolina. PARTICIPANTS:Adults aged 60 and older with income of 200% of the federal poverty level or less who enrolled in th...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15617

    authors: Herity LB,Upchurch G,Schenck AP

    更新日期:2018-12-01 00:00:00

  • The effect of do-not-resuscitate orders on physician decision-making.

    abstract::The effect of do-not-resuscitate (DNR) orders on physicians' decisions to provide life-prolonging treatments other than cardiopulmonary resuscitation (CPR) for patients near the end of life was explored using a cross-sectional mailed survey. Each survey presented three patient scenarios followed by 10 treatment decisi...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1532-5415.2002.50620.x

    authors: Beach MC,Morrison RS

    更新日期:2002-12-01 00:00:00

  • Comparing the performance of health status measures for healthy older adults.

    abstract:OBJECTIVES:The specific goals of the study were to compare three health status measures among older adults for their correlations with similar scales and to examine whether extreme (positive) health states might lead to measurement problems. We also report on practical administration and response problems among older a...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1995.tb05569.x

    authors: Andresen EM,Patrick DL,Carter WB,Malmgren JA

    更新日期:1995-09-01 00:00:00

  • Development of a geriatric behavioral self-assessment scale.

    abstract::Described is the development of a self-rating geriatric behavioral scale modeled after the Sandoz Clinical Assessment-Geriatric (SCAG). This new Self-Assessment Scale-Geriatric (SASG) provides a valid and reliable measure of behavioral pathologic changes for the selective screening of elderly patients who manifest mil...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1981.tb02193.x

    authors: Yesavage JA,Adey M,Werner PD

    更新日期:1981-06-01 00:00:00