Current status of metals as therapeutic targets in Alzheimer's disease.

abstract：:Brain atrophy in 154 men and 147 women without neurologic deficits was quantitatively studied by means of computed tomography. The ages ranged from 20 to 79 years. The volume percentage of brain to cranial cavity (Craniocerebral Index, or CCI) was calculated by means of computer programs available in CT systems. The m...

journal_title：Journal of the American Geriatrics Society

authors： Hatazawa J,Ito M,Yamaura H,Matsuzawa T

更新日期：1982-04-01 00:00:00

abstract：:In reviewing the literature on treatment approaches with the psychiatric elderly, a large number of studies were found which espouse comprehensive rehabilitation programs that usually require supplementation of existing personnel and expansion of facilities. Although some agencies and institutions are fortunate in sec...

journal_title：Journal of the American Geriatrics Society

authors： Goga JA,Hambacher WO

更新日期：1977-07-01 00:00:00

abstract：OBJECTIVES:To estimate the independent effect of hospitalization for ischemic stroke on change in functional status, subsequent hospitalization, and mortality. DESIGN:Secondary analysis of the nationally representative Longitudinal Study on Aging. Baseline (1984) interview data were linked to Medicare hospitalization ...

journal_title：Journal of the American Geriatrics Society

authors： Wolinsky FD,Gurney JG,Wan GJ,Bentley DW

更新日期：1998-05-01 00:00:00

abstract：:Accumulating evidence from preclinical and clinical studies supports the hypothesis that oxidative stress may be associated with the onset and progression of Alzheimer's Disease (AD). Antioxidant therapies are being promoted in the lay press to enhance mental functions and delay cognitive losses with aging. An increas...

journal_title：Journal of the American Geriatrics Society

authors： Pitchumoni SS,Doraiswamy PM

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVES:To identify factors associated with incomplete bladder emptying in older women with overactive bladder (OAB) symptoms. DESIGN:Retrospective medical records review. SETTING:Urodynamic laboratory at a large academic health care system in the southeast United States. PARTICIPANTS:Medical records from women a...

journal_title：Journal of the American Geriatrics Society

authors： Park J,Palmer MH

更新日期：2015-07-01 00:00:00

abstract：:A dramatic increase in the number of ethics committees in long-term care facilities (LTCFs) has occurred since 1970 in the 487 nursing homes in Minnesota. Ten percent of the LTCFs had ethics committees which were mostly formed by administrators and nurses. The committees are most often found in large urban facilities ...

journal_title：Journal of the American Geriatrics Society

authors： Brown BA,Miles SH,Aroskar MA

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:To compare hearing loss screening results of four simple tests with those of hand-held audiometry. DESIGN:Cross-sectional study of individuals screened during intake for physicals and other routine procedures. SETTING:Two primary care clinics in the San Francisco Bay area. PARTICIPANTS:Older adults not we...

journal_title：Journal of the American Geriatrics Society

authors： Strawbridge WJ,Wallhagen MI

更新日期：2017-10-01 00:00:00

abstract：:In a 78-year-old woman receiving perhexiline maleate for intractable angina pectoris, a syndrome of parkinsonism and peripheral neuropathy developed. The neuropathy was confirmed by electromyographic and nerve conduction studies. The parkinsonism and peripheral neuropathy disappeared when perhexiline maleate was disco...

journal_title：Journal of the American Geriatrics Society

authors： Gordon M,Gordon AS

更新日期：1981-06-01 00:00:00

abstract：:Salivary gland function is generally well-preserved in healthy older persons. Similar results are observed in the laboratory rat. Older people are, however, more likely to experience salivary disorders due to disease or its treatment. For many patients with remaining salivary gland parenchymal tissue, improved functio...

journal_title：Journal of the American Geriatrics Society

authors： Baum BJ

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:To examine the relationship between cognitive function and self-reported oral health-related quality of life (HRQoL) in community-dwelling older adults. DESIGN:Cross-sectional. SETTING:Community in West Virginia. PARTICIPANTS:Two hundred twenty-six community-dwelling older adults. MEASUREMENTS:Oral HRQoL...

journal_title：Journal of the American Geriatrics Society

authors： Lee KH,Wu B,Plassman BL

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To determine whether performance speeds mediate the association between visual impairment and self-reported mobility disability over an 8-year period. DESIGN:Longitudinal analysis. SETTING:Salisbury, Maryland. PARTICIPANTS:Salisbury Eye Evaluation Study participants aged 65 and older (N=2,520). MEASUREME...

journal_title：Journal of the American Geriatrics Society

authors： Swenor BK,Bandeen-Roche K,Muñoz B,West SK

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN:Cross-sectional study. SETTING:French community-dwelling people. PARTICIPANTS:Elderly adults with...

journal_title：Journal of the American Geriatrics Society

authors： de Souto Barreto P,Andrieu S,Payoux P,Demougeot L,Rolland Y,Vellas B,Multidomain Alzheimer Preventive Trial\/Data Sharing Alzheimer Study Group.

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:To characterize illness and identify the etiology for two nursing home outbreaks of respiratory illness. DESIGN:Multisite outbreak investigations; cohort. SETTING:Two nursing homes in Pennsylvania. PARTICIPANTS:Facility A residents (n = 170), Facility B residents (n = 124), and employees (n = 91). MEASUR...

journal_title：Journal of the American Geriatrics Society

authors： Hicks LA,Shepard CW,Britz PH,Erdman DD,Fischer M,Flannery BL,Peck AJ,Lu X,Thacker WL,Benson RF,Tondella ML,Moll ME,Whitney CG,Anderson LJ,Feikin DR

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:To explore the effect of inflammation and undernutrition on the association between hypocholesterolemia and higher overall mortality in high-functioning older persons. DESIGN:Prospective cohort study. SETTING:Three U.S. communities. PARTICIPANTS:A cohort of 870 participants from the MacArthur Studies of S...

journal_title：Journal of the American Geriatrics Society

authors： Hu P,Seeman TE,Harris TB,Reuben DB

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:To determine whether serum calcium is associated with cognitive function in elderly individuals in the general population. DESIGN:Prospective follow-up study of two independent, population-based cohorts. SETTING:The Rotterdam Study (median follow-up 11 years) and the Leiden 85-plus Study (median follow-up ...

journal_title：Journal of the American Geriatrics Society

authors： Schram MT,Trompet S,Kamper AM,de Craen AJ,Hofman A,Euser SM,Breteler MM,Westendorp RG

更新日期：2007-11-01 00:00:00

abstract：:The US Department of Health and Human Services and the Foundation for the National Institutes of Health, through private sector support, sponsored the National Research Summit on Dementia Care: Building Evidence for Services and Supports (Summit) in 2017. Various workgroups were asked to address topics of interest in ...

journal_title：Journal of the American Geriatrics Society

authors： Weiss J,Tumosa N,Perweiler E,Forciea MA,Miles T,Blackwell E,Tebb S,Bailey D,Trudeau SA,Worstell M

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To compare characteristics, healthcare use, and costs of care of veterans in the rapidly expanding Veterans Health Administration (VHA) medical foster home (MFH) with those of three other VHA long-term care (LTC) programs. DESIGN:Descriptive, unmatched study. SETTING:VHA MFHs, home-based primary care (HBPC)...

journal_title：Journal of the American Geriatrics Society

authors： Levy C,Whitfield EA

更新日期：2016-12-01 00:00:00

abstract：:The contribution of frailty to human morbidity and mortality is immense. Yet it lacks a conceptual framework. By borrowing from the hypotheses provided by the thermophysicists, frailty can be understood in a way that both interrelates the relationship between form and function and provides medical science with an oper...

journal_title：Journal of the American Geriatrics Society

authors： Bortz WM 2nd

更新日期：1993-09-01 00:00:00

abstract：CONTEXT:Racial differences in receipt of cancer prevention services may be related to poorer outcomes for minorities. Understanding reasons for such differences could help target appropriate interventions. OBJECTIVES:To determine if racial differences exist in the use of cancer prevention services among older blacks a...

journal_title：Journal of the American Geriatrics Society

authors： Hegarty V,Burchett BM,Gold DT,Cohen HJ

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To determine whether the management of heart failure by specialized multidisciplinary heart failure disease-management programs was associated with improved outcomes. BACKGROUND:The advent of angiotensin-converting enzyme inhibitors, beta-blockers, and spironolactone has revolutionized the management of heart ...

journal_title：Journal of the American Geriatrics Society

authors： Ahmed A

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:To determine whether increasing kyphosis angle was independently associated with poorer mobility as measured according to the Timed Up and Go Test (TUG), after controlling for other established risk factors. DESIGN:Prospective cohort study. SETTING:Eleven clinical centers in the United States. PARTICIPANT...

journal_title：Journal of the American Geriatrics Society

authors： Katzman WB,Vittinghoff E,Ensrud K,Black DM,Kado DM

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To examine the longitudinal associations between aging with preserved functionality, i.e. independent aging and survival, and lifestyle variables, dietary pattern and cardiovascular risk factors. DESIGN:Cohort study. SETTING:Uppsala Longitudinal Study of Adult Men, Sweden. PARTICIPANTS:Swedish men (n = 1,...

journal_title：Journal of the American Geriatrics Society

authors： Franzon K,Byberg L,Sjögren P,Zethelius B,Cederholm T,Kilander L

更新日期：2017-09-01 00:00:00

abstract：:Low-income Latino immigrants are understudied in elder abuse research. Limited English proficiency, economic insecurity, neighborhood seclusion, a tradition of resolving conflicts within the family, and mistrust of authorities may impede survey research and suppress abuse reporting. To overcome these barriers, promoto...

journal_title：Journal of the American Geriatrics Society

authors： DeLiema M,Gassoumis ZD,Homeier DC,Wilber KH

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:To examine the neuropsychological and clinical profile of help-seekers in an early-detection community dementia program and to explore any relationship between profiles and time to seek help. DESIGN:Cross-sectional. SETTING:Early-detection community dementia program. PARTICIPANTS:Help-seekers (N = 1,005) ...

journal_title：Journal of the American Geriatrics Society

authors： Tang JY,Wong GH,Ng CK,Kwok DT,Lee MN,Dai DL,Lum TY

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:To determine factors that predict site of death (hospital vs nursing home (NH)), related costs, and geographic variation in site of death of NH residents admitted under the Medicare Part A Benefit. DESIGN:Retrospective cohort study. SETTING:NHs located in the United States (N=13,146). PARTICIPANTS:All per...

journal_title：Journal of the American Geriatrics Society

authors： Levy CR,Fish R,Kramer AM

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:To examine the effect of vitamin B12 deficiency on older veterans and its relationship to general health and cognitive impairment. DESIGN:Cross-sectional study. SETTING:Oklahoma City Veterans Affairs Medical Center. PARTICIPANTS:Data for this research were obtained from 303 ambulatory, older veterans who u...

journal_title：Journal of the American Geriatrics Society

authors： Bernard MA,Nakonezny PA,Kashner TM

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:To determine the efficacy of antidepressants in people with depression and dementia. DESIGN:A systematic review and meta-analysis based on a literature search of Medline and Cochrane Trials Registry for acute-phase, double-blind, placebo-controlled, parallel-design, random-assignment trials of antidepressan...

journal_title：Journal of the American Geriatrics Society

authors： Nelson JC,Devanand DP

更新日期：2011-04-01 00:00:00

abstract：:A prospective study was carried out to determine which social, functional, or medical factors influenced the decision to admit or not to admit aged people to a general hospital in Israel. The study also focused on characteristics of patients admitted to the geriatric ward of the medical division as distinct from those...

journal_title：Journal of the American Geriatrics Society

authors： Greenberg NS,Rosin AJ

更新日期：1982-10-01 00:00:00

abstract：:It has been reported that postural hypotension in the elderly is common. However, these studies included institutionalized and more or less disabled persons. Furthermore, postural hypotension may be related to baseline blood pressure. In this study, the influence of age and blood pressure on the hemodynamic and plasma...

journal_title：Journal of the American Geriatrics Society

authors： Jansen RW,Lenders JW,Thien T,Hoefnagels WH

更新日期：1989-06-01 00:00:00

abstract：:Thyroid disease in the aged, both hypothyroidism and hyperthyroidism, may be subtle or may be present with no clinical symptoms and signs, and is therefore difficult to diagnose on the basis of clinical evaluation. The help of the laboratory is essential in making the diagnosis of disease of the thyroid. Therapeutic s...

journal_title：Journal of the American Geriatrics Society

authors： Mokshagundam S,Barzel US

更新日期：1993-12-01 00:00:00