Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.

Abstract:

OBJECTIVES:To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN:Cross-sectional study. SETTING:French community-dwelling people. PARTICIPANTS:Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self-reported PA and amyloid-β brain deposition measured using positron emission tomography (PET) using the PET-ligand florbetapir F 18 (n = 268). MEASUREMENTS:A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR-). RESULTS:Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR- participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E ε4 carriers or noncarriers. PA was not associated with cognitive function. CONCLUSION:Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid-β brain deposition. Further studies are needed to determine whether PA (ideally measured at several time-points using objective measures) is involved in the pathophysiology of Alzheimer's disease.

journal_name

J Am Geriatr Soc

authors

de Souto Barreto P,Andrieu S,Payoux P,Demougeot L,Rolland Y,Vellas B,Multidomain Alzheimer Preventive Trial\/Data Sharing Alzheimer Study Group.

doi

10.1111/jgs.13530

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

1634-9

issue

8

eissn

0002-8614

issn

1532-5415

journal_volume

63

pub_type

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