Abstract:
OBJECTIVE:To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life. DESIGN:Cross-sectional study. SETTING:Four U.S. sites. PARTICIPANTS:Nine thousand three hundred forty-four women aged 65 and older (mean 71.6) who self-reported teenage, age 30, age 50, and late-life physical activity. MEASUREMENTS:Logistic regression was used to determine the association between physical activity status at each age and likelihood of cognitive impairment (modified Mini-Mental State Examination (mMMSE) score >1.5 standard deviations below the mean, mMMSE score=22). Models were adjusted for age, education, marital status, diabetes mellitus, hypertension, depressive symptoms, smoking, and body mass index. RESULTS:Women who reported being physically active had a lower prevalence of cognitive impairment in late life than women who were inactive at each time (teenage: 8.5% vs 16.7%, adjusted odds ratio (AOR)=0.65, 95% confidence interval (CI)=0.53-0.80; age 30: 8.9% vs 12.0%, AOR=0.80, 95% CI=0.67-0.96); age 50: 8.5% vs 13.1%, AOR=0.71, 95% CI=0.59-0.85; old age: 8.2% vs 15.9%, AOR=0.74, 95% CI=0.61-0.91). When the four times were analyzed together, teenage physical activity was most strongly associated with lower odds of late-life cognitive impairment (OR=0.73, 95% CI=0.58-0.92). However, women who were physically inactive as teenagers and became active in later life had lower risk than those who remained inactive. CONCLUSIONS:Women who reported being physically active at any point over the life course, especially as teenagers, had a lower likelihood of cognitive impairment in late life. Interventions should promote physical activity early in life and throughout the life course.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Middleton LE,Barnes DE,Lui LY,Yaffe Kdoi
10.1111/j.1532-5415.2010.02903.xsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
1322-6issue
7eissn
0002-8614issn
1532-5415pii
JGS2903journal_volume
58pub_type
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journal_title:Journal of the American Geriatrics Society
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更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To examine transitions that individuals with dementia experience longitudinally and to identify points of care when transitions are highest and the factors that contribute to those transitions. DESIGN:Population-based 10-year retrospective cohort study from 2000 to 2011. SETTING:General community. PARTICI...
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journal_title:Journal of the American Geriatrics Society
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更新日期:2004-08-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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更新日期:1975-05-01 00:00:00
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doi:10.1111/j.1532-5415.2008.02132.x
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abstract:BACKGROUND/OBJECTIVES:To explore the opinion of the Dutch general public and of physicians regarding euthanasia in patients with advanced dementia. DESIGN:A cross-sectional survey. SETTING:The Netherlands. PARTICIPANTS:Random samples of 1,965 citizens (response = 1,965/2,641 [75%]) and 1,147 physicians (response = 1...
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journal_title:Journal of the American Geriatrics Society
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更新日期:2020-12-31 00:00:00
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更新日期:2020-10-01 00:00:00
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更新日期:2019-11-01 00:00:00
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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更新日期:2000-08-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
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更新日期:1979-03-01 00:00:00
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更新日期:2017-03-01 00:00:00