Abstract:
OBJECTIVE:To evaluate the reclosure-promoting capacity of a neural stem cell line (F3) and a human bone marrow stem cell line (B10) injected into the amniotic cavity of spinal open neural tube defects (ONTDs) of chick embryos of Hamburger and Hamilton stage 18 or 19. METHODS:Fifteen chick embryos that survived the procedure were obtained for each of 4 groups: untreated control, F3-, B10-, and HFF-1 (human foreskin fibroblast)-treated groups. Embryos in the control group underwent ONTD surgery but no cell injection. RESULTS:Compared with the untreated control and HFF-1 groups, the B10 group showed enhanced reclosure at 3, 5, and 7 days after injection, whereas the F3 group did not. B10 cells were not incorporated into reclosed neural tubes but simply covered ONTDs during the process of reclosure. F3 cells did not cover ONTDs. The cell survival of F3 cells exposed to the chick amniotic fluid in vitro for 48 hours was significantly lower than that of B10 cells. CONCLUSION:The results confirmed that B10 cells enhance reclosure of ONTDs by covering and protecting neural tissues, not by direct cell incorporation. The lack of reclosure capacity in the F3 group may be related to the poor survival of F3 cells in the amniotic fluid.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Lee DH,Phi JH,Kim SK,Cho BK,Kim SU,Wang KCdoi
10.1227/01.NEU.0000371048.76494.0Fsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
129-35; discussion 135issue
1eissn
0148-396Xissn
1524-4040pii
00006123-201007000-00018journal_volume
67pub_type
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