Cancer after spinal fusion: the role of bone morphogenetic protein.

Abstract:

BACKGROUND:Bone morphogenetic protein (BMP) is used in tens of thousands of spinal fusions each year. A trial evaluating a high-dose BMP formulation demonstrated that its use may be associated with an increased risk of cancer. OBJECTIVE:To evaluate whether BMP, as commonly used today, is associated with an increased risk of cancer or benign tumors. METHODS:We performed a retrospective study using the Thomson Reuter MarketScan database. We retained all patients who had no previous diagnosis of cancer or benign tumor and had at least 2 years of uninterrupted enrollment in the database before and after their operations. A propensity score--matched cohort was created to ensure greater covariate balance between treatment groups. RESULTS:Within the propensity score--matched cohort (n = 4698), BMP-exposed patients had a nonsignificant increase in the rate of cancer diagnosis (9.37% vs 7.92%; P = .08). After adjustment for covariates, BMP exposure was associated with a 31% increased risk of benign tumor diagnosis (odds ratio, 1.31; 95% confidence interval, 1.02-1.68; P < .05). When the benign tumor diagnoses were stratified by organ type, BMP patients had significantly more diagnoses of benign nervous system tumors (0.81% vs 0.34%; P = .03), and within this group, benign tumors of the spinal meninges were much more common in the BMP-treated group (0.13% vs 0.02%; P = .002). CONCLUSION:The results of this large, independent, propensity-matched study suggest that the use of BMP in lumbar fusions is associated with a significantly higher rate of benign neoplasms but not malignancies.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Lad SP,Bagley JH,Karikari IO,Babu R,Ugiliweneza B,Kong M,Isaacs RE,Bagley CA,Gottfried ON,Patil CG,Boakye M

doi

10.1227/NEU.0000000000000018

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

440-9

issue

3

eissn

0148-396X

issn

1524-4040

journal_volume

73

pub_type

杂志文章
  • Late magnetic resonance imaging related to neurobehavioral functioning after aneurysmal subarachnoid hemorrhage.

    abstract::Twenty patients who underwent early aneurysm surgery--that is, surgery within 72 hours after rupture--underwent further follow-up examination including magnetic resonance imaging (MRI) of the brain and a comprehensive neuropsychological assessment. Significant statistical correlation between tissue loss as seen on a l...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-198909000-00012

    authors: Romner B,Sonesson B,Ljunggren B,Brandt L,Säveland H,Holtås S

    更新日期:1989-09-01 00:00:00

  • Neuropsychological functioning and recovery after mild head injury in collegiate athletes.

    abstract:OBJECTIVE:This study prospectively examined neuropsychological functioning in 2300 collegiate football players from 10 National Collegiate Athletic Association Division A universities. The study was designed to determine the presence and duration of neuropsychological symptoms after mild head injury. METHODS:A nonequi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Macciocchi SN,Barth JT,Alves W,Rimel RW,Jane JA

    更新日期:1996-09-01 00:00:00

  • Neurosurgery and Manned Spaceflight.

    abstract::There has been a renewed interest in manned spaceflight due to endeavors by private and government agencies. Publicized goals include manned trips to or colonization of Mars. These missions will likely be of long duration, exceeding existing records for human exposure to extra-terrestrial conditions. Participants will...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1093/neuros/nyy531

    authors: Panesar SS,Fernandez-Miranda JC,Kliot M,Ashkan K

    更新日期:2020-03-01 00:00:00

  • Systemic administration of the iron chelator deferiprone attenuates subarachnoid hemorrhage-induced cerebral vasospasm in the rabbit.

    abstract:OBJECTIVE:Iron catalyzed generation of injurious free radicals has been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). The present study assessed the effects of the iron chelator deferiprone on cerebral vasospasm in an in vivo rabbit model of SAH. METHODS:Twenty-four rabbits ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199712000-00028

    authors: Arthur AS,Fergus AH,Lanzino G,Mathys J,Kassell NF,Lee KS

    更新日期:1997-12-01 00:00:00

  • Angioplasty and stenting of basilar artery stenosis: technical case report.

    abstract:OBJECTIVE AND IMPORTANCE:Symptomatic basilar artery stenosis has a poor prognosis. Treatment options are limited. Surgical bypasses are technically demanding and of no proven benefit. Percutaneous angioplasty is associated with a significant complication rate, because of intraplaque dissection, restenosis secondary to ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199908000-00047

    authors: Lanzino G,Fessler RD,Miletich RS,Guterman LR,Hopkins LN

    更新日期:1999-08-01 00:00:00

  • Children with cerebral venous thrombosis diagnosed with magnetic resonance imaging and magnetic resonance angiography.

    abstract::From 1985 to 1991, 13 children were diagnosed at the University of Illinois College of Medicine at Peoria, Saint Francis Medical Center, with cerebral venous thrombosis (CVT) by magnetic resonance imaging scan. Ages ranged from newborn to 5 years. Six children were premature neonates, five were term neonates and two w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199211000-00007

    authors: Medlock MD,Olivero WC,Hanigan WC,Wright RM,Winek SJ

    更新日期:1992-11-01 00:00:00

  • Hemangiomatous anomaly of bone in Crouzon's syndrome: case report.

    abstract::A striking and diffuse hemangiomatous architecture was identified by microscopic examination of bone specimens obtained at cranial synostectomy and from the craniofacial area of a young boy with Kleeblättschadel deformity and Crouzon's syndrome. A retrospective review of the histopathological appearance of bone specim...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198503000-00019

    authors: Alpers CE,Edwards MS

    更新日期:1985-03-01 00:00:00

  • Effect of the dural application of Zenker's solution on the feline brain.

    abstract::Zenker's solution is a tissue fixative containing mercuric chloride, potassium bichromate, sodium sulfate, and glacial acetic acid. In 1956, Anderson and Johnson reported its use in clinical neurosurgery. They applied the solution to the exposed dura after craniectomy. Delayed bone formation was thought to be due to t...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198001000-00006

    authors: Marlin AE,Brown WE Jr,Huntington HW,Epstein F

    更新日期:1980-01-01 00:00:00

  • Thermal damage assessment of novel bipolar forceps in a sheep model of spinal surgery.

    abstract:BACKGROUND:Heat transfer from bipolar tips to adjacent tissue presents a risk of thermal injury during spine surgery. OBJECTIVE:The present study was designed to determine wither bipolar forceps using a novel heat pipe thermal regulation technology resulted in decreased collateral thermal injury of adjacent tissue com...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000370246.82005.6f

    authors: Elliott-Lewis EW,Jolette J,Ramos J,Benzel EC

    更新日期:2010-07-01 00:00:00

  • Characteristics of incidental pineal cysts on magnetic resonance imaging.

    abstract::Three patients with different neurological complaints were studied by magnetic resonance imaging. Coincidentally, all studies showed cystic changes within the pineal bodies. These cysts appeared hypointense on T1-weighted, spin-echo pulse sequences and hyperintense on T2-weighted images. Spin-density sequences display...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-198910000-00020

    authors: Sandhu JS,McLaughlin JR,Gomez CR

    更新日期:1989-10-01 00:00:00

  • Socioeconomic costs of open surgery and gamma knife radiosurgery for benign cranial base tumors.

    abstract:OBJECTIVE:The aim of this study was to evaluate the relative socioeconomic costs of benign cranial base tumors treated with open surgery and gamma knife radiosurgery. METHODS:In a retrospective study, we studied 174 patients with benign cranial base tumors, less than 3 cm in diameter (or volume less than 30 ml), admit...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000209892.42585.9B

    authors: Cho DY,Tsao M,Lee WY,Chang CS

    更新日期:2006-05-01 00:00:00

  • Multimodal reperfusion therapy in patients with acute basilar artery occlusion.

    abstract:OBJECTIVE:Multimodal reperfusion therapy (MMRT) has been advocated for the treatment of acute basilar artery occlusion (ABAO). We aimed to identify prognostic factors in patients with ABAO who underwent MMRT. METHODS:Clinical and radiological data from consecutive ABAO patients were analyzed. All patients underwent MM...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1227/01.NEU.0000350862.35963.49

    authors: Raphaeli G,Eichel R,Ben-Hur T,Leker RR,Cohen JE

    更新日期:2009-09-01 00:00:00

  • Combined-modality treatment of leptomeningeal gliomatosis.

    abstract:OBJECTIVE:Leptomeningeal gliomatosis (LG) is a clinically uncommon metastatic complication of high-grade gliomas (HGGs), for which there is no consensus regarding treatment. The goal of this study was to determine the toxicity and response rate of combined-modality therapy for the treatment of patients with HGGs and LG...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000043929.31608.62

    authors: Chamberlain MC

    更新日期:2003-02-01 00:00:00

  • Acute aggravation of subdural effusion associated with pachymeningitis carcinomatosa: case report.

    abstract::The authors present a case of acute aggravation of subdural effusion associated with pachymeningitis carcinomatosa. Microscopic examination of a surgical specimen revealed diffuse involvement of the dura mater by a metastatic adenocarcinoma in which the tumor cells invaded venules located in the areolar layer in parti...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199109000-00025

    authors: Kamada K,Isu T,Houkin K,Ohsato T,Katoh M,Kojima H

    更新日期:1991-09-01 00:00:00

  • Computer-aided intelligence: application of an expert system to brachial plexus injuries.

    abstract::When confronted with a patient with a brachial plexus injury, how often as neurosurgeons do we consult an atlas to confirm the anatomy of the brachial plexus and then attempt to establish the location of the lesion? Similar difficulties are encountered with lumbar and sacral plexus lesions. In a project organized to a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Fisher WS 3rd

    更新日期:1990-11-01 00:00:00

  • Occurrence, Risk Factors, and Time Trends for Late Reoperations due to Degenerative Cervical Spine Disease: A Finnish National Register Study of 19 377 Patients Operated on Between 1999 and 2015.

    abstract:BACKGROUND:Surgery for degenerative cervical spine disease has escalated since the 1990s. Fusion has become the mainstay of surgery despite concerns regarding adjacent segment degeneration. The patient-specific trends in reoperations have not been studied previously. OBJECTIVE:To analyze the occurrence, risk factors, ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyaa464

    authors: Kotkansalo A,Leinonen V,Korajoki M,Korhonen K,Rinne J,Malmivaara A

    更新日期:2020-12-28 00:00:00

  • Lateral extracavitary vs. costotransversectomy approaches to the thoracic spine: reflections on lessons learned.

    abstract:BACKGROUND:The lateral extracavitary approach (LECA) and costotransversectomy (CTE) are 2 dorsolateral approaches that avoid entrance into the pleural cavity and facilitate ventral decompression. The indications and outcomes of each of these approaches have not been fully defined in the literature. OBJECTIVE:To assess...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3182706102

    authors: Lubelski D,Abdullah KG,Mroz TE,Shin JH,Alvin MD,Benzel EC,Steinmetz MP

    更新日期:2012-12-01 00:00:00

  • Long-term impact of cognitive deficits and epilepsy on quality of life in patients with low-grade meningiomas.

    abstract:BACKGROUND:WHO Grade I meningiomas are common, usually benign, primary brain tumors. Little is known about the health-related quality of life (HRQOL) of patients with meningiomas. OBJECTIVE:To investigate the long-term HRQOL in patients with meningiomas and its association with cognitive deficits and epilepsy. METHOD...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318212badb

    authors: Waagemans ML,van Nieuwenhuizen D,Dijkstra M,Wumkes M,Dirven CM,Leenstra S,Reijneveld JC,Klein M,Stalpers LJ

    更新日期:2011-07-01 00:00:00

  • Treatment of cerebrospinal fluid and syringosubarachnoid shunt infection with systemic and intrathecal antibiotics.

    abstract::We present a case of a patient with two preexisting Silastic syringosubarachnoid shunt catheters who developed Enterobacter meningitis. The infection was treated successfully with systemic and intrathecal antibiotics without removal of the catheters. With careful sequential clinical and laboratory monitoring, even thi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198508000-00015

    authors: Tomaszek DE,Powers SK

    更新日期:1985-08-01 00:00:00

  • Performance of a new type of suction tip attachment during intramedullary tumor dissection: technical note.

    abstract:OBJECTIVE:We describe an innovative 1.7-mm-diameter, latex-free aspirator tip attachment (Circle Medical B.V., Wijchen, The Netherlands). This tip is designed to be used during tumor resection to avoid surgical trauma to the spinal cord surrounding an intramedullary tumor and the associated blood vessels. PATIENTS AND...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000303975.14430.1f

    authors: Lefranc F,Brotchi J

    更新日期:2007-11-01 00:00:00

  • Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model.

    abstract:OBJECTIVE:Endovascular occlusive therapy of human saccular cerebral artery aneurysms may fail because of thrombus recanalization and incomplete neointima formation. Bone marrow-derived progenitor cells may contribute to these processes, but their role in human saccular cerebral artery aneurysms and experimental aneurys...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000210260.55124.A4

    authors: Frösen J,Marjamaa J,Myllärniemi M,Abo-Ramadan U,Tulamo R,Niemelä M,Hernesniemi J,Jääskeläinen J

    更新日期:2006-05-01 00:00:00

  • Double dissociation between visual recognition and picture naming: a study of the visual language connectivity using tractography and brain stimulation.

    abstract:BACKGROUND:Study of the corticosubcortical functional anatomy of reading and picture naming. OBJECTIVE:To study the role of the left basal occipitotemporal area and its white matter pathways. METHODS:Three patients underwent awake surgery for lesions in the left basal posterotemporal region with intraoperative electr...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318282a361

    authors: Gil-Robles S,Carvallo A,Jimenez Mdel M,Gomez Caicoya A,Martinez R,Ruiz-Ocaña C,Duffau H

    更新日期:2013-04-01 00:00:00

  • Duration of cognitive impairment after sports concussion.

    abstract:OBJECTIVE:We sought to determine the duration of cognitive impairment after sports concussion. METHODS:We conducted a study with a prospective design in which 729 athletes underwent preseason baseline testing by being administered a computerized neuropsychological test battery, followed by retesting at regular interva...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000118820.33396.6a

    authors: Bleiberg J,Cernich AN,Cameron K,Sun W,Peck K,Ecklund PJ,Reeves D,Uhorchak J,Sparling MB,Warden DL

    更新日期:2004-05-01 00:00:00

  • Multiphoton excitation of autofluorescence for microscopy of glioma tissue.

    abstract:OBJECTIVE:Intraoperative detection of residual tumor tissue in glioma surgery remains an important challenge because the extent of tumor removal is related to the prognosis of the disease. Multiphoton excited fluorescence tomography of living tissues provides high-resolution structural and photochemical imaging at a su...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000204885.45644.22

    authors: Leppert J,Krajewski J,Kantelhardt SR,Schlaffer S,Petkus N,Reusche E,Hüttmann G,Giese A

    更新日期:2006-04-01 00:00:00

  • Cine magnetic resonance imaging of spinal intradural arachnoid cysts.

    abstract:OBJECTIVE:The diagnostic value of cine magnetic resonance imaging (CMRI) that visualizes fluid and tissue movement was evaluated in patients with spinal intradural arachnoid cysts, a rare but increasingly detected cause of spinal cord dysfunction. METHODS:Four patients with thoracic spinal intradural arachnoid cysts w...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199707000-00020

    authors: Shimizu H,Tominaga T,Takahashi A,Yoshimoto T

    更新日期:1997-07-01 00:00:00

  • Ranging accuracy test of the sonic microstereometric system.

    abstract::We have recently introduced a new type of ultrasonic-based, three-dimensional ranging system for the localization of small handheld surgical tools to be used during operation in open stereotactic brain surgery. This targeting system has now been extensively laboratory tested during thousands of measuring cycles with a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199404000-00030

    authors: Horstmann GA,Reinhardt HF

    更新日期:1994-04-01 00:00:00

  • Development of a unique phantom to assess the geometric accuracy of magnetic resonance imaging for stereotactic localization.

    abstract:OBJECTIVE:To test the spatial accuracy of coordinates generated from magnetic resonance imaging (MRI) scans, using the Brown-Roberts-Wells head frame and localizer system (Radionics, Inc., Burlington, MA). METHODS:An anthropomorphic head phantom, consisting of a two-dimensional lattice of acrylic spheres (4-mm diamete...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199912000-00030

    authors: Orth RC,Sinha P,Madsen EL,Frank G,Korosec FR,Mackie TR,Mehta MP

    更新日期:1999-12-01 00:00:00

  • Association of Severe Traumatic Brain Injury Patient Outcomes With Duration of Cerebrovascular Autoregulation Impairment Events.

    abstract:BACKGROUND:Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. Temporal CA failure is associated with worse outcomes in various acute neurological diseases. An int...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001192

    authors: Preiksaitis A,Krakauskaite S,Petkus V,Rocka S,Chomskis R,Dagi TF,Ragauskas A

    更新日期:2016-07-01 00:00:00

  • High-resolution three-dimensional magnetic resonance angiography and three-dimensional spoiled gradient-recalled imaging in the evaluation of neurovascular compression in patients with trigeminal neuralgia: a double-blind pilot study.

    abstract:OBJECTIVE:To assess the value of high-resolution three-dimensional (3D) time-of-flight (TOF) magnetic resonance (MR) angiography and gadolinium (Gad)-enhanced 3D spoiled gradient-recalled imaging in the visualization of neurovascular compression in patients with trigeminal neuralgia. METHODS:Forty-eight patients with ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000197117.34888.DE

    authors: Anderson VC,Berryhill PC,Sandquist MA,Ciaverella DP,Nesbit GM,Burchiel KJ

    更新日期:2006-04-01 00:00:00

  • Most intracranial meningiomas are not cleavable tumors: anatomic-surgical evidence and angiographic predictibility.

    abstract:OBJECTIVE:The statement that intracranial meningiomas are cleavable tumors has to be seriously questioned from a surgical standpoint. The purpose of this study was 1) to analyze the operative reports of a personal series of meningiomas to evaluate the percentages of the tumors that could be dissected by passing in the ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199803000-00007

    authors: Sindou MP,Alaywan M

    更新日期:1998-03-01 00:00:00