In vivo induction of the lymphokine-activated killer phenomenon: interleukin 2-dependent human non-major histocompatibility complex-restricted cytotoxicity generated in vivo during administration of human recombinant interleukin 2.

abstract：:Fifty-eight skin biopsies and three primary internal tumors from patients affected by the rare hereditary disease xeroderma pigmentosum (XP) were studied by an improved PCR-single strand conformation polymorphism analysis to detect the mutations of the tumor suppressor gene p53. The results from cutaneous XP tumors, i...

journal_title：Cancer research

authors： Giglia G,Dumaz N,Drougard C,Avril MF,Daya-Grosjean L,Sarasin A

更新日期：1998-10-01 00:00:00

abstract：:The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with constitutive activation of the NF-κB pathway, and oncogenic lesions have been identified in its regulators, including CARD11/CARMA1 (caspase recruitment domain-co...

journal_title：Cancer research

authors： Naylor TL,Tang H,Ratsch BA,Enns A,Loo A,Chen L,Lenz P,Waters NJ,Schuler W,Dörken B,Yao YM,Warmuth M,Lenz G,Stegmeier F

更新日期：2011-04-01 00:00:00

abstract：:We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). Because colorectal metastasis to the lun...

journal_title：Cancer research

authors： Banerjee D,Gorlick R,Liefshitz A,Danenberg K,Danenberg PC,Danenberg PV,Klimstra D,Jhanwar S,Cordon-Cardo C,Fong Y,Kemeny N,Bertino JR

更新日期：2000-05-01 00:00:00

abstract：:The selective ubiquitination of proteins by ubiquitin E3 ligases plays an important regulatory role in control of cell differentiation, growth, and transformation and their dysregulation is often associated with pathologic outcomes, including tumorigenesis. RNF5 is an E3 ubiquitin ligase that has been implicated in mo...

journal_title：Cancer research

authors： Bromberg KD,Kluger HM,Delaunay A,Abbas S,DiVito KA,Krajewski S,Ronai Z

更新日期：2007-09-01 00:00:00

abstract：:The human glioma-derived cell line D-54 MG and the human medulloblastoma-derived cell line TE-671 have been shown to be sensitive in culture to the pharmacological interference with glutamine metabolism by acivicin, 6-diazo-5-oxo-L-norleucine, and methionine sulfoximine. Using as a guide the multiple contributions of ...

journal_title：Cancer research

authors： Dranoff G,Elion GB,Friedman HS,Bigner DD

更新日期：1985-09-01 00:00:00

abstract：:Phosphorylation of histone H3 at Ser-10 is required for maintenance of properchromosome dynamics during mitosis. AIM-1, a mammalian Ipl1/aurora kinase involved in H3 phosphorylation, is transcriptionally overexpressed in many tumor cell lines. Increased expression of the AIM-1 gene has been observed in human colorecta...

journal_title：Cancer research

authors： Ota T,Suto S,Katayama H,Han ZB,Suzuki F,Maeda M,Tanino M,Terada Y,Tatsuka M

更新日期：2002-09-15 00:00:00

abstract：:APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall biological function remains unclear. Using a yeast two-hybrid system, we attempted t...

journal_title：Cancer research

authors： Nakagawa H,Koyama K,Murata Y,Morito M,Akiyama T,Nakamura Y

更新日期：2000-01-01 00:00:00

abstract：:We have performed isobologram analyses of the ability of tamoxifen (TAM) to alter the response to Adriamycin (ADR) and vinblastine (VBL) in human breast cancer cells. MCF-7 cells express functional receptors for estrogen and progesterone but do not express detectable levels of M(r) 170,000 glycoprotein (gp170). CL 10....

journal_title：Cancer research

authors： Leonessa F,Jacobson M,Boyle B,Lippman J,McGarvey M,Clarke R

更新日期：1994-01-15 00:00:00

abstract：:Targeted therapies for cancer are inherently limited by the inevitable recurrence of resistant disease after initial responses. To define early molecular changes within residual tumor cells that persist after treatment, we analyzed drug-sensitive lung adenocarcinoma cell lines exposed to reversible or irreversible epi...

journal_title：Cancer research

authors： Fan W,Tang Z,Yin L,Morrison B,Hafez-Khayyata S,Fu P,Huang H,Bagai R,Jiang S,Kresak A,Howell S,Vasanji A,Flask CA,Halmos B,Koon H,Ma PC

更新日期：2011-07-01 00:00:00

abstract：:The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has...

journal_title：Cancer research

authors： Kawakami K,Terabe M,Kawakami M,Berzofsky JA,Puri RK

更新日期：2006-04-15 00:00:00

abstract：:Retrospective studies of breast cancer patients suggest that primary tumor Her-2 overexpression or trastuzumab therapy is associated with a devastating complication: the development of central nervous system (brain) metastases. Herein, we present Her-2 expression trends from resected human brain metastases and data fr...

journal_title：Cancer research

authors： Palmieri D,Bronder JL,Herring JM,Yoneda T,Weil RJ,Stark AM,Kurek R,Vega-Valle E,Feigenbaum L,Halverson D,Vortmeyer AO,Steinberg SM,Aldape K,Steeg PS

更新日期：2007-05-01 00:00:00

abstract：:Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective in preventing fluid accumulation. In this study, ...

journal_title：Cancer research

authors： Moughon DL,He H,Schokrpur S,Jiang ZK,Yaqoob M,David J,Lin C,Iruela-Arispe ML,Dorigo O,Wu L

更新日期：2015-11-15 00:00:00

abstract：:Regulation of tyrosine aminotransferase gene expression was studied in an adult rat hepatocyte line (RALA255-10G) which is temperature sensitive for the maintenance of the differentiated liver phenotype. Glucocorticoid hormones such as cortisol were necessary for expression of the aminotransferase gene. In the absence...

journal_title：Cancer research

authors： Chou JY,Yeoh GC

更新日期：1987-10-15 00:00:00

abstract：:Pim serine/threonine kinases contribute to prostate tumorigenesis and therapeutic resistance, yet Pim kinase inhibitors seem to have only limited effects on prostate cancer cell survival. Because overexpression of Bcl-2 family members are implicated in chemotherapeutic resistance in prostate cancer, we investigated th...

journal_title：Cancer research

authors： Song JH,Kraft AS

更新日期：2012-01-01 00:00:00

abstract：:Transduction of mitogenic signals in cells can be mediated by molecules derived from the synthesis and breakdown of the major membrane phospholipid, phosphotidylcholine. Studies were performed on human mammary epithelial cells in culture to understand the impact of malignant transformation and progression on membrane ...

journal_title：Cancer research

authors： Aboagye EO,Bhujwalla ZM

更新日期：1999-01-01 00:00:00

abstract：:Peripheral lymphocytes from cancer patients receiving mitomycin C treatment were examined for cytogenetic effects. The treatment consisted of i.v. injections of mitomycin C at a dose of 4 mg given twice a week for 2 weeks. The lymphocytes were cultured in vitro for 72 hr with phytohemagglutinin and 5-bromodeoxyuridine...

journal_title：Cancer research

authors： Ohtsuru M,Ishii Y,Takai S,Higashi H,Kosaki G

更新日期：1980-02-01 00:00:00

abstract：:The effects of N-5-dimethyl-9-(2-methoxy-4-methylsulfonylamino)-phenylamino-4- acridinecarboxamide (CI-921; NSC 343499), a lipophilic and water-soluble derivative of amsacrine (NSC 249992), on cell viability, growth, clonogenicity, and progression through the cell cycle were investigated in suspension cultures of Frie...

journal_title：Cancer research

authors： Traganos F,Bueti C,Darzynkiewicz Z,Melamed MR

更新日期：1987-01-15 00:00:00

abstract：:The mechanism of in vitro cytotoxicity by tumor necrosis serum (TNS) and a purified fraction was examined using sensitive L-M cells. Cell death was assessed by uptake of the dye trypan blue and/or by release of radiolabeled chromium. Cell killing was time and dose dependent. Cell survival was assessed by counting the ...

journal_title：Cancer research

authors： Kull FC Jr,Cuatrecasas P

更新日期：1981-12-01 00:00:00

abstract：:It has been shown in previous studies that a variety of estrogen receptor (ER) beta mRNA transcripts are expressed in human breast cancer cell lines and tumors. To complement the RNA expression studies, we have developed ER-beta-specific antibodies to characterize ER-beta protein expression in breast cancer cell lines...

journal_title：Cancer research

authors： Fuqua SA,Schiff R,Parra I,Friedrichs WE,Su JL,McKee DD,Slentz-Kesler K,Moore LB,Willson TM,Moore JT

更新日期：1999-11-01 00:00:00

abstract：:Fusarium moniliforme (FM) is a major fungal pathogen of corn and is involved with stalk rot disease. FM is widely spread throughout the world, including the United States. Most strains of FM produce several mycotoxins, the most prominent of which is called fumonisin. Recent epidemiological studies indicated that inges...

journal_title：Cancer research

authors： Huang C,Dickman M,Henderson G,Jones C

更新日期：1995-04-15 00:00:00

abstract：:Integral membrane proteins are visualized as intramembrane particles (IMP; also called membrane-associated particles) at the cleaved surfaces of freeze-fractured plasma membranes. Topographical distributions of the IMP of urothelial cell membranes in normal human bladder and for a small series of low-grade noninvasive...

journal_title：Cancer research

authors： Weinstein RS

更新日期：1976-07-01 00:00:00

abstract：:To reach a clinically detectable size, neoplasms must be able to suppress or evade a host immune response. Activated T cells may enter apoptosis in the presence of Fas ligand (FasL) (1), and tissue expression of FasL has been shown to contribute to immune privilege in the eye and testis (2, 3). We have demonstrated th...

journal_title：Cancer research

authors： Niehans GA,Brunner T,Frizelle SP,Liston JC,Salerno CT,Knapp DJ,Green DR,Kratzke RA

更新日期：1997-03-15 00:00:00

abstract：:IFN regulatory factor 8 (IRF8) is a key transcription factor for myeloid cell differentiation and its expression is frequently lost in hematopoietic cells of human myeloid leukemia patients. IRF8-deficient mice exhibit uncontrolled clonal expansion of undifferentiated myeloid cells that can progress to a fatal blast c...

journal_title：Cancer research

authors： Hu X,Yang D,Zimmerman M,Liu F,Yang J,Kannan S,Burchert A,Szulc Z,Bielawska A,Ozato K,Bhalla K,Liu K

更新日期：2011-04-15 00:00:00

abstract：:The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm2...

journal_title：Cancer research

authors： Wang L,Patel U,Ghosh L,Chen HC,Banerjee S

更新日期：1993-02-15 00:00:00

abstract：:Monoclonal antibodies (MABs) reactive with human renal cell carcinoma (RCC) were generated following immunization of mice with either RCC homogenates, RCC cell lines, or fetal kidney homogenates. The characteristics of four highly reactive immunoglobulin G1 MABs, designated UMVA-RCC-A6H, UMVA-RCC-A36, UMVA-RCC-C5H and...

journal_title：Cancer research

authors： Vessella RL,Moon TD,Chiou RK,Nowak JA,Arfman EW,Palme DF,Peterson GA,Lange PH

更新日期：1985-12-01 00:00:00

abstract：:Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular heterogeneity, it remains unclear whether CCIC within a tumor contain distinct subpopulations. Here, we describe the co-existence of ...

journal_title：Cancer research

authors： Srinivasan T,Walters J,Bu P,Than EB,Tung KL,Chen KY,Panarelli N,Milsom J,Augenlicht L,Lipkin SM,Shen X

更新日期：2016-06-01 00:00:00

abstract：:Poly (ADP-ribose) glycohydrolase (PARG) is the main enzyme responsible for catabolism of poly (ADP-ribose) (PAR), synthesized by PARP. PARG dysfunction sensitizes certain cancer cells to alkylating agents and cisplatin by perturbing the DNA damage response. The gene mutations that sensitize cancer cells to PARG dysfun...

journal_title：Cancer research

authors： Sasaki Y,Fujimori H,Hozumi M,Onodera T,Nozaki T,Murakami Y,Ashizawa K,Inoue K,Koizumi F,Masutani M

更新日期：2019-08-01 00:00:00

abstract：:Meningiomas are common tumors, representing 15% to 25% of all central nervous system tumors. NF2 gene inactivation on chromosome 22 has been shown as an early event in tumorigenesis; however, few factors underlying tumor growth and progression have been identified. The chromosomal abnormalities of 14q32 are often asso...

journal_title：Cancer research

authors： Zhang X,Gejman R,Mahta A,Zhong Y,Rice KA,Zhou Y,Cheunsuchon P,Louis DN,Klibanski A

更新日期：2010-03-15 00:00:00

abstract：:Tumor antigen-induced inhibition of leukocyte adherence was adapted and modified for use in glass test tubes for the study of cell-mediated antitumor immunity to human adenocarcinoma of the breast. Peripheral blood leukocytes from 40 to 47 patients with proven breast cancer responded to an antigenic extract of breast ...

journal_title：Cancer research

authors： Grosser N,Thomson DM

更新日期：1975-09-01 00:00:00

abstract：:The ability of interleukin-4 (IL-4) to mediate an antitumor response to human gliomas was studied in vivo in nude mice. To allow the effect of IL-4 to be exerted over a relatively short distance and at an optimal concentration, a transfected tumor cell line expressing a high level of IL-4 was used in mixed tumor trans...

journal_title：Cancer research

authors： Yu JS,Wei MX,Chiocca EA,Martuza RL,Tepper RI

更新日期：1993-07-01 00:00:00